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11.发明授权Occlusion device with deployable paddles for detection and occlusion of blood vessels 失效闭塞装置具有用于检测和阻塞血管的可展开的桨公开(公告)号：US07354444B2
公开(公告)日：2008-04-08
申请号：US10300116
申请日：2002-11-19
IPC分类号： A61B17/08
CPC分类号： A61B8/06 , A61B5/026 , A61B8/12 , A61B17/00234 , A61B17/122 , A61B17/1227 , A61B17/128 , A61B17/1285 , A61B17/42 , A61B2017/0046
摘要： Devices, systems and methods for temporarily reducing or abolishing blood flow by occluding blood vessels are provided. A blood vessel-occlusion device embodying features of the invention includes a deployable pressure-applying member with a location sensor, and an applicator. The location sensor is configured to detect a blood vessel, which may be occluded by compression from the pressure-applying member. A pressure-applying member may be released from the applicator, with blood-vessel compression maintained after release. The applicator is configured to engage a guide, such as a tenaculum, to aid in the placement and operation of the applicator. A pressure-applying member may also engage the guide. The invention finds use in, for example, treating uterine disorders and conditions which may be treated by occlusion of the uterine arteries, such as uterine fibroids, dysfunctional uterine bleeding, post-partum hemorrhage, and bleeding associated with caesarian section.
摘要翻译： 提供了通过闭塞血管临时减少或消除血流的装置，系统和方法。 体现本发明特征的血管闭塞装置包括具有位置传感器的可部署的施加压力部件和施加器。 位置传感器被配置为检测血管，其可以通过来自压力施加构件的压缩而被阻塞。 压力施加构件可以从施用器释放，释放后保持血管压缩。 施用器被配置成接合引导件，例如构件，以帮助施用器的放置和操作。 压力施加构件还可以接合引导件。 本发明可用于例如治疗可通过闭塞子宫动脉（例如子宫肌瘤），功能失调性子宫出血，产后出血以及与切片相关的出血治疗的子宫疾病和病症。
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公开(公告)号：US07207996B2
公开(公告)日：2007-04-24
申请号：US10115422
申请日：2002-04-04
CPC分类号： A61B17/0482 , A61B5/026 , A61B8/06 , A61B8/12 , A61B17/122 , A61B17/282 , A61B17/42
摘要： A compression and ligation device includes a pair of jaws including one or more Doppler chips oriented to send and receive Doppler signals across the jaws, to assist a practitioner in determining whether or not a uterine artery is between the jaws. A suture leader with an attached suture can be pushed through a channel on one of the jaws, through tissue behind the uterine artery, into another channel on the other jaw, and proximally out the device so that the practitioner can ligate the artery and effect hemostasis.
摘要翻译： 压缩和结扎装置包括一对钳口，包括一个或多个多普勒芯片，其针对跨越钳口发送和接收多普勒信号，以帮助从业者确定子宫动脉是否在钳口之间。 具有连接缝合线的缝合线头可以通过其中一个钳口上的通道，通过子宫动脉后面的组织推入另一个钳口上的另一个通道，并向近端推出该装置，使得医师可以连接动脉并实现止血 。
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公开(公告)号：US06506156B1
公开(公告)日：2003-01-14
申请号：US09488467
申请日：2000-01-19
申请人： Michael L. Jones , Jill Uyeno , Greig E. Altieri
发明人： Michael L. Jones , Jill Uyeno , Greig E. Altieri
IPC分类号： A61B800
CPC分类号： A61K49/223 , A61B8/0833 , A61B2090/0481 , A61B2090/3925
摘要： Medical devices that are coated with an echogenic material that includes an electrically insulative base layer and an echogenic layer demonstrate both improved ultrasonic imaging and protection against RF electrical breakdown. The echogenic layer includes a polymeric matrix that (i) defines a plurality of void spaces, (ii) includes glass microsphere particles, or (iii) both defines a plurality of void spaces and includes glass microsphere particles. Medical instruments exhibit enhanced ultrasonic imaging even when viewed along their lengths.
摘要翻译： 涂覆有包含电绝缘基层和回声层的回声材料的医疗装置显示出改进的超声波成像和防止RF电击穿的保护。 回声层包括聚合物基体，其中（i）限定多个空隙空间，（ii）包括玻璃微球颗粒，或（iii）均限定多个空隙空间并且包括玻璃微球颗粒。 医疗仪器即使在沿其长度方向观察时也能表现出增强的超声波成像。
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公开(公告)号：US07329265B2
公开(公告)日：2008-02-12
申请号：US10430880
申请日：2003-05-06
IPC分类号： A61B17/08
CPC分类号： A61B17/12 , A61B17/2812 , A61B17/42 , A61B2017/00057 , A61B2017/2837 , A61B2090/064 , A61B2090/378
摘要： The invention is directed to a uterine artery clamp and the relatively non-invasive treatment procedure utilizing this clamp. The uterine clamp includes a clamping member having a jaw with tissue-contacting surfaces for applying pressure to target tissue and a stabilizing member which is configured to be inserted into the patient's uterine cervical canal. The clamp may be provided with elongated handles to manually adjust the spacing between the jaw and stabilizer and thereby apply pressure to a uterine artery beneath a bundle of tissue held between the jaw and stabilizer. Uterine clamps embodying features of the invention by be used in procedures for treating uterine disorders such as fibroids, DUB, PPH and the like.
