公开(公告)号：US20230357445A1

公开(公告)日：2023-11-09

申请号：US18132131

申请日：2023-04-07

Applicant: Genentech, Inc.

Inventor： Justin SCHEER ,  Christoph SPIESS ,  Daniel G. YANSURA

IPC: C07K16/46 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K16/468 ,  C07K16/244 ,  C07K16/247 ,  C07K16/2863 ,  C07K16/30 ,  A61K2039/505

Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

公开(公告)号：US20220409725A1

公开(公告)日：2022-12-29

申请号：US17395400

申请日：2021-08-05

Applicant: Genentech, Inc.

Inventor： Paul CARTER ,  Christoph SPIESS ,  Yiyuan YIN ,  Jianhui ZHOU ,  Wendy SANDOVAL ,  Jacob CORN ,  Michael DILLON

IPC: A61K39/44 ,  C07K16/46 ,  G16B20/50 ,  G16B20/30 ,  A61K39/395

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

公开(公告)号：US20210179715A1

公开(公告)日：2021-06-17

申请号：US17119753

申请日：2020-12-11

Applicant: Genentech, Inc.

Inventor： WeiYu LIN ,  Christoph SPIESS ,  Liping SUN ,  Yan WU ,  Cecilia P.C. CHIU ,  Walter Christian DARBONNE ,  Michael Andrew DILLON

IPC: C07K16/28

Abstract: Provided herein are anti-Ly6G6D (lymphocyte antigen 6 complex, locus G61) antibodies and methods of using the same.

公开(公告)号：US20180030434A1

公开(公告)日：2018-02-01

申请号：US15782616

申请日：2017-10-12

Applicant: Genentech, Inc.

Inventor： Twyla Noelle LOMBANA ,  Rebekah MCKENNA ,  Christoph SPIESS ,  Karthik VEERAVALLI ,  Michael DILLON

IPC: C12N15/10 ,  G01N33/569 ,  C07K14/195 ,  C07K16/12 ,  G01N33/53 ,  G01N33/68 ,  C12Q1/68

CPC classification number: C12N15/1037 ,  C07K14/195 ,  C07K16/12 ,  C07K16/22 ,  C07K16/244 ,  C07K2317/30 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/40 ,  C12Q1/689 ,  G01N33/5306 ,  G01N33/56911 ,  G01N33/6854 ,  G01N33/6857 ,  G01N33/686 ,  G01N2469/20

Abstract: The invention provides methods of identifying bacteria comprising binding polypeptides. The invention also provides methods of identifying bacteria with improved expression of binding polypeptides. The invention also provides methods of identifying binding polypeptides with improved expression. The invention also provides engineered bacteria suitable for use in the methods of the invention. The invention also provides compositions that can be obtained using the methods, for example, anti-interleukin-13 (IL-13) antibodies with improved expression and/or stability. The invention also provides libraries comprising binding polypeptide (e.g., antibody) variants.