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    METHOD OF PRODUCING TRANSDERMAL ABSORPTION SHEET
    12.
    发明申请
    METHOD OF PRODUCING TRANSDERMAL ABSORPTION SHEET 审中-公开

    公开(公告)号：US20170333342A1

    公开(公告)日：2017-11-23

    申请号：US15600797

    申请日：2017-05-22

    Applicant: FUJIFILM Corporation

    Inventor： Satoshi WAKAMATSU

    IPC: A61K9/00 ,  A61M37/00 ,  B29C39/24 ,  B29L31/00

    CPC classification number: A61K9/0021 ,  A61K9/7007 ,  A61K47/36 ,  A61K47/38 ,  A61M37/0015 ,  A61M2037/0053 ,  B29C39/24 ,  B29D7/01 ,  B29L2031/7544

    Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions on a mold having the needle-like recessed portions with a polymer solution; drying the filled polymer solution to form a polymer layer; and peeling off the polymer layer, wherein, in drying the polymer solution, low rate drying conditions are set in a concentration range in which an average solid content concentration of the polymer solution is 70 wt % to 80 wt %. When a constant drying rate of water is used as an index, in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % to 80 wt %, and the constant drying rate is lower than a maximum value of a constant drying rate under a drying condition where the average solid content concentration of the polymer solution is less than 70 wt % and more than 80 wt %.

    NANOIMPRINTING MOLD, METHOD FOR PRODUCING THE NANOIMPRINTING MOLD, NANOIMPRINTING METHOD USING THE NANOIMPRINTING MOLD, AND METHOD FOR PRODUCING PATTERNED SUBSTRATES
    13.
    发明申请
    NANOIMPRINTING MOLD, METHOD FOR PRODUCING THE NANOIMPRINTING MOLD, NANOIMPRINTING METHOD USING THE NANOIMPRINTING MOLD, AND METHOD FOR PRODUCING PATTERNED SUBSTRATES 有权
    纳米模塑料，生产纳米模塑料的方法，使用纳米模塑料的纳米压印方法以及用于生产图案基材的方法

    公开(公告)号：US20140209565A1

    公开(公告)日：2014-07-31

    申请号：US14228501

    申请日：2014-03-28

    Applicant: FUJIFILM Corporation

    Inventor： Kazuharu NAKAMURA ,  Satoshi WAKAMATSU

    IPC: B29C59/00 ,  B29C59/02

    CPC classification number: B29C59/002 ,  B29C33/58 ,  B29C39/026 ,  B29C43/021 ,  B29C59/02 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  G03F7/161

    Abstract: A nanoimprinting mold includes: a mold main body having a fine pattern of protrusions and recesses on a surface thereof; and a mold release layer formed on the surface of the mold main body. The mold release layer is formed within a mold release layer forming region, which is a region of the mold main body that includes a patterned region where the fine pattern of protrusions and recesses is formed and has an outer edge positioned outside the outer edge of the patterned region. An outer peripheral mold release layer has a thickness distribution in which the thickness of the outer peripheral mold release layer is locally maximal at positions outside the outer edge of the patterned region, substantially continuously along the entire periphery. Thereby, it becomes possible to restrict the region in which resist flows during nanoimprinting, without employing a mesa type substrate.

    Abstract translation: 纳米压印模具包括：模具主体，其表面上具有突出和凹陷的精细图案; 以及形成在模具主体的表面上的脱模层。 脱模层形成在脱模层形成区域内，脱模层形成区域是模具主体的区域，其包括形成有突出和凹部的精细图案的图案区域，并且具有位于外部边缘外侧的外边缘 图案区域。 外周脱模层具有厚度分布，其中外周脱模层的厚度在图案化区域的外边缘外部的位置处局部最大，沿着整个周边大致连续。 由此，可以在不使用台面型基板的情况下限制抗蚀剂在纳米压印过程中流动的区域。

    METHOD FOR FORMING PATTERNS AND METHOD FOR PRODUCING PATTERNED SUBSTRATES
    15.
    发明申请
    METHOD FOR FORMING PATTERNS AND METHOD FOR PRODUCING PATTERNED SUBSTRATES 有权
    用于形成图案的方法和用于生产图案的基板的方法

    公开(公告)号：US20130032971A1

    公开(公告)日：2013-02-07

    申请号：US13647849

    申请日：2012-10-09

    Applicant: FUJIFILM CORPORATION

    Inventor： Tadashi OMATSU ,  Satoshi WAKAMATSU

    IPC: B29C59/02

    CPC classification number: C08F2/46 ,  B82Y10/00 ,  B82Y40/00 ,  C08F2/54 ,  G03F7/0002 ,  H01L21/3086

