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    Injectable Depot Compositions and Uses Thereof
    14.
    发明申请
    Injectable Depot Compositions and Uses Thereof 审中-公开
    可注射仓库组合物及其用途

    公开(公告)号：US20130108681A1

    公开(公告)日：2013-05-02

    申请号：US13593371

    申请日：2012-08-23

    申请人： Guohua Chen ,  Paul R. Houston ,  Lothar Walter Kleiner ,  John J. Spaltro

    发明人： Guohua Chen ,  Paul R. Houston ,  Lothar Walter Kleiner ,  John J. Spaltro

    IPC分类号： A61K9/00

    CPC分类号： A61K38/1858 ,  A61K9/0002 ,  A61K9/0024 ,  A61K9/1617 ,  A61K31/445 ,  A61K38/27 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

    摘要： Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patients body surface by injection.

    摘要翻译： 提供了可注射的储库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中的混溶性小于或等于7wt。 ％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。 溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。 组合物已经显着改善了剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

    SHORT DURATION DEPOT FORMULATIONS
    19.
    发明申请
    SHORT DURATION DEPOT FORMULATIONS 审中-公开
    短期DEPOT制剂

    公开(公告)号：US20060165800A1

    公开(公告)日：2006-07-27

    申请号：US11278472

    申请日：2006-04-03

    申请人： Guohua Chen ,  David Priebe

    发明人： Guohua Chen ,  David Priebe

    IPC分类号： A61K9/14

    CPC分类号： A61K9/0024 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/06 ,  A61K31/445 ,  A61K38/27 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

    摘要： Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

    摘要翻译： 描述了通过将有益剂植入受试者进行全身或局部施用的方法和组合物，并且包括例如将凝胶组合物储存在可以注射到所需位置并且可以在短时间内提供受益药物的受控释放 的时间。 组合物包括低分子量生物相容性聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成粘性凝胶并限制植入物吸收水分，以及有益剂。

    Beneficial agent delivery system with membrane plug and method for controlling delivery of beneficial agents
    20.
    发明授权
    Beneficial agent delivery system with membrane plug and method for controlling delivery of beneficial agents 失效
    具有膜塞的有益代理输送系统和用于控制有益药物输送的方法

    公开(公告)号：US6113938A

    公开(公告)日：2000-09-05

    申请号：US121835

    申请日：1998-07-24

    申请人： Guohua Chen ,  Scott Lautenbach ,  Keith Dionne ,  Lawton Hom

    发明人： Guohua Chen ,  Scott Lautenbach ,  Keith Dionne ,  Lawton Hom

    IPC分类号： A61K9/00 ,  A61K9/52 ,  A61F2/02

    CPC分类号： A61K9/0004

    摘要： An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule containing a beneficial agent and an osmotic agent which swells on contact with water causing the release of the beneficial agent over time. The osmotic delivery system has a membrane plug which allows water to pass through the plug from an exterior of the capsule while preventing the compositions within the capsule from passing out of the capsule. A delivery rate for delivery of the beneficial agent from the implant capsule is controlled by varying a core diameter of the membrane plug within a constant diameter capsule. The membrane plug has a variable water permeation rate depending on an extent to which the membrane plug is constrained by the capsule walls.

    摘要翻译： 用于有益药物的受控递送的渗透递送系统包括含有有益剂的植入物胶囊和在与水接触时溶胀的渗透剂，随着时间推移释放有益剂。 渗透递送系统具有膜塞，其允许水从胶囊的外部通过塞子，同时防止胶囊内的组合物从胶囊中流出。 通过在恒定直径的胶囊内改变膜塞的芯直径来控制从植入物胶囊输送有益剂的递送速率。 膜塞具有可变的水渗透速率，这取决于膜塞被胶囊壁约束的程度。