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公开(公告)号：US20070092484A1
公开(公告)日：2007-04-26
申请号：US11471652
申请日：2006-06-21
申请人： Zurit Levine , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman , Sarah Pollock
发明人： Zurit Levine , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman , Sarah Pollock
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/523 , C12Q2600/156 , C12Q2600/158
摘要： Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
摘要翻译： 提供了新的MCP-1剪接变体多肽和编码它们的多核苷酸。 还提供了包含剪接变体多肽和多核苷酸的药物组合物，载体和包含其的宿主细胞。 本发明的组合物可用于治疗各种MCP-1相关疾病以及用于诊断，确定各种疾病的倾向和/或预后。
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12.发明授权公开(公告)号：US08415455B2
公开(公告)日：2013-04-09
申请号：US12676359
申请日：2008-09-03
申请人： Zurit Levine , Tania Pergam , Dalit Landesman-Milo , Anat Cohen-Dayag , Amir Toporik , Yaron Kinar , Sergey Nemzer , Avi Rosenberg , Galit Rotman , Amit Novik , Cynthia Koifman , Merav Beiman , Liat Dassa , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Ofer Levy , Marina Bubis
发明人： Zurit Levine , Tania Pergam , Dalit Landesman-Milo , Anat Cohen-Dayag , Amir Toporik , Yaron Kinar , Sergey Nemzer , Avi Rosenberg , Galit Rotman , Amit Novik , Cynthia Koifman , Merav Beiman , Liat Dassa , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Ofer Levy , Marina Bubis
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.
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13.发明申请POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 有权多肽和多核苷酸，以及作为药物和生物学药物目标的用途公开(公告)号：US20120134997A1
公开(公告)日：2012-05-31
申请号：US12676359
申请日：2008-09-03
申请人： Zurit Levine , Tania Pergam , Dalit Milo , Anat Cohen-Dayag , Amir Toporik , Yaron Kinar , Sergey Nemzer , Avi Rosenberg , Galit Rotman , Amit Novik , Cynthia Koifman , Merav Beiman , Liat Dassa , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Oler Levy , Marina Bubis
发明人： Zurit Levine , Tania Pergam , Dalit Milo , Anat Cohen-Dayag , Amir Toporik , Yaron Kinar , Sergey Nemzer , Avi Rosenberg , Galit Rotman , Amit Novik , Cynthia Koifman , Merav Beiman , Liat Dassa , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Oler Levy , Marina Bubis
IPC分类号： A61K39/395 , C07K19/00 , C12N15/11 , C12N15/62 , C12N15/63 , C12P21/02 , C12N1/21 , C12N5/10 , C12N1/19 , A61K38/00 , A61K31/7088 , A61K35/00 , A61P37/02 , A61P37/06 , A61P19/02 , A61P1/00 , A61P29/00 , C07K16/00 , C12N9/96 , A61P35/00 , A61P35/02 , A61P35/04 , G01N33/566 , C07K14/00
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.
摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供了针对VSIG1，ILDR1，LOC253012，AI216611，C1ORF32或FXYD3抗原的治疗性抗体，其是预测的共刺激家族成员，并且在包括肺癌，卵巢癌和结肠癌在内的癌症中差异表达， 诊断和治疗用途。 还提供了这些抗体用于调节B7共刺激和相关疗法（例如治疗自身免疫）的用途。 本发明还涉及VSIG1及其变体FXYD3及其变体ILDR1及其变体，LOC253012及其变体，AI216611及其变体和作为免疫治疗，癌症治疗的合适靶标的C1ORF32及其变体的细胞外结构域的发现 ，药物开发。
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14.发明申请POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 审中-公开多肽和多核苷酸，以及作为药物和生物学药物目标的用途公开(公告)号：US20110311450A1
公开(公告)日：2011-12-22
申请号：US13131879
申请日：2009-12-08
申请人： Zurit Levine , Avi Rosenberg , Galit Rotman , Amit Novik , Amir Toporik , Yaron Kinar , Sergey Nemzer , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Liat Dassa , Merav Beiman , Anat Cohen-Dayag , Ofer Levy
发明人： Zurit Levine , Avi Rosenberg , Galit Rotman , Amit Novik , Amir Toporik , Yaron Kinar , Sergey Nemzer , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Liat Dassa , Merav Beiman , Anat Cohen-Dayag , Ofer Levy
IPC分类号： A61K49/00 , C12N9/96 , A61P35/00 , A61K39/395 , C40B30/04 , G01N33/574 , C07K16/30 , C12N5/078
CPC分类号： C07K16/28 , A61K38/00 , A61K39/39558 , A61K2039/505 , C07K14/47 , C07K16/30 , C07K16/3015 , C07K16/3038 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12Q1/6886 , C12Q2600/136 , G01N33/57484 , G01N33/577 , G01N2333/47
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTCAP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.
摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供针对在癌症中差异表达的KRTCAP3，FAM26F，MGC52498，FAM70A或TMEM154抗原以及诊断和治疗用途的治疗性抗体。 本发明还涉及KRTCAP3，FAM26F，MGC52498，FAM70A和TMEM154蛋白质和变体的细胞外结构域及其治疗用途。
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15.发明申请Polynucleotides encoding novel ErbB-2 polypeptides and kits and methods using same 审中-公开编码新型ErbB-2多肽的多核苷酸和使用其的试剂盒和方法公开(公告)号：US20050123538A1
公开(公告)日：2005-06-09
申请号：US10956373
申请日：2004-10-04
申请人： Ronen Shemesh , Anat Oren , Galit Rotman , Osnat Sella-Tavor , Shira Walach , Shirley Sameach-Greenwald , Merav Beiman , Dani Eshel , Kinneret Savitsky
发明人： Ronen Shemesh , Anat Oren , Galit Rotman , Osnat Sella-Tavor , Shira Walach , Shirley Sameach-Greenwald , Merav Beiman , Dani Eshel , Kinneret Savitsky
IPC分类号： A61K39/395 , C07H21/04 , C07K14/71 , C07K14/72 , C07K14/82 , C07K16/28 , C07K16/32 , C12Q1/68
摘要： Isolated polynucleotides encoding novel ErbB-2 polypeptides are provided. Also provided are methods and kits using same for diagnosing prognosing and treating ErbB-related cancer.
摘要翻译： 提供了编码新型ErbB-2多肽的分离的多核苷酸。 还提供了用于诊断预后和治疗ErbB相关癌症的方法和试剂盒。
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公开(公告)号：US20100166733A1
公开(公告)日：2010-07-01
申请号：US12305953
申请日：2006-06-21
申请人： Zurit Levin , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman
发明人： Zurit Levin , Amir Toporik , Michal Ayalon-Soffer , Iris Hecht , Merav Beiman , Dani Eshel , Tali Handelsman
IPC分类号： A61K39/395 , C07H21/00 , C07K16/00 , C12N15/74 , C12N5/10 , C12P21/00 , A61K31/7088 , A61K45/00 , A61P3/10 , A61P11/06 , A61P11/08 , A61P9/10 , A61P21/00 , A61P37/02
CPC分类号： C07K14/523 , A61K38/00
摘要： Novel MCP-1 splice variant polypeptides and polynucleotides encoding same are provided. Also provided are pharmaceutical compositions comprising the splice variant polypeptides and polynucleotides, vectors and host cells comprising same. The compositions of the present invention are useful to treat various MCP-1 related disorders as well as for diagnosing, determining predisposition and/or prognosis of various disorders.
摘要翻译： 提供了新的MCP-1剪接变体多肽和编码它们的多核苷酸。 还提供了包含剪接变体多肽和多核苷酸，载体和包含其的宿主细胞的药物组合物。 本发明的组合物可用于治疗各种MCP-1相关疾病以及用于诊断，确定各种疾病的倾向和/或预后。
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公开(公告)号：US20110003708A1
公开(公告)日：2011-01-06
申请号：US12824010
申请日：2010-06-25
申请人： Yaron Kinar , Merav Beiman , Eve Montia , Shira Walach , Tania Pergam , Amit Novik , Shirley Sameah-Greenwald , Gad S. Cojocaru , Anat Cohen-Dayag , Yael Furman
发明人： Yaron Kinar , Merav Beiman , Eve Montia , Shira Walach , Tania Pergam , Amit Novik , Shirley Sameah-Greenwald , Gad S. Cojocaru , Anat Cohen-Dayag , Yael Furman
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/142 , C12Q2600/158 , C12Q2600/16 , G01N33/6893 , G01N2800/347 , G01N2800/52 , Y10T436/143333
摘要： The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of novel as well as known polynucleotides and proteins, and to kits utilizing same.
摘要翻译： 本发明涉及用于通过测量多核苷酸和蛋白质的表达来预测肾损伤的发作的方法和方法，特别是关于测量新颖的以及已知的多核苷酸和蛋白质的组合的表达，以及使用它们的试剂盒。
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