公开(公告)号：US06432050B1

公开(公告)日：2002-08-13

申请号：US09303644

申请日：1999-05-03

申请人： Yariv Porat ,  Avi Penner ,  Eyal Doron

发明人： Yariv Porat ,  Avi Penner ,  Eyal Doron

IPC分类号： A61B500

CPC分类号： A61B5/02158 ,  A61B5/0031 ,  A61B5/026 ,  A61B5/031 ,  A61B5/413 ,  A61B2562/028 ,  A61M2205/3523 ,  G01F1/36 ,  G01F1/72 ,  H01L41/1138 ,  H04R17/00

摘要： An implantable biosensor system for monitoring and optionally alleviating a physiological condition in a patient is provided and includes (a) at least one sensor for sensing at least one parameter of a physiological condition and for generating electrical sensor signals representative of the physiological condition; and (b) a first acoustic activatable transducer being directly or indirectly coupled with the at least one sensor, the first acoustic activatable transducer being for converting a received acoustic interrogation signal from outside the patient's body into an electrical power for energizing the processor, the first acoustic activatable transducer further being for converting the electrical sensor signals of the at least one sensor into acoustic signals receivable out of the patient's body, such that information pertaining to the at least one parameter of the physiological condition can be relayed outside the patient's body upon generation of an acoustic interrogation signal.

摘要翻译： 提供了一种用于监测和任选地减轻患者生理状况的植入式生物传感器系统，其包括（a）至少一个用于感测至少一个生理状态参数并用于产生代表生理状态的电传感器信号的传感器; 所述第一声学可激活换能器用于将接收到的来自患者身体外部的声学询问信号转换成用于激励所述处理器的电力，所述第一声学可激活换能器与所述至少一个传感器直接或间接耦合， 声学可激活的换能器还用于将至少一个传感器的电传感器信号转换成可从患者身体接收的声信号，使得与生理状况的至少一个参数相关的信息可以在生成后被中继到患者体外 的声讯讯号。

公开(公告)号：US06239724B1

公开(公告)日：2001-05-29

申请号：US09316397

申请日：1999-05-21

申请人： Eyal Doron ,  Yariv Porat ,  Avi Penner

发明人： Eyal Doron ,  Yariv Porat ,  Avi Penner

IPC分类号： G08C1912

CPC分类号： A61B5/0535 ,  A61B5/0031 ,  A61B5/413 ,  A61B2562/028 ,  A61N1/37288 ,  G01F1/36 ,  G01F1/72 ,  H01L41/1132 ,  H04R17/00 ,  Y10S128/903

摘要： A telemetry system and method for providing spatial positioning information from within a patient's body are disclosed. The system includes at least one implantable telemetry unit which includes (a) at least one first transducer being for converting a power signal received from outside the body, into electrical power for powering the at least one implantable telemetry unit; (b) at least one second transducer being for receiving a positioning field signal being received from outside the body; and (c) at least one third transducer being for transmitting a locating signal transmittable outside the body in response to the positioning field signal.

摘要翻译： 公开了一种用于从患者体内提供空间定位信息的遥测系统和方法。 该系统包括至少一个可植入遥测单元，其包括（a）用于将从身体外部接收的功率信号转换成用于为至少一个可植入遥测单元供电的电力的至少一个第一换能器; （b）至少一个第二换能器，用于接收从身体外部接收的定位场信号; 和（c）至少一个第三换能器，用于响应于所述定位场信号，传送可发射到身体外部的定位信号。

公开(公告)号：US08591423B2

公开(公告)日：2013-11-26

申请号：US12557384

申请日：2009-09-10

申请人： Eyal Doron

发明人： Eyal Doron

IPC分类号： A61B5/0215

CPC分类号： A61B5/029 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/36571

摘要： Systems and methods for determining cardiac output are disclosed. An illustrative method of determining cardiac output includes sensing an arterial pressure waveform using a pressure sensor located within a pulmonary artery, identifying a valve closure time associated with the pulmonary valve using the sensed arterial pressure waveform, estimating stroke volume using the systolic portion of the arterial pressure waveform and the valve closure time, and obtaining a measure of cardiac output based on the estimated stroke volume.

