公开(公告)号：US20050198023A1

公开(公告)日：2005-09-08

申请号：US11056733

申请日：2005-02-11

申请人： Christina James ,  Mark Brighton ,  Lisa Nathan ,  Ethan Bradford ,  David Kay

发明人： Christina James ,  Mark Brighton ,  Lisa Nathan ,  Ethan Bradford ,  David Kay

IPC分类号： G06F17/22 ,  G06F17/27 ,  G06F7/00

CPC分类号： G06F3/0236 ,  G06F17/276 ,  Y10S707/99931 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99935 ,  Y10S707/99936

摘要： The invention provides a process for selecting and ordering one or more sets of linguistic objects. The invention orders a current list of items for selection that comprises a first list of one or more items of a first language and a second list of one or more items of a second language, the current list of items being displayed in an order based on the first language having a priority over the second language. In response to a user selection of one item from the second list, the invention changes a priority for ordering a subsequent list of items to order the subsequent list of items based on the second language having a priority over the first language.

摘要翻译： 本发明提供了一种用于选择和排序一组或多组语言对象的过程。 本发明命令包括第一语言的一个或多个项目的第一列表和第二语言的一个或多个项目的第二列表的当前列表，该当前项目列表以基于 第一语言优先于第二语言。 响应于用户从第二列表中选择一个项目，本发明改变了排序随后的项目列表的优先级，以便基于具有优先于第一语言的优先级的第二语言来订购随后的项目列表。

公开(公告)号：US07580829B2

公开(公告)日：2009-08-25

申请号：US11056733

申请日：2005-02-11

申请人： Christina James ,  Mark Brighton ,  Lisa Nathan ,  Ethan Bradford ,  David Kay

发明人： Christina James ,  Mark Brighton ,  Lisa Nathan ,  Ethan Bradford ,  David Kay

IPC分类号： G06F17/20

CPC分类号： G06F3/0236 ,  G06F17/276 ,  Y10S707/99931 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99935 ,  Y10S707/99936

摘要： The invention provides a process for selecting and ordering one or more sets of linguistic objects. The invention orders a current list of items for selection that comprises a first list of one or more items of a first language and a second list of one or more items of a second language, the current list of items being displayed in an order based on the first language having a priority over the second language. In response to a user selection of one item from the second list, the invention changes a priority for ordering a subsequent list of items to order the subsequent list of items based on the second language having a priority over the first language.

摘要翻译： 本发明提供了一种用于选择和排序一组或多组语言对象的过程。 本发明命令包括第一语言的一个或多个项目的第一列表和第二语言的一个或多个项目的第二列表的当前列表，该当前项目列表以基于 第一语言优先于第二语言。 响应于用户从第二列表中选择一个项目，本发明改变了排序随后的项目列表的优先级，以便基于具有优先于第一语言的优先级的第二语言来订购随后的项目列表。

公开(公告)号：US20050234722A1

公开(公告)日：2005-10-20

申请号：US11043506

申请日：2005-01-25

申请人： Alex Robinson ,  Ethan Bradford ,  David Kay ,  Pim Meurs ,  James Stephanick

发明人： Alex Robinson ,  Ethan Bradford ,  David Kay ,  Pim Meurs ,  James Stephanick

IPC分类号： G06K9/22 ,  G06K9/72 ,  G10L15/18 ,  G10L15/24

CPC分类号： G06K9/222 ,  G06K9/72 ,  G06K2209/01 ,  G10L15/183 ,  G10L15/24

摘要： A hybrid approach to improve handwriting recognition and voice recognition in data process systems is disclosed. In one embodiment, a front end is used to recognize strokes, characters and/or phonemes. The front end returns candidates with relative or absolute probabilities of matching to the input. Based on linguistic characteristics of the language, e.g. alphabetical or ideographic language for the words being entered, e.g. frequency of words and phrases being used, likely part of speech of the word entered, the morphology of the language, or the context in which the word is entered), a back end combines the candidates determined by the front end from inputs for words to match with known words and the probabilities of the use of such words in the current context.

