公开(公告)号：US07435425B2

公开(公告)日：2008-10-14

申请号：US09908464

申请日：2001-07-17

申请人： Zhen Qian ,  A. Edward Osawa ,  Cary J. Reich

发明人： Zhen Qian ,  A. Edward Osawa ,  Cary J. Reich

IPC分类号： A61F13/00 ,  A61F2/00

CPC分类号： A61K38/4833 ,  A61L24/0031 ,  A61L24/104 ,  A61L2400/04

摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.

摘要翻译： 制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。 在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。 已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。

公开(公告)号：US07320962B2

公开(公告)日：2008-01-22

申请号：US10761922

申请日：2004-01-20

申请人： Cary J. Reich ,  A. Edward Osawa ,  Helen Tran

发明人： Cary J. Reich ,  A. Edward Osawa ,  Helen Tran

IPC分类号： A61K38/17 ,  A61K31/74 ,  A61K35/14 ,  A61K9/00

CPC分类号： A61K9/0019 ,  A61K9/1652 ,  A61K9/1658 ,  A61K38/00 ,  A61K47/36 ,  A61K47/42 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2400/04 ,  C07K14/4732 ,  C07K14/4741 ,  C07K14/75 ,  C07K14/76 ,  C07K14/78 ,  C07K14/805 ,  Y10S435/81 ,  Y10S514/944

摘要： Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to solubilize relatively rapidly when exposed to blood. The non-cross-linked polymer serves as a binder for holding the materials in desired geometries, such as sheets, pellets, plugs, or the like. Usually, the cross-linked polymer will be present in a particulate or fragmented form. The materials are particularly suitable for hemostasis and drug delivery.

摘要翻译： 干燥的活性材料包括交联的生物相容性聚合物和非交联的生物相容性聚合物。 选择交联聚合物以在暴露于血液时形成水凝胶。 选择非交联聚合物当暴露于血液时相对快速地溶解。 非交联聚合物用作用于将材料保持在所需几何形状的粘合剂，例如片材，丸粒，塞子等。 通常，交联聚合物将以颗粒或碎片形式存在。 该材料特别适用于止血和药物输送。

公开(公告)号：US20090227779A1

公开(公告)日：2009-09-10

申请号：US12468316

申请日：2009-05-19

申请人： Zhen Qian ,  A. Edward Osawa ,  Cary J. Reich

发明人： Zhen Qian ,  A. Edward Osawa ,  Cary J. Reich

IPC分类号： C07K14/78

CPC分类号： A61K38/4833 ,  A61L24/0031 ,  A61L24/104 ,  A61L2400/04

摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.

摘要翻译： 制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。 在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。 已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。

公开(公告)号：US06706690B2

公开(公告)日：2004-03-16

申请号：US09330315

申请日：1999-06-10

申请人： Cary J. Reich ,  A. Edward Osawa ,  Helen Tran

发明人： Cary J. Reich ,  A. Edward Osawa ,  Helen Tran

IPC分类号： A61K3817

CPC分类号： A61K9/1652 ,  A61K9/1658 ,  A61K38/00 ,  A61K47/36 ,  A61K47/42 ,  A61L26/008 ,  A61L27/52 ,  A61L31/145 ,  A61L2400/04 ,  C07K14/4732 ,  C07K14/4741 ,  C07K14/75 ,  C07K14/76 ,  C07K14/78 ,  C07K14/805 ,  Y10S435/81 ,  Y10S514/944

摘要： Dried hemoactive materials comprise both a cross-linked biologically compatible polymer and a non-cross-linked biologically compatible polymer. The cross-linked polymer is selected to form a hydrogel when exposed to blood. The non-cross-linked polymer is chosen to solubilize relatively rapidly when exposed to blood. The non-cross-linked polymer serves as a binder for holding the materials in desired geometries, such as sheets, pellets, plugs, or the like. Usually, the cross-linked polymer will be present in a particulate or fragmented form. The materials are particularly suitable for hemostasis and drug delivery.

公开(公告)号：US07547446B2

公开(公告)日：2009-06-16

申请号：US11766516

申请日：2007-06-21

申请人： Zhen Qian ,  A. Edward Osawa ,  Cary J. Reich

发明人： Zhen Qian ,  A. Edward Osawa ,  Cary J. Reich

IPC分类号： A61K13/00 ,  A61F2/00 ,  A61K9/14 ,  A61K9/50 ,  A61K9/16

CPC分类号： A61K38/4833 ,  A61L24/0031 ,  A61L24/104 ,  A61L2400/04

摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.

摘要翻译： 制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。 在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。 已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。

公开(公告)号：US08092820B2

公开(公告)日：2012-01-10

申请号：US12468316

申请日：2009-05-19

申请人： Zhen Qian ,  A. Edward Osawa ,  Cary J. Reich

发明人： Zhen Qian ,  A. Edward Osawa ,  Cary J. Reich

IPC分类号： A61F13/00 ,  A61F2/00 ,  A61K9/14 ,  A61K9/50

CPC分类号： A61K38/4833 ,  A61L24/0031 ,  A61L24/104 ,  A61L2400/04

摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.

