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    Device for collection and assay of oral fluids
    11.
    发明授权
    Device for collection and assay of oral fluids 有权
    用于收集和测定口腔液的装置

    公开(公告)号：US08062908B2

    公开(公告)日：2011-11-22

    申请号：US12350488

    申请日：2009-01-08

    申请人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

    发明人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

    IPC分类号： G01N33/53

    CPC分类号： A61B10/0051 ,  A61B2010/0006 ,  G01N30/90 ,  Y10S435/974 ,  Y10S436/81

    摘要： A method for rapid collection and assay of oral fluids is disclosed. The method comprising the steps of: (a) placing an assay device into an oral cavity, (b) removing said assay device from said oral cavity; and (c) determining the presence or absence of at least one analyte. The assay device used in the method comprises: (i) an assay portion housing an immunochrornatographic lateral flow assay strip, the lateral flow assay strip containing at least one reagent selected from an antigen and an antibody that is used to detect one of the presence or absence of at least one analyte in a fluid; (ii) a neck portion extending from the assay portion, the neck portion forming a channel for delivery of fluid to said assay strip and the channel being defined by a first, narrow part proximal to the assay portion and a second part including an opening for receiving the oral fluid, wherein the second part includes a channel width that is substantially wider than the channel width at the narrow end; (iii) a collection strip in fluid communication with the lateral flow assay strip, the collection strip having a first portion disposed within the channel and a second portion protruding outwardly from the neck portion opening; and (iv) a blocking strip coupled between and in flow communication with the lateral flow assay strip and the collection strip.

    摘要翻译： 公开了一种用于快速收集和测定口腔液体的方法。 该方法包括以下步骤：（a）将测定装置放入口腔，（b）从所述口腔中除去所述测定装置; 和（c）确定至少一种分析物的存在或不存在。 该方法中使用的测定装置包括：（i）容纳免疫色谱横向测定条的测定部分，所述侧流测定条含有至少一种选自抗原和抗体的试剂，所述试剂用于检测其中的一种存在或 在流体中不存在至少一种分析物; （ii）从分析部分延伸的颈部，颈部形成用于将流体输送到所述测定条的通道，并且所述通道由靠近测定部分的第一窄部分限定，第二部分包括用于 接收所述口腔流体，其中所述第二部分包括基本上宽于所述狭窄端处的通道宽度的通道宽度; （iii）与所述侧流测定条流体连通的收集条，所述收集条具有设置在所述通道内的第一部分和从所述颈部开口向外突出的第二部分; 和（iv）连接在侧流测定条和收集条之间并与其流动连通的阻挡条。

    COLLECTION DEVICE FOR ASSAY OF ORAL FLUIDS
    12.
    发明申请
    COLLECTION DEVICE FOR ASSAY OF ORAL FLUIDS 审中-公开
    用于测定口腔液的收集装置

    公开(公告)号：US20100239458A1

    公开(公告)日：2010-09-23

    申请号：US12544333

    申请日：2009-08-20

    申请人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

    发明人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

    IPC分类号： G01N30/88 ,  G01N31/22

    CPC分类号： G01N33/558 ,  B01L3/5023 ,  B01L2300/0825 ,  B01L2300/12 ,  B01L2400/0406 ,  G01N30/91

    摘要： An apparatus and process for transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. A lateral chromatographic strip is placed within a cavity defined in a housing. The lateral chromatography strip extends within the cavity and is disposed along the housing to an inspection site. At least one inspection site to the lateral chromate phic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. This porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. By observing the lateral chromatographic strip while the entire test device is in the mouth immediate test results are obtained.

    摘要翻译： 公开了一种用于将水性流体从口腔输送到用于测试的侧向色谱条的装置和方法。 侧向色谱条被放置在限定在壳体中的空腔内。 侧向色谱条在腔内延伸并且沿着壳体设置到检查位置。 提供至少一个侧向铬酸盐条带的检查部位，以便检查侧向色谱条上的选定部位以进行测试。 多孔芯材料在一端从外壳突出到外壳的收集位置，并在另一端与侧向色谱条连通。 该多孔芯材料具有颗粒结构，该颗粒吸附口腔液体水以将流体从嘴部输送到侧向色谱条而无需实质的吸收。 多孔芯材料的颗粒被结合在一起以限定用于要输送的口腔液体的流动的连续间隙体积，并被处理为与吸附的口腔液体亲水。 多孔芯材料容易地将口腔液体释放到侧向色谱条上。 由于多孔芯材料的迂回流动路径，防止从侧向色谱条带逆向流入口腔。 通过在整个测试装置处于口中立即测试结果，观察侧向色谱条。

    Simultaneous collection of DNA and non-nucleic analytes
    13.
    发明授权
    Simultaneous collection of DNA and non-nucleic analytes 失效
    同时收集DNA和非核酸分析物

