公开(公告)号：US06198965B1

公开(公告)日：2001-03-06

申请号：US09312760

申请日：1999-05-17

申请人： Avi Penner ,  Eyal Doron ,  Yariv Porat

发明人： Avi Penner ,  Eyal Doron ,  Yariv Porat

IPC分类号： A61B500

CPC分类号： A61B5/0031 ,  A61B5/0535 ,  A61B5/413 ,  A61B2562/028 ,  A61N1/37252 ,  A61N1/37288 ,  H04R17/00

摘要： A telemetry system for monitoring a rejection reaction of a transplanted organ being transplanted within a patient's body is provided. The telemetry system includes (a) a telemetry control unit located outside the body of the patient; and (b) a telemetry monitoring unit implanted within the body of the patient, the telemetry monitoring unit including: (i) at least one acoustic transducer being for receiving an acoustic signal from the telemetry control unit and converting the acoustic signal into a first electrical signal, the at least one acoustic transducer further being for receiving a second electrical signal and converting the second electrical signal into a transmitted acoustic signal receivable by the telemetry monitoring unit; and (ii) a plurality of electrodes positionable in intimate contact with, or deep within, the transplanted organ and being in communication with the at least one acoustic transducer, the plurality of electrodes being for passing the first electrical signal through the transplanted organ for monitoring the electrical impedance thereof and further being for relaying the second electrical signal corresponding to the electrical impedance to the at least one acoustic transducer so as to enable the monitoring of the presence or absence of the rejection reaction.

摘要翻译： 提供了一种用于监测被移植在患者体内的移植器官的排斥反应的遥测系统。 遥测系统包括（a）位于患者体外的遥测控制单元; 遥测监测单元植入患者体内，遥测监测单元包括：（i）至少一个声换能器，用于接收来自遥测单元的声信号，并将声信号转换为第一电 信号，所述至少一个声换能器还用于接收第二电信号并将所述第二电信号转换成可由所述遥测监测单元接收的传输声信号; 和（ii）多个电极，其定位成与移植的器官紧密接触或深入移动的器官并且与至少一个声换能器连通，所述多个电极用于使第一电信号通过移植器官用于监测 其电阻抗并且还用于将对应于电阻抗的第二电信号中继到至少一个声换能器，以便能够监测是否存在排斥反应。

公开(公告)号：US06431175B1

公开(公告)日：2002-08-13

申请号：US09305442

申请日：1999-05-06

申请人： Avi Penner ,  Yariv Porat ,  Eyal Doron

发明人： Avi Penner ,  Yariv Porat ,  Eyal Doron

IPC分类号： A61B1900

CPC分类号： H01L41/1132 ,  A61B5/0031 ,  A61B5/413 ,  A61B2562/028 ,  A61N1/37288 ,  A61N5/1048 ,  A61N5/1071 ,  A61N2005/1072 ,  H04R17/00

摘要： A system for monitoring, directing and controlling the dose of radiation in a medical procedure for irradiating a specific region of a patient's body. In its generic form, the system includes at least one sensor being implantable within, or in proximity to, the specific region of the patient's body, the at least one sensor being for sensing at least one parameter associated with the radiation. The system further includes a relaying device which is in communication with the sensor(s). The relaying device serves for relaying the information outside of the patient's body.

摘要翻译： 用于在用于照射患者身体的特定区域的医疗程序中监测，指导和控制辐射剂量的系统。 在其通用形式中，该系统包括可植入在患者身体的特定区域内或附近的至少一个传感器，所述至少一个传感器用于感测与辐射相关联的至少一个参数。 该系统还包括与传感器通信的中继设备。 中继装置用于将病人身体外的信息中继。

公开(公告)号：US06432050B1

公开(公告)日：2002-08-13

申请号：US09303644

申请日：1999-05-03

申请人： Yariv Porat ,  Avi Penner ,  Eyal Doron

发明人： Yariv Porat ,  Avi Penner ,  Eyal Doron

IPC分类号： A61B500

CPC分类号： A61B5/02158 ,  A61B5/0031 ,  A61B5/026 ,  A61B5/031 ,  A61B5/413 ,  A61B2562/028 ,  A61M2205/3523 ,  G01F1/36 ,  G01F1/72 ,  H01L41/1138 ,  H04R17/00

