公开(公告)号：US09217702B2

公开(公告)日：2015-12-22

申请号：US13299197

申请日：2011-11-17

Applicant: Benjamin Sullivan

Inventor： Benjamin Sullivan

IPC: G01N33/48 ,  G01N13/04 ,  G01N27/26 ,  G06F19/24

CPC classification number: G01N13/04 ,  B01L3/502715 ,  B01L2300/0654 ,  G01N21/6486 ,  G01N27/07 ,  G01N27/26 ,  G01N33/487 ,  G01N2800/162 ,  G01N2800/24 ,  G06F19/24

Abstract: A fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyzes of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values.

Abstract translation: 用泪液测量系统测量流体样品，所述泪液膜测量系统包括处理装置，所述处理装置接收包含被配置为容纳等分试样体积的样品流体的样品区域的样品芯片，所述处理装置被配置为进行渗透压的分析和一种或多种生物标志物 在样品流体中，其中生物标志物的分析包括生物标志物浓度值的归一化。

公开(公告)号：US08507218B2

公开(公告)日：2013-08-13

申请号：US12866732

申请日：2009-02-09

Applicant: Michael Heller ,  Geert W. Schmid-Schoenbein ,  Roy B. Lefkowitz ,  Benjamin Sullivan

Inventor： Michael Heller ,  Geert W. Schmid-Schoenbein ,  Roy B. Lefkowitz ,  Benjamin Sullivan

IPC: C12Q1/37

CPC classification number: G01N33/54386 ,  C07K5/1008 ,  C07K7/06 ,  C07K7/08 ,  C12Q1/34 ,  C12Q1/37 ,  G01N33/53 ,  G01N33/573

Abstract: Provided herein are methods useful in detecting degradative enzymes in bodily fluid samples.

Abstract translation: 本文提供了可用于检测体液样品中降解酶的方法。

公开(公告)号：US20130039865A1

公开(公告)日：2013-02-14

申请号：US13574095

申请日：2011-01-19

Applicant: Edward R. Truitt, III ,  Benjamin Sullivan ,  Nicholas Tennison

Inventor： Edward R. Truitt, III ,  Benjamin Sullivan ,  Nicholas Tennison

IPC: A61K8/64 ,  A61Q11/00 ,  A61K8/73

CPC classification number: A61K38/1709

Abstract: Provided herein is a pharmaceutical or oral care product for treating or preventing oral diseases that is prepared with proteoglycan 4 (PRG4) as an active ingredient, the preparing method thereof and the use thereof in manufacturing medicaments or oral care products for treating or preventing oral diseases and maintenance of oral health. PRG4 may have efficacy in maintaining oral health and treating or preventing oral disease. This secreted glycoprotein, which is also called lubricin and superficial zone protein, is known to protect against frictional forces, cell adhesion and protein deposition.

Abstract translation: 本文提供了用于治疗或预防用蛋白多糖4（PRG4）作为活性成分制备的口腔疾病的药物或口腔护理产品，其制备方法及其在制备用于治疗或预防口腔疾病的药物或口腔护理产品中的用途 并维持口腔健康。 PRG4可能具有维持口腔健康和治疗或预防口腔疾病的功效。 已知这种分泌的糖蛋白也称为润滑剂和表面区蛋白，以防止摩擦力，细胞粘附和蛋白质沉积。

公开(公告)号：US20120134925A1

公开(公告)日：2012-05-31

申请号：US13321532

申请日：2010-05-24

Applicant: Benjamin Sullivan ,  Tannin Schmidt ,  Edward R. Truitt ,  Nicole Barbara Justis Truitt ,  David Sullivan

Inventor： Benjamin Sullivan ,  Tannin Schmidt ,  Edward R. Truitt ,  Nicole Barbara Justis Truitt ,  David Sullivan

IPC: A61K38/14 ,  A61K38/44 ,  A61K38/54 ,  A61K33/14 ,  A61K33/10 ,  A61K9/70 ,  A61K36/886 ,  A61K8/64 ,  A61K38/02 ,  A61K39/395 ,  A61K31/7052 ,  A61K49/00 ,  A61K47/42 ,  A61P43/00 ,  A61P29/00 ,  A61P25/00 ,  A61K9/68