摘要翻译： 公开了用于确定心输出量的系统和方法。 确定心输出量的说明性方法包括使用位于肺动脉内的压力传感器来感测动脉压波形，使用感测到的动脉压波形识别与肺动脉瓣相关的瓣膜闭合时间，使用动脉的收缩部分估计运动量 压力波形和阀关闭时间，并且基于估计的行程体积获得心输出量的测量值。

公开(公告)号：US20100094144A1

公开(公告)日：2010-04-15

申请号：US12557384

申请日：2009-09-10

申请人： Eyal Doron

发明人： Eyal Doron

IPC分类号： A61B5/0215 ,  A61B5/0402

CPC分类号： A61B5/029 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/36571

摘要： Systems and methods for determining cardiac output are disclosed. An illustrative method of determining cardiac output includes sensing an arterial pressure waveform using a pressure sensor located within a pulmonary artery, identifying a valve closure time associated with the pulmonary valve using the sensed arterial pressure waveform, estimating stroke volume using the systolic portion of the arterial pressure waveform and the valve closure time, and obtaining a measure of cardiac output based on the estimated stroke volume.

摘要翻译： 公开了用于确定心输出量的系统和方法。 确定心输出量的说明性方法包括使用位于肺动脉内的压力传感器来感测动脉压波形，使用感测到的动脉压波形识别与肺动脉瓣相关的瓣膜闭合时间，使用动脉的收缩部分估计运动量 压力波形和阀关闭时间，并且基于估计的行程体积获得心输出量的测量值。

公开(公告)号：US20080077440A1

公开(公告)日：2008-03-27

申请号：US11860498

申请日：2007-09-24

申请人： Eyal Doron

发明人： Eyal Doron

IPC分类号： G06Q50/00 ,  G06F17/00

CPC分类号： A61B5/4839 ,  A61B5/021 ,  A61B5/0402 ,  A61B5/053 ,  A61B5/076 ,  A61B5/145 ,  A61B5/14532 ,  A61B7/00 ,  A61J7/049 ,  G06F19/3462 ,  G06Q50/22 ,  G07F17/0092

摘要： An automatic drug dispensing system that dispenses variable amounts or types of drugs to treat a particular medical condition of a patient, the system comprising a medical sensor which may be implanted in or otherwise coupled to a body surface of a patient, wherein the sensor is configured to measure one or more physiological parameters of the patient; a user interface configured for receiving input relating to the patient's current condition; and a processor configured to determine one or more of a drug selection, dosage, and timing regime based at least in part on information received from the medical sensor and user interface.

摘要翻译： 一种自动药物分配系统，其分配可变量或类型的药物以治疗患者的特定医疗状况，所述系统包括可植入或以其他方式耦合到患者身体表面的医疗传感器，其中所述传感器被配置 测量患者的一个或多个生理参数; 用户接口，被配置为接收与患者的当前状况有关的输入; 以及处理器，其被配置为至少部分地基于从所述医疗传感器和用户界面接收的信息来确定药物选择，剂量和定时方案中的一个或多个。

公开(公告)号：US07024248B2

公开(公告)日：2006-04-04

申请号：US09989912

申请日：2001-11-19

申请人： Avl Penner ,  Eyal Doron

发明人： Avl Penner ,  Eyal Doron

IPC分类号： A61N1/18

CPC分类号： A61N1/37217 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/1112 ,  A61B5/14539 ,  A61B5/4839 ,  A61B8/4281 ,  A61B8/4472 ,  A61B8/56 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2560/0242 ,  A61B2560/0257 ,  A61B2560/0412 ,  A61B2562/028 ,  A61N1/08 ,  A61N1/37235 ,  A61N1/37252 ,  A61N1/3787 ,  Y10S128/903

摘要： Systems and methods for communicating with an implant within a patient's body using acoustic telemetry includes an external communications device attachable to the patient's skin. The device includes an acoustic transducer for transmitting acoustic signals into the patient's body and/or for receiving acoustic signals from the implant. The device includes a battery for providing electrical energy to operate the device, a processor for extracting data from acoustic signals received from the implant, and memory for storing the data. The device may include an interface for communicating with a recorder or computer, e.g., to transfer data from the implant and/or to receive instructions for controlling the implant. The device is secured to the patient's skin for controlling, monitoring, or otherwise communicating with the implant, while allowing the patient to remain mobile.

