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公开(公告)号：US09611323B2
公开(公告)日：2017-04-04
申请号：US14577006
申请日：2014-12-19
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Ryan Jefferson Watts , Yunhua Joy Yu , Yin Zhang
CPC classification number: C07K16/468 , A61K47/68 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/2881 , C07K16/40 , C07K2317/31 , C07K2317/54 , C07K2317/70 , C07K2317/76 , C07K2317/92 , Y02A50/466
Abstract: The present invention relates to antibodies that bind blood brain barrier receptors (BBB-R) and methods of using the same.
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公开(公告)号：US20230041134A1
公开(公告)日：2023-02-09
申请号：US17720717
申请日：2022-04-14
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: C07K16/32 , A61K47/68 , A61K39/395 , C07K16/28 , G01N33/574 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K49/00 , C07K16/30
Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20210292440A1
公开(公告)日：2021-09-23
申请号：US17161068
申请日：2021-01-28
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Ryan Jefferson Watts , Yunhua Yu Zuchero , Yin Zhang
Abstract: The present invention relates to antibodies that bind blood brain barrier receptors (BBB-R) and methods of using the same.
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公开(公告)号：US10752703B2
公开(公告)日：2020-08-25
申请号：US16544421
申请日：2019-08-19
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Janet Jackman , James T. Koerber , Mason Lu , Henry R. Maun , Kathila Rajapaksa , Saroja Ramanujan , Tracy Staton , Lawren Wu , Tangsheng Yi
IPC: C07K16/40 , A61K39/395 , A61K39/00 , A61K47/18 , A61K47/22 , A61K47/26 , A61K47/10 , A61K45/06 , C07K16/24
Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.
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公开(公告)号：US10377825B2
公开(公告)日：2019-08-13
申请号：US15842590
申请日：2017-12-14
Applicant: Genentech, Inc.
Inventor： Mary Mathieu , Mark Dennis
IPC: A61K39/395 , C07K16/28 , C07K16/32 , A61P35/00
Abstract: The invention provides anti-HER2 antibodies, including anti-HER2 antibodies of improved stability or affinity, and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20190177429A1
公开(公告)日：2019-06-13
申请号：US16170819
申请日：2018-10-25
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: C07K16/32 , G01N33/574 , A61K49/00 , A61K39/395 , A61K31/704 , A61K31/675 , A61K31/5517 , C07K16/30 , A61K47/68 , C07K16/28
Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
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17.发明授权公开(公告)号：US08771966B2
公开(公告)日：2014-07-08
申请号：US13692888
申请日：2012-12-03
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Jan Marik , Paul Polakis , Bonnee Rubinfeld , Simon Williams
IPC: G01N33/53
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。 提供检测或确定STEAP-1蛋白存在的方法。
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公开(公告)号：US20140115729A1
公开(公告)日：2014-04-24
申请号：US14137927
申请日：2013-12-20
Applicant: Genentech, Inc.
Inventor： Lawren Wu , Mercedesz Balazs , Hans Brightbill , Andrew Chan , Yvonne Chen , Anan Chuntharapai , Mark Dennis , Terence Wong
IPC: C07K16/42
CPC classification number: C07K16/4291 , A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/0387 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/73
Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.
Abstract translation: 本申请涉及凋亡性抗IgE抗体，编码它的核酸，其治疗组合物及其在治疗IgE介导的病症中的用途。
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公开(公告)号：US20140080152A1
公开(公告)日：2014-03-20
申请号：US13963286
申请日：2013-08-09
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
IPC: C07K16/18
CPC classification number: C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：USRE48558E1
公开(公告)日：2021-05-18
申请号：US15908703
申请日：2018-02-28
Applicant: GENENTECH, INC.
Inventor： Yvonne Chen , Mark Dennis , David Dornan , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
IPC: A61K51/00 , A61K39/44 , C07K19/00 , C07K16/28 , A61K47/68 , A61K31/537 , A61K38/05 , A61K39/395 , A61K45/06 , A61K51/10 , C07K16/30 , G01N33/574 , A61K39/00
Abstract: The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194), (ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195), (iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196), (iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202), (v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and (vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204) and to methods of using those compositions of matter for the treatment of hematopoietic tumor in mammals.
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