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177 条记录 (耗时 0.029 秒)

    (5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)-alkanoic acids and alkanimidamides bearing novel functional 9a-substituents
    11.
    发明授权
    (5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)-alkanoic acids and alkanimidamides bearing novel functional 9a-substituents 失效
    （5,6-二氯-3-氧代-2,3,9,9a-四氢芴-7-基） - 链烷酸和带有新的功能性9a取代基的烷酰亚胺

    公开(公告)号：US4731471A

    公开(公告)日：1988-03-15

    申请号：US926170

    申请日：1986-11-03

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr. ,  Adolph M. Pietruszkiewicz

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr. ,  Adolph M. Pietruszkiewicz

    IPC分类号： C07C45/46 ,  C07C45/67 ,  C07C45/75 ,  C07C69/94

    CPC分类号： C07C45/67 ,  C07C45/46 ,  C07C45/75 ,  C07C2103/18

    摘要： The invention relates to novel [(5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)]alkanoic acids and alkanimidamides bearing novel functional 9a-substituents, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, the neurological problems caused by AIDS, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions and elevated intracranial pressure.

    摘要翻译： 本发明涉及新的[（5,6-二氯-3-氧代-2,3,9,9a-四氢芴-7-基）]链烷酸和具有新的功能性9a-取代基及其衍生物及其盐的链烷酰胺。 这些化合物可用于治疗和预防脑损伤以及头部创伤，中风（特别是缺血性），呼吸停止，心脏停搏，雷氏综合症，脑血栓形成，脑栓塞，艾滋病引起的神经系统问题， 脑出血，脑肿瘤，脑脊髓炎，脊髓损伤，脑积水，术后脑损伤创伤，脑部感染引起的水肿，各种脑震荡和颅内压升高。

    Substituted-3- (2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, useful for treating persons with gray matter edema
    12.
    发明授权
    Substituted-3- (2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, useful for treating persons with gray matter edema 失效
    取代的3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮，用于治疗患有灰质水肿的人

    公开(公告)号：US4634717A

    公开(公告)日：1987-01-06

    申请号：US605738

    申请日：1984-05-01

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    IPC分类号： C07D207/44 ,  C07D207/456 ,  C07D409/10 ,  A61K31/40 ,  C07D207/40

    CPC分类号： C07D207/456 ,  C07D409/10

    摘要： The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代-3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮，其类似物及其盐。 这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。

    Substituted (2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy) alkanoic acids, their derivatives and their salts
    13.
    发明授权
    Substituted (2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy) alkanoic acids, their derivatives and their salts 失效
    取代的（2,3-二氢-4-（3-氧代-1-环己烯-1-基）苯氧基）链烷酸，其衍生物及其盐

    公开(公告)号：US4625047A

    公开(公告)日：1986-11-25

    申请号：US812669

    申请日：1985-12-23

    申请人： Edward J. Cragoe, Jr. ,  Adolph M. Pietruszkiewicz ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Adolph M. Pietruszkiewicz ,  Otto W. Woltersdorf, Jr.

    IPC分类号： C07C59/88 ,  C07C69/76

    CPC分类号： C07C59/88

    摘要： The invention relates to novel substituted [2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy]-alkanoic acids their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代的2,3-二氢-4-（3-氧代-1-环己烯-1-基）苯氧基] - 链烷酸及其盐。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。