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11.发明授权Medical device and delivery system for modification of left atrial appendage and methods thereof 有权用于修改左心耳的医疗装置和输送系统及其方法公开(公告)号：US09351716B2
公开(公告)日：2016-05-31
申请号：US13450755
申请日：2012-04-19
CPC分类号： A61B17/12122 , A61B17/00234 , A61B17/0057 , A61B17/12022 , A61B17/12172 , A61B17/12177 , A61B2017/00243 , A61B2017/00309 , A61B2017/00327 , A61B2017/0053 , A61B2017/00575 , A61B2017/0069 , A61B2017/12054
摘要： Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a delivery system for use in occluding an opening in the tissue of a body includes an actuation assembly operatively coupled to a medical device including an anchor portion and an occluder portion. The actuation assembly is configured to move the anchor portion between a deployed state and retracted state while the occluder portion maintains a deployed state. With this arrangement, the deployed occluder portion can be visualized via imaging at a preferred position prior to deploying the anchor portion of the medical device.
摘要翻译： 提供装置，方法和系统用于阻塞身体的组织内的开口，例如左心耳。 在一个实施例中，用于阻塞身体组织中的开口的输送系统包括可操作地联接到包括锚固部分和封堵器部分的医疗装置的致动组件。 致动组件构造成在封堵器部分保持展开状态的同时在展开状态和缩回状态之间移动锚定部分。 通过这种布置，在部署医疗装置的锚定部分之前，可以在优选位置处经由成像来可视化部署的封堵器部分。
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公开(公告)号：US08979941B2
公开(公告)日：2015-03-17
申请号：US11836037
申请日：2007-08-08
CPC分类号： A61B17/0057 , A61B17/0487 , A61B17/083 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00654 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884 , A61B2017/0488 , A61B2017/0496 , A61B2017/12054
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a body portion operatively associated with a first anchor and a second anchor. The body portion can include a plurality of segments defining a multi-cellular structure. The closure device can be configured to apply lateral force to tissue of the internal tissue opening to bring tissue together. The closure device can have a substantially flat aspect, and can include a member adapted to induce tissue growth. The anchors can extend from the body portion and return back to the body portion to define a closed periphery. The anchors can include undulations and can include multiple segments. A method of forming a closure device can include positioning a material on a working surface and cutting a closure device from the material.
摘要翻译： 用于治疗内部组织开口的医疗系统可以包括闭合装置和相关联的递送装置。 闭合装置可以包括与第一锚固件和第二锚固件可操作地相关联的主体部分。 身体部分可以包括限定多细胞结构的多个片段。 闭合装置可以构造成向内部组织开口的组织施加横向力以将组织带到一起。 闭合装置可以具有基本平坦的方面，并且可以包括适于诱导组织生长的构件。 锚固件可以从主体部分延伸并返回到主体部分以限定封闭的外围。 锚点可以包括起伏并且可以包括多个段。 形成闭合装置的方法可以包括将材料定位在工作表面上并从材料切割闭合装置。
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13.发明授权公开(公告)号：US08864809B2
公开(公告)日：2014-10-21
申请号：US11836013
申请日：2007-08-08
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00654 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884 , A61B2017/12054
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a multi-cellular body portion operatively associated with a first anchor and a second anchor. The closure device can be configured to apply lateral force to tissue of the internal tissue opening for tissue approximation. The closure device can also include an ingrowth material. The delivery device can include an actuating assembly configured to partially deploy the closure device by a first movement, and deploy a second portion of the closure device by a second movement. The delivery device can also include a release assembly to selectively release or disconnect the closure device from the delivery device.
摘要翻译： 用于治疗内部组织开口的医疗系统可以包括闭合装置和相关联的递送装置。 闭合装置可以包括与第一锚固件和第二锚固件可操作地相关联的多细胞主体部分。 闭合装置可以被配置为向内部组织开口的组织施加横向力用于组织近似。 闭合装置还可以包括向内生长材料。 输送装置可以包括构造成通过第一运动部分展开闭合装置的致动组件，并且通过第二运动来展开闭合装置的第二部分。 递送装置还可以包括释放组件，用于选择性地将封闭装置从输送装置释放或断开。
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14.发明授权公开(公告)号：US08840655B2
公开(公告)日：2014-09-23
申请号：US11836051
申请日：2007-08-08
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00654 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884 , A61B2017/12054
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The delivery device can include an actuating assembly configured to partially deploy the closure device by a first movement, and deploy a second portion of the closure device by a second movement. The delivery device can also include a release assembly to selectively release or disconnect the closure device from the delivery device. The delivery device can include a tip member coupled to the distal end of a catheter. The tip member can include a first passageway and a second passageway being in a spaced apart arrangement. A guidewire can be received into the first passageway to facilitate positioning of the delivery device. The second passageway can house and facilitate delivery of the closure device.
