公开(公告)号：US08076086B2

公开(公告)日：2011-12-13

申请号：US11499835

申请日：2006-08-04

申请人： Susan J. Kirst ,  Douglas A. Holtzman ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas S. Barnes

发明人： Susan J. Kirst ,  Douglas A. Holtzman ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas S. Barnes

IPC分类号： G01N33/53 ,  A61K38/00 ,  C07K17/00

CPC分类号： C07K16/18 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K16/28 ,  G01N33/5058

摘要： The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质和核酸的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20120270219A1

公开(公告)日：2012-10-25

申请号：US13540352

申请日：2012-07-02

申请人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

发明人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

IPC分类号： C07K14/47 ,  C12N5/10 ,  C12P21/02 ,  C07K16/18 ,  C12Q1/68 ,  C12N5/071 ,  C12N15/12 ,  C12N15/85 ,  G01N33/566

CPC分类号： C07K14/705 ,  C07K14/70503 ,  G01N33/54313

摘要： The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供了分离的TANGO 509核酸分子和多肽分子。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20100062487A1

公开(公告)日：2010-03-11

申请号：US12387959

申请日：2009-05-08

申请人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

发明人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

IPC分类号： C12P21/02 ,  C07H21/04 ,  C12N5/00 ,  C12N1/00 ,  C07K14/00 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y02A50/411 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US07033780B1

公开(公告)日：2006-04-25

申请号：US09333159

申请日：1999-06-14

申请人： Sean A. McCarthy ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas M. Barnes

发明人： Sean A. McCarthy ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas M. Barnes

IPC分类号： C12N15/00

CPC分类号： C07K14/47

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20120045777A1

公开(公告)日：2012-02-23

申请号：US13169686

申请日：2011-06-27

申请人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

发明人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

IPC分类号： G01N33/53 ,  C12Q1/37 ,  C12P21/02 ,  C12N9/99 ,  C12N9/64 ,  C12N15/57 ,  C12N5/00 ,  C12N15/63 ,  G01N33/50 ,  C07K14/00 ,  C07K16/18 ,  C07H21/04 ,  G01N33/573 ,  C12N5/10

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y02A50/411 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20090136959A1

公开(公告)日：2009-05-28

申请号：US12288775

申请日：2008-10-23

申请人： Sean A. McCarthy ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas M. Barnes ,  Susan J. Kirst ,  Paul S. Myers ,  Nicholas Wrighton ,  Andrew D.J. Goodearl ,  Douglas A. Holtzman ,  Mehran Khodadoust

发明人： Sean A. McCarthy ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas M. Barnes ,  Susan J. Kirst ,  Paul S. Myers ,  Nicholas Wrighton ,  Andrew D.J. Goodearl ,  Douglas A. Holtzman ,  Mehran Khodadoust

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C07K14/00 ,  G01N33/00 ,  C07K1/00 ,  C07K16/18 ,  C12P21/04 ,  G01N33/53

CPC分类号： C07K14/47

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US06960651B2

公开(公告)日：2005-11-01

申请号：US10188495

申请日：2002-07-02

申请人： Susan J. Kirst ,  Douglas A. Holtzman ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas S. Barnes

发明人： Susan J. Kirst ,  Douglas A. Holtzman ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas S. Barnes

IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K39/00

CPC分类号： C07K16/18 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K16/28 ,  G01N33/5058

摘要： The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质和核酸的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US06242206B1

公开(公告)日：2001-06-05

申请号：US09498809

申请日：2000-02-07

申请人： Xue-Chiou C. Choiu ,  Ruth M. Kramer ,  Richard T. Pickard ,  John D. Sharp ,  Beth A. Strifler

发明人： Xue-Chiou C. Choiu ,  Ruth M. Kramer ,  Richard T. Pickard ,  John D. Sharp ,  Beth A. Strifler

IPC分类号： C12Q134

CPC分类号： C12Y301/01004 ,  C12N9/20 ,  H04L51/00

摘要： The invention provides a novel phospholipase A2 enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.

摘要翻译： 本发明提供了一种新型磷脂酶A2酶，编码这种酶的多核苷酸以及用于筛选由花生四烯酸级联介导的抗炎活性的未知化合物的方法。

公开(公告)号：US6025178A

公开(公告)日：2000-02-15

申请号：US827208

申请日：1997-03-28

申请人： Xue-Chiou C. Choiu ,  Ruth M. Kramer ,  Richard T. Pickard ,  John D. Sharp ,  Beth A. Strifler

发明人： Xue-Chiou C. Choiu ,  Ruth M. Kramer ,  Richard T. Pickard ,  John D. Sharp ,  Beth A. Strifler

IPC分类号： C12N9/20 ,  H04L12/58 ,  C07H21/04 ,  C12N1/20 ,  C12P21/06

CPC分类号： C12Y301/01004 ,  C12N9/20 ,  H04L12/58

摘要： The invention provides a novel phospholipase A.sub.2 enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.

摘要翻译： 本发明提供了一种新型磷脂酶A2酶，编码这种酶的多核苷酸以及用于筛选由花生四烯酸级联介导的抗炎活性的未知化合物的方法。

公开(公告)号：US5328842A

公开(公告)日：1994-07-12

申请号：US46508

申请日：1993-04-12

申请人： Xue-Chiou C. Chiou ,  JoAnn Hoskins ,  Ruth M. Kramer ,  John D. Sharp ,  Donald L. White

发明人： Xue-Chiou C. Chiou ,  JoAnn Hoskins ,  Ruth M. Kramer ,  John D. Sharp ,  Donald L. White

IPC分类号： C12N1/21 ,  A61K38/00 ,  C12N9/16 ,  C12N9/18 ,  C12N15/09 ,  C12N15/55 ,  C12N15/85 ,  C12Q1/18 ,  C12Q1/44 ,  C12R1/19 ,  C12N15/70

CPC分类号： C12N15/85 ,  C12N9/18 ,  A61K38/00

摘要： The invention includes recombinant DNA compounds, vectors and methods useful for expressing an exceptionally rare, human, cytosolic phospholipase A.sub.2 (cPLA.sub.2) enzyme. The invention also includes a method for screening compounds to identify inhibitors of cPLA.sub.2 which is believed to partake in several disease processes.

摘要翻译： 本发明包括重组DNA化合物，用于表达极罕见的，人的胞质磷脂酶A2（cPLA2）酶的载体和方法。 本发明还包括一种筛选化合物以鉴定被认为参与若干疾病过程的cPLA2抑制剂的方法。