CPC classification number: A61K8/02 ,  A61K8/64 ,  A61K8/735 ,  A61K9/0014 ,  A61K9/0041 ,  A61K9/0048 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/0063 ,  A61K31/728 ,  A61K36/886 ,  A61K38/1709 ,  A61L27/50 ,  A61Q11/00 ,  A61Q19/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/4725 ,  C07K2317/41 ,  A61K2300/00

Abstract: The present invention relates to the uses of the protein PRG4 and therapeutic modulation thereof. In particular, the present invention relates compositions and methods utilizing PRG4 and therapeutic modulation thereof, including, use as a surgical lubricant, use in a treatment for prevention or reduction of post-surgical adhesions, use in a treatment for oral ulcerations, use as an athletic lubricating patch, use as a dermal filler, use in a treatment for dry mouth, use in a drug delivery method or composition, and use in nursing lubrication.

Abstract translation: 本发明涉及蛋白质PRG4的用途及其治疗调节。 特别地，本发明涉及使用PRG4的组合物和方法及其治疗调节剂，其包括用作外科润滑剂，用于预防或减少手术后粘连的治疗，用于口腔溃疡治疗中的用途，用作 运动润滑贴片，用作皮肤填充剂，用于治疗口干，用于药物递送方法或组合物，并用于护理润滑。

公开(公告)号：US20110154224A1

公开(公告)日：2011-06-23

申请号：US12970062

申请日：2010-12-16

Applicant: Dan Bates ,  Scott Holmes ,  Benjamin Sullivan

Inventor： Dan Bates ,  Scott Holmes ,  Benjamin Sullivan

IPC: G06F3/01 ,  G06F15/16

CPC classification number: G06Q10/10 ,  H04L12/1822 ,  H04N21/4788 ,  H04N21/812

Abstract: Described herein are methods, systems, and devices comprising or utilizing a digital processing device comprising an operating system that is configured to read executable instructions for creating at least one contextual-based chatroom that is focused on a topic of interest that is in common between at least a first user (including e.g., a pulled or pushed user) and at least a second user (including e.g., a pulled or pushed user) of an interconnected network.

Abstract translation: 这里描述了包括或利用数字处理设备的方法，系统和设备，该数字处理设备包括操作系统，该操作系统被配置为读取可执行指令，用于创建至少一个基于语境的聊天室，该聊天室专注于感兴趣的主题， 至少一个第一用户（包括例如，被拉或被推的用户）和至少一个互连网络的第二用户（包括例如拉或被推的用户）。

公开(公告)号：US20110059902A1

公开(公告)日：2011-03-10

申请号：US12940370

申请日：2010-11-05

Applicant: Benjamin Sullivan ,  Tannin A. Schmidt ,  David A. Sullivan

Inventor： Benjamin Sullivan ,  Tannin A. Schmidt ,  David A. Sullivan

IPC: A61K38/17 ,  A61P27/02

CPC classification number: A61K38/14 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/568 ,  A61K31/685 ,  A61K31/688 ,  A61K31/715 ,  A61K31/728 ,  A61K38/13 ,  A61K38/17 ,  A61K38/1709 ,  A61K38/1841 ,  A61K45/06 ,  A61K47/02 ,  A61K47/24 ,  A61K2300/00

Abstract: The present invention provides a pharmaceutical composition, and methods of use thereof, for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface. The pharmaceutical composition of the present invention comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The pharmaceutical composition of the present invention may also comprise one or more ophthalmically acceptable agents selected from the group consisting of an ophthalmically acceptable demulcent, excipient, astringent, vasoconstrictor, emollient, sodium hyaluronate, hyaluronic acid, and surface active phospholipids, in a pharmaceutically acceptable carrier for topical administration.