摘要翻译： 用于治疗内部组织开口的医疗系统可以包括闭合装置和相关联的递送装置。 输送装置可以包括构造成通过第一运动部分展开闭合装置的致动组件，并且通过第二运动来展开闭合装置的第二部分。 递送装置还可以包括释放组件，用于选择性地将封闭装置从输送装置释放或断开。 输送装置可以包括联接到导管的远端的尖端构件。 尖端构件可以包括第一通道和间隔开的布置的第二通道。 导丝可以被接收到第一通道中以便于输送装置的定位。 第二通道可容纳和便于封闭装置的输送。
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公开(公告)号：US08235988B2
公开(公告)日：2012-08-07
申请号：US12359223
申请日：2009-01-23
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/042 , A61B18/082 , A61B18/18 , A61B2017/00367 , A61B2017/0046 , A61B2017/00575 , A61B2017/00867 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00351 , A61B2018/00375 , A61B2018/00577 , A61B2018/00839 , A61B2018/1435 , A61M2025/0183 , A61M2025/1047 , A61M2025/1052
摘要： Embodiments of the present invention are directed to ablation catheter systems configured, for example, to ablate tissue adjacent an ostium of the pulmonary vein in a left atria of a heart. In one embodiment, an ablation catheter system includes a handle including an actuator and a catheter coupled to the handle defining a lumen extending through a length of the catheter, the catheter including a tip portion at a distal end thereof. The ablation catheter system may also include an electrode coupled to the handle with lines extending through the lumen of the catheter, the electrode being configured to be constrained within the tip portion of the catheter and configured to be deployed from the tip portion and self expand to an expanded configuration. With this arrangement, the electrode is configured to self expand to a conical configuration with a tip portion configured to be disposed within the pulmonary vein.
摘要翻译： 本发明的实施例涉及消融导管系统，其被配置为例如在心脏的左心房内消融邻近肺静脉的口的组织。 在一个实施例中，消融导管系统包括手柄，其包括致动器和联接到手柄的导管，其限定延伸穿过导管的一段长度的内腔，所述导管在其远端处包括尖端部分。 消融导管系统还可以包括连接到手柄的电极，线路延伸穿过导管的内腔，电极被配置为被限制在导管的尖端部分内并且被构造成从尖端部分展开并自我扩张到 扩展配置。 通过这种布置，电极被配置成自膨胀成圆锥形构造，其中末端部分构造成设置在肺静脉内。
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16.发明授权Methods, systems and devices for reducing the size of an internal tissue opening 有权用于减小内部组织开口尺寸的方法，系统和装置公开(公告)号：US08167894B2
公开(公告)日：2012-05-01
申请号：US11836123
申请日：2007-08-08
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/00084 , A61B2017/00407 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00619 , A61B2017/00623 , A61B2017/00654 , A61B2017/00858 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884 , A61B2017/12054
摘要： A medical system for treating an internal tissue opening can include a closure device and associated delivery device. The closure device can include a multi-cellular body portion operatively associated with a first anchor and a second anchor. The closure device can be configured to apply lateral force to tissue of the internal tissue opening for tissue approximation. The closure device can have a substantially flat aspect, and have a depth that is substantially greater than the thickness of a majority of the members forming the closure device. The closure device can also include an in-growth material. The delivery device can include an actuating assembly configured to partially deploy the closure device by a first movement, and deploy a second portion of the closure device by a second movement. The delivery device can also include a release assembly to selectively release or disconnect the closure device from the delivery device.
摘要翻译： 用于治疗内部组织开口的医疗系统可以包括闭合装置和相关联的递送装置。 闭合装置可以包括与第一锚固件和第二锚固件可操作地相关联的多细胞主体部分。 闭合装置可以被配置为向内部组织开口的组织施加横向力用于组织近似。 闭合装置可以具有基本平坦的方面，并且具有基本上大于形成闭合装置的构件的大部分的厚度的深度。 闭合装置还可以包括生长内材料。 输送装置可以包括构造成通过第一运动部分展开闭合装置的致动组件，并且通过第二运动来展开闭合装置的第二部分。 递送装置还可以包括释放组件，用于选择性地将封闭装置从输送装置释放或断开。
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公开(公告)号：US20110130619A1
公开(公告)日：2011-06-02
申请号：US12938030
申请日：2010-11-02
IPC分类号： A61M1/12
CPC分类号： A61M1/122 , A61B17/00234 , A61B17/11 , A61B2017/00243 , A61B2017/00252 , A61B2017/00292 , A61B2017/1107 , A61B2017/1135 , A61B2017/3425 , A61B2017/3484 , A61B2017/3488 , A61F2/06 , A61F2/064 , A61M1/10 , A61M1/1008 , A61M1/101 , A61M1/1086 , A61M1/12 , A61M1/125 , A61M1/127 , A61M27/002 , A61M2205/32 , A61M2205/3334
摘要： A method and system are provided for percutaneously gaining access to oxygenated blood with one or more anastomosis devices and pumping such oxygenated blood directly to the aorta adjacent to the right atrium or left atrium via a VAD system. In one embodiment, a VAD system can be implanted with open surgery.