摘要翻译： 本发明涉及一种子宫动脉钳和利用该钳夹的相对非侵入性治疗方法。 子宫夹具包括具有钳口的夹持构件，其具有用于向目标组织施加压力的组织接触表面和被构造成插入到患者子宫颈管中的稳定构件。 夹具可以设置有细长的手柄，以手动调节钳口和稳定器之间的间隔，从而对保持在钳口和稳定器之间的组织束下面的子宫动脉施加压力。 通过用于治疗子宫疾病如子宫肌瘤，DUB，PPH等的程序中使用体现本发明特征的子宫夹钳。
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公开(公告)号：US07875036B2
公开(公告)日：2011-01-25
申请号：US11256768
申请日：2005-10-24
申请人： Fred H. Burbank , Greig E. Altieri , Michael L. Jones , Ed Olson
发明人： Fred H. Burbank , Greig E. Altieri , Michael L. Jones , Ed Olson
IPC分类号： A61B17/42
CPC分类号： A61B17/42 , A61B17/12 , A61B17/282
摘要： A method and device for treating a female patient's uterine disorder by occluding one or both of the patient's uterine artery. The treatment involves occluding one or both of the patient's uterine arteries with an intravaginal device to form a thrombus within the occluded artery or arteries and administering an agent which will prolong the occlusion of the artery or arteries after removal of the occluding device or initiate or accelerate fibroid cell apoptosis (programmed cell death). The intravaginal device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member.
摘要翻译： 一种用于通过闭塞患者的子宫动脉中的一者或两者来治疗女性患者的子宫疾病的方法和装置。 该治疗涉及用阴道内装置阻塞患者的子宫动脉中的一者或两者，以在闭塞的动脉或动脉内形成血栓并施用一种药剂，其将在移除闭塞装置之后延长动脉或动脉的闭塞，或启动或加速 纤维细胞凋亡（程序性细胞死亡）。 阴道内装置具有一对枢转连接的闭塞构件，其中至少一个阻塞构件在闭塞构件的远侧轴部上具有可移动的闭塞元件。
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公开(公告)号：US07686817B2
公开(公告)日：2010-03-30
申请号：US10721857
申请日：2003-11-25
申请人： Fred H. Burbank , Greig E. Altieri , Michael L. Jones , Ed Olson
发明人： Fred H. Burbank , Greig E. Altieri , Michael L. Jones , Ed Olson
IPC分类号： A61B17/42
CPC分类号： A61B17/42 , A61B17/12 , A61B2017/2927 , A61B2017/2944 , A61B2017/4216 , A61B2017/4225
摘要： An occluding device is disclosed for occluding a female patient's uterine arteries which have unsymmetrical anatomy with respect to the patient's uterine cervix. The occluding device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member. The position and orientation of the occluding elements on the distal shaft sections may be adjusted by operative members on the proximal shaft sections of the occluding members to accommodate for asymmetrical uterine artery anatomy. The occluding elements have pressure applying surfaces with one or more blood flow sensors such as Doppler chips which help the physician to better identify the uterine artery and to monitor blood flow therein. A tenaculum-like guiding element configured to be secured within the patient's uterine cervix, may be provided to guide the occluding device to the patient's cervix.
摘要翻译： 公开了一种闭塞装置，用于阻塞相对于患者的子宫颈具有不对称解剖结构的女性患者的子宫动脉。 闭塞装置具有一对枢转连接的闭塞构件，其中至少一个阻塞构件在闭塞构件的远侧轴部上具有可移动的闭塞元件。 封闭元件在远侧轴部分上的位置和取向可以通过闭塞构件的近侧轴部分上的操作构件来调节，以适应不对称的子宫动脉解剖。 闭塞元件具有一个或多个血液流量传感器（例如多普勒碎片）的压力施加表面，其帮助医生更好地识别子宫动脉并监测其中的血液流动。 构造成固定在患者子宫颈内的十字形引导元件可被设置成将闭塞装置引导到病人的子宫颈。
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公开(公告)号：US07325546B2
公开(公告)日：2008-02-05
申请号：US10718222
申请日：2003-11-20
CPC分类号： A61B5/6834 , A61B5/026 , A61B5/489 , A61B8/06 , A61B17/12 , A61B17/42 , A61B2017/4216
摘要： An intravaginal uterine artery occlusion device is used for treating uterine disorders such as fibroids, dysfunctional uterine bleeding, postpartum hemorrhage and the like. A occlusion device has a cervical receptacle with an open distal end for receiving the patients uterine cervix, an elongated shaft having a distal end secured to the closed proximal end of the cervical receptacle, and an inner lumen extending to the distal end of the shaft. The patient's uterine cervix is held within the interior of the receptacle by the application of a vacuum to the interior of the receptacle through the inner lumen of the shaft while the leading edge(s) of the cervical receptacle press against the patient's vaginal fornix to occlude the uterine artery. A blood flow sensor may be provided on the leading edge of the receptacle to aid in locating a uterine artery and to monitor blood flow through the uterine artery.
