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11.发明授权Nucleic acids corresponding to TANGO 294 a gene encoding a lipase—like protein 失效对应于TANGO 294的编码脂肪酶样蛋白的基因的核酸公开(公告)号：US07033780B1
公开(公告)日：2006-04-25
申请号：US09333159
申请日：1999-06-14
IPC分类号： C12N15/00
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。
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公开(公告)号：US07544491B2
公开(公告)日：2009-06-09
申请号：US11900016
申请日：2007-09-07
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白 结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US07109319B2
公开(公告)日：2006-09-19
申请号：US10384850
申请日：2003-03-10
CPC分类号： C07K14/70535 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The invention provides isolated nucleic acid molecules, designated FAIL, which encode polypeptide molecules containing Ig and Ig-like domains and which are homologous to FcγRI. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供了分离的核酸分子，命名为FAIL，其编码含有Ig和Ig样结构域的多肽分子，它们与FcγRRI同源。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US07083793B2
公开(公告)日：2006-08-01
申请号：US10107857
申请日：2002-03-26
IPC分类号： A61K39/00 , C07K19/00 , C07K14/435
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein). The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also described/disclosed.
摘要翻译： 本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白 结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还描述/公开了利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US07432062B2
公开(公告)日：2008-10-07
申请号：US10644671
申请日：2003-08-20
IPC分类号： G01N33/53
CPC分类号： C07K14/70532 , Y10S435/81
摘要： Novel B7-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length B7-like proteins, the invention further provides isolated B7-like fusion proteins, antigenic peptides, and anti-B7-like antibodies. The invention also provides B7-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 公开了新的B7样多肽，蛋白质和核酸分子。 除了分离的全长B7样蛋白之外，本发明还提供分离的B7样融合蛋白，抗原肽和抗B7样抗体。 本发明还提供了B7样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入或破坏了B7样基因的非人类转基因动物 。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US20080176281A1
公开(公告)日：2008-07-24
申请号：US11900016
申请日：2007-09-07
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白 结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US07285398B2
公开(公告)日：2007-10-23
申请号：US10929052
申请日：2004-08-27
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein). The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白 结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US08187819B2
公开(公告)日：2012-05-29
申请号：US12386835
申请日：2009-04-23
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白 结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US20090269783A1
公开(公告)日：2009-10-29
申请号：US12229202
申请日：2008-08-20
IPC分类号： G01N33/567 , C12P21/02 , C12N5/10 , C12N5/06 , C12N15/63 , G01N33/53 , G01N33/536 , C07K14/47 , C07K16/18 , C07H21/04
CPC分类号： C07K14/70532 , Y10S435/81
摘要： Novel B7-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length B7-like proteins, the invention further provides isolated B7-like fusion proteins, antigenic peptides, and anti-B7-like antibodies. The invention also provides B7-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
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20.发明授权公开(公告)号：US07160694B2
公开(公告)日：2007-01-09
申请号：US09766511
申请日：2001-01-19
IPC分类号： C12P21/06
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。
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