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公开(公告)号：US06620922B1
公开(公告)日：2003-09-16
申请号：US09636215
申请日：2000-08-09
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C07H2104
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5156 , A61K2039/53 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16222
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US06395278B1
公开(公告)日：2002-05-28
申请号：US09352616
申请日：1999-07-13
IPC分类号： A61K3848
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/5156 , C07K14/705 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。
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13.发明授权公开(公告)号：US06261562B1
公开(公告)日：2001-07-17
申请号：US09020956
申请日：1998-02-09
申请人： Jiangchun Xu , Davin C. Dillon
发明人： Jiangchun Xu , Davin C. Dillon
IPC分类号： A61K3900
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/705 , C07K2319/00 , C12N9/90
摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
摘要翻译： 提供了治疗前列腺癌的化合物和方法。 本发明化合物包括含有前列腺肿瘤蛋白质的至少一部分的多肽。 包含此类多肽的前列腺癌的免疫治疗用疫苗和药物组合物或编码此类多肽的DNA分子也与制备本发明多肽的DNA分子一起提供。
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14.发明申请公开(公告)号：US20110150919A1
公开(公告)日：2011-06-23
申请号：US11929831
申请日：2007-10-30
IPC分类号： A61K39/00 , C07K2/00 , C07H21/04 , A61P35/00 , G01N33/68 , C12N5/0783 , A61K35/12 , A61P37/04
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/53 , C07K14/4748 , C07K14/82 , C07K16/3015 , C07K2317/21 , C07K2317/34 , C07K2319/00 , C12Q1/6886
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。
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公开(公告)号：US20080226620A1
公开(公告)日：2008-09-18
申请号：US11929396
申请日：2007-10-30
申请人： Jiangchun Xu , John A. Stolk , Michael D. Kalos
发明人： Jiangchun Xu , John A. Stolk , Michael D. Kalos
IPC分类号： A61K39/395 , C07K7/00 , C07K11/00 , C12N15/64 , C12N5/08 , C07K16/00 , G01N33/53 , C07K19/00 , A61K45/00 , C07H21/04 , C12Q1/68 , C12Q1/02 , A61K38/04 , A61K38/16 , A61K31/7088 , A61P37/02 , A61P35/00
CPC分类号： C07K14/005 , A01K2227/105 , A01K2267/0331 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/124 , A61K2039/505 , A61K2039/5156 , A61K2039/53 , A61K2039/55566 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/565 , C07K2317/73 , C07K2319/00 , C12N9/6424 , C12N2760/16222 , G01N33/57434
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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16.发明授权公开(公告)号：US07270980B2
公开(公告)日：2007-09-18
申请号：US09232880
申请日：1999-01-15
IPC分类号： C12P19/34 , C12Q1/00 , C12Q1/68 , G01N33/567 , G01N33/574 , G01N33/53 , G01N33/537 , A61K38/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00
CPC分类号： C07K14/4748 , A61K39/00 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158 , Y10T436/25
摘要： Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
摘要翻译： 提供了用于诊断前列腺癌的化合物和方法。 本发明化合物包括含有前列腺肿瘤蛋白质的至少一部分的多肽。 本发明的多肽可用于产生可用于诊断和监测前列腺癌的抗体。 还提供了用于制备探针，引物和多肽的核酸序列。
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17.发明授权Compositions for the treatment and diagnosis of breast cancer and methods for their use 失效用于乳腺癌治疗和诊断的组合及其使用方法公开(公告)号：US06844325B2
公开(公告)日：2005-01-18
申请号：US09551621
申请日：2000-04-17
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , C07K14/47 , C12N9/00 , C12Q1/68 , A01N43/04 , A61K31/70 , C07H21/04 , C07H21/02 , C12N15/74
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/4748 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/158 , Y10S530/806 , Y10S530/828
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。
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公开(公告)号：US06800746B2
公开(公告)日：2004-10-05
申请号：US09759143
申请日：2001-01-12
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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公开(公告)号：US06720146B2
公开(公告)日：2004-04-13
申请号：US09970966
申请日：2001-10-02
IPC分类号： G01N3348
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , Y10S436/813 , Y10T436/143333
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
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公开(公告)号：US06512094B1
公开(公告)日：2003-01-28
申请号：US09593793
申请日：2000-06-13
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C07K100
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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