公开(公告)号：US20240084241A1

公开(公告)日：2024-03-14

申请号：US18464135

申请日：2023-09-08

Applicant: GENENTECH, INC.

Inventor： Arthi NARAYANAN ,  Aditya Avdhut WALVEKAR ,  Georo L. ZHOU ,  Nicholas RUMMEL ,  Zheng LI ,  Steven J. MEIER

IPC: C12M1/36 ,  G16B40/20

CPC classification number: C12M41/48 ,  G16B40/20

Abstract: A method, system, and non-transitory computer readable medium for predicting a glycan distribution of one or more glycans attached to molecules during a biomolecules manufacturing process are disclosed. In various embodiments, at least three manufacturing process parameters related to the process for manufacturing the molecules are input into a probabilistic graphical model that is trained to predict glycan distribution. The trained probabilistic graphical model may then analyze the at least three manufacturing process parameters to predict the distribution of the glycans that are attached to the molecules.

公开(公告)号：US20210371587A1

公开(公告)日：2021-12-02

申请号：US17319886

申请日：2021-05-13

Applicant: Genentech, Inc.

Inventor： Ganesh Prasadh VISSVESVARAN ,  Robert David KISS ,  Steven J. MEIER ,  Inchan KWON ,  Kara CALHOUN ,  Kate WINCHESTER ,  Amelia ADAMS ,  Marion GLENN ,  Stefan KOENIG ,  Alan DEESE

IPC: C08G65/30 ,  C12N5/00 ,  C07K16/00

Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.

公开(公告)号：US20130281355A1

公开(公告)日：2013-10-24

申请号：US13841864

申请日：2013-03-15

Applicant: GENENTECH, INC.

Inventor： Natarajan VIJAYASANKARAN ,  Steven J. MEIER ,  Melissa S. MUN ,  Sharat VARMA ,  Yi YANG ,  Boyan ZHANG ,  Silvana R. AREVALO ,  Martin GAWLITZEK ,  Veronica CARVALHAL

IPC: C12N5/00 ,  C07K16/00 ,  C12P21/00

CPC classification number: C12N5/0018 ,  C07K16/00 ,  C12N5/005 ,  C12N2500/24 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2501/39 ,  C12P21/00

Abstract: Cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. Compositions comprising polypeptides produced by the methods are also provided.