公开(公告)号：US06486588B2

公开(公告)日：2002-11-26

申请号：US09872129

申请日：2001-06-01

申请人： Eyal Doron ,  Avi Penner

发明人： Eyal Doron ,  Avi Penner

IPC分类号： H01L4108

CPC分类号： A61B5/031 ,  A61B5/0031 ,  A61B5/02014 ,  A61B5/413 ,  A61B2562/028 ,  A61M2205/3523 ,  H01L41/1132 ,  H04R17/00

摘要： An acoustic biosensor is provided for deployment at an implantation site within a body, such as an abdominal aortic aneurysm. The biosensor includes a sensor element for measuring a physiological condition at the implantation site, and for generating an information signal representative of the physiological condition. The biosensor further includes a piezoelectric transducer element for converting an externally originated acoustic interrogation signal into energy for operating the sensor, and for modulating the interrogation signal, e.g., by employing a switching element to alternate the mechanical impedance of the transducer element, to transmit the information signal outside of the body.

摘要翻译： 提供声学生物传感器用于在体内的植入部位，例如腹主动脉瘤。 生物传感器包括用于测量植入部位的生理状况的传感器元件，并且用于生成表示生理状态的信息信号。 生物传感器还包括用于将外部产生的声讯讯信号转换成用于操作传感器的能量的压电换能器元件，并且例如通过使用开关元件来交替换能器元件的机械阻抗来调制询问信号， 身体外的信息信号。

公开(公告)号：US06475170B1

公开(公告)日：2002-11-05

申请号：US09523413

申请日：2000-03-10

申请人： Eyal Doron ,  Avi Penner

发明人： Eyal Doron ,  Avi Penner

IPC分类号： A61B5103

CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/02158 ,  A61B5/026 ,  A61B5/031 ,  A61B5/413 ,  A61B2562/028 ,  A61M2205/3523 ,  G01F1/36 ,  G01F1/72 ,  H04R17/00

摘要： An acoustic biosensor is provided for deployment at an implantation site within a body, such as an abdominal aortic aneurysm. The biosensor includes a sensor element for measuring a physiological condition at the implantation site, and for generating an information signal representative of the physiological condition. The biosensor further includes a piezoelectric transducer element for converting an externally originated acoustic interrogation signal into energy for operating the sensor, and for modulating the interrogation signal, e.g., by employing a switching element to alternate the mechanical impedance of the transducer element, to transmit the information signal outside of the body.

公开(公告)号：US06198965B1

公开(公告)日：2001-03-06

申请号：US09312760

申请日：1999-05-17

申请人： Avi Penner ,  Eyal Doron ,  Yariv Porat

发明人： Avi Penner ,  Eyal Doron ,  Yariv Porat

IPC分类号： A61B500

CPC分类号： A61B5/0031 ,  A61B5/0535 ,  A61B5/413 ,  A61B2562/028 ,  A61N1/37252 ,  A61N1/37288 ,  H04R17/00

摘要： A telemetry system for monitoring a rejection reaction of a transplanted organ being transplanted within a patient's body is provided. The telemetry system includes (a) a telemetry control unit located outside the body of the patient; and (b) a telemetry monitoring unit implanted within the body of the patient, the telemetry monitoring unit including: (i) at least one acoustic transducer being for receiving an acoustic signal from the telemetry control unit and converting the acoustic signal into a first electrical signal, the at least one acoustic transducer further being for receiving a second electrical signal and converting the second electrical signal into a transmitted acoustic signal receivable by the telemetry monitoring unit; and (ii) a plurality of electrodes positionable in intimate contact with, or deep within, the transplanted organ and being in communication with the at least one acoustic transducer, the plurality of electrodes being for passing the first electrical signal through the transplanted organ for monitoring the electrical impedance thereof and further being for relaying the second electrical signal corresponding to the electrical impedance to the at least one acoustic transducer so as to enable the monitoring of the presence or absence of the rejection reaction.

