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    (4-alkoxypyran-4-yl) substituted arylalkylaryl-, aryalkenylaryl-, and aryalkynylarylurea inhibitors of 5-lipoxygenase
    13.
    发明授权
    (4-alkoxypyran-4-yl) substituted arylalkylaryl-, aryalkenylaryl-, and aryalkynylarylurea inhibitors of 5-lipoxygenase 失效
    （4-烷氧基吡喃-4-基）取代的芳基烷基芳基 - 芳烯基芳基和芳氧基炔基芳基脲抑制剂5-脂氧合酶

    公开(公告)号：US5432194A

    公开(公告)日：1995-07-11

    申请号：US236001

    申请日：1994-05-09

    申请人： Joseph F. Dellaria ,  Anwer Basha ,  Lawrence A. Black ,  Linda J. Chernesky ,  Wendy Lee

    发明人： Joseph F. Dellaria ,  Anwer Basha ,  Lawrence A. Black ,  Linda J. Chernesky ,  Wendy Lee

    IPC分类号： C07D309/12 ,  C07D405/12 ,  A61K31/35 ,  C07D309/10

    CPC分类号： C07D405/12 ,  C07D309/12

    摘要： Compounds of the structure ##STR1## wherein W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.6 and R.sup.7 are hydrogen or alkyl, or R.sup.6 and R.sup.7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## R.sup.8 is selected from hydrogen, alkyl, haloalkyl, optionally substituted phenyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, (alkoxycarbonyl)alkyl, and (alkylaminocarbonyl)alkyl; Z is --CH.sub.2 --, oxygen, sulfur, or --NR.sup.9 where R.sup.9 is hydrogen or alkyl, L.sup.1 and L.sup.2 are selected from a valence bond, alkylene, propenylene, and propynylene, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from alkyl, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is selected from oxygen, --NR.sup.10, where R.sup.10 is hydrogen or alkyl, and ##STR4## where n=0, 1, or 2, and R.sup.5 is alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

    摘要翻译： 其中W选自其中Q是氧或硫的结构的化合物，R6和R7是氢或烷基，或R6和R7与它们所连接的氮原子一起定义为 烷基，卤代烷基，任选取代的苯基，羟基烷基，氨基烷基，羧基烷基，（烷氧基羰基）烷基和（烷基氨基羰基）烷基; Z是-CH 2 - ，氧，硫或-NR 9，其中R 9是氢或烷基，L 1和L 2选自价键，亚烷基，亚丙烯基和亚丙炔基，R 1，R 2，R 3和R 4独立地选自烷基 卤素，卤素，氰基，氨基，烷氧基羰基和二烷基氨基羰基，Y选自氧，-NR10，其中R10是氢或烷基，和其中n = 0,1或2，R5是烷基，抑制 白三烯的生物合成。 这些化合物可用于治疗或改善过敏性和炎性疾病状态。

    Pyran-4-ylmethyl substituted arylalkylaryl-, arylalkenylylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase
    17.
    发明授权
    Pyran-4-ylmethyl substituted arylalkylaryl-, arylalkenylylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase 失效
    吡喃-4-基甲基取代的芳烷基芳基 - ，芳基烯基芳基 - 和芳基炔基芳基脲抑制剂5-脂氧合酶

    公开(公告)号：US5484786A

    公开(公告)日：1996-01-16

    申请号：US111090

    申请日：1993-08-24

    申请人： Joseph F. Dellaria ,  Anwer Basha ,  Lawrence A. Black ,  Linda J. Chernesky ,  Wendy Lee

    发明人： Joseph F. Dellaria ,  Anwer Basha ,  Lawrence A. Black ,  Linda J. Chernesky ,  Wendy Lee