摘要翻译： 提供了一种方法和系统，用于通过一个或多个吻合装置经皮吸收进入含氧血液，并且通过VAD系统将这些氧合血液直接泵送到与右心房或左心房相邻的主动脉。 在一个实施例中，可以用开放手术植入VAD系统。
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18.发明申请公开(公告)号：US20100324585A1
公开(公告)日：2010-12-23
申请号：US12818041
申请日：2010-06-17
IPC分类号： A61M29/00
CPC分类号： A61B17/12122 , A61B17/0057 , A61B17/12022 , A61B17/12172 , A61B17/12177 , A61B2017/00309 , A61B2017/00327 , A61B2017/00575 , A61B2017/0069 , A61B2017/12054
摘要： Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a system for use in occluding an opening in the tissue of a body includes a handle, a catheter coupled with the handle and a medical device disposed within a lumen of the catheter. The medical device includes an anchor system having a plurality of anchor segments coupled with an anchor hub. The medical device further includes an occluder system having a plurality of occluder segments coupled with an occluder hub. A first actuator is configured to displace the occluder hub independent of, and relative to, the anchor hub to deploy the occluder system from a refracted state to an expanded state while the anchor system remains in a retracted state.
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19.发明申请MEDICAL DEVICE FOR MODIFICATION OF LEFT ATRIAL APPENDAGE AND RELATED SYSTEMS AND METHODS 有权用于修改左心室附件的医疗装置及相关系统及方法公开(公告)号：US20100228285A1
公开(公告)日：2010-09-09
申请号：US12684795
申请日：2010-01-08
申请人： Scott D. Miles , Daryl R. Edmiston
发明人： Scott D. Miles , Daryl R. Edmiston
IPC分类号： A61B17/00
CPC分类号： A61B17/1215 , A61B17/00234 , A61B17/0057 , A61B17/0401 , A61B17/0487 , A61B17/06166 , A61B17/12022 , A61B17/12031 , A61B17/1204 , A61B17/12122 , A61B17/12131 , A61B17/12159 , A61B17/12172 , A61B17/122 , A61B2017/00243 , A61B2017/00526 , A61B2017/00575 , A61B2017/00579 , A61B2017/00588 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/0061 , A61B2017/00632 , A61B2017/00867 , A61B2017/00884 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0437 , A61B2017/0446 , A61B2017/0448 , A61B2017/0459 , A61B2017/0464 , A61B2017/1205 , Y10T29/49826
摘要： Medical devices, systems and methods for modifying a left atrial appendage (“LAA”). In one embodiment, a medical device system includes a jailing member or structure positioned over the ostium of an LAA and at least one tissue growth member positioned within the LAA and retained within the LAA by the jailing member. In another embodiment, a medical device includes an atrial stent coupled with a patch that is configured to cover the ostium of an LAA. The patch may have a tissue growth member associated therewith. In another embodiment, the patch may include an open-cell frame which may be used as a jailing member or structure.
摘要翻译： 用于修改左心耳（“LAA”）的医疗设备，系统和方法。 在一个实施例中，医疗装置系统包括位于LAA的口上方的锁定构件或结构，以及定位在LAA内的至少一个组织生长构件，并且由锁定构件保持在LAA内。 在另一个实施例中，医疗装置包括与构造成覆盖LAA的口的贴片配合的心房支架。 贴片可以具有与其相关联的组织生长部件。 在另一个实施例中，贴片可以包括可用作挂钩构件或结构的开放式框架。
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公开(公告)号：US20100004501A1
公开(公告)日：2010-01-07
申请号：US12436056
申请日：2009-05-05
申请人： Brian K. Whisenant , Scott D. Miles
发明人： Brian K. Whisenant , Scott D. Miles
IPC分类号： A61M1/12
CPC分类号： A61F2/06 , A61B2017/00243 , A61B2017/00252 , A61B2017/3425 , A61B2017/3484 , A61B2017/3488 , A61F2/064 , A61M27/002
摘要： A method and system are provided for percutaneously gaining access to oxygenated blood with an anastomosis device and pumping such oxygenated blood to other arterial regions of the vascular system via an LVAD system. In one embodiment, a system may include an anastomosis device extending through an opening of the atrial septum. A filament may be coupled to the anastomosis device. A snare device may access the right atrium through the superior vena cava, grasp the filament, and withdraw the filament through the superior vena cava. The filament may then be used as a guide to direct a catheter, a conduit or some other structure into the right atrium of the heart via the superior vena cava. A flow path may be defined between the anastomosis device and an arterial location, such as in the aorta, such that at least some oxygenated blood may by-pass the left ventricle and be discharged into the aorta.
摘要翻译： 提供了一种方法和系统，用于通过吻合装置经皮获得含氧血液，并经由LVAD系统将这种氧合血液泵送到血管系统的其他动脉区域。 在一个实施例中，系统可以包括延伸穿过心房隔膜的开口的吻合装置。 丝可以连接到吻合装置。 圈套装置可以通过上腔静脉进入右心房，抓住细丝，并通过上腔静脉取出细丝。 然后可以将细丝用作引导件，以将导管，导管或一些其它结构经由上腔静脉引导到心脏的右心房。 可以在吻合装置和动脉位置（例如主动脉）之间限定流动路径，使得至少一些含氧血液可以绕过左心室并排出到主动脉。
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