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41 条记录 (耗时 0.031 秒)

    Cocaine receptor binding ligands
    12.
    发明授权
    Cocaine receptor binding ligands 失效
    可卡因受体结合配体

    公开(公告)号：US5496953A

    公开(公告)日：1996-03-05

    申请号：US164576

    申请日：1993-12-10

    申请人： Michael J. Kuhar ,  Frank I. Carroll ,  Joh W. Boja ,  Anita H. Lewin ,  Philip Abraham

    发明人： Michael J. Kuhar ,  Frank I. Carroll ,  Joh W. Boja ,  Anita H. Lewin ,  Philip Abraham

    IPC分类号： A61K51/04 ,  C07D451/02 ,  C07F7/08 ,  C07F7/22

    CPC分类号： C07D451/02 ,  A61K51/0448 ,  C07F7/0812 ,  C07F7/2212 ,  A61K2123/00

    摘要： Novel compounds show high affinity for specific cocaine receptors in the brain, particularly dopamine transporter sites, and have the formula ##STR1## Wherein Y=CONRR.sub.2, R.sub.1 =hydrogen, C.sub.1-5 alkyl,X=H, C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.1-4 alkoxy, C.sub.1-6 alkynyl, halogen, amino, acylamido,R and R.sup.2 may be saturated or unsaturated substituents of 1-6 carbon atoms, aromatic, or combine to form pyrrolidinyl, morpholinyl or piperidinyl moieties, andZ=H, I, Br, Cl, F, CN, CF.sub.3 NO.sub.2, N.sub.3, OR.sub.1, CO.sub.2 NH.sub.2, CO.sub.2 R.sub.1, C.sub.1-6 alkyl, NR.sub.4 R.sub.5, NHCOF.sub.5, NHCO.sub.2 R.sub.6,wherein R.sub.4 -R.sub.6 are each C.sub.1-6 alkyl.

    摘要翻译： 新型化合物对脑中特定的可卡因受体，特别是多巴胺转运蛋白位点表现出高亲和力，并且具有下式：其中Y = CONRR2，R1 =氢，C1-5烷基，X = H，C1-6烷基，C3- 8环烷基，C 1-4烷氧基，C 1-6炔基，卤素，氨基，酰基酰氨基，R和R 2可以是1-6个碳原子的饱和或不饱和取代基，芳族或结合形成吡咯烷基，吗啉基或哌啶基部分，Z = H，I，Br，Cl，F，CN，CF 3 NO 2，N 3，OR 1，CO 2 NH 2，CO 2 R 1，C 1-6烷基，NR 4 R 5，NHCOF 5，NHCO 2 R 6，其中R 4 -R 6各自为C 1-6烷基。

    Azabicyloalkane phenyl substituted alkane carboxylates, their preparation and use as anticholinergic agents
    13.
    发明授权
    Azabicyloalkane phenyl substituted alkane carboxylates, their preparation and use as anticholinergic agents 失效
    氮杂环烷基苯基取代的烷烃羧酸盐，它们的制备和用作抗胆碱剂

    公开(公告)号：US4713391A

    公开(公告)日：1987-12-15

    申请号：US855857

    申请日：1986-04-17

    申请人： Peter K. Chiang ,  Michelle M. Richard ,  Felipe N. Padilla ,  Frank I. Carroll ,  Philip Abraham

    发明人： Peter K. Chiang ,  Michelle M. Richard ,  Felipe N. Padilla ,  Frank I. Carroll ,  Philip Abraham

    IPC分类号： C07D209/02

    CPC分类号： C07D209/02

    摘要： This invention relates to novel compositions, their preparation and the use thereof as anticholinergic agents in the treatment or prophylaxis of organophosphate or nerve gas poisoning in animals. These compositions and pharmaceutical preparations containing them in their free base form and acid addition salts thereof are represented by the formula ##STR1## wherein R represents lower alkyl groups containing 1 to 7 carbon atoms; R.sup.1 represents hydrogen, phenyl, cyclohexyl, and cyclopentyl; and R.sup.2 represents lower alkyl groups containing 1 to 7 carbon atoms, hydroxymethyl, and hydroxyl.

