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公开(公告)号：US20240383922A1
公开(公告)日：2024-11-21
申请号：US18631866
申请日：2024-04-10
Applicant: Gilead Sciences, Inc.
Inventor： Wilian Augusto Cortopassi Coelho , Chaodi Dai , Katherine De La Fuente , Julie Farand , Juan A. Guerrero , Tezcan Guney , Hongyan Guo , Safaa S. Jamshed , Darryl Kato , Irene N. Kiburu , Scott E. Lazerwith , James B.C. Mack , Joshua L. Martin , Jessica L. McKinley , Jonathan William Medley , Hyung-Jung Pyun , Thomas P. Stratton , Rhiannon Thomas-Tran , Maoqun Tian , Vickie H. Tsui , William J. Watkins , Jie Xu , Adam D. Zajdlik , Jennifer R. Zhang
IPC: C07D519/00 , A61K31/553 , A61K45/06
Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
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公开(公告)号：US20240199596A1
公开(公告)日：2024-06-20
申请号：US18413767
申请日：2024-01-16
Applicant: Gilead Sciences, Inc.
Inventor： Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Jesse M. Jacobsen , Tetsuya Kobayashi , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung
IPC: C07D413/14 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D417/12 , C07D471/04
CPC classification number: C07D413/14 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D417/12 , C07D471/04 , C07B2200/05
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US11976072B2
公开(公告)日：2024-05-07
申请号：US17845534
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Julian A. Codelli , Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Tetsuya Kobayashi , Yasamin Moazami , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung , QingMing Zhu
IPC: C07D487/04 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US11926628B2
公开(公告)日：2024-03-12
申请号：US17844871
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Julian A. Codelli , Michael Graupe , Juan A. Guerrero , Jesse M. Jacobsen , Tetsuya Kobayashi , Jonathan William Medley , Yasamin Moazami , Leena B. Patel , Jie Xu , Suet C. Yeung
IPC: C07D471/14 , A61K31/519
CPC classification number: C07D471/14
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US20230060354A1
公开(公告)日：2023-03-02
申请号：US17845534
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Julian A. Codelli , Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Tetsuya Kobayashi , Yasamin Moazami , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung , QingMing Zhu
IPC: C07D487/04 , C07D519/00
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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Patent Agency Ranking
公开(公告)号：US11352329B2
公开(公告)日：2022-06-07
申请号：US16925096
申请日：2020-07-09
Applicant: Gilead Sciences, Inc.
Inventor： Zhenhong R. Cai , Aesop Cho , Ana Zurisadai Gonzalez Buenrostro , Xiaochun Han , Salman Y. Jabri , Ryan McFadden , Yingmei Qi , Johannes Voigt , Jie Xu , Lianhong Xu , Hong Yang
IPC: C07D247/00 , A61P31/18 , C07D401/10 , C07D403/14 , C07D233/88 , C07D487/04 , C07D417/10 , C07D471/04 , C07D417/14 , C07D491/107 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/10 , C07D413/10 , A61K45/06
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US11318119B2
公开(公告)日：2022-05-03
申请号：US16849747
申请日：2020-04-15
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , John O. Link , Jie Xu
IPC: A61K31/4196 , A61K31/52 , A61K31/537 , A61K31/675 , A61K45/06 , A61P31/18 , A61K31/7076 , C07D403/10 , C07D403/14
Abstract: The present disclosure provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject using these compounds. The present disclosure also provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject using these compounds.
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公开(公告)号：US11236085B2
公开(公告)日：2022-02-01
申请号：US16660219
申请日：2019-10-22
Applicant: Gilead Sciences, Inc.
Inventor： Zhimin Du , Michael Graupe , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Eric Q. Parkhill , Barton W. Phillips , Scott P. Simonovich , Peiyuan Wang , Jie Xu , Christopher A. Ziebenhaus
IPC: C07D471/04 , C07D217/04 , C07D401/12 , C07D401/14 , C07D413/10 , C07D471/08 , C07D487/04 , C07D495/04 , C07D513/04 , C07K16/28 , C07K16/40
Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US20210323922A1
公开(公告)日：2021-10-21
申请号：US17098171
申请日：2020-11-13
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Todd Appleby , Aesop Cho , Zhimin Du , Michael Graupe , Juan A. Guerrero , Salman Y. Jabri , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Gregory Notte , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D213/69 , A61K45/06 , A61K31/444 , C07D401/14 , A61K31/5377 , C07D213/85 , A61K31/44 , C07D213/30 , C07D295/088 , A61K31/4545 , C07D401/04 , A61K31/497 , C07D519/00 , C07D487/10 , C07D487/08 , C07D213/64 , C07D491/107 , C07D498/04 , C07D213/61 , C07D405/14
Abstract: Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US10774071B2
公开(公告)日：2020-09-15
申请号：US16510647
申请日：2019-07-12
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Aesop Cho , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Devan Naduthambi , Barton W. Phillips , Scott Preston Simonovich , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D401/14 , C07D471/08 , A61K31/444 , A61K31/497 , A61K31/704 , A61K31/7068 , A61K39/395 , A61P31/20
Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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