Abstract translation: 本发明提供了一种药物组合物及其使用方法，用于治疗眼部边界不足，与之相关的症状，或与眼表面相关或导致眼部边界缺陷的不期望状况。 本发明的药物组合物包含悬浮在眼科可接受的平衡盐溶液中的人PRG4蛋白，润滑剂片段，同系物或同种型。 本发明的药物组合物还可以包含一种或多种选自以下的眼科学上可接受的试剂：药学上可接受的药物，所述药剂选自眼科可接受的抑制剂，赋形剂，收敛剂，血管收缩剂，润肤剂，透明质酸钠，透明质酸和表面活性磷脂 载体用于局部给药。

公开(公告)号：US20090221443A1

公开(公告)日：2009-09-03

申请号：US11914122

申请日：2006-05-11

Applicant: Michael Heller ,  Benjamin Sullivan ,  Dietrich Dehlinger

Inventor： Michael Heller ,  Benjamin Sullivan ,  Dietrich Dehlinger

IPC: C40B60/14 ,  C40B50/14 ,  C40B40/00 ,  C40B40/18 ,  C40B40/14 ,  C40B40/06

CPC classification number: G01N33/531 ,  B82Y30/00 ,  C12Q1/68 ,  G01N33/48721

Abstract: The invention relates to processes and devices for the controlled fabrication of nanostructures from starting components that have high fidelity recognition properties and multiple binding groups. In one embodiment, the invention relates to the formation of nanostructures using controlled sequential addition of nanocomponents at regular intervials via sequential formation of binding pairs or other chemical binding reactions.

Abstract translation: 本发明涉及从具有高保真度识别特性和多个结合基团的起始组分控制制造纳米结构的方法和装置。 在一个实施方案中，本发明涉及使用通过连续形成结合对或其它化学结合反应在常规间隔区内以受控顺序添加纳米组分形成纳米结构。

公开(公告)号：US20080148821A1

公开(公告)日：2008-06-26

申请号：US12001243

申请日：2007-12-11

Applicant: Eric Donsky ,  Benjamin Sullivan

Inventor： Eric Donsky ,  Benjamin Sullivan

IPC: G01N13/04

CPC classification number: G01N13/04 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/165 ,  C12Q1/00 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/77 ,  G01N33/487 ,  G01N33/68 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2021/7786 ,  G01N2201/06113 ,  Y10T436/24

Abstract: A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

Abstract translation: 一种样品接收芯片，包括接收样品流体的等分试样体积和基底的样品区域的基底，其尺寸使得样品流体的体积足以可操作地覆盖样品区域的一部分。 被送入样品流体的能量被样品区域转导以产生指示样品流体的能量特性的输出信号。 样品接收芯片还包括形成在衬底中的通道，通道被配置为收集样品流体的等分试样体积，并将样品流体的等分试样体积转移到样品区域。

公开(公告)号：US07111502B2

公开(公告)日：2006-09-26

申请号：US10810780

申请日：2004-03-25

Applicant: Benjamin Sullivan ,  Eric Donsky

Inventor： Benjamin Sullivan ,  Eric Donsky

IPC: G01N13/04

CPC classification number: G01N13/04

Abstract: An osmolarity measuring system includes the ability to recognize patterns within the electrical profile of nanoliters of fluid an account for corruptive signals in the electrical profile. These corruptive signals are mainly caused by the mechanical relaxation of the sample fluid after delivery or evaporation across the electrodes.

Abstract translation: 渗透压测量系统包括识别流体中纳升管的电气剖面中的图案的能力的能力，以考虑电气剖面中的腐蚀信号。 这些腐蚀性信号主要是由于在分送或蒸发电极之后样品流体的机械松弛引起的。

公开(公告)号：US20210251338A1

公开(公告)日：2021-08-19

申请号：US17306894

申请日：2021-05-03

Applicant: Nicole Justis Truitt ,  Benjamin Sullivan ,  Zeyad Moussa ,  Daniel Kincade

Inventor： Nicole Justis Truitt ,  Benjamin Sullivan ,  Zeyad Moussa ,  Daniel Kincade

IPC: A43B23/02 ,  B81C1/00 ,  A41D27/08 ,  G02B5/24 ,  G02B26/00 ,  G09F13/24 ,  A43B1/00 ,  A43B3/00 ,  A43B3/24 ,  G09F21/02 ,  A41D27/00 ,  A43B23/24 ,  B44C5/00

Abstract: Provided herein are methods for the modulation of appearance or material properties within items of apparel or equipment. Also provided herein are design articles having alterable designs.