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    METHODS AND DEVICES FOR VENTRICULAR RESHAPING AND HEART VALVE RESHAPING
    12.
    发明申请
    METHODS AND DEVICES FOR VENTRICULAR RESHAPING AND HEART VALVE RESHAPING 审中-公开

    公开(公告)号：US20200069426A1

    公开(公告)日：2020-03-05

    申请号：US16549957

    申请日：2019-08-23

    申请人： Edwards Lifesciences Corporation

    发明人： Brian S. Conklin ,  Maria L. Saravia ,  Adam J. Yestrepsky ,  Derrick Johnson ,  Rodolfo Rodriguez ,  Sai Prasad Uppalapati ,  Louis A. Campbell

    IPC分类号： A61F2/24

    摘要： Systems, apparatuses, and methods disclosed herein are provided for medical treatment, including transcatheter medical treatments and/or for treatment of dilated hearts (e.g., dilated left ventricle) or functional mitral valve regurgitation within a human heart. The systems, apparatuses, and methods disclosed herein may include applying one or more heart splints to the patient's heart to apply pressure to the heart to reshape the heart. Anchors disclosed herein may be utilized in plugs for treating openings in a septum between two chambers of a heart, e.g., ventricular septal defects (VSD), atrial septal defects (ASD), and patent foramen ovale (PFO). In addition, the anchors disclosed herein may be utilized to reshape an annulus of a patient's heart valve, including a tricuspid valve of a patient's heart. The anchors disclosed herein may also be utilized to reposition a heart valve leaflet to reduce heart valve leaflet prolapse.

    PROSTHETIC VALVE HOLDERS, SYSTEMS, AND METHODS
    13.
    发明申请
    PROSTHETIC VALVE HOLDERS, SYSTEMS, AND METHODS 审中-公开

    公开(公告)号：US20190224009A1

    公开(公告)日：2019-07-25

    申请号：US16252140

    申请日：2019-01-18

    申请人： Edwards Lifesciences Corporation

    发明人： Brian S. Conklin

    IPC分类号： A61F2/24

    摘要： Valve holders and introducers for delivering a prosthetic heart valve to an implant site are configured to facilitate insertion of prosthetic valves through small incisions or access sites on a patient's body. The valve holders can also be configured to reduce or eliminate the occurrence of suture looping or other damage to the prosthetic valve during implantation. A valve holder according to embodiments of the invention includes features that reduce or eliminate mistakes during implantation of the prosthetic valves, such as a handle that prevents implantation of the valve prior to proper deployment or adjustment of the holder. An introducer is provided which can facilitate temporary deformation of a nitinol prosthetic valve to pass between adjacent ribs of a patient without rib spreading. Valves are provided having a wireform and stiffener band made of materials that exhibit superelastic properties. Valve holders, introducers, and valves according to the various embodiments can be used in minimally invasive procedures, such as thoracotomy procedures.

    METHODS OF DELIVERY OF HEART VALVES
    17.
    发明申请
    METHODS OF DELIVERY OF HEART VALVES 审中-公开

    公开(公告)号：US20180125644A1

    公开(公告)日：2018-05-10

    申请号：US15864992

    申请日：2018-01-08

    申请人： Edwards Lifesciences Corporation

    发明人： Brian S. Conklin

    IPC分类号： A61F2/24

    CPC分类号： A61F2/243 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/006 ,  A61F2250/0071

    摘要： A prosthetic heart valve can include a valve frame having a wireform portion and a stent portion. The wireform and stent portions can be undetachably coupled together via a plurality of upright struts so as to form a one-piece prosthetic heart valve frame. Alternatively, a self-expanding wireform portion and a balloon-expandable stent portion can be coupled together via one or more leaflets and a subassembly having a flexible leaflet support stent and a sealing ring. The wireform portion can include cusps and commissures configured to support a plurality of leaflets. The prosthetic valve can be radially collapsible for minimally invasive and/or transcatheter delivery techniques. Disclosed embodiments can also provide flexion of the wireform portion (e.g., of the commissures) in response to physiologic pulsatile loading when the valve is implanted in a patient's native valve annulus. Methods of making and using prosthetic heart valves are also disclosed.

    HYBRID HEART VALVES ADAPTED FOR POST-IMPLANT EXPANSION
    18.
    发明申请
    HYBRID HEART VALVES ADAPTED FOR POST-IMPLANT EXPANSION 审中-公开
    混合心脏瓣适合后植入扩张

    公开(公告)号：US20170000603A1

    公开(公告)日：2017-01-05

    申请号：US15199743

    申请日：2016-06-30

    申请人： Edwards Lifesciences Corporation

    发明人： Brian S. Conklin ,  Qinggang Zeng

    IPC分类号： A61F2/24

    摘要： A hybrid prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be expanded post implant in order to receive and/or support an expandable prosthetic heart valve therein (a valve-in-valve procedure). The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible for delivery and expandable post-implant to facilitate a valve-in-valve procedure.

