公开(公告)号：US5391181A

公开(公告)日：1995-02-21

申请号：US141769

申请日：1993-10-22

申请人： Erin M. Johnson ,  Mark A. Lazzeri

发明人： Erin M. Johnson ,  Mark A. Lazzeri

IPC分类号： A61B17/28 ,  A61B17/88 ,  A61B17/00

CPC分类号： A61B17/282 ,  A61B17/8894

摘要： An orthopaedic holding forceps 1 for simultaneously holding a screw 60 and a screwdriver 70. The forceps 1 includes a distal tip 42 having an upper chamber 43 adapted for receiving an enlarged gripping head 72 of the screwdriver 70 and a lower chamber 44 adapted for receiving the enlarged head 61 of screw 60. The distal tip 42 also includes an interconnecting chamber 45 between the upper and lower chambers 43 and 44 adapted for receiving the distal driving tip 73 of the screwdriver 70.

摘要翻译： 用于同时保持螺钉60和螺丝刀70的整形外科夹持钳1.镊子1包括具有适于容纳螺丝刀70的扩大夹头72的上室43的远侧末端42和适于接收螺丝刀70的下室44。 螺钉60的扩大头61.远侧末端42还包括适于容纳螺丝刀70的远侧驱动尖端73的上下腔室43和44之间的互连腔室45。

公开(公告)号：US20090215729A1

公开(公告)日：2009-08-27

申请号：US12389325

申请日：2009-02-19

申请人： Erin M. Johnson ,  Mark E. Johnson

发明人： Erin M. Johnson ,  Mark E. Johnson

IPC分类号： A61K31/663 ,  A61P35/00

CPC分类号： A61K9/143 ,  A61K9/5115

摘要： This invention provides pharmaceutical compositions and methods related to the prevention and treatment of primary tumors and metastatic, malignant or spreading cancers by selectively targeting cancer associated myeloid derived cells by the targeted delivery of a bisphosphonate formulated with a non-liposomal particle carrier. In some aspects, the bisphosphonate particles have one or more properties suitable for phagocytosis by cancer associated myeloid derived cells and release of the bisphosphonate within the macrophages. Advantageously, administering the particles to a subject reduces the level and/or activity of cancer associated myeloid derived cells in the subject.

摘要翻译： 本发明提供了通过靶向递送用非脂质体颗粒载体配制的双膦酸盐选择性地靶向癌相关骨髓来源的细胞来预防和治疗原发性肿瘤和转移性，恶性或扩散性癌症的药物组合物和方法。 在一些方面，双膦酸盐颗粒具有一种或多种适用于癌相关骨髓衍生细胞的吞噬作用和在巨噬细胞内双膦酸盐释放的性质。 有利地，向受试者施用颗粒降低了受试者中癌相关骨髓衍生细胞的水平和/或活性。

公开(公告)号：US07022142B2

公开(公告)日：2006-04-04

申请号：US10613330

申请日：2003-07-03

申请人： Erin M. Johnson

发明人： Erin M. Johnson

IPC分类号： A61F2/32

CPC分类号： A61F2/34 ,  A61B17/86 ,  A61F2/32 ,  A61F2002/30131 ,  A61F2002/30153 ,  A61F2002/30154 ,  A61F2002/30156 ,  A61F2002/3023 ,  A61F2002/30232 ,  A61F2002/30324 ,  A61F2002/30382 ,  A61F2002/30433 ,  A61F2002/30492 ,  A61F2002/305 ,  A61F2002/30604 ,  A61F2002/30785 ,  A61F2002/30797 ,  A61F2002/30808 ,  A61F2002/30827 ,  A61F2002/3233 ,  A61F2002/3275 ,  A61F2002/3433 ,  A61F2002/3443 ,  A61F2002/3493 ,  A61F2002/4631 ,  A61F2002/4638 ,  A61F2002/4641 ,  A61F2002/4642 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2230/0013 ,  A61F2230/0019 ,  A61F2230/0021 ,  A61F2230/0023 ,  A61F2230/0069 ,  A61F2250/0036

摘要： A prosthetic acetabular component for a hip joint that is inserted into a bone cavity of the natural acetabulum. The acetabular component consists of an articulating component and a constraining component. The articulating component has a hemispherical or dome shape that defines a hemispherical cavity for receiving a femoral ball of a femoral hip stem. The constraining component has a body that connects to the articulating component to capture the femoral ball within the cavity of the articulating component. A locking mechanism connects the constraining component to the articulating component.

