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    SYSTEM FOR PROVIDING SURGICAL ACCESS
    12.
    发明申请
    SYSTEM FOR PROVIDING SURGICAL ACCESS 审中-公开
    提供手术治疗的系统

    公开(公告)号：US20120071921A1

    公开(公告)日：2012-03-22

    申请号：US13214092

    申请日：2011-08-19

    申请人： John F. Shanley ,  Stephen H. Diaz ,  Alan E. Shluzas ,  Frank Litvack

    发明人： John F. Shanley ,  Stephen H. Diaz ,  Alan E. Shluzas ,  Frank Litvack

    IPC分类号： A61B17/04

    CPC分类号： A61B17/0625 ,  A61B17/0057 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/06 ,  A61B17/06066 ,  A61B17/34 ,  A61B17/3403 ,  A61B90/06 ,  A61B90/08 ,  A61B90/37 ,  A61B2017/00044 ,  A61B2017/00243 ,  A61B2017/00575 ,  A61B2017/00628 ,  A61B2017/00663 ,  A61B2017/0414 ,  A61B2017/0417 ,  A61B2017/0443 ,  A61B2017/047 ,  A61B2017/0472 ,  A61B2017/0475 ,  A61B2017/0496 ,  A61B2017/06023 ,  A61B2017/06042 ,  A61B2017/06076 ,  A61B2017/06171 ,  A61B2017/06176 ,  A61B2017/3405 ,  A61B2017/3409 ,  A61B2017/3413 ,  A61B2090/062 ,  A61B2090/065 ,  A61B2090/0807 ,  A61B2090/0811 ,  A61B2090/3735

    摘要： One embodiment is directed to a system for providing surgical access across a wall of a tissue structure, comprising: a delivery member having proximal and distal ends; a first helical member having proximal and distal ends and a helical shape, the proximal end coupled to the delivery member distal end, the distal end extending distally of the delivery member distal end; an anchor member removably coupled to the helical member distal end; a suture member coupled distally to a portion of the anchor member and extending proximally to a position wherein at least a portion of it may be freely manipulated by an operator; and a tissue interface indentor member coupled to the delivery member and operatively coupled to the first helical member, the tissue interface indentor member comprising a distally protruding shape feature configured to contact one or more portions of the tissue structure adjacent to the distal end of the helical member and change an available angle of penetration between such portions and the distal tip of the first helical member as the distal tip is inserted into the tissue structure; wherein upon rotation of the delivery member in a first direction, the indentor member is urged against the tissue structure and the first helical member and coupled anchor member are advanced across at least a portion of the wall of the tissue structure, pulling along the distal portion of the suture member in a deployed suture pattern which remains coupled to the anchor member.

    摘要翻译： 一个实施例涉及一种用于提供穿过组织结构的壁的手术进入的系统，包括：具有近端和远端的递送构件; 第一螺旋构件，其具有近端和远端以及螺旋形状，所述近端联接到所述输送构件远端，所述远端延伸到所述输送构件远端; 锚固构件可拆卸地联接到所述螺旋构件远端; 缝合构件，其远端配合到锚定构件的一部分并且向近侧延伸到其中至少一部分可由操作者自由地操纵的位置; 以及组织接口压头构件，其联接到所述输送构件并且可操作地联接到所述第一螺旋构件，所述组织接口压头构件包括远端突出的形状特征，所述远端突出形状特征构造成接触所述组织结构的邻近螺旋的远端的一个或多个部分 并且当所述远侧末端插入所述组织结构中时，改变所述部分与所述第一螺旋构件的远侧末端之间的可穿透角度; 其中当沿着第一方向转动所述传送构件时，所述压头构件被推靠在所述组织结构上，并且所述第一螺旋构件和所述联接的锚固构件在所述组织结构的所述壁的至少一部分上前进， 的缝合构件处于部署的缝合线图案中，该缝合线图案保持联接到锚定构件。

    METHODS AND DEVICES FOR REDUCING TISSUE DAMAGE AFTER ISCHEMIC INJURY
    13.
    发明申请
    METHODS AND DEVICES FOR REDUCING TISSUE DAMAGE AFTER ISCHEMIC INJURY 审中-公开
    用于减少身体损伤后组织损伤的方法和装置