    摘要翻译： 一种混合式假体心脏瓣膜，其构造成替代原生心脏瓣膜并具有支撑框架，所述支撑框架被配置为在植入物之后扩张，以便在其中接收和/或支撑可扩张的假体心脏瓣膜（阀门过程）。 假体心脏瓣膜可以被构造成当最初植入时具有大致刚性和/或抗膨胀的构造，以替代天然瓣膜（或其他假体心脏瓣膜），但是当受到向外的力（例如， 由膨胀气球或其他机械膨胀机提供。 流入支架框架是可扩张的，用于将阀固定在适当位置，并且可具有用于输送和可扩展的植入后可折叠的流出端，以便于阀门过程。

    Surgical heart valves identifiable post-implant
    19.
    发明授权
    Surgical heart valves identifiable post-implant 有权
    手术心脏瓣膜可识别植入后

    公开(公告)号：US09504566B2

    公开(公告)日：2016-11-29

    申请号：US14745287

    申请日：2015-06-19

    申请人： Edwards Lifesciences Corporation

    发明人： Jessica Guttenberg ,  Da-Yu Chang ,  Derrick Johnson ,  Brian S. Conklin ,  Qinggang Zeng ,  Myron Howanec, Jr. ,  Grace M. Kim

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2250/0085 ,  A61F2250/0089 ,  A61F2250/0098

    摘要： A prosthetic heart valve configured to replace a native heart valve and for post-implant expansion and having a valve-type indicator thereon visible from outside the body post-implant. The indicator communicates information about the valve, such as the size or orifice diameter of the valve, and/or that the valve has the capacity for post-implant expansion. The indicator can be an alphanumeric symbol or other symbol or combination of symbols that represent information about the characteristics of the valve such as the valve size. The capacity for post-implant expansion facilitates a valve-in-valve procedure, where the valve-type indicator conveys information to the surgeon about whether the implanted valve is suitable for the procedure and informs the choice of the secondary valve.

    摘要翻译： 一种假体心脏瓣膜，其构造成代替天然心脏瓣膜并用于植入后扩张，并且在体外植入物后面具有可从其上观察到的瓣膜型指示器。 指示器传达关于阀的信息，例如阀的尺寸或孔直径，和/或阀具有用于植入物扩张的能力。 指示符可以是代表关于阀的特性的信息的字母数字符号或其它符号或符号的组合，例如阀的尺寸。 植入后扩张的能力有利于瓣膜瓣膜手术，其中瓣膜型指示器向外科医生传达关于植入的瓣膜是否适于手术并且通知二次瓣膜的选择的信息。

    CATHETER-BASED CLUTCHED HEART VALVE SIZER
    20.
    发明申请
    CATHETER-BASED CLUTCHED HEART VALVE SIZER 审中-公开
    基于导管的离合器心瓣尺寸

    公开(公告)号：US20160183843A1

    公开(公告)日：2016-06-30

    申请号：US15063353

    申请日：2016-03-07

    申请人： Edwards Lifesciences Corporation

    发明人： Brian S. Conklin ,  Da-Yu Chang

    IPC分类号： A61B5/107 ,  A61B5/02 ,  A61B5/00 ,  A61F2/24

    CPC分类号： A61B5/1076 ,  A61B5/02028 ,  A61B5/6859 ,  A61B2090/064 ,  A61B2090/065 ,  A61B2090/066 ,  A61F2/243 ,  A61F2/2496

    摘要： A valve sizer for determining an appropriate replacement valve size when performing a heart valve replacement procedure is provided. In one version the valve sizer has a hollow shaft with proximal and distal ends. A movable sizing element couples to the distal end of the shaft and is radially expandable between first, contracted and second, expanded positions. An actuator assembly on a handle includes an actuator coupled to a clutch member via a ball-spring-detent clutch. A rod extends through the shaft and maintains a fixed distance between the handle and a distal hub in the sizing element. Movement of the actuator causes axial movement of the shaft, thereby causing radial expansion of sizing petals relative to the hub. The clutch slips when a predetermined reaction force from the surrounding valve annulus is met by the petals.

    摘要翻译： 提供了一种用于在执行心脏瓣膜置换过程时确定适当的更换瓣膜尺寸的瓣膜分选机。 在一个版本中，阀门分级器具有中空轴，其具有近端和远端。 可移动的施胶元件联接到轴的远端并且可在第一，收缩和第二扩展位置之间径向扩张。 手柄上的致动器组件包括经由球弹簧止动离合器联接到离合器构件的致动器。 杆延伸穿过轴并且在手柄和施胶元件中的远侧轮毂之间保持固定的距离。 致动器的运动导致轴的轴向移动，从而引起尺寸花瓣相对于毂的径向膨胀。 当来自周围的瓣膜环的预定反作用力被花瓣满足时，离合器滑动。