公开(公告)号：US20050192802A1

公开(公告)日：2005-09-01

申请号：US11043525

申请日：2005-01-25

申请人： Alex Robinson ,  Ethan Bradford ,  David Kay ,  Pim Meurs ,  James Stephanick

发明人： Alex Robinson ,  Ethan Bradford ,  David Kay ,  Pim Meurs ,  James Stephanick

IPC分类号： G10L15/00

CPC分类号： G06K9/723 ,  G06K9/00872 ,  G06K9/726 ,  G06K2209/01 ,  G10L15/18

摘要： A hybrid approach to improve handwriting recognition and voice recognition in data process systems is disclosed. In one embodiment, a front end is used to recognize strokes, characters and/or phonemes. The front end returns candidates with relative or absolute probabilities of matching to the input. Based on linguistic characteristics of the language, e.g. alphabetical or ideographic language for the words being entered, e.g. frequency of words and phrases being used, likely part of speech of the word entered, the morphology of the language, or the context in which the word is entered), a back end combines the candidates determined by the front end from inputs for words to match with known words and the probabilities of the use of such words in the current context.

摘要翻译： 公开了一种改进数据处理系统中的手写识别和语音识别的混合方法。 在一个实施例中，前端用于识别笔画，字符和/或音素。 前端返回具有与输入匹配的相对或绝对概率的候选。 基于语言的语言特征，例如 输入字词的字母或表意语言。 使用的单词和短语的频率，输入的词的可能部分语言，语言的形态或输入单词的上下文），后端将由前端确定的候选词与词的输入相结合 与已知单词匹配以及在当前上下文中使用这些单词的概率。

公开(公告)号：US20080100579A1

公开(公告)日：2008-05-01

申请号：US11853320

申请日：2007-09-11

申请人： B. Robinson ,  Michael Longe ,  David Kay ,  Gordon Waddell

发明人： B. Robinson ,  Michael Longe ,  David Kay ,  Gordon Waddell

IPC分类号： G09G5/00

CPC分类号： G06F3/0219 ,  G06F3/0233 ,  G06F3/0237 ,  G06F3/0238 ,  G06F3/04886 ,  G06F3/0489 ,  G06F3/14 ,  G06F17/273 ,  G09G2354/00

摘要： There is disclosed an enhanced text entry system which uses word-level analysis to automatically correct inaccuracies in user keystroke entries on reduced keyboards such as those implemented on a touch-sensitive panel or display screen, or on mechanical keyboard systems. A method and system are defined which determine one or more alternate textual interpretations of each sequence of inputs detected within a designated auto-correcting keyboard region. The actual contact locations for the keystrokes may occur outside the boundaries of the specific keyboard key regions associated with the actual characters of the word interpretations proposed or offered for selection, where the distance from each contact location to each corresponding intended character may in general increase with the expected frequency of the intended word in the language or in a particular context. Likewise, in a mechanical keyboard system, the keys actuated may differ from the keys actually associated with the letters of the word interpretations. Each such sequence corresponds to a complete word, and the user can easily select the intended word from among the generated interpretations. Additionally, when the system cannot identify a sufficient number of likely word interpretation candidates of the same length as the input sequence, candidates are identified whose initial letters correspond to a likely interpretation of the input sequence. The approach utilizes the information contained in the entire sequence of keystrokes corresponding to a word in order to determine the user's likely intention for each character of the sequence. The system also accommodates punctuation characters such as hyphens or apostrophes that are commonly embedded in words such as hyphenated compounds and contractions in English, and characters with special diacritics such as are commonly found in various European languages, e.g., diacritic accent. Special functions may be applied depending on where the user touches the intended string in a displayed word selection list. Once the user selects the desired string, it is automatically “accepted” for output and the next input detected starts a new input sequence corresponding to the entry of a next word.

公开(公告)号：US09630956B2

公开(公告)日：2017-04-25

申请号：US13106476

申请日：2011-05-12

申请人： Jean-Damien Charrier ,  Hayley Marie Binch ,  Dennis James Hurley ,  Thomas Cleveland ,  Pramod Joshi ,  Lev Tyler Dewey Fanning ,  Joanne Pinder ,  Michael O'Donnell ,  Anisa Nizarali Virani ,  Ronald Marcellus Alphonsus Knegtel ,  Steven John Durrant ,  Stephen Clinton Young ,  Pierre-Henri Storck ,  David Kay ,  Philip Michael Reaper ,  Matthew Paul Grote

发明人： Jean-Damien Charrier ,  Hayley Marie Binch ,  Dennis James Hurley ,  Thomas Cleveland ,  Pramod Joshi ,  Lev Tyler Dewey Fanning ,  Joanne Pinder ,  Michael O'Donnell ,  Anisa Nizarali Virani ,  Ronald Marcellus Alphonsus Knegtel ,  Steven John Durrant ,  Stephen Clinton Young ,  Pierre-Henri Storck ,  David Kay ,  Philip Michael Reaper ,  Matthew Paul Grote

