公开(公告)号：US20080228240A1

公开(公告)日：2008-09-18

申请号：US11629257

申请日：2005-06-15

申请人： David J. Edell ,  Ronald R. Riso

发明人： David J. Edell ,  Ronald R. Riso

IPC分类号： A61N1/05

CPC分类号： A61B5/04888 ,  A61B5/0031 ,  A61B5/4047 ,  A61B5/4052 ,  A61B5/4528

摘要： A long term bi-directional axon-electronic communication system that provides signaling capability at the level of individual nerve fascicles, bundles of axon and even axons is disclosed. The bi-directional communication system is a modular approach for achieving a chronic enduring interface to peripheral or central nerve atoms for the purpose of restoring function to disabled persons or animals with sensory and/or motor impairments. One embodiment of the communication system includes a multi-channeled nerve-muscle graft chamber for making the nerve-muscle connection. Another embodiment includes a regeneration based microtube nerve interface for bi-directional communication. The interface communication system permits amputees to obtain simultaneous control of multi-degree of freedom powered prostheses by means of naturally produced neural activity from the stamps of the amputated nerves in their residual limbs.

摘要翻译： 公开了一种长期的双向轴突电子通信系统，其在单个神经束集，轴突束和甚至轴突的水平提供信号传导能力。 双向通信系统是用于实现与周围或中枢神经原子的长期持久接口的模块化方法，以便恢复具有感觉和/或运动障碍的残疾人或动物的功能。 通信系统的一个实施例包括用于产生神经 - 肌肉连接的多通道神经 - 肌肉移植室。 另一个实施例包括用于双向通信的基于再生的微管神经接口。 接口通信系统允许被截肢者通过在其残肢中被截肢的神经的邮票自然产生的神经活动来同时控制多自由度动力假体。

公开(公告)号：US06898464B2

公开(公告)日：2005-05-24

申请号：US09969871

申请日：2001-10-03

申请人： David J. Edell ,  Bruce C. Larson ,  Sean V. Sexton

发明人： David J. Edell ,  Bruce C. Larson ,  Sean V. Sexton

IPC分类号： A61B5/00 ,  A61N1/08 ,  A61N1/372 ,  H04B10/00 ,  A61N1/36

CPC分类号： A61B5/0017 ,  A61B5/0002 ,  A61B5/0028 ,  A61N1/08 ,  H04B10/807 ,  Y10S128/903

摘要： An apparatus and corresponding method for providing data communications to and from a location within a body cavity in which an internal transmitter receives a first data stream from an in vivo sensor, electrode, or transducer. The internal transmitter is configured and arranged to asynchronously modulate the first data stream and to provide as an output a first optical signal carrying the asynchronously modulated first data stream. The apparatus further includes an external receiver that is configured and arranged external to the body cavity such that an optical input to the external receiver is optically coupled to the internal transmitter output and receives the optical signal therefrom. The external receiver asynchronously demodulates the received optical signal and provides as an output at least one signal indicative of the first data stream.

摘要翻译： 一种用于向体腔内的位置提供数据通信的装置和相应方法，其中内部发射器从体内传感器，电极或换能器接收第一数据流。 内部发射机被配置和布置成异步地调制第一数据流并提供携带异步调制的第一数据流的第一光信号作为输出。 该装置还包括外部接收器，其被配置和布置在体腔外部，使得到外部接收器的光输入被光耦合到内部发射器输出并从其接收光信号。 外部接收机异步地解调所接收的光信号，并提供指示第一数据流的至少一个信号作为输出。

公开(公告)号：US5078137A

公开(公告)日：1992-01-07

申请号：US859453

申请日：1986-05-05

申请人： David J. Edell ,  Stephen K. Burns ,  Harry F. Bowman ,  James C. Weaver

发明人： David J. Edell ,  Stephen K. Burns ,  Harry F. Bowman ,  James C. Weaver

IPC分类号： A61B5/00 ,  A61B5/01 ,  G01K1/02 ,  G01K3/14

CPC分类号： A61B5/14542 ,  A61B5/01 ,  A61B5/1473 ,  G01K1/026 ,  G01K3/14

摘要： A probe adapted for insertion in living tissue for measuring oxygen partial pressure and temperature at a plurality of sites in living tissue is provided. A temperature sensitive resistor is positioned adjacent each of a plurality of oxygen sensors so that the oxygen partial pressure measured can be adjusted for tissue temperature. The probe substrate has thermal properties similar to living tissue and the resistors are formed of a material having a temperature sensitive resistance. Temperature at each temperature sensitive resistor is obtained by measuring resistance with a four point measurement and correlating the resistance to temperature.

