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公开(公告)号：US06620922B1
公开(公告)日：2003-09-16
申请号：US09636215
申请日：2000-08-09
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C07H2104
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5156 , A61K2039/53 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16222
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US06800746B2
公开(公告)日：2004-10-05
申请号：US09759143
申请日：2001-01-12
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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公开(公告)号：US06512094B1
公开(公告)日：2003-01-28
申请号：US09593793
申请日：2000-06-13
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C07K100
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US06630305B1
公开(公告)日：2003-10-07
申请号：US09685166
申请日：2000-10-10
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/53 , C07K14/47 , C07K2319/00 , C12N9/6424 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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5.发明授权公开(公告)号：US07517952B1
公开(公告)日：2009-04-14
申请号：US09593793
申请日：2000-06-13
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
CPC分类号： C07K14/47 , A61K2039/505 , C07K14/4748 , C07K16/3069 , C07K2317/34 , C07K2317/565
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。
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6.发明授权公开(公告)号：US06894146B1
公开(公告)日：2005-05-17
申请号：US09657279
申请日：2000-09-06
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , C07K14/11 , C07K14/47 , C07K14/705 , C12N9/64 , C07K5/00 , C07K14/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。
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公开(公告)号：US07033827B2
公开(公告)日：2006-04-25
申请号：US10144678
申请日：2002-05-09
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Robert A. Henderson , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , John Hural , Patricia D. McNeill , Raymond L. Houghton , Carlota Vinals y de Bassols , Teresa M. Foy , Yoshihiro Watanabe , Madeleine Joy Meagher , Ta Deng
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Robert A. Henderson , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , John Hural , Patricia D. McNeill , Raymond L. Houghton , Carlota Vinals y de Bassols , Teresa M. Foy , Yoshihiro Watanabe , Madeleine Joy Meagher , Ta Deng
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/124 , A61K2039/505 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/34 , C07K2319/00 , C12N9/6424 , C12N2710/14143 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。
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公开(公告)号：US06943236B2
公开(公告)日：2005-09-13
申请号：US10012896
申请日：2001-12-10
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson , John Hural , Patricia D. McNeill , Raymond L. Houghton , Carlota Vinals y de Bassols , Teresa M. Foy , Yoshihiro Watanabe , Madeleine Joy Meagher
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson , John Hural , Patricia D. McNeill , Raymond L. Houghton , Carlota Vinals y de Bassols , Teresa M. Foy , Yoshihiro Watanabe , Madeleine Joy Meagher
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/11 , C07K14/47 , C07K14/705 , C07K16/30 , C12N9/64 , C07K14/00 , C07H21/02 , C12Q1/68 , C12N1/20
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/124 , A61K2039/505 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C12N9/6424 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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9.发明授权公开(公告)号：US06818751B1
公开(公告)日：2004-11-16
申请号：US09651236
申请日：2000-08-29
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C07H2104
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2710/14143 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。
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10.发明授权公开(公告)号：US06759515B1
公开(公告)日：2004-07-06
申请号：US09679426
申请日：2000-10-02
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C07K1400
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。
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