    IPC分类号： C07D309/04 ,  C07D309/06 ,  C07D405/12 ,  A61K31/35 ,  A61K31/495 ,  C07D239/04 ,  C07D315/00

    CPC分类号： C07D405/12 ,  C07D309/04 ,  C07D309/06

    摘要： Compounds of structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.5 and R.sup.6 are independently selected from hydrogen and alkyl, or R.sup.5 and R.sup.6, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## L.sup.1 and L.sup.2 are independently selected from a valence bond, alkylene, propenylene, and propynylene, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is oxygen, >NR.sup.9 where R.sup.9 is hydrogen or alkyl, or ##STR4## where n=0, 1, or 2, and A is selected from ##STR5## inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

    摘要翻译： 其中W选自 的结构的化合物，其中Q是氧或硫，R5和R6独立地选自氢和烷基，或R5和R6连同它们所连接的氮原子 定义式为基团的基团，L1和L2独立地选自价键，亚烷基，亚丙烯基和亚丙炔基，R 1，R 2，R 3和R 4独立地选自烷基，烷氧基，卤代烷基，卤素，氰基，氨基 ，烷氧基羰基和二烷基氨基羰基，Y是氧，NR9，其中R9是氢或烷基，或者其中n = 0,1或2的A，并且A选自抑制白细胞三烯的生物合成。 这些化合物可用于治疗或改善过敏性和炎性疾病状态。

    (4-alkoxypyran-4-yl) substituted arylalkylaryl-, arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase
    19.
    发明授权
    (4-alkoxypyran-4-yl) substituted arylalkylaryl-, arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase 失效
    （4-烷氧基吡喃-4-基）取代的芳烷基芳基 - ，芳基烯基芳基 - 和芳基炔基芳基脲抑制剂5-脂氧合酶

    公开(公告)号：US5346914A

    公开(公告)日：1994-09-13

    申请号：US61988

    申请日：1993-05-14

    申请人： Joseph F. Dellaria ,  Anwer Basha ,  Lawrence A. Black ,  Linda J. Dorn ,  Wendy Lee

    发明人： Joseph F. Dellaria ,  Anwer Basha ,  Lawrence A. Black ,  Linda J. Dorn ,  Wendy Lee

    IPC分类号： C07D309/12 ,  C07D405/12 ,  A61K31/35 ,  A61K31/415 ,  A61K31/495 ,  C07D309/10 ,  C07D405/10

    CPC分类号： C07D405/12 ,  C07D309/12

    摘要： Compounds of the structure ##STR1## wherein W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.6 and R.sup.7 are hydrogen or alkyl, or R.sup.6 and R.sup.7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## R.sup.8 is selected from hydrogen, alkyl, haloalkyl, optionally substituted phenyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, (alkoxycarbonyl)alkyl, and (alkylaminocarbonyl)alkyl; Z is --CH.sub.2 --, oxygen, sulfur, or --NR.sup.9 where R.sup.9 is hydrogen or alkyl, L.sup.1 and L.sup.2 are selected from a valence bond, alkylene, propenylene, and propynylene, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from alkyl, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is selected from oxygen, --NR.sup.10, where R.sup.10 is hydrogen or alkyl, and ##STR4## where n=0, 1, or 2, and R.sup.5 is alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

    摘要翻译： 其中W选自其中Q是氧或硫的结构的化合物，R6和R7是氢或烷基，或R6和R7与它们所连接的氮原子一起定义为 烷基，卤代烷基，任选取代的苯基，羟基烷基，氨基烷基，羧基烷基，（烷氧基羰基）烷基和（烷基氨基羰基）烷基; Z是-CH 2 - ，氧，硫或-NR 9，其中R 9是氢或烷基，L 1和L 2选自价键，亚烷基，亚丙烯基和亚丙炔基，R 1，R 2，R 3和R 4独立地选自烷基 卤素，卤素，氰基，氨基，烷氧基羰基和二烷基氨基羰基，Y选自氧，-NR10，其中R10是氢或烷基，和其中n = 0,1或2，R5是烷基，抑制 白三烯的生物合成。 这些化合物可用于治疗或改善过敏性和炎性疾病状态。