公开(公告)号：US20140356949A1

公开(公告)日：2014-12-04

申请号：US14461860

申请日：2014-08-18

Applicant: General Electric Company

Inventor： Brian Michael Davis ,  Kenneth Roger Conway ,  Evelina Roxana Loghin ,  Andrew Arthur Paul Burns ,  David Gilles Gascoyne ,  Scott Michael Miller

IPC: C12N5/074

CPC classification number: C12N5/0696 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/90 ,  C12N2535/10 ,  C12N2537/00 ,  Y10T156/1039

Abstract: A carrier for expansion of induced pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of making the carrier, and culturing induced pluripotent stem cells using the same carrier are also provided.

Abstract translation: 提供了用于诱导多能干细胞扩增的载体，其中所述载体包括包含一个或多个外表面的基底，其中所述一个或多个外表面用气体等离子体处理进行修饰，以及一个或多个结构化凹陷 外表面。 载体的长度至少约0.2mm，宽度至少约0.2mm，高度在约0.05mm至1.2mm的范围内，并且每个结构化凹陷的长轴在约0.1mm至 0.5mm，短轴在约0.1mm至0.5mm的范围内，深度在约0.025mm至约0.5mm的范围内。 还提供了制造载体的方法，以及使用相同的载体培养诱导的多能干细胞。

公开(公告)号：US11047239B2

公开(公告)日：2021-06-29

申请号：US16208033

申请日：2018-12-03

Applicant: General Electric Company

Inventor： Hannah Rice James ,  Kenneth Paul Zarnoch ,  Wendy Wenling Lin ,  Scott Michael Miller ,  Laura Liou

IPC: F01D5/14 ,  F15D1/00

Abstract: A method of making a master cure tool for applying a texture to an aerodynamic surface includes the steps of: providing a foil which is metallic and has a textured surface; applying the foil to a forming surface of a rigid forming tool which is compound curved, and plastically deforming the foil to conform to the forming surface, so as to define a foil layer; annealing the foil layer using heat or a combination of heat and pressure; and bonding the foil layer to a support body, thereby defining the master cure tool.

公开(公告)号：US10814427B2

公开(公告)日：2020-10-27

申请号：US15867104

申请日：2018-01-10

Applicant: General Electric Company

Inventor： Victor Petrovich Ostroverkhov ,  Harry Kirk Mathews, Jr. ,  Justin John Gambone, Jr. ,  Jason Harris Karp ,  Kevin George Harding ,  Scott Michael Miller ,  William Thomas Carter

IPC: B23K26/342 ,  G01B11/27 ,  B33Y30/00 ,  B23K26/082 ,  B23K26/03 ,  B23K26/042 ,  B33Y50/02 ,  G01B11/00 ,  B22F3/105

Abstract: An additive manufacturing system includes a laser device, a build plate, a first scanning device, and an alignment system. The laser device is configured to generate a laser beam. The build plate has a position relative to the laser device. The first scanning device is configured to selectively direct the laser beam across the build plate. The laser beam generates a melt pool on the build plate. The alignment system includes a fiducial marks projector configured to project a plurality of fiducial marks across the build plate. Each fiducial mark has a location on the build plate. The alignment system also includes an optical detector configured to detect the location of each of the fiducial marks on the build plate. The alignment system is configured to detect the position of the build plate relative to the laser device.

公开(公告)号：US10288539B2

公开(公告)日：2019-05-14

申请号：US15230488

申请日：2016-08-08

Applicant: General Electric Company

Inventor： Andrew Arthur Paul Burns ,  Eugene Pauling Boden ,  Scott Michael Miller ,  Kathryn Amanda Misner ,  Terry Lee Saunders ,  Donald Joseph Buckley, Jr.

IPC: G01N3/20 ,  G01N3/42 ,  G01N3/32

Abstract: Provided herein are methods and systems for rapid testing of films used in the manufacture of bioprocess bags. The methods described herein allow for determination of resistance to flexural fatigue while mimicking actual conditions in bioprocesses such as flexion and subsequent fatigue and failure of a bioprocess bag made of a film when it is placed on a rocking platform.

