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公开(公告)号：US09249196B2
公开(公告)日：2016-02-02
申请号：US13359442
申请日：2012-01-26
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/095 , A61K39/00 , C07K14/22 , A61K38/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US20120164166A1
公开(公告)日：2012-06-28
申请号：US13359471
申请日：2012-01-26
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US20120156236A1
公开(公告)日：2012-06-21
申请号：US13359459
申请日：2012-01-26
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
摘要翻译： 本发明提供脑膜炎奈瑟氏球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。 蛋白质被预测为用于疫苗和/或诊断的有用的抗原。
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公开(公告)号：US20050191316A1
公开(公告)日：2005-09-01
申请号：US10915740
申请日：2004-08-11
申请人： Claire Fraser , Erin Hickey , Jeremy Peterson , Herve Tettelin , Craig Venter , Vega Masignani , Cesira Galeotti , Marirosa Mora , Giulio Ratti , Maria Scarselli , Vincenzo Scarlato , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
发明人： Claire Fraser , Erin Hickey , Jeremy Peterson , Herve Tettelin , Craig Venter , Vega Masignani , Cesira Galeotti , Marirosa Mora , Giulio Ratti , Maria Scarselli , Vincenzo Scarlato , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
IPC分类号： G01N33/53 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/095 , A61K39/395 , A61K48/00 , A61P31/04 , C07K14/22 , C07K16/12 , C12N15/09 , C12N15/11 , C12P21/02 , C12P21/08 , C12Q1/68 , C07H21/04 , C12N1/21 , C12P21/04
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , C12Q1/689 , C12Q2600/156
摘要： The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供了从包括奈瑟氏球菌在内的基因组序列获得免疫原性蛋白质的方法，包括氨基酸序列和相应的核苷酸序列，以及脑膜炎奈瑟氏球菌B的基因组序列。如此获得的蛋白质是疫苗，免疫原性组合物和 /或诊断。
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公开(公告)号：US20120148616A1
公开(公告)日：2012-06-14
申请号：US13359442
申请日：2012-01-26
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/095 , C07K14/22 , A61P37/04 , C07K7/08
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US07576176B1
公开(公告)日：2009-08-18
申请号：US09674546
申请日：1999-04-30
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： C07K1/00 , A61K38/04 , A61K39/02 , A61K39/095 , A61K38/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
摘要翻译： 本发明提供脑膜炎奈瑟氏球菌的蛋白质，包括氨基酸序列和相应的核苷酸序列。 蛋白质被预测为用于疫苗和/或诊断的有用的抗原。
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公开(公告)号：US20120034230A1
公开(公告)日：2012-02-09
申请号：US13144149
申请日：2010-01-12
IPC分类号： A61K39/40 , C07K19/00 , C07K14/31 , C07K17/02 , C12N15/31 , C12N15/63 , C12P21/02 , C07K16/12 , C12N1/21 , C12N1/19 , C12N5/10 , A61K39/09 , A61K39/085 , A61K39/116 , A61P37/04 , A61P31/04 , C07K14/315
CPC分类号： C07K14/315 , A61K39/085 , A61K39/092 , A61K2039/55566 , C07K16/44 , C12N15/03 , C12N15/63
摘要： The invention provides protective antigens which are useful in vaccine compositions to induce protection against gram positive bacteria, particularly against S. agalactiae, S. pyogenes, S. pneumoniae, S. aureus, S. suis, and S. equi.
摘要翻译： 本发明提供了可用于疫苗组合物中的保护性抗原，以诱导针对革兰氏阳性细菌的保护，特别是针对无乳链球菌，化脓性链球菌，肺炎链球菌，金黄色葡萄球菌，猪链球菌和马赛克氏菌。
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18.发明授权公开(公告)号：US09102740B2
公开(公告)日：2015-08-11
申请号：US13912472
申请日：2013-06-07
IPC分类号： C12N15/03 , C12P21/04 , C07H21/04 , C07K14/315 , C12N15/63 , A61K39/085 , A61K39/09 , C07K16/44 , A61K39/00
CPC分类号： C07K14/315 , A61K39/085 , A61K39/092 , A61K2039/55566 , C07K16/44 , C12N15/03 , C12N15/63
摘要： The invention provides protective antigens which are useful in vaccine compositions to induce protection against gram positive bacteria, particularly against S. agalactiae, S. pyogenes, S. pneumoniae, S. aureus, S. suis, and S. equi.
摘要翻译： 本发明提供了可用于疫苗组合物中的保护性抗原，以诱导针对革兰氏阳性细菌的保护，特别是针对无乳链球菌，化脓性链球菌，肺炎链球菌，金黄色葡萄球菌，猪链球菌和马赛克氏菌。
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公开(公告)号：US20140017727A1
公开(公告)日：2014-01-16
申请号：US13912472
申请日：2013-06-07
IPC分类号： C07K14/315 , C07K16/44
CPC分类号： C07K14/315 , A61K39/085 , A61K39/092 , A61K2039/55566 , C07K16/44 , C12N15/03 , C12N15/63
摘要： The invention provides protective antigens which are useful in vaccine compositions to induce protection against gram positive bacteria, particularly against S. agalactiae, S. pyogenes, S. pneumoniae, S. aureus, S. suis, and S. equi.
摘要翻译： 本发明提供了可用于疫苗组合物中的保护性抗原，以诱导针对革兰氏阳性细菌的保护，特别是针对无乳链球菌，化脓性链球菌，肺炎链球菌，金黄色葡萄球菌，猪链球菌和马赛克氏菌。
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公开(公告)号：US08465751B2
公开(公告)日：2013-06-18
申请号：US13144149
申请日：2010-01-12
IPC分类号： A61K39/09 , C12N1/20 , C07K14/315
CPC分类号： C07K14/315 , A61K39/085 , A61K39/092 , A61K2039/55566 , C07K16/44 , C12N15/03 , C12N15/63
摘要： The invention provides protective antigens which are useful in vaccine compositions to induce protection against gram positive bacteria, particularly against S. agalactiae, S. pyogenes, S. pneumoniae, S. aureus, S. suis, and S. equi.
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