公开(公告)号：US20110003708A1

公开(公告)日：2011-01-06

申请号：US12824010

申请日：2010-06-25

申请人： Yaron Kinar ,  Merav Beiman ,  Eve Montia ,  Shira Walach ,  Tania Pergam ,  Amit Novik ,  Shirley Sameah-Greenwald ,  Gad S. Cojocaru ,  Anat Cohen-Dayag ,  Yael Furman

发明人： Yaron Kinar ,  Merav Beiman ,  Eve Montia ,  Shira Walach ,  Tania Pergam ,  Amit Novik ,  Shirley Sameah-Greenwald ,  Gad S. Cojocaru ,  Anat Cohen-Dayag ,  Yael Furman

IPC分类号： C40B30/04 ,  C07H21/04 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/50 ,  C07H21/00

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/142 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/6893 ,  G01N2800/347 ,  G01N2800/52 ,  Y10T436/143333

摘要： The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the expression of sets of novel as well as known polynucleotides and proteins, and to kits utilizing same.

摘要翻译： 本发明涉及用于通过测量多核苷酸和蛋白质的表达来预测肾损伤的发作的方法和方法，特别是关于测量新颖的以及已知的多核苷酸和蛋白质的组合的表达，以及使用它们的试剂盒。

公开(公告)号：US20120134997A1

公开(公告)日：2012-05-31

申请号：US12676359

申请日：2008-09-03

申请人： Zurit Levine ,  Tania Pergam ,  Dalit Milo ,  Anat Cohen-Dayag ,  Amir Toporik ,  Yaron Kinar ,  Sergey Nemzer ,  Avi Rosenberg ,  Galit Rotman ,  Amit Novik ,  Cynthia Koifman ,  Merav Beiman ,  Liat Dassa ,  Shira Walach ,  Eve Montia ,  Shirley Sameach-Greenwald ,  Oler Levy ,  Marina Bubis

发明人： Zurit Levine ,  Tania Pergam ,  Dalit Milo ,  Anat Cohen-Dayag ,  Amir Toporik ,  Yaron Kinar ,  Sergey Nemzer ,  Avi Rosenberg ,  Galit Rotman ,  Amit Novik ,  Cynthia Koifman ,  Merav Beiman ,  Liat Dassa ,  Shira Walach ,  Eve Montia ,  Shirley Sameach-Greenwald ,  Oler Levy ,  Marina Bubis

IPC分类号： A61K39/395 ,  C07K19/00 ,  C12N15/11 ,  C12N15/62 ,  C12N15/63 ,  C12P21/02 ,  C12N1/21 ,  C12N5/10 ,  C12N1/19 ,  A61K38/00 ,  A61K31/7088 ,  A61K35/00 ,  A61P37/02 ,  A61P37/06 ,  A61P19/02 ,  A61P1/00 ,  A61P29/00 ,  C07K16/00 ,  C12N9/96 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  G01N33/566 ,  C07K14/00

CPC分类号： C07K16/30 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/39 ,  A61K39/395 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  A61N5/10 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/82 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/60 ,  C07K2319/70 ,  G01N33/564 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2500/04

摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.

摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供了针对VSIG1，ILDR1，LOC253012，AI216611，C1ORF32或FXYD3抗原的治疗性抗体，其是预测的共刺激家族成员，并且在包括肺癌，卵巢癌和结肠癌在内的癌症中差异表达， 诊断和治疗用途。 还提供了这些抗体用于调节B7共刺激和相关疗法（例如治疗自身免疫）的用途。 本发明还涉及VSIG1及其变体FXYD3及其变体ILDR1及其变体，LOC253012及其变体，AI216611及其变体和作为免疫治疗，癌症治疗的合适靶标的C1ORF32及其变体的细胞外结构域的发现 ，药物开发。

公开(公告)号：US08415455B2

公开(公告)日：2013-04-09

申请号：US12676359

申请日：2008-09-03

申请人： Zurit Levine ,  Tania Pergam ,  Dalit Landesman-Milo ,  Anat Cohen-Dayag ,  Amir Toporik ,  Yaron Kinar ,  Sergey Nemzer ,  Avi Rosenberg ,  Galit Rotman ,  Amit Novik ,  Cynthia Koifman ,  Merav Beiman ,  Liat Dassa ,  Shira Walach ,  Eve Montia ,  Shirley Sameach-Greenwald ,  Ofer Levy ,  Marina Bubis

