公开(公告)号：US20210087517A1

公开(公告)日：2021-03-25

申请号：US17114501

申请日：2020-12-08

Applicant: FUJIFILM CORPORATION

Inventor： Yuta MURAKAMI ,  Tatsuya FUJINAMI ,  Kenta MATSUBARA ,  Katsuko SATO ,  Ayako YAMAMOTO ,  Hidetoshi TAKAYAMA ,  Takashi WAKUI ,  Satoshi AIBA ,  Shinichi KIKUCHI ,  Masaya NAGASE ,  Xiao LING

IPC: C12M1/36 ,  G16B5/00 ,  C12N5/074

Abstract: Provided is an information processing apparatus including an acquiring unit that acquires cell information indicating a state of a cell from production of a pluripotent stem cell to differentiation of the pluripotent stem cell into a specific differentiated cell by differentiation induction, and process history information indicating a history of a processing process for obtaining the differentiated cell, and a deriving unit that derives differentiation potency information indicating differentiation potency of the pluripotent stem cell based on the cell information and the process history information which are acquired by the acquiring unit.

公开(公告)号：US20180305669A1

公开(公告)日：2018-10-25

申请号：US16023685

申请日：2018-06-29

Applicant: FUJIFILM Cellular Dynamics, Inc. ,  FUJIFILM Corporation

Inventor： Michael Kenneth HANCOCK ,  Coby Bennett CARLSON ,  David A. MANN ,  Yuta MURAKAMI

IPC: C12N5/071

CPC classification number: C12N5/0671 ,  C12N2501/237 ,  C12N2506/45 ,  C12N2509/00 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/90

Abstract: Provided herein are methods of producing three-dimensional (3-D) microtissue from a starting cell suspension of pluripotent stem cell (PSC)-derived hepatocytes. Such a method may comprise supplementing the cell suspension with cell adhesion-promoting components and culturing the PSC-derived hepatocytes on a non-adhesive surface to produce the microtissue.

公开(公告)号：US20170022473A1

公开(公告)日：2017-01-26

申请号：US15291246

申请日：2016-10-12

Applicant: FUJIFILM Corporation

Inventor： Yuta MURAKAMI ,  Rie IWATA ,  Yoshihide IWAKI ,  Tasuku SASAKI

IPC: C12N5/00 ,  C07K14/00 ,  C12N5/074

CPC classification number: C12N5/0068 ,  C07K14/001 ,  C07K14/47 ,  C07K14/78 ,  C12N5/0607 ,  C12N5/0696 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2537/00

Abstract: A polypeptide including: (1) a first region containing at least one selected from the group consisting of an amino acid sequence represented by CSYYQSC (SEQ ID NO:1) and an amino acid sequence represented by RGD; and (2) a second region containing (2-i) an amino acid sequence represented by PRPSLAKKQRFRHRNRKGYRSQRGHSRGRNQN (SEQ ID NO:2), (2-ii) an amino acid sequence having an identity of not less than 50% to the amino acid sequence represented by SEQ ID NO:2 and having an adsorption ability to a cultivation container, or (2-iii) an amino acid sequence that is the amino acid sequence represented by SEQ ID NO:2 in which from 1 to 30 amino acid residues are added, substituted, or deleted, and has an adsorption ability to a cultivation container, in which the polypeptide includes from 40 to 450 amino acid residues.

Abstract translation: 一种多肽，包括：（1）含有选自由CSYYQSC（SEQ ID NO：1）表示的氨基酸序列和由RGD表示的氨基酸序列组成的组中的至少一种的第一区域; 和（2）含有（2-i）由PRPSLAKKQRFRHRNRKGYRSQRGHSRGRNQN（SEQ ID NO：2）表示的氨基酸序列的第二区域，（2-ii）与氨基酸具有不小于50％的同一性的氨基酸序列 由SEQ ID NO：2表示的具有对培养容器的吸附能力的序列，或（2-iii）作为SEQ ID NO：2所示的氨基酸序列的氨基酸序列，其中含有1〜30个氨基酸残基 被添加，取代或缺失，并且对培养容器具有吸附能力，其中多肽包含40至450个氨基酸残基。