    摘要翻译： 本发明涉及新型组合物，其制备方法及其作为抗胆碱能药物用于治疗或预防动物中的有机磷酸盐或神经气体中毒的用途。 含有它们游离碱形式的这些组合物和药物制剂及其酸加成盐由下式表示：其中R代表含有1至7个碳原子的低级烷基; R1代表氢，苯基，环己基和环戊基; 并且R 2表示含有1至7个碳原子的低级烷基，羟甲基和羟基。

    Antibodies against drugs of abuse
    17.
    发明申请
    Antibodies against drugs of abuse 审中-公开
    针对滥用药物的抗体

    公开(公告)号：US20050013809A1

    公开(公告)日：2005-01-20

    申请号：US10725962

    申请日：2003-12-02

    申请人： Samuel Owens ,  Frank Carroll ,  Philip Abraham ,  Melinda Gunnell ,  Mary Haak-Frendscho ,  Xiao Feng

    发明人： Samuel Owens ,  Frank Carroll ,  Philip Abraham ,  Melinda Gunnell ,  Mary Haak-Frendscho ,  Xiao Feng

    IPC分类号： C07K16/44 ,  A61K39/395 ,  C07K16/18 ,  C12N5/06

    CPC分类号： C07K16/44 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567

    摘要： The present invention is related to antibodies directed to various drugs of abuse and uses of such antibodies. In preferred embodiments, the drugs of abuse are amphetamine, methamphetamine, or phencyclidine (PCP). In particular, in accordance with the present invention, there are provided fully man monoclonal antibodies directed to drugs of abuse. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR3 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

    摘要翻译： 本发明涉及针对各种滥用药物的抗体和使用此类抗体的抗体。 在优选的实施方案中，滥用药物是苯丙胺，甲基苯丙胺或苯环利定（PCP）。 特别地，根据本发明，提供了针对滥用药物的完全人单克隆抗体。 编码Nuclotide序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR3或CDR1至CDR3 ，提供。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs
    18.
    发明授权
    Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs 有权
    用于治疗与苯丙胺类药物相关的医疗问题的单克隆抗体拮抗剂

    公开(公告)号：US06669937B2

    公开(公告)日：2003-12-30

    申请号：US09839549

    申请日：2001-04-20

    申请人： Samuel M. Owens ,  Frank Ivy Carroll ,  Philip Abraham

    发明人： Samuel M. Owens ,  Frank Ivy Carroll ,  Philip Abraham

    IPC分类号： A61K39395

    CPC分类号： C07K16/44 ,  A61K2039/505 ,  C07B2200/07 ,  C07C217/60 ,  C07C233/18 ,  C07K2317/55

    摘要： The invention includes synthetic immunochemical haptens for the generation of antibodies, the antibodies, and the medical treatment applications for using the antibodies. The antibodies are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants, and will have insignificant cross-reactivity with endogenous substrates (e.g. dopamine) or over-the-counter medications (e.g. 1-methamphetamine, pseudoephedrine, phenylpropanolamine and ephedrine). These monoclonal antibodies and their antigen binding fragments are useful in treatment plans for recovering addicts, in emergency room settings for rapidly reversing a drug overdose, in protection of fetuses or fetus from drug-abusing pregnant mothers or in a psychiatric setting to reduce the exacerbation of psychotic disorders caused by stimulant drugs.

    摘要翻译： 本发明包括用于产生抗体的合成免疫化学半抗原，抗体和用于使用抗体的医疗治疗应用。 这些抗体被设计成识别出甲基苯丙胺类滥用兴奋剂的常见分子特征，并且将与内源底物（如多巴胺）或非处方药（例如1-甲基苯丙胺，伪麻黄碱，苯丙醇胺和 麻黄碱）。 这些单克隆抗体及其抗原结合片段可用于恢复吸毒成瘾者的急救室设置，以迅速逆转药物过量，保护胎儿或胎儿免受滥用怀孕母亲或精神病治疗的治疗计划，以减少恶化 兴奋剂引起的精神病。

    Apparatuses, methods, and systems for hardware-assisted lockstep of processor cores
    19.
    发明授权
    Apparatuses, methods, and systems for hardware-assisted lockstep of processor cores 有权

    公开(公告)号：US11340960B2

    公开(公告)日：2022-05-24

    申请号：US16833454

    申请日：2020-03-27

    申请人： Umberto Santoni ,  Philip Abraham

    发明人： Umberto Santoni ,  Philip Abraham

    IPC分类号： G06F9/30 ,  G06F9/52 ,  G06F9/38 ,  G06F11/16

    摘要： Systems, methods, and apparatuses relating to circuitry to implement lockstep of processor cores are described. In one embodiment, a hardware processor comprises a first processor core comprising a first control flow signature register and a first execution circuit, a second processor core comprising a second control flow signature register and a second execution circuit, and at least one signature circuit to perform a first state history compression operation on a first instruction that executes on the first execution circuit of the first processor core to produce a first result, store the first result in the first control flow signature register, perform a second state history compression operation on a second instruction that executes on the second execution circuit of the second processor core to produce a second result, and store the second result in the second control flow signature register.