摘要： An implantable biosensor system for monitoring and optionally alleviating a physiological condition in a patient is provided and includes (a) at least one sensor for sensing at least one parameter of a physiological condition and for generating electrical sensor signals representative of the physiological condition; and (b) a first acoustic activatable transducer being directly or indirectly coupled with the at least one sensor, the first acoustic activatable transducer being for converting a received acoustic interrogation signal from outside the patient's body into an electrical power for energizing the processor, the first acoustic activatable transducer further being for converting the electrical sensor signals of the at least one sensor into acoustic signals receivable out of the patient's body, such that information pertaining to the at least one parameter of the physiological condition can be relayed outside the patient's body upon generation of an acoustic interrogation signal.

摘要翻译： 提供了一种用于监测和任选地减轻患者生理状况的植入式生物传感器系统，其包括（a）至少一个用于感测至少一个生理状态参数并用于产生代表生理状态的电传感器信号的传感器; 所述第一声学可激活换能器用于将接收到的来自患者身体外部的声学询问信号转换成用于激励所述处理器的电力，所述第一声学可激活换能器与所述至少一个传感器直接或间接耦合， 声学可激活的换能器还用于将至少一个传感器的电传感器信号转换成可从患者身体接收的声信号，使得与生理状况的至少一个参数相关的信息可以在生成后被中继到患者体外 的声讯讯号。

公开(公告)号：US06239724B1

公开(公告)日：2001-05-29

申请号：US09316397

申请日：1999-05-21

申请人： Eyal Doron ,  Yariv Porat ,  Avi Penner

发明人： Eyal Doron ,  Yariv Porat ,  Avi Penner

IPC分类号： G08C1912

CPC分类号： A61B5/0535 ,  A61B5/0031 ,  A61B5/413 ,  A61B2562/028 ,  A61N1/37288 ,  G01F1/36 ,  G01F1/72 ,  H01L41/1132 ,  H04R17/00 ,  Y10S128/903

摘要： A telemetry system and method for providing spatial positioning information from within a patient's body are disclosed. The system includes at least one implantable telemetry unit which includes (a) at least one first transducer being for converting a power signal received from outside the body, into electrical power for powering the at least one implantable telemetry unit; (b) at least one second transducer being for receiving a positioning field signal being received from outside the body; and (c) at least one third transducer being for transmitting a locating signal transmittable outside the body in response to the positioning field signal.

摘要翻译： 公开了一种用于从患者体内提供空间定位信息的遥测系统和方法。 该系统包括至少一个可植入遥测单元，其包括（a）用于将从身体外部接收的功率信号转换成用于为至少一个可植入遥测单元供电的电力的至少一个第一换能器; （b）至少一个第二换能器，用于接收从身体外部接收的定位场信号; 和（c）至少一个第三换能器，用于响应于所述定位场信号，传送可发射到身体外部的定位信号。

公开(公告)号：US06486588B2

公开(公告)日：2002-11-26

申请号：US09872129

申请日：2001-06-01

申请人： Eyal Doron ,  Avi Penner

发明人： Eyal Doron ,  Avi Penner

IPC分类号： H01L4108

CPC分类号： A61B5/031 ,  A61B5/0031 ,  A61B5/02014 ,  A61B5/413 ,  A61B2562/028 ,  A61M2205/3523 ,  H01L41/1132 ,  H04R17/00

摘要： An acoustic biosensor is provided for deployment at an implantation site within a body, such as an abdominal aortic aneurysm. The biosensor includes a sensor element for measuring a physiological condition at the implantation site, and for generating an information signal representative of the physiological condition. The biosensor further includes a piezoelectric transducer element for converting an externally originated acoustic interrogation signal into energy for operating the sensor, and for modulating the interrogation signal, e.g., by employing a switching element to alternate the mechanical impedance of the transducer element, to transmit the information signal outside of the body.

