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公开(公告)号：US09949994B2
公开(公告)日：2018-04-24
申请号：US15246240
申请日：2016-08-24
Applicant: Gilead Sciences, Inc.
Inventor： Byoung Kwon Chun , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: C07H15/18 , C07H7/06 , A61K31/685 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00
CPC classification number: A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：US20160361330A1
公开(公告)日：2016-12-15
申请号：US15246240
申请日：2016-08-24
Applicant: Gilead Sciences, Inc.
Inventor： Byoung Kwon Chun , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: A61K31/685 , A61K31/675 , A61K45/06 , C07F9/6561 , A61K31/53 , C07D487/04
CPC classification number: A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
Abstract translation: 所提供的化合物，组合物和方法特别可用于治疗马尔堡病毒，埃博拉病毒和奇瓦病毒感染。
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公开(公告)号：US20230027727A1
公开(公告)日：2023-01-26
申请号：US17748400
申请日：2022-05-19
Applicant: Gilead Sciences, Inc.
Inventor： Michael O`Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC: A61K31/706 , A61K31/7056
Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I. wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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Patent Agency Ranking
公开(公告)号：US11382926B2
公开(公告)日：2022-07-12
申请号：US17222066
申请日：2021-04-05
Applicant: Gilead Sciences, Inc.
Inventor： Michael O'Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC: A61K31/706 , A61K31/7056
Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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公开(公告)号：US20210393659A1
公开(公告)日：2021-12-23
申请号：US17222066
申请日：2021-04-05
Applicant: Gilead Sciences, Inc.
Inventor： Michael O`Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC: A61K31/706 , A61K31/7056
Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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公开(公告)号：US11007208B2
公开(公告)日：2021-05-18
申请号：US16863566
申请日：2020-04-30
Applicant: GILEAD SCIENCES, INC.
Inventor： Michael O' Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC: A61K31/7056 , A61K31/706
Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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公开(公告)号：US20180311263A1
公开(公告)日：2018-11-01
申请号：US15902690
申请日：2018-02-22
Applicant: Gilead Sciences, Inc.
Inventor： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: A61K31/685 , A61K31/53 , A61K31/00 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07H15/18 , C07H11/00 , C07H1/02 , C07H1/00 , A61K45/06 , A61K31/675 , C07F9/6561 , C07F9/24 , C07D519/00
CPC classification number: A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K31/7056 , A61K31/706 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：US09724360B2
公开(公告)日：2017-08-08
申请号：US14926062
申请日：2015-10-29
Applicant: Gilead Sciences, Inc.
Inventor： Byoung Kwon Chun , Michael O' Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC: C07H15/18 , C07H7/06 , A61K31/685 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00
CPC classification number: A61K31/685 , A61K31/00 , A61K31/53 , A61K31/6615 , A61K31/665 , A61K31/675 , A61K31/683 , A61K45/06 , C07D487/04 , C07D519/00 , C07F9/2429 , C07F9/65616 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K2300/00
Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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