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1.发明申请METHOD AND DEVICE FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE USING A MICROPROJECTION ARRAY 有权使用微阵列阵列进行直接递送帕拉霉素激素的方法和装置公开(公告)号：US20110276028A1
公开(公告)日：2011-11-10
申请号：US13101071
申请日：2011-05-04
IPC分类号： A61M5/00
CPC分类号： A61K9/0021 , A61K38/29 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/36 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要： A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
摘要翻译： 提供了以脉动方式经皮给药甲状旁腺激素（PTH）的方法和药物递送系统，其中药物递送系统包括每个包含PTH的微阵列阵列。
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2.发明授权公开(公告)号：US09687641B2
公开(公告)日：2017-06-27
申请号：US13101071
申请日：2011-05-04
CPC分类号： A61K9/0021 , A61K38/29 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/36 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要： A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.
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3.发明申请Water-absorbent adhesive compositions and associated methods of manufacture and use 审中-公开吸水粘合剂组合物及其相关的制造和使用方法公开(公告)号：US20050215727A1
公开(公告)日：2005-09-29
申请号：US11028702
申请日：2005-01-03
申请人： Mikhail Feldstein , Danir Bairamov , Mikhail Novikov , Valery Kulichikhin , Nicolai Plate , Gary Cleary , Parminder Singh
发明人： Mikhail Feldstein , Danir Bairamov , Mikhail Novikov , Valery Kulichikhin , Nicolai Plate , Gary Cleary , Parminder Singh
CPC分类号： B05D5/10 , A61K8/042 , A61K8/8152 , A61K8/8176 , A61K8/8182 , A61K8/86 , A61K47/32 , A61K2800/262 , A61K2800/54 , A61L15/42 , A61L15/585 , A61Q11/00 , C08K5/06 , C08K5/11 , C08L33/04 , C08L39/06 , C08L71/02 , C09J133/14 , C08L2666/02
摘要： An adhesive composition is provided that is water-insoluble yet water-absorbent, i.e., capable of absorbing up to 15 wt. % water or more. The composition is composed of a film-forming hydrophilic polymer with at least one linear segment having a plurality of recurring polar groups along the polymer backbone, a complementary multifunctional polymer with a plurality of recurring functional groups that noncovalently bind to the polar groups on the film-forming polymer, and a plasticizer. A method for manufacturing the adhesive composition is provided as well.
摘要翻译： 提供了一种粘合剂组合物，其是不溶于水的吸水剂，即能够吸收高达15wt。 ％水或更多。 该组合物由具有至少一个线性区段的成膜亲水性聚合物组成，所述至少一个线性区段沿着聚合物主链具有多个重复极性基团，具有多个与膜上的极性基团非共价结合的重复官能团的互补多官能聚合物 形成聚合物和增塑剂。 还提供了制造粘合剂组合物的方法。
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公开(公告)号：US20060182788A1
公开(公告)日：2006-08-17
申请号：US11341085
申请日：2006-01-27
申请人： Parminder Singh , Eun Lee , Appala Sagi , Mikhail Feldstein , Danir Bairamov
发明人： Parminder Singh , Eun Lee , Appala Sagi , Mikhail Feldstein , Danir Bairamov
CPC分类号： A61L15/44 , A61B5/04087 , A61K9/7061 , A61K47/32 , A61L15/585 , A61L2300/402 , A61L2300/404 , A61L2300/412 , A61L2300/602 , A61N1/0428 , A61N1/0444 , A61N1/0448 , A61N1/0456 , A61N1/0468 , A61N1/0496 , Y10T442/2525 , C08L33/06
摘要： This invention relates to the use of hydrophilic, biocompatible adhesives in drug delivery systems, wound dressings, bioelectrodes, and other systems in which hydrophilic, biocompatible adhesives are desirable. In particular, the invention relates to water-swellable, water-insoluble polymers that in combination render a composition adhesive upon contact with moisture, wherein a first water-swellable, water-insoluble polymer is cationic, a second water-swellable, water-insoluble polymer is anionic, and the polymers are ionically associated with each other to form a polymer matrix.