    Abstract: A resist layer constituted by a resist composition (which may include unavoidable impurities) including a polymerizable compound that includes polyfunctional monomers that become polymers having three dimensional structures by cross linking when polymerized and a polymerization initiating agent which is activated by one of light and an electron beam is formed on a substrate. A surface of a mold having a predetermined pattern of protrusions and recesses is pressed against the resist layer. Light is irradiated onto the resist layer to cure the resist layer. The mold is separated from the resist layer under conditions that the temperature of the resist layer is 40° C. or greater.

    Abstract translation: 由抗蚀剂组合物（其可包括不可避免的杂质）构成的抗蚀剂层包括可聚合化合物，该可聚合化合物包括当聚合时成为具有交联的三维结构的聚合物的多官能单体和由光和电子之一激活的聚合引发剂 光束形成在基板上。 具有预定图案的突起和凹陷的模具的表面被压靠在抗蚀剂层上。 光照射到抗蚀剂层上以固化抗蚀剂层。 在抗蚀剂层的温度为40℃以上的条件下，将模具与抗蚀剂层分离。

    METHOD OF MANUFACTURING MICRONEEDLE ARRAY
    16.
    发明申请
    METHOD OF MANUFACTURING MICRONEEDLE ARRAY 审中-公开

    公开(公告)号：US20190351204A1

    公开(公告)日：2019-11-21

    申请号：US16391338

    申请日：2019-04-23

    Applicant: FUJIFILM Corporation

    Inventor： Yoshiki SAKAZAKI ,  Ikuo TAKANO ,  Satoshi WAKAMATSU ,  Keio OKANO ,  Kenichiro TAMAKI

    IPC: A61M37/00 ,  B29C39/10 ,  B29C39/42 ,  B29C39/44

    Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

    METHOD OF PRODUCING TRANSDERMAL ABSORPTION SHEET FOR MEDICAL USE
    18.
    发明申请
    METHOD OF PRODUCING TRANSDERMAL ABSORPTION SHEET FOR MEDICAL USE 审中-公开

    公开(公告)号：US20180147399A1

    公开(公告)日：2018-05-31

    申请号：US15825111

    申请日：2017-11-29

    Applicant: FUJIFILM Corporation

    Inventor： Satoshi WAKAMATSU

    IPC: A61M37/00 ,  A61K9/00 ,  A61K9/70

    CPC classification number: A61M37/0015 ,  A61K8/0204 ,  A61K9/0021 ,  A61K9/703 ,  A61K38/385 ,  A61K47/36 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29L2031/7544

    Abstract: The method of producing a transdermal absorption sheet includes, in this order, a filtration step of carrying out sterile filtration on a base liquid, a base liquid feeding step of feeding the base liquid to a surface of a mold having needle-like recessed portions, tip ends of which are filled with a drug solution, while leaving a space between the drug solution and the base liquid, a drying step of drying the drug solution and the base liquid, and a peeling-off step of peeling off a formed transdermal absorption sheet in which an average concentration of solid contents of the base liquid in the drying step is increased by 5% by weight or more from an average concentration in the base liquid feeding step, and then in a state in which the average concentration is 75% by weight or less, the base liquid is moved into the needle-like recessed portions.

    TRANSDERMAL ABSORPTION SHEET AND METHOD OF PRODUCING THE SAME
    19.
    发明申请
    TRANSDERMAL ABSORPTION SHEET AND METHOD OF PRODUCING THE SAME 审中-公开

    公开(公告)号：US20170361080A1

    公开(公告)日：2017-12-21

    申请号：US15694409

    申请日：2017-09-01

    Applicant: FUJIFILM Corporation

    Inventor： Satoshi WAKAMATSU

    IPC: A61M37/00 ,  B29C39/02 ,  B81B1/00 ,  B81C1/00 ,  B29C39/26 ,  B29L31/00 ,  B29K105/00

    Abstract: Provided are a transdermal absorption sheet capable of achieving control of the dissolution rate and suppression of diffusion of a drug, and a method of producing the same. A transdermal absorption sheet includes a sheet portion, and a plurality of needle-like protruding portions formed by a plurality of frustum portions arranged on the sheet portion and needle portions arranged on the frustum portions, in which at least one of the needle-like protruding portions has a cavity portion extending from the sheet portion to the frustum portion.

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