公开(公告)号：US20180000815A1

公开(公告)日：2018-01-04

申请号：US15703572

申请日：2017-09-13

Applicant: H. Lundbeck A/S

Inventor： Connie Sanchez Morillo ,  Karina Krøjer Søby ,  Benny Bang-Andersen

IPC: A61K31/495 ,  A61K9/00 ,  A61K9/08

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/40 ,  A61K2300/00

Abstract: A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which together with said first composition quickly achieves a steady-state plasma level of vortioxetine in said patient which steady-state plasma level is the same as the steady-state vortioxetine plasma level achieved by the administration to said patient of said first composition alone.

公开(公告)号：US09820984B1

公开(公告)日：2017-11-21

申请号：US15636238

申请日：2017-06-28

Applicant: H. Lundbeck A/S

Inventor： Connie Sanchez Morillo ,  Karina Krøjer Søby ,  Benny Bang-Andersen

IPC: A61K31/497 ,  A61K31/495 ,  A61K9/00 ,  A61K9/08

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/40 ,  A61K2300/00

Abstract: A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which together with said first composition quickly achieves a steady-state plasma level of vortioxetine in said patient which steady-state plasma level is the same as the steady-state vortioxetine plasma level achieved by the administration to said patient of said first composition alone.

公开(公告)号：US20160137620A1

公开(公告)日：2016-05-19

申请号：US14744197

申请日：2015-06-19

Applicant: H. Lundbeck A/S

Inventor： Thomas Ruhland ,  Garrick Paul Smith ,  Benny Bang-Andersen ,  Ask Puschl ,  Ejner Knud Moltzen ,  Kim Andersen

IPC: C07D295/145 ,  C07D295/033

CPC classification number: C07D295/145 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08 ,  C07D295/033 ,  C07D295/096

Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

Abstract translation: 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。

公开(公告)号：US20150073018A1

公开(公告)日：2015-03-12

申请号：US14542210

申请日：2014-11-14

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Andre Faldt ,  Tine Bryan Stensbol ,  Silke Miller ,  Heidi Lopez De Diego

IPC: C07D211/20

CPC classification number: C07D211/20 ,  C07B2200/13 ,  C07C55/08 ,  C07C55/12 ,  C07C59/08 ,  C07C229/24

Abstract: Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine and salts thereof are provided, e.g., for the treatment of neuropathic pain.

Abstract translation: 提供4- [2-（4-甲基苯基硫基） - 苯基]哌啶及其盐的结晶形式，例如用于治疗神经性疼痛。

公开(公告)号：US20140315921A1

公开(公告)日：2014-10-23

申请号：US14326725

申请日：2014-07-09

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Andre Faldt ,  Arne Mork ,  Heidi Lopez de Diego ,  Rene Holm ,  Tine Bryan Stensbol ,  Nicholas Moore

IPC: C07D295/096

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: This disclosure relates to 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine or a pharmaceutically acceptable salt thereof in a crystalline form.

Abstract translation: 本公开涉及结晶形式的1- [2-（2,4-二甲基苯基硫烷基） - 苯基]哌嗪或其药学上可接受的盐。

公开(公告)号：US20140248356A1

公开(公告)日：2014-09-04

申请号：US14242510

申请日：2014-04-01

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Arne Mork ,  Nicholas Moore ,  Tine Bryan Stensbol

IPC: C07D295/096

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

公开(公告)号：US20140248355A1

公开(公告)日：2014-09-04

申请号：US14242337

申请日：2014-04-01

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Arne Mork ,  Nicholas Moore ,  Tine Bryan Stensbol

IPC: C07D295/096

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

公开(公告)号：US20210276966A1

公开(公告)日：2021-09-09

申请号：US17078055

申请日：2020-10-22

Applicant: H. Lundbeck A/S

Inventor： Thomas Ruhland ,  Garrick Paul Smith ,  Benny Bang-Andersen ,  Ask Puschl ,  Ejner Knud Moltzen ,  Kim Andersen

IPC: C07D295/145 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08 ,  C07D295/096 ,  C07D295/033

Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

公开(公告)号：US20170037006A1

公开(公告)日：2017-02-09

申请号：US15072608

申请日：2016-03-17

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Andre Faldt ,  Tine Bryan Stensbol ,  Silke Miller ,  Heidi Lopez De Diego

IPC: C07D211/20

CPC classification number: C07D211/20 ,  C07B2200/13 ,  C07C55/08 ,  C07C55/12 ,  C07C59/08 ,  C07C229/24

Abstract: Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine and salts thereof are provided, e.g., for the treatment of neuropathic pain.

Abstract translation: 提供4- [2-（4-甲基苯基硫基） - 苯基]哌啶及其盐的结晶形式，例如用于治疗神经性疼痛。

公开(公告)号：US09125908B2

公开(公告)日：2015-09-08

申请号：US14242510

申请日：2014-04-01

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Arne Mork ,  Tine Bryan Stensbol ,  Andre Faldt ,  Rene Holm ,  Heidi Lopez de Diego

IPC: A61K31/495 ,  C07D295/096

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

Abstract translation: 1- [2-（2,4-二甲基苯基硫烷基）苯基]哌嗪显示出对SERT，5-HT3和5-HT1A的有效活性，并且可以用于治疗认知障碍，特别是抑郁症患者。