摘要翻译： 本发明涉及在药物递送系统，伤口敷料，生物电极和其中需要亲水性，生物相容性粘合剂的其它系统中使用亲水性，生物相容性粘合剂。 特别地，本发明涉及水溶胀性水不溶性聚合物，其在与水分接触时组合粘合剂，其中第一水溶胀性水不溶性聚合物是阳离子的，第二水溶胀性的，水不溶性的 聚合物是阴离子的，并且聚合物彼此离子键合以形成聚合物基质。
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5.发明申请Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components 审中-公开使用聚合物组分之间的相互作用机理制备聚合物粘合剂组合物的方法公开(公告)号：US20050113510A1
公开(公告)日：2005-05-26
申请号：US10936887
申请日：2004-09-08
申请人： Mikhail Feldstein , Danir Bairamov , Nicolai Plate , Valery Kulichikhin , Anatoly Chalykh , Gary Cleary , Parminder Singh
发明人： Mikhail Feldstein , Danir Bairamov , Nicolai Plate , Valery Kulichikhin , Anatoly Chalykh , Gary Cleary , Parminder Singh
IPC分类号： A61C19/06 , A61K6/00 , A61K8/04 , A61K8/22 , A61K8/73 , A61K8/81 , A61K8/86 , A61L15/60 , A61Q11/00 , C08F20/10
CPC分类号： A61Q11/00 , A61C19/066 , A61K6/0067 , A61K8/0208 , A61K8/042 , A61K8/22 , A61K8/731 , A61K8/8152 , A61K8/817 , A61K8/8176 , A61K8/86 , A61K9/7007 , A61K2800/262 , A61K2800/54 , A61K2800/5422 , A61K2800/5424 , A61L15/585 , A61L15/60 , C08L2312/00 , C08L53/00
摘要： A method of selecting components for use in water-absorbing pressure-sensitive adhesive compositions is provided. The method involves selecting a film-forming polymer, a ladder-like non-covalent crosslinker that is capable of forming a ladder-like interpolymer complex with the film-forming polymer selected, and selecting a carcass-like non-covalent crosslinker that is capable of forming a carcass-like complex with at least one of the film-forming polymer selected or the ladder-like non-covalent crosslinker selected. The adhesive hydrogels provide high adhesion in a swollen state and bridge the gap between conventional pressure sensitive adhesives and bioadhesives. Methods for preparing and using the resulting compositions are also disclosed.
摘要翻译： 提供了一种选择用于吸水压敏粘合剂组合物中的组分的方法。 该方法包括选择成膜聚合物，能够与选择的成膜聚合物形成梯状共聚体络合物的阶梯状非共价交联剂，并且选择能够形成的胎体状非共价交联剂 与选择的成膜聚合物中的至少一种或阶梯状非共价交联剂形成胎体状络合物。 粘合剂水凝胶在膨胀状态下提供高粘合性并桥接常规压敏粘合剂和生物粘合剂之间的间隙。 还公开了制备和使用所得组合物的方法。
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公开(公告)号：US20050208110A1
公开(公告)日：2005-09-22
申请号：US11047964
申请日：2005-01-31
申请人： Parminder Singh , Sri Mudumba , Danir Bairamov , Valery Kulichikhin , Mikhail Feldstein , Gary Cleary
发明人： Parminder Singh , Sri Mudumba , Danir Bairamov , Valery Kulichikhin , Mikhail Feldstein , Gary Cleary
CPC分类号： A61K9/7007 , A61K9/0014 , A61K9/0056 , A61K9/006
摘要： A rapidly dissolving film is provided for delivery of an active agent to a moist body surface, e.g., mucosal tissue. The film comprises a film-forming binder, a rapidly dissolving polymeric material, and an active agent.
