公开(公告)号：US09107773B2

公开(公告)日：2015-08-18

申请号：US13555056

申请日：2012-07-20

申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F13/12 ,  A61F9/00 ,  A61F9/013 ,  A61F9/04 ,  A61L27/18 ,  G02C7/04 ,  A61F9/008

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

公开(公告)号：US20100255061A1

公开(公告)日：2010-10-07

申请号：US12696678

申请日：2010-01-29

申请人： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

发明人： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

IPC分类号： A61F9/00 ,  A61K39/395 ,  A61P27/02 ,  A61K31/5575 ,  A61K31/58 ,  A61F2/14 ,  B23P17/04

CPC分类号： G01N33/558 ,  A61F9/0017 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K38/385 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/55 ,  Y10T29/49826

摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧，以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口，使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ，例如当器件长时间植入时，可以使用颗粒，细胞，细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器，使得该装置可以从输送装置的内腔输送，并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。

公开(公告)号：US20130070200A1

公开(公告)日：2013-03-21

申请号：US13503842

申请日：2010-10-25

申请人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F9/00 ,  G02C7/04

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

公开(公告)号：US08459793B2

公开(公告)日：2013-06-11

申请号：US13615111

申请日：2012-09-13

申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61B3/14 ,  A61B3/00

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

公开(公告)号：US08399006B2

公开(公告)日：2013-03-19

申请号：US12696678

申请日：2010-01-29

申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela Macfarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela Macfarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

IPC分类号： A61M37/00 ,  A61M31/00

CPC分类号： G01N33/558 ,  A61F9/0017 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K38/385 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/55 ,  Y10T29/49826

摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧，以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口，使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ，例如当器件长时间植入时，可以使用颗粒，细胞，细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器，使得该装置可以从输送装置的内腔输送，并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。

公开(公告)号：US20130025606A1

公开(公告)日：2013-01-31

申请号：US13615111

申请日：2012-09-13

申请人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F9/00

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

摘要翻译： 适形覆盖物包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分并提供用于上皮再生的环境。 覆盖物的内部部分可以以许多方式配置，以便至少部分地符合消融的基质表面，以便矫正视力。 适形的内部部分可以具有至少一些刚性，以便平滑上皮，使得上皮迅速再生并且被覆盖物引导以形成平滑的视觉层。 内部部分可以包括在约1×10 -4 Pa * m 3至约5×10 -4 Pa * m 3的范围内的刚性量，以便至少部分地偏转并符合消融的角膜并使内部部分平滑 的消融量在偏转时具有一定的压力。

公开(公告)号：US20120029470A1

公开(公告)日：2012-02-02

申请号：US13252942

申请日：2011-10-04

申请人： Eugene de Juan, JR. ,  Yair Alster ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Douglas Sutton

发明人： Eugene de Juan, JR. ,  Yair Alster ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela MacFarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Douglas Sutton

IPC分类号： A61F9/00

CPC分类号： G01N33/558 ,  A61F9/0017 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K38/385 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/55 ,  Y10T29/49826

摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

公开(公告)号：US09498385B2

公开(公告)日：2016-11-22

申请号：US13503842

申请日：2010-10-25

申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela MacFarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela MacFarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F13/00 ,  A61F13/12 ,  A61F9/00 ,  A61F9/013 ,  A61F9/04 ,  A61L27/18 ,  G02C7/04 ,  A61F9/008

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

公开(公告)号：US20130204209A1

公开(公告)日：2013-08-08

申请号：US13831695

申请日：2013-03-15

申请人： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela Macfarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

发明人： Eugene de Juan, JR. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela Macfarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

IPC分类号： A61F9/00

CPC分类号： G01N33/558 ,  A61F9/0017 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K38/385 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/55 ,  Y10T29/49826

摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

公开(公告)号：US20120310133A1

公开(公告)日：2012-12-06

申请号：US13555056

申请日：2012-07-20

申请人： Eugene De Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene De Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F9/00

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

摘要翻译： 适形覆盖物包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分并提供用于上皮再生的环境。 覆盖物的内部部分可以以许多方式配置，以便至少部分地符合消融的基质表面，以便矫正视力。 适形的内部部分可以具有至少一些刚性，以便平滑上皮，使得上皮迅速再生并且被覆盖物引导以形成平滑的视觉层。 内部部分可以包括在约1×10 -4 Pa * m 3至约5×10 -4 Pa * m 3的范围内的刚性量，以便至少部分地偏转并符合消融的角膜并使内部部分平滑 的消融量在偏转时具有一定的压力。