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    Systems and methods for reducing the effect of corruptive signals during nanoliter osmometry
    11.
    发明申请
    Systems and methods for reducing the effect of corruptive signals during nanoliter osmometry 有权
    降低纳升渗透压测量中腐蚀信号影响的系统和方法

    公开(公告)号：US20050149275A1

    公开(公告)日：2005-07-07

    申请号：US10810780

    申请日：2004-03-25

    Applicant: Benjamin Sullivan ,  Eric Donsky

    Inventor： Benjamin Sullivan ,  Eric Donsky

    IPC: G01N13/04 ,  G01N11/00

    CPC classification number: G01N13/04

    Abstract: An osmolarity measuring system includes the ability to recognize patterns within the electrical profile of nanoliters of fluid an account for corruptive signals in the electrical profile. These corruptive signals are mainly caused by the mechanical relaxation of the sample fluid after delivery or evaporation across the electrodes.

    Abstract translation: 渗透压测量系统包括识别流体中纳升管的电气剖面中的图案的能力的能力，以考虑电气剖面中的腐蚀信号。 这些腐蚀性信号主要是由于在分送或蒸发电极之后样品流体的机械松弛引起的。

    Systems and methods for calibrating osmolarity measuring devices
    14.
    发明授权
    Systems and methods for calibrating osmolarity measuring devices 有权
    用于校准渗透压测量装置的系统和方法

    公开(公告)号：US07051569B2

    公开(公告)日：2006-05-30

    申请号：US10772084

    申请日：2004-02-03

    Applicant: Benjamin Sullivan ,  Eric Donsky

    Inventor： Benjamin Sullivan ,  Eric Donsky

    IPC: G01N21/00

    CPC classification number: G01N13/04

    Abstract: An osmolarity measuring system comprising microscale electrode arrays is configured to account for variations and defects in the arrays using a tiered approach comprising several calibration methods. One method accounts for the intrinsic conductivity of the electrodes and subtracts out the intrinsic conductivity on a pair-wise basis, when determining osmolarity of a sample fluid. Other methods in the tiered approach use standards to determine calibration factors for the electrodes that can then be used to adjust subsequent osmolarity measurements for a sample fluid. The use of a standard can also be combined with a washing step.

    Abstract translation: 包括微电极阵列的渗透压测量系统被配置为使用包括几种校准方法的分层方法来解决阵列中的变化和缺陷。 当确定样品流体的渗透压浓度时，一种方法考虑了电极的固有电导率，并在成对的基础上减去固有电导率。 分层方法中的其他方法使用标准来确定电极的校准因子，然后其可用于调节样品流体的随后渗透压测量。 标准的使用也可以与洗涤步骤相结合。

    Systems and methods for calibrating osmolarity measuring devices
    15.
    发明申请
    Systems and methods for calibrating osmolarity measuring devices 有权

    公开(公告)号：US20060107729A1

    公开(公告)日：2006-05-25

    申请号：US11327884

    申请日：2006-01-09

    Applicant: Benjamin Sullivan ,  Eric Donsky

    Inventor： Benjamin Sullivan ,  Eric Donsky

    IPC: G01N37/00

    CPC classification number: G01N13/04

    Abstract: An osmolarity measuring system comprising microscale electrode arrays is configured to account for variations and defects in the arrays using a tiered approach comprising several calibration methods. One method accounts for the intrinsic conductivity of the electrodes and subtracts out the intrinsic conductivity on a pair-wise basis, when determining osmolarity of a sample fluid. Other methods in the tiered approach use standards to determine calibration factors for the electrodes that can then be used to adjust subsequent osmolarity measurements for a sample fluid. The use of a standard can also be combined with a washing step.

    Nanofabrication processes and devices for the controlled assembly of functionalized nanostructures
    17.
    发明授权
    Nanofabrication processes and devices for the controlled assembly of functionalized nanostructures 有权
    用于受控组装功能化纳米结构的纳米加工工艺和装置

    公开(公告)号：US08202689B2

    公开(公告)日：2012-06-19

    申请号：US11914122

    申请日：2006-05-11

    Applicant: Michael Heller ,  Benjamin Sullivan ,  Dietrich Dehlinger

    Inventor： Michael Heller ,  Benjamin Sullivan ,  Dietrich Dehlinger

    IPC: C12Q1/68

    CPC classification number: G01N33/531 ,  B82Y30/00 ,  C12Q1/68 ,  G01N33/48721

    Abstract: The invention relates to processes and devices for the controlled fabrication of nanostructures from starting components that have high fidelity recognition properties and multiple binding groups. In one embodiment, the invention relates to the formation of nanostructures using controlled sequential addition of nanocomponents at regular intervials via sequential formation of binding pairs or other chemical binding reactions.

    Abstract translation: 本发明涉及用于从具有高保真度识别特性和多个结合基团的起始组分控制制造纳米结构的方法和装置。 在一个实施方案中，本发明涉及使用通过连续形成结合对或其它化学结合反应在常规间隔区内以受控顺序添加纳米组分形成纳米结构。

    Biomarker normalization
    19.
    发明授权
    Biomarker normalization 有权
    生物标志物归一化

    公开(公告)号：US09217702B2

    公开(公告)日：2015-12-22

    申请号：US13299197

    申请日：2011-11-17

    Applicant: Benjamin Sullivan

    Inventor： Benjamin Sullivan

    IPC: G01N33/48 ,  G01N13/04 ,  G01N27/26 ,  G06F19/24

    CPC classification number: G01N13/04 ,  B01L3/502715 ,  B01L2300/0654 ,  G01N21/6486 ,  G01N27/07 ,  G01N27/26 ,  G01N33/487 ,  G01N2800/162 ,  G01N2800/24 ,  G06F19/24

    Abstract: A fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyzes of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values.

    Abstract translation: 用泪液测量系统测量流体样品，所述泪液膜测量系统包括处理装置，所述处理装置接收包含被配置为容纳等分试样体积的样品流体的样品区域的样品芯片，所述处理装置被配置为进行渗透压的分析和一种或多种生物标志物 在样品流体中，其中生物标志物的分析包括生物标志物浓度值的归一化。

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