摘要翻译： 提供声学生物传感器用于在体内的植入部位，例如腹主动脉瘤。 生物传感器包括用于测量植入部位的生理状况的传感器元件，并且用于生成表示生理状态的信息信号。 生物传感器还包括用于将外部产生的声讯讯信号转换成用于操作传感器的能量的压电换能器元件，并且例如通过使用开关元件来交替换能器元件的机械阻抗来调制询问信号， 身体外的信息信号。

公开(公告)号：US06475170B1

公开(公告)日：2002-11-05

申请号：US09523413

申请日：2000-03-10

申请人： Eyal Doron ,  Avi Penner

发明人： Eyal Doron ,  Avi Penner

IPC分类号： A61B5103

CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/02158 ,  A61B5/026 ,  A61B5/031 ,  A61B5/413 ,  A61B2562/028 ,  A61M2205/3523 ,  G01F1/36 ,  G01F1/72 ,  H04R17/00

摘要： An acoustic biosensor is provided for deployment at an implantation site within a body, such as an abdominal aortic aneurysm. The biosensor includes a sensor element for measuring a physiological condition at the implantation site, and for generating an information signal representative of the physiological condition. The biosensor further includes a piezoelectric transducer element for converting an externally originated acoustic interrogation signal into energy for operating the sensor, and for modulating the interrogation signal, e.g., by employing a switching element to alternate the mechanical impedance of the transducer element, to transmit the information signal outside of the body.

公开(公告)号：USRE42378E1

公开(公告)日：2011-05-17

申请号：US11491533

申请日：2006-07-20

申请人： Lone Wolinsky ,  Eyal Doron ,  Alon Ben-Yoseph ,  Avi Penner

发明人： Lone Wolinsky ,  Eyal Doron ,  Alon Ben-Yoseph ,  Avi Penner

IPC分类号： A61B5/04

CPC分类号： A61B5/0028 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/031 ,  A61B5/053 ,  A61B5/076 ,  A61B5/14539 ,  A61B2560/0219 ,  A61B2562/0247 ,  A61B2562/028 ,  A61N1/37217 ,  A61N1/3787 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0651

摘要： An implant includes a pressure sensor, a controller for acquiring pressure data from the sensor, and an acoustic transducer for converting energy between electrical energy and acoustic energy. A capacitor is coupled to the acoustic transducer for storing electrical energy converted by the transducer and/or for providing electrical energy to operate the implant. The acoustic transducer may operate alternatively or simultaneously as an energy exchanger or an acoustic transmitter. During use, the implant is implanted within a patient's body, and an external transducer transmits a first acoustic signal into the patient's body, to energize the capacitor. The implant then obtains pressure data, and transmits a second acoustic signal to the external transducer, the second acoustic signal including the pressure data.

摘要翻译： 植入物包括压力传感器，用于从传感器获取压力数据的控制器和用于在电能和声能之间转换能量的声换能器。 电容器耦合到声换能器，用于存储由换能器转换的电能和/或用于提供电能以操作植入物。 声换能器可以作为能量交换器或声发射器交替地或同时地操作。 在使用期间，将植入物植入患者体内，并且外部换能器将第一声信号传送到患者体内，以激励电容器。 然后，植入物获得压力数据，并将第二声学信号发送到外部换能器，第二声学信号包括压力数据。

公开(公告)号：US20080103553A1

公开(公告)日：2008-05-01

申请号：US11876620

申请日：2007-10-22

申请人： Avi Penner ,  Eyal Doron

发明人： Avi Penner ,  Eyal Doron

IPC分类号： A61N1/08

CPC分类号： A61N1/37217 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/1112 ,  A61B5/14539 ,  A61B5/4839 ,  A61B8/4281 ,  A61B8/4472 ,  A61B8/56 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2560/0242 ,  A61B2560/0257 ,  A61B2560/0412 ,  A61B2562/028 ,  A61N1/08 ,  A61N1/37235 ,  A61N1/37252 ,  A61N1/3787 ,  Y10S128/903

摘要： Systems and methods for communicating with an implant within a patient's body using acoustic telemetry includes an external communications device attachable to the patient's skin. The device includes an acoustic transducer for transmitting acoustic signals into the patient's body and/or for receiving acoustic signals from the implant. The device includes a battery for providing electrical energy to operate the device, a processor for extracting data from acoustic signals received from the implant, and memory for storing the data. The device may include an interface for communicating with a recorder or computer, e.g., to transfer data from the implant and/or to receive instructions for controlling the implant. The device is secured to the patient's skin for controlling, monitoring, or otherwise communicating with the implant, while allowing the patient to remain mobile.