公开(公告)号：US20170151736A1

公开(公告)日：2017-06-01

申请号：US14955632

申请日：2015-12-01

Applicant: General Electric Company

Inventor： Mark Marshall Meyers ,  Masako Yamada ,  Paul Richard Myers ,  Scott Michael Miller ,  Siavash Yazdanfar

IPC: B29D11/00 ,  F21V8/00 ,  B29C45/14

CPC classification number: B29D11/00663 ,  B29C33/306 ,  B29C33/424 ,  B29C45/2673 ,  B29C45/372 ,  B29L2011/00 ,  G02B6/0038 ,  G02B6/0058 ,  G02B6/0061 ,  G02B6/0063 ,  G02B6/0065 ,  G02B6/0095

Abstract: A modular method of manufacturing a waveguide is disclosed. The method includes positioning a mold insert including a plurality of mold prototypes, along at least one side wall of a molding equipment such that micro-optic structures of each mold prototype in the plurality of mold prototypes, faces a mold cavity. Each mold prototype extends along a length of the mold insert and the plurality of mold prototypes is disposed adjacent one another along a height of the mold insert. The method further includes feeding a material into the mold cavity for molding the material in the mold cavity to generate waveguide including a major surface having an optical pattern, where the optical pattern includes a plurality of elongated facets. Each of the plurality of elongated facets extends into the major surface and along a length of the waveguide. Further, the optical pattern extends along a height of the waveguide.

公开(公告)号：US20140120023A1

公开(公告)日：2014-05-01

申请号：US13665370

申请日：2012-10-31

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Surinder Prabhjot Singh ,  Anthony Yu-Chung Ku ,  Scott Michael Miller ,  Roger Allen Shisler ,  Dhaval Ajit Bhandari

IPC: C01C1/04 ,  B01J14/00

CPC classification number: B01J14/00 ,  C01B3/025 ,  C01B2203/0261 ,  C01B2203/0266 ,  C01B2203/0283 ,  C01B2203/041 ,  C01B2203/0445 ,  C01B2203/0475 ,  C01B2203/068 ,  C01C1/0405 ,  Y02P20/52

Abstract: A method for ammonia synthesis using a water-gas shift membrane reactor (WGSMR) is presented. The method includes carrying out a water-gas shift reaction in the WGSMR to form a first product stream and a carbon dioxide (CO2) stream, wherein the first product stream includes nitrogen (N2) and hydrogen (H2), and a molar ratio of H2 to N2 in the first product stream is about 3. The method further includes separating at least a portion of the residual CO2 in the first product stream in a CO2 separation unit to form a second product stream, and separating at least a portion of the residual CO2 and carbon monoxide (CO) in the second product stream in a methanator unit to form a third product stream. The method further includes generating an ammonia stream from the third product stream in an ammonia synthesis unit. A system for ammonia synthesis is also presented.

Abstract translation: 提出了一种使用水煤气变换膜反应器（WGSMR）进行氨合成的方法。 该方法包括在WGSMR中进行水煤气变换反应以形成第一产物流和二氧化碳（CO 2）流，其中第一产物流包括氮（N 2）和氢（H 2），摩尔比 第一产物流中的H 2至N 2为约3.该方法还包括在CO 2分离单元中分离第一产物流中的残余CO 2的至少一部分以形成第二产物流，并将至少一部分 在甲烷化器单元中的第二产物流中的残余CO 2和一氧化碳（CO），以形成第三产物流。 该方法还包括在氨合成单元中从第三产物流产生氨流。 还提出了一种氨合成系统。

公开(公告)号：US20130210140A1

公开(公告)日：2013-08-15

申请号：US13839409

申请日：2013-03-15

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Andrew Arthur Paul Burns ,  David Gilles Gascoyne ,  Scott Michael Miller

IPC: C12M1/32

CPC classification number: C12M23/12 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2535/10

Abstract: A carrier for growing stem cells is provided, the carrier comprises a substrate comprising one or more outer surfaces; and a hydrophilic, water soluble coating material disposed and dried on one or more of the outer surfaces. The carrier comprises one or more structured indentations on one or more of the outer surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of culturing stem cells and stromal cells using the same carrier are also provided.

Abstract translation: 提供了用于生长干细胞的载体，载体包括包含一个或多个外表面的基底; 以及在一个或多个外表面上设置和干燥的亲水的水溶性涂层材料。 载体在一个或多个外表面上包括一个或多个结构化的凹陷，其中载体的长度至少约0.2mm，宽度至少约0.2mm，高度在约0.05mm至1.2mm 并且每个所述结构化缺口具有在约0.1mm至0.5mm的范围内的长轴，在约0.1mm至0.5mm的范围内的短轴和在约0.025mm至约0.5mm的范围内的深度。 还提供了使用相同载体培养干细胞和基质细胞的方法。