摘要翻译： 阴道内子宫动脉闭塞装置用于治疗子宫肌瘤，功能障碍性子宫出血，产后出血等。 闭塞装置具有颈部插座，其具有用于接收患者子宫颈的开放远端，具有固定到颈部容纳件的封闭近端的远端的细长轴以及延伸到轴的远端的内腔。 患者的子宫颈通过穿过轴的内腔通过真空施加到容器的内部而保持在容器的内部，而颈部容器的前缘压靠患者的阴道穹窿阻塞 子宫动脉。 可以在容器的前缘上设置血流传感器，以帮助定位子宫动脉并监测通过子宫动脉的血流。
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公开(公告)号：US07645284B2
公开(公告)日：2010-01-12
申请号：US11284658
申请日：2005-11-22
申请人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri , RJ Serra
发明人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri , RJ Serra
IPC分类号： A61B17/10
CPC分类号： A61B17/0482 , A61B5/026 , A61B8/06 , A61B8/12 , A61B17/122 , A61B17/282 , A61B17/42
摘要： A compression and ligation device includes a pair of jaws including one or more Doppler chips oriented to send and receive Doppler signals across the jaws, to assist a practitioner in determining whether or not a uterine artery is between the jaws. A suture leader with an attached suture can be pushed through a channel on one of the jaws, through tissue behind the uterine artery, into another channel on the other jaw, and proximally out the device so that the practitioner can ligate the artery and effect hemostasis.
摘要翻译： 压缩和结扎装置包括一对钳口，包括一个或多个多普勒芯片，其针对跨越钳口发送和接收多普勒信号，以帮助从业者确定子宫动脉是否在钳口之间。 具有连接缝合线的缝合线头可以通过其中一个钳口上的通道，通过子宫动脉后面的组织推入另一个钳口上的另一个通道，并向近端推出该装置，使得医师可以连接动脉并实现止血 。
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19.发明授权公开(公告)号：US06905506B2
公开(公告)日：2005-06-14
申请号：US10107810
申请日：2002-03-28
IPC分类号： A61B17/12 , A61B5/026 , A61B8/06 , A61B17/00 , A61B17/122 , A61B17/128 , A61B17/42 , A61B18/00 , A61M25/00
CPC分类号： A61B17/12 , A61B5/026 , A61B5/415 , A61B5/418 , A61B8/06 , A61B8/12 , A61B17/00234 , A61B17/122 , A61B17/128 , A61B17/1285 , A61B17/2812 , A61B17/42 , A61B2017/0046 , A61B2017/4216
摘要： A system is provided for compressing one or both of the uterine arteries of a patient which is at least in part shaped to complement the shape of the exterior of the cervix, which allows the system to be self-positioning. One or more Doppler chips can be mounted or incorporated into the system which permit the practitioner to better identify the uterine artery and monitor blood flow therein. The system includes a pair of pivotally joined elements which can be moved toward and away from the cervix to compress a uterine artery.
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公开(公告)号：US07172603B2
公开(公告)日：2007-02-06
申请号：US10300495
申请日：2002-11-19
申请人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri , Ed Olson
发明人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri , Ed Olson
IPC分类号： A61B17/42
CPC分类号： A61B17/1227 , A61B5/026 , A61B8/06 , A61B8/12 , A61B17/1285 , A61B17/42
摘要： Devices, systems and methods for occluding blood vessels include a deployable constrictor having opposed pressure-applying portions, a delivery shaft configured to intravaginally advance the constrictor to the patient's cervix, a location sensor configured to detect a blood vessel, a deployment member for deploying the constrictor about the patient's cervix, and optionally a guide. The constrictor has a first configuration to receive a cervix and a second configuration to apply pressure to the cervical area to occlude a uterine artery by compression from the pressure-applying members. The pressure-applying members may be released from the cervix after a limited therapeutically effective time. The constrictor is for treating uterine disorders and conditions which may be treated by occlusion of the uterine arteries, such as uterine fibroids, dysfunctional uterine bleeding, post-partum hemorrhage, and bleeding associated with caesarian sections.
摘要翻译： 用于闭塞血管的装置，系统和方法包括具有相对的压力施加部分的可展开的收缩器，配置成将阴囊推进到患者的子宫颈的输送轴，配置成检测血管的位置传感器，用于部署 关于患者的子宫颈的收缩，以及可选的导引。 收缩器具有接收子宫颈的第一构造和第二构造，以通过压力从压力施加构件压迫宫颈区域以阻塞子宫动脉。 压力施加构件可在有限的治疗有效时间后从子宫颈释放。 压缩器用于治疗可通过闭塞子宫动脉（例如子宫肌瘤），功能障碍性子宫出血，产后出血以及与切片相关的出血治疗的子宫疾病和病症。
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