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18 条记录 (耗时 0.033 秒)

    DROSOPHILA G PROTEIN COUPLED RECEPTORS, NUCLEIC ACIDS, AND MEHTODS RELATED TO THE SAME
    12.
    发明申请
    DROSOPHILA G PROTEIN COUPLED RECEPTORS, NUCLEIC ACIDS, AND MEHTODS RELATED TO THE SAME 审中-公开
    DROSOPHILA G蛋白偶联受体，核酸和与其相关的酶

    公开(公告)号：US20080241961A1

    公开(公告)日：2008-10-02

    申请号：US12032029

    申请日：2008-02-15

    申请人： David E. Lowery ,  Valdin G. Smith ,  Teresa M. Kubiak ,  Martha J. Larsen

    发明人： David E. Lowery ,  Valdin G. Smith ,  Teresa M. Kubiak ,  Martha J. Larsen

    IPC分类号： G01N33/566

    CPC分类号： C07K14/705 ,  C12N2799/021

    摘要： The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.

    摘要翻译： 本发明提供了一种果蝇黑腹果蝇GPCR（DmGPCR）多肽和鉴定和编码这种DmGPCR的多核苷酸。 此外，本发明提供表达载体，宿主细胞及其生产方法。 本发明还提供了用于鉴定其他动物和DmGPCR激动剂/拮抗剂的同系物的方法，其用于治疗动物疾病和控制对植物或动物有害或有害的昆虫。

    G protein-coupled receptor-like receptors and modulators thereof
    13.
    发明授权
    G protein-coupled receptor-like receptors and modulators thereof 失效
    G蛋白偶联受体样受体及其调节剂

    公开(公告)号：US06632621B1

    公开(公告)日：2003-10-14

    申请号：US09721870

    申请日：2000-11-24

    申请人： David E. Lowery ,  Timothy G. Geary ,  Teresa M. Kubiak ,  Martha J. Larsen

    发明人： David E. Lowery ,  Timothy G. Geary ,  Teresa M. Kubiak ,  Martha J. Larsen

    IPC分类号： G01N33569

    CPC分类号： C07K14/70571

    摘要： The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.

    摘要翻译： 本发明提供神经肽配体，G蛋白偶联受体和筛选受体活性调节剂的方法。 鉴定的调节剂，包括神经肽配体模拟物，可用作不同范围的生物杀灭剂和杀生物剂，范围从限制于特定无脊椎寄生虫的致死活性到广泛无脊椎动物（包括蠕虫和昆虫）活性的广谱无脊椎寄生虫寄生虫。

    Methods of vaccine administration, new feline caliciviruses, and treatments for immunizing animals against feline paraovirus and feline herpes virus
    15.
    发明授权
    Methods of vaccine administration, new feline caliciviruses, and treatments for immunizing animals against feline paraovirus and feline herpes virus 有权
    疫苗施用方法，新的猫科动物病毒和用于免疫动物抗猫病毒和猫疱疹病毒的治疗

    公开(公告)号：US07790169B2

    公开(公告)日：2010-09-07

    申请号：US11494825

    申请日：2006-07-28

    申请人： David E. Lowery ,  Sing Rong ,  Paul M. Guimond ,  Paula M. Clare ,  Cassius M. Tucker ,  Thomas Jack Newby

    发明人： David E. Lowery ,  Sing Rong ,  Paul M. Guimond ,  Paula M. Clare ,  Cassius M. Tucker ,  Thomas Jack Newby

    IPC分类号： A61A35/00 ,  C12N7/00

    CPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2750/10034 ,  C12N2750/14334 ,  C12N2770/16021 ,  C12N2770/16022 ,  C12N2770/16034 ,  G01N33/56983 ,  G01N2469/10

    摘要： The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus. Also disclosed is a method of immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of first and second FCV vaccines. The first vaccine is administered orally or parenterally (e.g., subcutaneously, intramuscularly, and the like). The second vaccine is administered orally or oronasally N days following administration of the first vaccine, wherein N is an integer from 3 to 120, inclusive. A third vaccine administration may also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccine, and in particular cats against both FPV or Feline Parvovirus, which has also been called Panleukopenia or FPL and against another disease, FHV or Feline Herpes Virus, which has also been called Feline Rhinotracheitis Virus.