摘要翻译： 用于髋关节的假体髋臼部件，其插入天然髋臼的骨腔中。 髋臼部件由铰接部件和约束部件组成。 关节部件具有半球形或圆顶形状，其限定用于接收股骨髋部柄的股骨球的半球形腔。 限制部件具有连接到关节部件以在关节部件的腔内捕获股骨球的主体。 锁定机构将约束部件连接到关节部件。

公开(公告)号：US6117138A

公开(公告)日：2000-09-12

申请号：US293187

申请日：1999-04-16

申请人： James W. Burrows ,  Erin M. Johnson

发明人： James W. Burrows ,  Erin M. Johnson

IPC分类号： A61B17/16 ,  A61B17/17 ,  A61F2/00 ,  A61F2/36 ,  A61F2/46

CPC分类号： A61B17/1668 ,  A61B17/1659 ,  A61F2/4684 ,  A61B17/175 ,  A61F2/3662 ,  A61F2002/30332 ,  A61F2002/3611 ,  A61F2002/3625 ,  A61F2002/3631 ,  A61F2002/3643 ,  A61F2002/365 ,  A61F2002/3652 ,  A61F2002/3694 ,  A61F2220/0033

摘要： A variety of surgical instruments facilitate implantation of a femoral stem component of an implantable prosthesis. A skeletal member is prepared by securing a reamer in the member. A broach is mounted on the reamer for broaching the member. A variety of adapters are selectively used with a head trial to check for location of the head trial. After trial placement is satisfactory, the instruments are removed so that the prosthesis can be implanted.

摘要翻译： 各种手术器械便于植入可植入假体的股骨柄部件的植入。 通过将铰刀固定在构件中来制备骨架构件。 拉刀用于拉削成员。 选择性地使用各种适配器进行头部试验以检查头部试验的位置。 在试验放置令人满意之后，移除器械，使得可以植入假体。

公开(公告)号：US6048365A

公开(公告)日：2000-04-11

申请号：US53584

申请日：1998-04-01

申请人： James W. Burrows ,  Erin M. Johnson

发明人： James W. Burrows ,  Erin M. Johnson

IPC分类号： A61F2/00 ,  A61F2/30 ,  A61F2/36

CPC分类号： A61F2/3609 ,  A61F2/30724 ,  A61F2002/30156 ,  A61F2002/30235 ,  A61F2002/30332 ,  A61F2002/30377 ,  A61F2002/3038 ,  A61F2002/30382 ,  A61F2002/30532 ,  A61F2002/30616 ,  A61F2002/3611 ,  A61F2002/3625 ,  A61F2002/365 ,  A61F2002/3656 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2230/0023 ,  A61F2230/0069

摘要： A set of modular components from among which an implantable orthopedic hip prosthesis can be assembled. First and second implantable orthopedic femoral hip stem prosthesis each have a neck, the neck having a male conical taper surface. An implantable orthopedic femoral head prosthesis has a female conical taper surface. The respective male and female conical taper surfaces are sized and configured for mutual taper-locked interconnection if engaged, but at least one of the first and second implantable orthopedic femoral hip stem prosthesis is keyed in combination with the implantable orthopedic femoral head prosthesis to prevent engagement of the respective male conical taper surface with the female conical taper surface.

摘要翻译： 一组模块化组件，其中可组装可植入矫形髋关节假体。 第一和第二可植入矫形的股骨髋关节假体各具有颈部，颈部具有凸锥形锥形表面。 可植入矫形股骨头假体具有阴锥形锥面。 相应的公和锥形锥形表面的尺寸和构造用于相互锥形锁定互连，如果接合，但是第一和第二可植入矫形股骨髋关节假体中的至少一个与可植入的矫形股骨头假体结合，以防止接合 的相应的凸锥形锥面与阴锥形锥面。

公开(公告)号：US5284483A

公开(公告)日：1994-02-08

申请号：US945558

申请日：1992-09-16

申请人： Erin M. Johnson ,  Leroy C. Bayliss

发明人： Erin M. Johnson ,  Leroy C. Bayliss

IPC分类号： A61B17/28 ,  A61F2/34 ,  A61F2/46 ,  A61F5/00 ,  A61F2/32

CPC分类号： A61F2/4609 ,  A61B17/2841 ,  A61B2017/2837 ,  A61F2002/3404 ,  A61F2002/4623 ,  A61F2002/4629

摘要： An acetabular cup inserting instrument includes a first handle and a second handle rotatable about and extending from the first handle. The second handle is ratchetable about the first handle and selectively lockable in a desired position with respect to the first handle. The ratchet mechanism of the second handle includes a biased pawl that engages radially spaced notches on the first handle.

摘要翻译： 髋臼杯插入仪器包括第一手柄和可绕第一手柄旋转并从第一手柄延伸的第二手柄。 第二把手可绕第一手柄棘轮并相对于第一把手可选择性地锁定在期望的位置。 第二手柄的棘轮机构包括偏置的棘爪，其接合在第一手柄上的径向隔开的凹口。