公开(公告)号：US08628731B2

公开(公告)日：2014-01-14

申请号：US13299277

申请日：2011-11-17

Applicant: Eric Donsky ,  Benjamin Sullivan

Inventor： Eric Donsky ,  Benjamin Sullivan

IPC: G01N3/00 ,  G01N33/48

CPC classification number: G01N13/04 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/165 ,  C12Q1/00 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/77 ,  G01N33/487 ,  G01N33/68 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2021/7786 ,  G01N2201/06113 ,  Y10T436/24

Abstract: A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

Abstract translation: 一种样品接收芯片，包括接收样品流体的等分试样体积和基底的样品区域的基底，其尺寸使得样品流体的体积足以可操作地覆盖样品区域的一部分。 被送入样品流体的能量被样品区域转导以产生指示样品流体的能量特性的输出信号。 样品接收芯片还包括形成在衬底中的通道，通道被配置为收集样品流体的等分试样体积并将等分试样体积的样品流体转移到样品区域。

公开(公告)号：US20050120772A1

公开(公告)日：2005-06-09

申请号：US10772084

申请日：2004-02-03

Applicant: Benjamin Sullivan ,  Eric Donsky

Inventor： Benjamin Sullivan ,  Eric Donsky

IPC: G01N13/04 ,  G01N27/07

CPC classification number: G01N13/04

Abstract: An osmolarity measuring system comprising microscale electrode arrays is configured to account for variations and defects in the arrays using a tiered approach comprising several calibration methods. One method accounts for the intrinsic conductivity of the electrodes and subtracts out the intrinsic conductivity on a pair-wise basis, when determining osmolarity of a sample fluid. Other methods in the tiered approach use standards to determine calibration factors for the electrodes that can then be used to adjust subsequent osmolarity measurements for a sample fluid. The use of a standard can also be combined with a washing step.

Abstract translation: 包括微电极阵列的渗透压测量系统被配置为使用包括几种校准方法的分层方法来解决阵列中的变化和缺陷。 当确定样品流体的渗透压浓度时，一种方法考虑了电极的固有电导率，并在成对的基础上减去固有电导率。 分层方法中的其他方法使用标准来确定电极的校准因子，然后其可用于调节样品流体的随后渗透压测量。 标准的使用也可以与洗涤步骤相结合。

公开(公告)号：US07810380B2

公开(公告)日：2010-10-12

申请号：US12001243

申请日：2007-12-11

Applicant: Eric Donsky ,  Benjamin Sullivan

Inventor： Eric Donsky ,  Benjamin Sullivan

IPC: G01N13/04

CPC classification number: G01N13/04 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/165 ,  C12Q1/00 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/77 ,  G01N33/487 ,  G01N33/68 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2021/7786 ,  G01N2201/06113 ,  Y10T436/24

Abstract: A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

Abstract translation: 一种样品接收芯片，包括接收样品流体的等分试样体积和基底的样品区域的基底，其尺寸使得样品流体的体积足以可操作地覆盖样品区域的一部分。 被送入样品流体的能量被样品区域转导以产生指示样品流体的能量特性的输出信号。 样品接收芯片还包括形成在衬底中的通道，通道被配置为收集样品流体的等分试样体积并将等分试样体积的样品流体转移到样品区域。

公开(公告)号：US20080148821A1

公开(公告)日：2008-06-26

申请号：US12001243

申请日：2007-12-11

Applicant: Eric Donsky ,  Benjamin Sullivan

Inventor： Eric Donsky ,  Benjamin Sullivan

IPC: G01N13/04

CPC classification number: G01N13/04 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/165 ,  C12Q1/00 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/77 ,  G01N33/487 ,  G01N33/68 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2021/7786 ,  G01N2201/06113 ,  Y10T436/24

Abstract: A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

Abstract translation: 一种样品接收芯片，包括接收样品流体的等分试样体积和基底的样品区域的基底，其尺寸使得样品流体的体积足以可操作地覆盖样品区域的一部分。 被送入样品流体的能量被样品区域转导以产生指示样品流体的能量特性的输出信号。 样品接收芯片还包括形成在衬底中的通道，通道被配置为收集样品流体的等分试样体积，并将样品流体的等分试样体积转移到样品区域。

公开(公告)号：US07111502B2

公开(公告)日：2006-09-26

申请号：US10810780

申请日：2004-03-25

Applicant: Benjamin Sullivan ,  Eric Donsky

Inventor： Benjamin Sullivan ,  Eric Donsky

IPC: G01N13/04

CPC classification number: G01N13/04

Abstract: An osmolarity measuring system includes the ability to recognize patterns within the electrical profile of nanoliters of fluid an account for corruptive signals in the electrical profile. These corruptive signals are mainly caused by the mechanical relaxation of the sample fluid after delivery or evaporation across the electrodes.