IPC分类号： A61K31/497 ,  A61K33/24 ,  C07D413/14 ,  C07D401/14 ,  C07D241/10

CPC分类号： C07D413/14

摘要： The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

公开(公告)号：US08557818B2

公开(公告)日：2013-10-15

申请号：US13356924

申请日：2012-01-24

申请人： Jean-Damien Charrier ,  Ronald Knegtel ,  David Kay

发明人： Jean-Damien Charrier ,  Ronald Knegtel ,  David Kay

IPC分类号： A61K31/519 ,  A61P31/00

CPC分类号： C07D475/00

摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

公开(公告)号：US08524720B2

公开(公告)日：2013-09-03

申请号：US12651639

申请日：2010-01-04

申请人： David Bebbington ,  Hayley Binch ,  Ronald Knegtel ,  Julian M.C. Golec ,  Sanjay Patel ,  Jean-Damien Charrier ,  David Kay ,  Robert Davies ,  Pan Li ,  Marion Wannamaker ,  Cornelia Forster ,  Albert Pierce

发明人： David Bebbington ,  Hayley Binch ,  Ronald Knegtel ,  Julian M.C. Golec ,  Sanjay Patel ,  Jean-Damien Charrier ,  David Kay ,  Robert Davies ,  Pan Li ,  Marion Wannamaker ,  Cornelia Forster ,  Albert Pierce

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P25/28 ,  A61P3/10

CPC分类号： C07D401/14 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/16 ,  C07D487/04 ,  C07D491/04 ,  C07D491/10 ,  C07D493/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

摘要： This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2′, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

摘要翻译： 本发明描述了式IV的新型吡唑化合物：其中环D是5-7元单环或选自芳基，杂芳基，杂环基或碳环基的8-10元双环; R x和R y独立地选自T-R 3，或与它们的插入原子一起形成具有1-3个选自氧，硫或氮的环杂原子的稠合的，不饱和的或部分不饱和的5-8元环; R2，R2'，T和R3如说明书中所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。

公开(公告)号：US08268829B2

公开(公告)日：2012-09-18

申请号：US12436407

申请日：2009-05-06

申请人： Jean-Damien Charrier ,  Francesca Mazzei ,  David Kay ,  Andrew Miller

发明人： Jean-Damien Charrier ,  Francesca Mazzei ,  David Kay ,  Andrew Miller

IPC分类号： C07D403/14 ,  A61K31/4155

CPC分类号： C07D403/14 ,  C07D239/34 ,  C07D401/14 ,  C07D403/12 ,  C07D453/02

摘要： The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.

摘要翻译： 本发明提供了制备三取代和四取代嘧啶的简便方法。 该方法可用于制备蛋白激酶抑制剂，特别是Aurora激酶。 这些抑制剂可用于治疗或减轻Aurora介导的疾病或病症的严重性。

公开(公告)号：US20120027874A1

公开(公告)日：2012-02-02

申请号：US13106476

申请日：2011-05-12

申请人： Jean-Damien Charrier ,  Hayley Marie Binch ,  Dennis James Hurley ,  Thomas Cleveland ,  Pramod Joshi ,  Lev Tyler Dewey Fanning ,  Joanne Pinder ,  Michael O'Donnell ,  Anisa Nizarali Virani ,  Ronald Marcellus Alphonsus Knegtel ,  Steven John Durrant ,  Stephen Clinton Young ,  Pierre-Henri Storck ,  David Kay ,  Philip Michael Reaper

发明人： Jean-Damien Charrier ,  Hayley Marie Binch ,  Dennis James Hurley ,  Thomas Cleveland ,  Pramod Joshi ,  Lev Tyler Dewey Fanning ,  Joanne Pinder ,  Michael O'Donnell ,  Anisa Nizarali Virani ,  Ronald Marcellus Alphonsus Knegtel ,  Steven John Durrant ,  Stephen Clinton Young ,  Pierre-Henri Storck ,  David Kay ,  Philip Michael Reaper

IPC分类号： A61K31/497 ,  A61K33/24 ,  A61P35/00 ,  C07D413/14

CPC分类号： C07D413/14

摘要： The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.