    公开(公告)号：US20090252778A1

    公开(公告)日：2009-10-08

    申请号：US12295879

    申请日：2007-04-05

    申请人： Theodore L. Parker ,  Thai Minh Nguyen ,  John F. Shanley ,  Frank Litvack

    发明人： Theodore L. Parker ,  Thai Minh Nguyen ,  John F. Shanley ,  Frank Litvack

    IPC分类号： A61F2/04 ,  A61K38/28 ,  A61K31/337 ,  A61K31/436 ,  A61K9/00

    CPC分类号： A61K31/337 ,  A61F2/91 ,  A61F2250/003 ,  A61F2250/0068 ,  A61K38/28 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45

    摘要： Methods and devices are provided for the delivery of therapeutic agents which reduce myocardial tissue damage due to ischemia and anti-restenotic agents which inhibit restenosis following a cardiac procedure such as stent implantation. The anti-ischemia agents are delivered to the myocardial tissue over an administration period sufficient to achieve reduction in ischemic or reperfusion injury of the myocardial tissue. The anti-restenotic agents are delivered over an administration period sufficient to reduce the re-narrowing of a blood vessel following a cardiac procedure such as implantation of a device. Preferred anti-restenotic drugs are those that do not reduce the beneficial effects provided by the anti-ischemic drug, such as drugs that do not act on the mammalian target of rapamycin (mTOR).

    摘要翻译： 提供了用于递送治疗剂的方法和装置，其减少由于局部缺血引起的心肌组织损伤和在心脏手术如支架植入之后抑制再狭窄的抗再狭窄剂。 在足以实现心肌组织的缺血或再灌注损伤减少的给药期间将抗缺血剂递送至心肌组织。 抗再狭窄剂在足以减少心脏手术如植入装置后的血管再狭窄的给药期内递送。 优选的抗再狭窄药物是不减少由抗缺血药物提供的有益效果的那些，例如不作用于雷帕霉素哺乳动物靶标（mTOR）的药物。

    Rapid exchange stent delivery catheter
    19.
    发明申请
    Rapid exchange stent delivery catheter 审中-公开
    快速交换支架输送导管

    公开(公告)号：US20080171979A1

    公开(公告)日：2008-07-17

    申请号：US11582521

    申请日：2006-10-17

    申请人： Peter S. Brown ,  Lawrence John Voss ,  Frank Litvack

    发明人： Peter S. Brown ,  Lawrence John Voss ,  Frank Litvack

    IPC分类号： A61M29/00 ,  A61M31/00 ,  A61M37/00

    CPC分类号： A61M25/10 ,  A61F2/958 ,  A61M2025/0183

    摘要： A rapid exchange balloon catheter has a short rapid exchange length for faster catheter exchanges the balloon catheter includes a balloon structure having a balloon leg connected to a catheter shaft. Marker bands may be provided in the balloon leg for facilitating measurement of a dimension of physiological features. A stiffening wire extending longitudinally at least partially into the balloon leg may be provided to supplement and control the flexibility characteristics of the balloon leg.

    摘要翻译： 快速交换气囊导管具有短的快速交换长度以用于更快的导管交换，气囊导管包括具有连接到导管轴的气囊腿的球囊结构。 可以在气球腿中设置标记带，以便于测量生理特征的维度。 可以提供纵向延伸至少部分地进入气囊腿的加强线，以补充和控制气囊腿的柔性特性。

    Rapid exchange stent delivery catheter
    20.
    发明申请
    Rapid exchange stent delivery catheter 审中-公开
    快速交换支架输送导管

    公开(公告)号：US20070073331A1

    公开(公告)日：2007-03-29

    申请号：US11582520

    申请日：2006-10-17

    申请人： Peter Brown ,  Lawrence Voss ,  Frank Litvack

    发明人： Peter Brown ,  Lawrence Voss ,  Frank Litvack

    IPC分类号： A61M29/00

    CPC分类号： A61F2/958 ,  A61M25/0045 ,  A61M25/0108 ,  A61M25/0662 ,  A61M2025/0063 ,  A61M2025/0183

    摘要： A rapid exchange balloon catheter has a short rapid exchange length for faster catheter exchanges the balloon catheter includes a balloon structure having a balloon leg connected to a catheter shaft. Marker bands may be provided in the balloon leg for facilitating measurement of a dimension of physiological features. A stiffening wire extending longitudinally at least partially into the balloon leg may be provided to supplement and control the flexibility characteristics of the balloon leg.

    摘要翻译： 快速交换气囊导管具有短的快速交换长度以用于更快的导管交换，气囊导管包括具有连接到导管轴的气囊腿的球囊结构。 可以在气球腿中设置标记带，以便于测量生理特征的维度。 可以提供纵向延伸至少部分地进入气囊腿的加强线，以补充和控制气囊腿的柔性特性。