摘要翻译： 使用声学遥测与患者体内的植入物进行通信的系统和方法包括可附接到患者皮肤的外部通信装置。 该装置包括用于将声信号传送到患者体内和/或用于从植入物接收声信号的声换能器。 该装置包括用于提供电能以操作装置的电池，用于从从植入物接收的声信号中提取数据的处理器，以及用于存储数据的存储器。 该装置可以包括用于与记录器或计算机通信的接口，例如从植入物传送数据和/或接收用于控制植入物的指令。 该装置被固定到患者的皮肤上，用于控制，监测或以其他方式与植入物通信，同时允许患者保持移动。

公开(公告)号：US06628989B1

公开(公告)日：2003-09-30

申请号：US09690615

申请日：2000-10-16

申请人： Avi Penner ,  Eyal Doron

发明人： Avi Penner ,  Eyal Doron

IPC分类号： A61N1372

CPC分类号： A61N1/3787 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/031 ,  A61B5/053 ,  A61B5/076 ,  A61B5/14539 ,  A61B2560/0219 ,  A61B2562/0247 ,  A61B2562/028 ,  A61N1/37217 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0651

摘要： An implant for insertion or implantation within a body includes an electrical circuit for performing one or more commands when the implant is activated, an energy storage device, and a switch coupled to the electrical circuit and the energy storage device. An acoustic transducer is coupled to the switch, the acoustic transducer being activatable upon acoustic excitation by an external acoustic energy source for closing the switch to allow current flow from the energy storage device to the electrical circuit. The one or more commands includes measuring a physiological parameter with a biosensor coupled to the electrical circuit, or controlling a therapeutic device coupled to the electrical circuit. The therapeutic device or biosensor may be activated for a predetermined time or until the switch is opened in response to another acoustic excitation of the acoustic transducer.

摘要翻译： 用于在体内插入或植入的植入物包括用于在植入物被激活时执行一个或多个命令的电路，能量存储装置和耦合到电路和能量存储装置的开关。 声换能器耦合到开关，声换能器可在通过用于闭合开关的外部声能源进行声激励时激活，以允许电流从能量存储装置流向电路。 一个或多个命令包括使用耦合到电路的生物传感器测量生理参数，或者控制耦合到电路的治疗装置。 治疗装置或生物传感器可以被激活预定时间，或者直到响应于声换能器的另一声激发而打开开关。

公开(公告)号：US07756587B2

公开(公告)日：2010-07-13

申请号：US11876620

申请日：2007-10-22

申请人： Avi Penner ,  Eyal Doron

发明人： Avi Penner ,  Eyal Doron

IPC分类号： A61N1/18

CPC分类号： A61N1/37217 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/1112 ,  A61B5/14539 ,  A61B5/4839 ,  A61B8/4281 ,  A61B8/4472 ,  A61B8/56 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2560/0242 ,  A61B2560/0257 ,  A61B2560/0412 ,  A61B2562/028 ,  A61N1/08 ,  A61N1/37235 ,  A61N1/37252 ,  A61N1/3787 ,  Y10S128/903

摘要： Systems and methods for communicating with an implant within a patient's body using acoustic telemetry includes an external communications device attachable to the patient's skin. The device includes an acoustic transducer for transmitting acoustic signals into the patient's body and/or for receiving acoustic signals from the implant. The device includes a battery for providing electrical energy to operate the device, a processor for extracting data from acoustic signals received from the implant, and memory for storing the data. The device may include an interface for communicating with a recorder or computer, e.g., to transfer data from the implant and/or to receive instructions for controlling the implant. The device is secured to the patient's skin for controlling, monitoring, or otherwise communicating with the implant, while allowing the patient to remain mobile.

摘要翻译： 使用声学遥测与患者体内的植入物进行通信的系统和方法包括可附接到患者皮肤的外部通信装置。 该装置包括用于将声信号传送到患者体内和/或用于从植入物接收声信号的声换能器。 该装置包括用于提供电能以操作装置的电池，用于从从植入物接收的声信号中提取数据的处理器，以及用于存储数据的存储器。 该装置可以包括用于与记录器或计算机通信的接口，例如从植入物传送数据和/或接收用于控制植入物的指令。 该装置被固定到患者的皮肤上，用于控制，监测或以其他方式与植入物通信，同时允许患者保持移动。