摘要翻译： 提供快速溶解的膜用于将活性剂递送到潮湿的身体表面，例如粘膜组织。 膜包括成膜粘合剂，快速溶解的聚合物材料和活性剂。
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公开(公告)号：US20060171906A1
公开(公告)日：2006-08-03
申请号：US11315423
申请日：2005-12-21
申请人： Parminder Singh , Eun Lee , Appala Sagi , Mikhail Feldstein , Danir Bairamov
发明人： Parminder Singh , Eun Lee , Appala Sagi , Mikhail Feldstein , Danir Bairamov
IPC分类号： A61K8/22
CPC分类号： A61K8/0208 , A61K8/22 , A61K8/42 , A61K8/731 , A61K8/8147 , A61K8/8152 , A61K8/817 , A61K8/8176 , A61K8/86 , A61Q11/00
摘要： A new tooth whitening composition provides sustained release of high levels of whitening agent and is moisture-activated without significant swelling. A preferred system for applying the composition to the teeth is flexible, self-adhesive, and well-tolerated by users. In certain embodiments the tooth whitening composition comprises a mixture of tooth whitening agents, with a first whitening agent selected so as to release peroxide gradually upon contact with moisture and produce an alkaline pH, and a second whitening agent selected so as to release peroxide rapidly upon contact with moisture.
摘要翻译： 新的牙齿美白组合物提供高水平的增白剂的持续释放并且被水分活化而没有明显的肿胀。 用于将组合物施用于牙齿的优选系统是柔性的，自粘性的并且被使用者良好地耐受。 在某些实施方案中，牙齿增白组合物包含牙齿增白剂的混合物，其中选择第一增白剂，以便在与水分接触时逐渐释放过氧化物并产生碱性pH，并且选择第二增白剂以便快速释放过氧化物 接触水分。
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8.发明申请公开(公告)号：US20050049365A1
公开(公告)日：2005-03-03
申请号：US10964431
申请日：2004-10-12
IPC分类号： A61K9/70 , A61L15/22 , A61L15/30 , A61L15/44 , A61L15/46 , A61L15/58 , A61L15/60 , C08L33/08 , C08L71/00 , C08L77/00 , C09J123/22 , C08F8/00
CPC分类号： A61K9/7053 , A61L15/44 , A61L15/46 , A61L15/585 , A61L15/60 , C08L33/08 , C08L71/00 , C08L77/00 , C08L2312/00 , C08L2666/20 , C09J123/22 , C08L23/22
摘要： A method is provided for preparing an adhesive composition that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a crosslinked hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding. The composition is useful as a bioadhesive, for affixing drug delivery systems, wound dressings, bandages, cushions, or the like to a body surface such as skin or mucosal tissue.
摘要翻译： 提供了一种制备含有疏水相和亲水相的粘合剂组合物的方法，其中疏水相由交联的疏水聚合物组合物组成，亲水相是亲水性聚合物和互补低聚物的吸水共混物 能够通过氢键，离子键合和/或共价键来交联亲水性聚合物。 该组合物可用作生物粘附剂，用于将药物递送系统，伤口敷料，绷带，垫子等固定在身体表面如皮肤或粘膜组织上。
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9.发明申请Two-phase, water-absorbent bioadhesive composition for delivery of an active agent to a patient 审中-公开用于将活性剂递送至患者的两相吸水生物粘合剂组合物公开(公告)号：US20050048103A1
公开(公告)日：2005-03-03
申请号：US10964379
申请日：2004-10-12
IPC分类号： A61K9/70 , A61L15/22 , A61L15/30 , A61L15/44 , A61L15/46 , A61L15/58 , A61L15/60 , C08L33/08 , C08L71/00 , C08L77/00 , C09J123/22 , A61F13/02 , A61L15/16
CPC分类号： A61K9/7053 , A61L15/44 , A61L15/46 , A61L15/585 , A61L15/60 , C08L33/08 , C08L71/00 , C08L77/00 , C08L2312/00 , C08L2666/20 , C09J123/22 , C08L23/22
摘要： An adhesive composition is provided that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a crosslinked hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding. The composition is useful as a bioadhesive, for affixing drug delivery systems, wound dressings, bandages, cushions, or the like to a body surface such as skin or mucosal tissue.
摘要翻译： 提供了含有疏水相和亲水相的粘合剂组合物，其中疏水相由交联的疏水聚合物组合物组成，亲水相是亲水性聚合物和能够交联的亲水性聚合物和互补低聚物的吸水共混物 亲水性聚合物通过氢键，离子键和/或共价键。 该组合物可用作生物粘附剂，用于将药物递送系统，伤口敷料，绷带，垫子等固定在身体表面如皮肤或粘膜组织上。
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