    摘要翻译： 本发明涉及用于免疫猫对猫科动物病毒的疫苗。 本发明还涉及编码分离的猫杯状病毒的衣壳蛋白的核酸克隆。 本发明还涉及包含分离的猫杯状病毒的活的或杀死的疫苗，包含分离的猫杯状病毒的衣壳蛋白的亚单位疫苗，包含分离的猫杯状病毒的核酸克隆的核酸疫苗和重组病毒载体 包含编码分离的猫杯状病毒的衣壳蛋白的核酸的疫苗。 本发明还涉及用于鉴定可用于产生疫苗组合物的猫杯状病毒病的方法和用于诊断感染猫杯状病毒的猫的测定方法。 还公开了免疫动物特别是猫的疾病，特别是针对猫杯状病毒（FCV）的方法。 该方法包括给予猫治疗有效量的第一和第二FCV疫苗。 第一种疫苗口服或肠胃外给药（例如皮下，肌肉内等）。 第二种疫苗在第一种疫苗给药后N天口服或鼻道给药，其中N为3至120的整数，包括端值在内。 也可以给予第三次疫苗管理。 本发明还描述了用疫苗治疗和免疫动物的方法和材料，特别是针对FPV或猫细小病毒的猫，其也称为泛素减少或FPL，并且与另一种疾病FHV或猫疱疹病毒 称为猫科鼻气管炎病毒。

    Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
    16.
    发明授权
    Drosophila G protein coupled receptors, nucleic acids, and methods related to the same 失效
    果蝇G蛋白偶联受体，核酸和与之相关的方法

    公开(公告)号：US07364866B2

    公开(公告)日：2008-04-29

    申请号：US10213821

    申请日：2002-08-06

    申请人： David E. Lowery ,  Valdin G. Smith ,  Teresa M. Kubiak ,  Martha J. Larsen

    发明人： David E. Lowery ,  Valdin G. Smith ,  Teresa M. Kubiak ,  Martha J. Larsen

    IPC分类号： G01N33/53 ,  C12N5/06 ,  C12N5/00 ,  C07K1/00 ,  C07K5/00

    CPC分类号： C07K14/705 ,  C12N2799/021

    摘要： The present invention provides Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells, and methods for its production. The invention also provides methods for the identification of homologs in other species and of DmGPCR agonists/antagonists useful as potential insecticides. The invention further provides methods for binding a DmGPCR, methods for identifying modulators of DmGPCR expression and activity, methods for controlling a population of insects with a DmGPCR antibody, a DmGPCR antisense polynucleotide, a DmGPCR binding partner or modulator, and methods of preventing or treating a disease or condition associated with an ectoparasite. Specifically, this invention discloses the matching of the orphan Drosophila drotachykinin, droleucokinin, and drostatin-C receptors with their cognate peptide ligands.

    摘要翻译： 本发明提供了果蝇黑腹果蝇GPCR（DmGPCR）多肽和鉴定和编码这种DmGPCR的多核苷酸。 此外，本发明提供表达载体，宿主细胞及其生产方法。 本发明还提供了用于鉴定其他物种中的同源物的方法和用作潜在杀虫剂的DmGPCR激动剂/拮抗剂。 本发明还提供了用于结合DmGPCR的方法，用于鉴定DmGPCR表达和活性的调节剂的方法，用DmGPCR抗体，DmGPCR反义多核苷酸，DmGPCR结合配偶体或调节剂控制昆虫群体的方法，以及预防或治疗方法 与外寄生物相关的疾病或病症。 具体地说，本发明公开了孤儿果蝇的洛匹心碱，泪果状蛋白和抑制素-C受体与其同源肽配体的匹配。

    Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
    17.
    发明授权
    Drosophila G protein coupled receptors, nucleic acids, and methods related to the same 失效
    果蝇G蛋白偶联受体，核酸和与之相关的方法

    公开(公告)号：US07354724B2

    公开(公告)日：2008-04-08

    申请号：US10736048

    申请日：2003-12-15

    申请人： David E. Lowery ,  Valdin G. Smith ,  Teresa M. Kubiak ,  Martha J. Larsen

    发明人： David E. Lowery ,  Valdin G. Smith ,  Teresa M. Kubiak ,  Martha J. Larsen

    IPC分类号： G01N33/53 ,  G01N33/566

    CPC分类号： C07K14/705 ,  C12N2799/021

    摘要： The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.

