公开(公告)号：US11266666B2

公开(公告)日：2022-03-08

申请号：US16881419

申请日：2020-05-22

Applicant: GILEAD SCIENCES, INC.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056 ,  A61K31/685 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20210052613A1

公开(公告)日：2021-02-25

申请号：US16881419

申请日：2020-05-22

Applicant: GILEAD SCIENCES, INC.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/685 ,  A61K31/706 ,  A61K31/7056 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US10695361B2

公开(公告)日：2020-06-30

申请号：US16265016

申请日：2019-02-01

Applicant: GILEAD SCIENCES, INC.

Inventor： Michael O'Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US20190275063A1

公开(公告)日：2019-09-12

申请号：US16274049

申请日：2019-02-12

Applicant: GILEAD SCIENCES, INC.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/685 ,  A61K31/683 ,  A61K31/706 ,  A61K31/6615 ,  C07H15/18 ,  C07H11/00 ,  C07H1/02 ,  C07H1/00 ,  A61K31/53 ,  A61K31/675 ,  C07F9/6561 ,  C07F9/24 ,  C07D519/00 ,  C07D487/04 ,  A61K31/00 ,  A61K45/06 ,  A61K31/7056 ,  A61K31/665

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20190255085A1

公开(公告)日：2019-08-22

申请号：US16265016

申请日：2019-02-01

Applicant: GILEAD SCIENCES, INC.

Inventor： Michael O' Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US20170071964A1

公开(公告)日：2017-03-16

申请号：US15267433

申请日：2016-09-16

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K45/06

CPC classification number: A61K31/706 ,  A61K31/7056 ,  A61K2300/00

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

Abstract translation: 其中核苷糖的1'位置被取代。 提供的化合物，组合物和方法特别可用于治疗Lassa病毒和Junin病毒感染。

公开(公告)号：US10251904B2

公开(公告)日：2019-04-09

申请号：US15267433

申请日：2016-09-16

Applicant: Gilead Sciences, Inc.

Inventor： Michael O'Neil Hanrahan Clarke ,  Joy Yang Feng ,  Robert Jordan ,  Richard L. Mackman ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

公开(公告)号：US20160122374A1

公开(公告)日：2016-05-05

申请号：US14926062

申请日：2015-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/685

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Abstract translation: 本发明提供了通过给予式IV的核糖苷，核苷磷酸酯及其前体药物治疗丝状病毒感染的化合物，方法和药物组合物：所提供的化合物，组合物和方法特别可用于治疗马尔堡病毒，埃博拉病毒和Cueva 病毒感染。

公开(公告)号：US10695357B2

公开(公告)日：2020-06-30

申请号：US16274049

申请日：2019-02-12

Applicant: GILEAD SCIENCES, INC.

Inventor： Byoung Kwon Chun ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056 ,  A61K31/685 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US10251898B2

公开(公告)日：2019-04-09

申请号：US15902690

申请日：2018-02-22

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056 ,  A61K31/685 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.