摘要翻译： 提供了适于在生物体组织中插入用于测量活组织中多个部位的氧分压和温度的探针。 温度敏感电阻器位于多个氧传感器中的每一个附近，使得可以针对组织温度调节测量的氧分压。 探针基板具有与活体组织相似的热性质，并且电阻由具有耐温敏性的材料形成。 每个温度敏感电阻器的温度通过用四点测量测量电阻并将其与温度相关联来获得。

公开(公告)号：US5045151A

公开(公告)日：1991-09-03

申请号：US422540

申请日：1989-10-17

申请人： David J. Edell

发明人： David J. Edell

IPC分类号： H01L23/29 ,  H01L23/31 ,  H01L23/49

CPC分类号： H01L24/05 ,  H01L23/293 ,  H01L23/3157 ,  H01L23/3178 ,  H01L24/03 ,  H01L24/48 ,  H01L2224/04042 ,  H01L2224/05082 ,  H01L2224/05181 ,  H01L2224/05552 ,  H01L2224/05644 ,  H01L2224/05669 ,  H01L2224/45144 ,  H01L2224/48463 ,  H01L2224/4847 ,  H01L2224/48644 ,  H01L2224/85205 ,  H01L2224/8592 ,  H01L24/45 ,  H01L2924/01006 ,  H01L2924/01014 ,  H01L2924/01023 ,  H01L2924/01027 ,  H01L2924/01029 ,  H01L2924/01055 ,  H01L2924/01072 ,  H01L2924/01073 ,  H01L2924/01074 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/05042 ,  H01L2924/10253 ,  H01L2924/14

摘要： A method of encapsulating a lead bonding pad region of an integrated circuit (such as a sensor used in an implantable medical device) is disclosed. The excapsulant (such as Teflon.TM.-TFE) is mechanically gripped on the surface of the circuit by anchor interlock portions which are held in undercut grooves, micromachined, in a predefined pattern, in the circuit substrate. The encapsulant is held down by the portions in the grooves, forms a tight mechanical seal with the substrate surface and with the insulation around an attached lead, and blocks intrusion of contaminants along the surfaces between these materials or through the encapsulant.

摘要翻译： 公开了一种封装集成电路（例如在可植入医疗装置中使用的传感器）的引线焊盘区域的方法。 通过固定在互锁部分的电路基板上以预定图案微机械地保持在底切凹槽中的方式将排除器（例如Teflon TM-TFE）机械地夹持在电路表面上。 密封剂被凹槽中的部分压住，与衬底表面形成紧密的机械密封，并且在附着的引线周围形成绝缘体，并且阻止污染物沿着这些材料之间的表面或通过密封剂的侵入。

公开(公告)号：US4955380A

公开(公告)日：1990-09-11

申请号：US285010

申请日：1988-12-15

申请人： David J. Edell

发明人： David J. Edell

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/1486

CPC分类号： A61B5/14542 ,  A61B5/1473

摘要： Flexible measurement probes are described for the determination of oxygen partial pressure; temperature and perfusion; and combined measurement of oxygen partial pressure, temperature, and perfusion. The probes are fabricated by patterning a metal coated substrate to form a conductive pattern of ribbon leads, insulating the conductive ribbon leads except for contact openings, and then attaching sensors to the conductive ribbon leads through noble metal plated open contacts. The plated contacts may be used directly to measure oxygen partial pressure.

摘要翻译： 描述了用于测定氧分压的柔性测量探针; 温度和灌注量; 并测量氧分压，温度和灌注。 通过图案化金属涂覆的基底以形成带状引线的导电图案，绝缘除了接触开口之外的导电带引线，然后将传感器附接到通过贵金属电镀的开放触点的导电带引线来制造探针。 电镀触点可以直接用于测量氧分压。

公开(公告)号：US4741343A

公开(公告)日：1988-05-03

申请号：US945120

申请日：1986-12-22

申请人： H. Frederick Bowman ,  Stephen K. Burns ,  David J. Edell ,  James C. Weaver

发明人： H. Frederick Bowman ,  Stephen K. Burns ,  David J. Edell ,  James C. Weaver

IPC分类号： A61B5/00 ,  A61B5/01 ,  G01K7/22 ,  G01N25/18 ,  A61N1/40

CPC分类号： A61B5/14542 ,  A61B5/01 ,  A61B5/1473 ,  G01K7/22 ,  G01N25/18

摘要： Oxygen partial pressure and temperature are measured in living tissue by inserting a thin probe into living tissue. The probe includes a plurality of spatially separated thermal sensors secured to the probe substrate. A plurality of oxygen sensors is positioned along the length of the probe substrate and each oxygen sensor is associated with and positioned adjacent to or is an integral part of one of the thermal sensors. Electrical parameters of the sensors located on the probe are measured and used to determine oxygen partial pressure and to determine temperature at each of a plurality of sites along the probe.

摘要翻译： 通过将薄探针插入活体组织，在生物体组织中测量氧分压和温度。 探针包括固定到探针基底的多个空间分离的热传感器。 多个氧传感器沿着探针基板的长度定位，并且每个氧传感器与热传感器中的一个相关联并定位成邻近或者是其中一个的传感器的组成部分。 测量位于探头上的传感器的电气参数，并用于确定氧气分压并确定探头沿着多个位置的每个位置处的温度。