    摘要翻译： 本发明提供了一种果蝇黑腹果蝇GPCR（DmGPCR）多肽和鉴定和编码这种DmGPCR的多核苷酸。 此外，本发明提供表达载体，宿主细胞及其生产方法。 本发明还提供了用于鉴定其他动物和DmGPCR激动剂/拮抗剂的同系物的方法，其用于治疗动物疾病和控制对植物或动物有害或有害的昆虫。

    METHODS OF VACCINE ADMINISTRATION, NEW FELINE CALICIVIRUSES, AND TREATMENTS FOR IMMUNIZING ANIMALS AGAINST FELINE PARAOVIRUS AND FELINE HERPES VIRUS
    18.
    发明申请
    METHODS OF VACCINE ADMINISTRATION, NEW FELINE CALICIVIRUSES, AND TREATMENTS FOR IMMUNIZING ANIMALS AGAINST FELINE PARAOVIRUS AND FELINE HERPES VIRUS 有权
    疫苗管理方法，新疫苗药物和用于免疫动物疫苗的疫苗和疫苗病毒的治疗方法

    公开(公告)号：US20110052619A1

    公开(公告)日：2011-03-03

    申请号：US12824287

    申请日：2010-06-28

    申请人： David E. Lowery ,  Sing Rong ,  Paul M. Guimond ,  Paula M. Clare ,  Cassius M. Tucker ,  Thomas Jack Newby

    发明人： David E. Lowery ,  Sing Rong ,  Paul M. Guimond ,  Paula M. Clare ,  Cassius M. Tucker ,  Thomas Jack Newby

    IPC分类号： A61K39/125 ,  A61P31/14

    CPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2750/10034 ,  C12N2750/14334 ,  C12N2770/16021 ,  C12N2770/16022 ,  C12N2770/16034 ,  G01N33/56983 ,  G01N2469/10

    摘要： The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus. Also disclosed is a method of immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of first and second FCV vaccines. The first vaccine is administered orally or parenterally (e.g., subcutaneously, intramuscularly, and the like). The second vaccine is administered orally or oronasally N days following administration of the first vaccine, wherein N is an integer from 3 to 120, inclusive. A third vaccine administration may also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccine, and in particular cats against both FPV or Feline Parvovirus, which has also been called Panleukopenia or FPL and against another disease, FHV or Feline Herpes Virus, which has also been called Feline Rhinotracheitis Virus.

    摘要翻译： 本发明涉及用于免疫猫对猫科动物病毒的疫苗。 本发明还涉及编码分离的猫杯状病毒的衣壳蛋白的核酸克隆。 本发明还涉及包含分离的猫杯状病毒的活的或杀死的疫苗，包含分离的猫杯状病毒的衣壳蛋白的亚单位疫苗，包含分离的猫杯状病毒的核酸克隆的核酸疫苗和重组病毒载体 包含编码分离的猫杯状病毒的衣壳蛋白的核酸的疫苗。 本发明还涉及用于鉴定可用于产生疫苗组合物的猫杯状病毒病的方法和用于诊断感染猫杯状病毒的猫的测定方法。 还公开了免疫动物特别是猫的疾病，特别是针对猫杯状病毒（FCV）的方法。 该方法包括给予猫治疗有效量的第一和第二FCV疫苗。 第一种疫苗口服或肠胃外给药（例如皮下，肌肉内等）。 第二种疫苗在第一种疫苗给药后N天口服或鼻道给药，其中N为3至120的整数，包括端值在内。 也可以给予第三次疫苗管理。 本发明还描述了用疫苗治疗和免疫动物的方法和材料，特别是针对FPV或猫细小病毒的猫，其也称为泛素减少或FPL，并且与另一种疾病FHV或猫疱疹病毒 称为猫科鼻气管炎病毒。