摘要翻译： 提供了一种用于监测被移植在患者体内的移植器官的排斥反应的遥测系统。 遥测系统包括（a）位于患者体外的遥测控制单元; 遥测监测单元植入患者体内，遥测监测单元包括：（i）至少一个声换能器，用于接收来自遥测单元的声信号，并将声信号转换为第一电 信号，所述至少一个声换能器还用于接收第二电信号并将所述第二电信号转换成可由所述遥测监测单元接收的传输声信号; 和（ii）多个电极，其定位成与移植的器官紧密接触或深入移动的器官并且与至少一个声换能器连通，所述多个电极用于使第一电信号通过移植器官用于监测 其电阻抗并且还用于将对应于电阻抗的第二电信号中继到至少一个声换能器，以便能够监测是否存在排斥反应。

公开(公告)号：US6140740A

公开(公告)日：2000-10-31

申请号：US553

申请日：1997-12-30

申请人： Yariv Porat ,  Yoseph Tsaliah ,  Eyal Doron

发明人： Yariv Porat ,  Yoseph Tsaliah ,  Eyal Doron

IPC分类号： A61B5/00 ,  A61B5/053 ,  G01F1/36 ,  G01F1/72 ,  H01L41/09 ,  H01L41/113 ,  H03H9/17 ,  H04R17/00 ,  H01L41/08

CPC分类号： A61B5/413 ,  A61B5/0031 ,  A61B5/0535 ,  G01F1/36 ,  G01F1/72 ,  H01L41/1132 ,  H04R17/00 ,  A61B2562/028 ,  A61N1/37288 ,  Y10S310/80

摘要： A miniature piezoelectric transducer element is provided, comprising; (a) a cell element having a cavity; (b) a flexible piezoelectric layer attached to the cell member, the piezoelectric layer having an external surface and an internal surface, the piezoelectric layer featuring such dimensions so as to enable fluctuations thereof at its resonance frequency upon impinging of an external acoustic wave; and (c) a first electrode attached to the external surface and a second electrode attached to the internal surface of the piezoelectric layer. At least one of the electrodes may be specifically shaped so as to provide a maximal electrical output, wherein the electrical output may be current, voltage or power. A preferred shape of the electrodes includes two cores interconnected by a connecting member. The transducer element may function as a transmitter. When used as a transmitter, the electrodes are electrically connected to an electrical circuit including a switching element for modulating the reflected acoustic wave by controllably changing the mechanical impedance of the piezoelectric layer according to the frequency of an electrical message signal arriving from an electronic member, such as a sensor. Third and fourth electrodes may be attached to the piezoelectric layer and the electrical circuit, such that the switching element alternately connects the electrodes in parallel and anti-parallel electrical connections so as to controllably change the mechanical impedance of the piezoelectric layer.

摘要翻译： 提供了一种微型压电传感器元件，包括： （a）具有空腔的电池元件; （b）安装在电池部件上的柔性压电体层，该压电体层具有外表面和内表面，该压电体层具有这样的尺寸，使其能够在外界声波入射时以其谐振频率发生波动; 和（c）附着到外表面的第一电极和附着在压电层的内表面上的第二电极。 电极中的至少一个可以被特别地成形为提供最大的电输出，其中电输出可​​以是电流，电压或功率。 电极的优选形状包括通过连接构件互连的两个芯。 换能器元件可以用作发射器。 当用作发射器时，电极电连接到包括用于通过可控地改变压电层的机械阻抗的调制反射声波的开关元件的电路，该电压根据从电子部件到达的电信号信号的频率， 例如传感器。 第三和第四电极可以附接到压电层和电路，使得开关元件以平行和反平行的电连接交替地连接电极，以便可控地改变压电层的机械阻抗。