Abstract translation: 渗透压测量系统包括识别流体中纳升管的电气剖面中的图案的能力的能力，以考虑电气剖面中的腐蚀信号。 这些腐蚀性信号主要是由于在分送或蒸发电极之后样品流体的机械松弛引起的。

公开(公告)号：US08713997B2

公开(公告)日：2014-05-06

申请号：US12874088

申请日：2010-09-01

Applicant: Eric Donsky ,  Benjamin Sullivan

Inventor： Eric Donsky ,  Benjamin Sullivan

IPC: G01N13/04

CPC classification number: G01N13/04 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/165 ,  C12Q1/00 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/77 ,  G01N33/487 ,  G01N33/68 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2021/7786 ,  G01N2201/06113 ,  Y10T436/24

Abstract: A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

公开(公告)号：US08020433B2

公开(公告)日：2011-09-20

申请号：US12058428

申请日：2008-03-28

Applicant: Benjamin Sullivan ,  Steve Zmina ,  Eric Donsky ,  Sasha Miu ,  Graeme John Bullock ,  Adam Ernest Donath ,  Fred Harry Davis ,  Andreas Knaack ,  Matthew Daniel Solomon ,  Erol Craig Harvey ,  Carl Gang Chen

Inventor： Benjamin Sullivan ,  Steve Zmina ,  Eric Donsky ,  Sasha Miu ,  Graeme John Bullock ,  Adam Ernest Donath ,  Fred Harry Davis ,  Andreas Knaack ,  Matthew Daniel Solomon ,  Erol Craig Harvey ,  Carl Gang Chen

IPC: G01N13/04

CPC classification number: A61B10/0045 ,  A61B2010/0067 ,  G01N13/04

Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.

Abstract translation: 一种流体收集装置，包括一个包括一个胶囊接口的主体，以及一个胶囊，配置成经由胶囊接口与身体接口并配置成保持样本接收芯片。 样品接收芯片包括接收样品流体的等分试样体积的基底，其中基底可操作地成形为通过毛细管作用接收样品流体的等分试样体积，以及基底的样品区域，其尺寸使得 样品流体足以可操作地覆盖样品区域的一部分，由此样品流体的能量特性可被转导以产生样品流体读数。

公开(公告)号：US20110011166A1

公开(公告)日：2011-01-20

申请号：US12874088

申请日：2010-09-01

Applicant: Eric Donsky ,  Benjamin Sullivan

Inventor： Eric Donsky ,  Benjamin Sullivan

IPC: G01N13/04

CPC classification number: G01N13/04 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/165 ,  C12Q1/00 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/77 ,  G01N33/487 ,  G01N33/68 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2021/7786 ,  G01N2201/06113 ,  Y10T436/24

Abstract: A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

Abstract translation: 一种样品接收芯片，包括接收样品流体的等分试样体积和基底的样品区域的基底，其尺寸使得样品流体的体积足以可操作地覆盖样品区域的一部分。 被送入样品流体的能量被样品区域转导以产生指示样品流体的能量特性的输出信号。 样品接收芯片还包括形成在衬底中的通道，通道被配置为收集样品流体的等分试样体积，并将样品流体的等分试样体积转移到样品区域。

公开(公告)号：US20080264151A1

公开(公告)日：2008-10-30

申请号：US12058428

申请日：2008-03-28

Applicant: Benjamin Sullivan ,  Steve Zmina ,  Eric Donsky ,  Sasha Miu ,  Graeme John Bullock ,  Adam Ernest Donath ,  Fred Harry Davis ,  Andreas Knaack ,  Matthew Daniel Solomon ,  Erol Craig Harvey ,  Carl Gang Chen

Inventor： Benjamin Sullivan ,  Steve Zmina ,  Eric Donsky ,  Sasha Miu ,  Graeme John Bullock ,  Adam Ernest Donath ,  Fred Harry Davis ,  Andreas Knaack ,  Matthew Daniel Solomon ,  Erol Craig Harvey ,  Carl Gang Chen

IPC: G01N13/04

CPC classification number: A61B10/0045 ,  A61B2010/0067 ,  G01N13/04

Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.

Abstract translation: 一种流体收集装置，包括一个包括一个胶囊接口的主体，以及一个胶囊，配置成经由胶囊接口与身体接口并配置成保持样本接收芯片。 样品接收芯片包括接收样品流体的等分试样体积的基底，其中基底可操作地成形为通过毛细管作用接收样品流体的等分试样体积，以及基底的样品区域，其尺寸使得 样品流体足以可操作地覆盖样品区域的一部分，由此样品流体的能量特性可被转导以产生样品流体读数。

公开(公告)号：US07204122B2

公开(公告)日：2007-04-17

申请号：US11327884

申请日：2006-01-09

Applicant: Benjamin Sullivan ,  Eric Donsky

Inventor： Benjamin Sullivan ,  Eric Donsky

IPC: G01N21/00

CPC classification number: G01N13/04

Abstract: An osmolarity measuring system comprising microscale electrode arrays is configured to account for variations and defects in the arrays using a tiered approach comprising several calibration methods. One method accounts for the intrinsic conductivity of the electrodes and subtracts out the intrinsic conductivity on a pair-wise basis, when determining osmolarity of a sample fluid. Other methods in the tiered approach use standards to determine calibration factors for the electrodes that can then be used to adjust subsequent osmolarity measurements for a sample fluid. The use of a standard can also be combined with a washing step.

Abstract translation: 包括微电极阵列的渗透压测量系统被配置为使用包括几种校准方法的分层方法来解决阵列中的变化和缺陷。 当确定样品流体的渗透压浓度时，一种方法考虑了电极的固有电导率，并在成对的基础上减去固有电导率。 分层方法中的其他方法使用标准来确定电极的校准因子，然后其可用于调节样品流体的随后渗透压测量。 标准的使用也可以与洗涤步骤相结合。