-
公开(公告)号：USRE39356E1
公开(公告)日：2006-10-17
申请号：US11056606
申请日：2005-02-11
申请人： Wen Sen Li , John E. Thornton , Zhenrong Guo , Shankar Swaminathan , Robert M. Borzilleri , Soong-Hoon Kim , Denis Favreau
发明人： Wen Sen Li , John E. Thornton , Zhenrong Guo , Shankar Swaminathan , Robert M. Borzilleri , Soong-Hoon Kim , Denis Favreau
IPC分类号： C07D491/00 , C07D417/00
摘要： The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
-
公开(公告)号：US07102001B2
公开(公告)日：2006-09-05
申请号：US11008719
申请日：2004-12-09
申请人： Shankar Swaminathan , Ashvinikumar V. Gavai , Junying Fan , Bharat P. Patel , Derek J. Norris , Richard Michael Corbett , Bin Zheng
发明人： Shankar Swaminathan , Ashvinikumar V. Gavai , Junying Fan , Bharat P. Patel , Derek J. Norris , Richard Michael Corbett , Bin Zheng
IPC分类号： C07D487/14 , C07D413/14 , C07D403/12 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides a process for preparing compounds of formula (I) or a pharmaceutically acceptable salt thereof. The compounds prepared by the process of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
摘要翻译： 本发明提供制备式（I）化合物或其药学上可接受的盐的方法。 通过本发明的方法制备的化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其可用作治疗癌症和其它疾病的抗增殖剂。
-
公开(公告)号：US20050209454A1
公开(公告)日：2005-09-22
申请号：US11008719
申请日：2004-12-09
申请人： Shankar Swaminathan , Ashvinikumar Gavai , Junying Fan , Bharat Patel , Derek Norris , Richard Corbett , Bin Zheng
发明人： Shankar Swaminathan , Ashvinikumar Gavai , Junying Fan , Bharat Patel , Derek Norris , Richard Corbett , Bin Zheng
IPC分类号： A61K20060101 , A61K31/53 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides a process for preparing compounds of formula (I) or a pharmaceutically acceptable salt thereof. The compounds prepared by the process of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
摘要翻译： 本发明提供制备式（I）化合物或其药学上可接受的盐的方法。 通过本发明的方法制备的化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其可用作治疗癌症和其它疾病的抗增殖剂。
-
公开(公告)号：US06515170B1
公开(公告)日：2003-02-04
申请号：US09843226
申请日：2001-04-26
申请人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Thomas P. Tully , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , William J. Winter , Neal G. Anderson , David A. Lust , Gerard Crispino , Sushil K. Srivastava
发明人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Thomas P. Tully , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , William J. Winter , Neal G. Anderson , David A. Lust , Gerard Crispino , Sushil K. Srivastava
IPC分类号： C07C3200
CPC分类号： C07K5/06139 , A61K38/00 , C07K14/8103 , C12N9/1096
摘要： The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
-
15.依法登记的发明7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same 失效可用于制备抗血栓形成和抗血管痉挛性化合物的7-氧杂双环庚烷羧酸前列腺素类似物中间体及其制备方法
公开(公告)号：USH1737H
公开(公告)日：1998-06-02
申请号：US828460
申请日：1997-03-28
IPC分类号： C07C237/06 , C07D493/08 , C07D263/52
CPC分类号： C07D493/08 , C07C237/06
摘要： A method is provided for preparing intermediates for 7-oxabicycloheptane carboxylic acid intermediates of the structures ##STR1## wherein R is alkyl, aryl, arylalkyl or cycloalkyl; R.sup.1 is alkyl, arylalkyl or cycloalkyl; R.sup.2 is aryl or arylalkyl; and of the structure ##STR2## where R and R.sup.1 are as defined above, which may be used in making the final anti-thrombotic--anti-vasospastic compounds.
摘要翻译： 提供了制备其中R为烷基，芳基，芳基烷基或环烷基的结构的7-氧杂双环庚烷羧酸中间体的中间体的方法; R1是烷基，芳烷基或环烷基; R2是芳基或芳基烷基; 和结构<IMAGE>，其中R和R 1如上所定义，其可用于制备最终的抗血栓形成 - 抗血管痉挛性化合物。
-
-
-
-
搜索结果
15 条记录 (耗时 0.033 秒)