摘要翻译： 制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。 在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。 已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。

公开(公告)号：US20080286376A1

公开(公告)日：2008-11-20

申请号：US12176945

申请日：2008-07-21

申请人： Zhen Qian ,  A. Edward Osawa ,  Cary J. Reich

发明人： Zhen Qian ,  A. Edward Osawa ,  Cary J. Reich

IPC分类号： A61K9/14 ,  A61K38/16 ,  A61P7/04

CPC分类号： A61K38/4833 ,  A61L24/0031 ,  A61L24/104 ,  A61L2400/04

摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.

公开(公告)号：US06334865B1

公开(公告)日：2002-01-01

申请号：US09361663

申请日：1999-07-27

申请人： Russell J. Redmond ,  Claude A. Vidal ,  Cary J. Reich ,  Felix Vega

发明人： Russell J. Redmond ,  Claude A. Vidal ,  Cary J. Reich ,  Felix Vega

IPC分类号： A61B1708

CPC分类号： A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/0065

摘要： A percutaneous tissue track closure assembly (2) includes a semipermeable barrier(26) mounted to the distal end of a tubular barrier carrier (20). The barrier is passed down a tissue track (12) and into a blood vessel (18) where the barrier is expanded to close off the blood vessel opening (14). A syringe device is used to drive a hemostatic flowable material (30) through a delivery tube (34) and into the tissue track. The semipermeable barrier permits blood to flow therethrough but prevents passage of the hemostatic flowable material therethrough. The hemostatic material includes a material which swells upon contact with blood, and a blood clotting agent. After an appropriate period of time, the barrier is collapsed and the barrier carrier and delivery tube are removed from the tissue track.

摘要翻译： 经皮组织跟踪闭合组件（2）包括安装在管状阻挡载体（20）的远端的半透性屏障（26）。 屏障通过组织轨迹（12）并进入血管（18），其中屏障被扩张以封闭血管开口（14）。 注射器装置用于通过输送管（34）驱动止血可流动材料（30）并进入组织轨道。 半渗透屏障允许血液流过其中，但是防止止血可流动材料通过其中。 止血材料包括与血液接触时膨胀的物质和凝血剂。 在适当的时间段之后，屏障被塌缩，并且屏障载体和输送管从组织轨道移除。

公开(公告)号：US5931165A

公开(公告)日：1999-08-03

申请号：US795744

申请日：1997-02-06

申请人： Cary J. Reich ,  Donald G. Wallace ,  Greg Dapper

发明人： Cary J. Reich ,  Donald G. Wallace ,  Greg Dapper

IPC分类号： A61B17/00 ,  A61B17/072 ,  A61B17/11 ,  A61B18/00 ,  A61B19/00 ,  A61L15/32 ,  A61L24/10 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14

CPC分类号： A61L31/148 ,  A61B17/00491 ,  A61B17/11 ,  A61L15/32 ,  A61L15/325 ,  A61L24/104 ,  A61L31/042 ,  A61L31/043 ,  A61L31/045 ,  A61L31/06 ,  A61L31/141 ,  A61B17/07292 ,  A61B18/042 ,  A61B2017/00504 ,  A61B2090/0816

摘要： Gelatin film compositions are useful for immobilization over tissue, usually by the application of energy to the films. Exemplary films comprise cross-linked and non-cross-linked granular and non-granular gelatin sheets, typically including a plasticizer. The gelatin films are dry, thin, and preferably meet certain pliability, elasticity, melting temperature, and other criteria. Methods are described for producing these films from collagen. Methods are further described for applying these films to tissue.

摘要翻译： 明胶膜组合物可用于固定在组织上，通常通过向膜施加能量。 示例性膜包括交联和非交联的颗粒状和非颗粒状明胶片，通常包括增塑剂。 明胶膜干燥，薄，并且优选满足一定的柔韧性，弹性，熔融温度和其它标准。 描述了从胶原制备这些膜的方法。 进一步描述了将这些膜应用于组织的方法。

公开(公告)号：US06613070B2

公开(公告)日：2003-09-02

申请号：US09882296

申请日：2001-06-14

申请人： Russell J. Redmond ,  Claude Vidal ,  Cary J. Reich ,  Felix Vega ,  Michael Collinson ,  Joseph F. Rondinone

发明人： Russell J. Redmond ,  Claude Vidal ,  Cary J. Reich ,  Felix Vega ,  Michael Collinson ,  Joseph F. Rondinone

IPC分类号： A61B1708

CPC分类号： A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00654

摘要： Systems and method for sealing vascular penetrations rely on placement of a temporary barrier on the posterior side of the penetration. Penetrations are then sealed by delivering a hemostatic gel to a region over the penetration, where the barrier both inhibits loss of the gel and promotes back flow of blood into the gel. A combination of natural clotting factors in the blood and hemostatic agents in the gel promote rapid and effective sealing of the vascular penetration. Specific systems for performing the method include a barrier carrier for temporary placement of the barrier within the blood vessel and a gel delivery tube which may be positioned within a tissue tract or line of penetration simultaneously with the barrier carrier to deliver the hemostatic gel.