发明人： Zurit Levine ,  Tania Pergam ,  Dalit Landesman-Milo ,  Anat Cohen-Dayag ,  Amir Toporik ,  Yaron Kinar ,  Sergey Nemzer ,  Avi Rosenberg ,  Galit Rotman ,  Amit Novik ,  Cynthia Koifman ,  Merav Beiman ,  Liat Dassa ,  Shira Walach ,  Eve Montia ,  Shirley Sameach-Greenwald ,  Ofer Levy ,  Marina Bubis

IPC分类号： C07K14/00 ,  A61K38/36

CPC分类号： C07K16/30 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/39 ,  A61K39/395 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  A61N5/10 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/82 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/60 ,  C07K2319/70 ,  G01N33/564 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2500/04

摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.

公开(公告)号：US20110311450A1

公开(公告)日：2011-12-22

申请号：US13131879

申请日：2009-12-08

申请人： Zurit Levine ,  Avi Rosenberg ,  Galit Rotman ,  Amit Novik ,  Amir Toporik ,  Yaron Kinar ,  Sergey Nemzer ,  Shira Walach ,  Eve Montia ,  Shirley Sameach-Greenwald ,  Liat Dassa ,  Merav Beiman ,  Anat Cohen-Dayag ,  Ofer Levy

发明人： Zurit Levine ,  Avi Rosenberg ,  Galit Rotman ,  Amit Novik ,  Amir Toporik ,  Yaron Kinar ,  Sergey Nemzer ,  Shira Walach ,  Eve Montia ,  Shirley Sameach-Greenwald ,  Liat Dassa ,  Merav Beiman ,  Anat Cohen-Dayag ,  Ofer Levy

IPC分类号： A61K49/00 ,  C12N9/96 ,  A61P35/00 ,  A61K39/395 ,  C40B30/04 ,  G01N33/574 ,  C07K16/30 ,  C12N5/078

CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/39558 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3038 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N33/577 ,  G01N2333/47

摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTCAP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.

摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供针对在癌症中差异表达的KRTCAP3，FAM26F，MGC52498，FAM70A或TMEM154抗原以及诊断和治疗用途的治疗性抗体。 本发明还涉及KRTCAP3，FAM26F，MGC52498，FAM70A和TMEM154蛋白质和变体的细胞外结构域及其治疗用途。

公开(公告)号：US07906635B2

公开(公告)日：2011-03-15

申请号：US12354641

申请日：2009-01-15

申请人： Gad S. Cojocaru ,  Sarah Pollock ,  Zurit Levine ,  Alexander Diber ,  Guy Kol ,  Amir Toporik ,  Rotem Sorek ,  Dvir Dahary ,  Michal Ayalon-Soffer ,  Pinchas Akiva ,  Amit Novik ,  Yossi Cohen ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Ronen Shemesh ,  Maxim Shklar

发明人： Gad S. Cojocaru ,  Sarah Pollock ,  Zurit Levine ,  Alexander Diber ,  Guy Kol ,  Amir Toporik ,  Rotem Sorek ,  Dvir Dahary ,  Michal Ayalon-Soffer ,  Pinchas Akiva ,  Amit Novik ,  Yossi Cohen ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Ronen Shemesh ,  Maxim Shklar

IPC分类号： C07H21/02 ,  C12Q1/68

CPC分类号： G01N33/57449 ,  C12Q1/6886 ,  C12Q2600/156 ,  Y10T436/143333

摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.

摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。

公开(公告)号：US07714100B2

公开(公告)日：2010-05-11

申请号：US11978203

申请日：2007-10-29

申请人： Yossi Cohen ,  Alexander Diber ,  Amir Toporik ,  Sarah Pollock ,  Zurit Levine ,  Michal Ayalon-Soffer ,  Gad S. Cojocaru ,  Amit Novik ,  Guy Kol ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Dvir Dahary ,  Ronen Shemesh

发明人： Yossi Cohen ,  Alexander Diber ,  Amir Toporik ,  Sarah Pollock ,  Zurit Levine ,  Michal Ayalon-Soffer ,  Gad S. Cojocaru ,  Amit Novik ,  Guy Kol ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Dvir Dahary ,  Ronen Shemesh

IPC分类号： A61K38/00

CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/18 ,  C07K2317/34 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/327

摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.

摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。

公开(公告)号：US20100248270A1

公开(公告)日：2010-09-30

申请号：US12623957

申请日：2009-11-23

申请人： Yossi Cohen ,  Alexander Diber ,  Amir Toporik ,  Sarah Pollock ,  Zurit Levine ,  Michal Ayalon-Soffer ,  Gad S. Cojocaru ,  Amit Novik ,  Guy Kol ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Dvir Dahary ,  Ronen Shemesh

发明人： Yossi Cohen ,  Alexander Diber ,  Amir Toporik ,  Sarah Pollock ,  Zurit Levine ,  Michal Ayalon-Soffer ,  Gad S. Cojocaru ,  Amit Novik ,  Guy Kol ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Dvir Dahary ,  Ronen Shemesh

IPC分类号： G01N33/53 ,  C07K16/00

CPC分类号： C07K14/705 ,  C07H21/04 ,  C07K16/18 ,  C07K2317/34 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/327

摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.

摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。

公开(公告)号：US20100068736A1

公开(公告)日：2010-03-18

申请号：US12557253

申请日：2009-09-10

申请人： Sarah Pollock ,  Zurit Levine ,  Amit Novik ,  Dvir Dahary ,  Rotem Sorek ,  Amir Toporik ,  Shirley Sameah-Greenwald ,  Osnat Sella-Tavor ,  Alexander Diber ,  Gad S. Cojocaru ,  Michal Ayalon-Soffer ,  Shira Walach ,  Pinchas Akiva ,  Naomi Keren ,  Ronen Shemesh

发明人： Sarah Pollock ,  Zurit Levine ,  Amit Novik ,  Dvir Dahary ,  Rotem Sorek ,  Amir Toporik ,  Shirley Sameah-Greenwald ,  Osnat Sella-Tavor ,  Alexander Diber ,  Gad S. Cojocaru ,  Michal Ayalon-Soffer ,  Shira Walach ,  Pinchas Akiva ,  Naomi Keren ,  Ronen Shemesh

IPC分类号： G01N33/53 ,  C07K2/00 ,  C07K16/00 ,  G01N33/574

CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.

摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。

公开(公告)号：US07667001B1

公开(公告)日：2010-02-23

申请号：US11978554

申请日：2007-10-30

申请人： Sarah Pollock ,  Zurit Levine ,  Amit Novik ,  Dvir Dahary ,  Rotem Sorek ,  Amir Toporik ,  Shirley Sameah-Greenwald ,  Osnat Sella-Tavor ,  Alexander Diber ,  Gad S. Cojocaru ,  Michal Avalon-Soffer ,  Shira Walach ,  Pinchas Akiva ,  Naomi Keren ,  Ronen Shemesh

发明人： Sarah Pollock ,  Zurit Levine ,  Amit Novik ,  Dvir Dahary ,  Rotem Sorek ,  Amir Toporik ,  Shirley Sameah-Greenwald ,  Osnat Sella-Tavor ,  Alexander Diber ,  Gad S. Cojocaru ,  Michal Avalon-Soffer ,  Shira Walach ,  Pinchas Akiva ,  Naomi Keren ,  Ronen Shemesh

IPC分类号： C07K16/00

CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.

摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。

公开(公告)号：US07345142B2

公开(公告)日：2008-03-18

申请号：US11043824

申请日：2005-01-27

申请人： Yossi Cohen ,  Alexander Diber ,  Amir Toporik ,  Sarah Pollock ,  Zurit Levine ,  Michal Ayalon-Soffer ,  Gad S. Cojocaru ,  Amit Novik ,  Guy Kol ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Dvir Dahary ,  Ronen Shemesh

发明人： Yossi Cohen ,  Alexander Diber ,  Amir Toporik ,  Sarah Pollock ,  Zurit Levine ,  Michal Ayalon-Soffer ,  Gad S. Cojocaru ,  Amit Novik ,  Guy Kol ,  Osnat Sella-Tavor ,  Shira Walach ,  Shirley Sameah-Greenwald ,  Dvir Dahary ,  Ronen Shemesh

IPC分类号： A61K38/00

CPC分类号： G01N33/6893 ,  C07K14/705 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/327

摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.

摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。