    公开(公告)号：US06309827B1

    公开(公告)日：2001-10-30

    申请号：US09049714

    申请日：1998-03-27

    申请人： Andrew S. Goldstein ,  Richard K. Bestwick

    发明人： Andrew S. Goldstein ,  Richard K. Bestwick

    IPC分类号： C12G168

    CPC分类号： C12Q1/6806 ,  C12N15/1006 ,  C12Q1/6883 ,  C12Q1/703 ,  C12Q2600/156 ,  Y10S436/811 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/2525 ,  Y10T436/25375 ,  C12Q2565/625

    摘要： This invention provides for a rapid and convenient method of simultaneous collection of both genomic and diagnostic information from a single sample on a bibulous pad by differential extraction of the diagnostic information from the genomic information. It is a surprising discovery of this invention that a PCR assay on the contents of the bibulous pad provides results comparable in reliability, specificity, and sensitivity to the best available serum (blood) based assays. The assays of this invention can be used to confirm each other, either by detecting the genomic information leading to the diagnostic information, or by detecting in the genomic information, a predisposition to a disease and confirming the presence of the disease through diagnostic testing.

    摘要翻译： 本发明提供了一种通过从基因组信息中差异提取诊断信息来同时收集来自吸收垫上的单个样品的基因组和诊断信息的快速和方便的方法。 对本发明的令人惊讶的发现是，针对吸水垫的内容物的PCR测定提供了与基于最佳可用血清（血液）测定法的可靠性，特异性和灵敏度相当的结果。 本发明的测定可以通过检测导致诊断信息的基因组信息，或者通过在基因组信息中检测疾病的易感性并通过诊断测试来确认疾病的存在来用于彼此确认。

    DIAGNOSTIC DEVICE AND METHOD FOR SENSING HYDRATION STATE OF A MAMMALIAN SUBJECT
    16.
    发明申请
    DIAGNOSTIC DEVICE AND METHOD FOR SENSING HYDRATION STATE OF A MAMMALIAN SUBJECT 失效
    诊断装置和感染MAMMALIAN主题水文状态的方法

    公开(公告)号：US20120083711A1

    公开(公告)日：2012-04-05

    申请号：US13249521

    申请日：2011-09-30

    申请人： Andrew S. Goldstein ,  Frank Bellizzi

    发明人： Andrew S. Goldstein ,  Frank Bellizzi

    IPC分类号： A61B5/00

    CPC分类号： A61B5/4875 ,  A61B5/4277 ,  A61B5/4848 ,  A61B5/682 ,  A61B10/0051 ,  A61B2562/0209 ,  A61B2562/029 ,  G01N33/48707

    摘要： Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.

    摘要翻译： 在预定体积容量的液体收集元件中收集唾液的定时感测可以用于确定唾液分泌速率，这可以指示脱水或脱水的状态。 通过感测唾液中至少一种分析物的浓度（例如，通过在侧流装置中进行的免疫色谱测定）来进一步增强唾液流速的感测，以便确定脱水或脱水的状态。 可以刺激唾液的产生，并且可以分析收集的唾液以产生指示所收集的唾液中至少一种分析物的浓度的存在和/或相关性的分析物检测信号，以感测脱水或脱水的状态。

    Device for collection and assay of oral fluids
    17.
    发明授权
    Device for collection and assay of oral fluids 有权
    用于收集和测定口腔液的装置

    公开(公告)号：US06303081B1

    公开(公告)日：2001-10-16

    申请号：US09292293

    申请日：1999-04-15

    申请人： Ronald W. Mink ,  Andrew S. Goldstein

    发明人： Ronald W. Mink ,  Andrew S. Goldstein

    IPC分类号： G01N3090

    CPC分类号： A61B10/0051 ,  A61B2010/0006 ,  G01N30/90 ,  Y10S435/974 ,  Y10S436/81 ,  Y10T436/25

    摘要： A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and/or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.

    摘要翻译： 公开了一种用于将含水流体从口腔收集和输送到用于测试的侧向色谱条的装置。 侧向色谱条放置在限定在壳体中的空腔内并沿其延伸。 提供至少一个侧向色谱条的检查位置，以便检查侧向色谱条上的选定位点以便测试结果。 多孔芯材料在一端从外壳突出到外壳的收集位置，并在另一端与侧向色谱条连通。 多孔芯材料具有颗粒结构，颗粒吸附口腔液体，以将流体从嘴部输送到侧向色谱条而无需实质吸收。 多孔芯材料的颗粒被结合在一起以限定用于要输送的口腔液体的流动的连续间隙体积，并被处理为与吸附的口腔液体亲水。 多孔芯材料容易地将口腔液体释放到侧向色谱条上。 由于多孔芯材料的迂回流动路径，防止从侧向色谱条带逆向流入口腔。 咬合板联接到壳体并且可插入患者的牙齿之间，以将多孔芯放置在口腔中以收集口腔液体。 咬合板通常通过牙齿的咬合力（优选地为臼齿和/或双尖牙）保持在适当的位置，以将多孔芯放置在口腔空间中。 在测试装置处于口中时，通过观察侧向色谱条即可得到结果。