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21 条记录 (耗时 0.018 秒)

    Process for the preparation of imidazoleacetic acid derivatives
    13.
    发明授权
    Process for the preparation of imidazoleacetic acid derivatives 失效
    咪唑乙酸衍生物的制备方法

    公开(公告)号：US4379927A

    公开(公告)日：1983-04-12

    申请号：US349416

    申请日：1982-02-16

    申请人： Helmut Vorbruggen ,  Norbert Schwarz

    发明人： Helmut Vorbruggen ,  Norbert Schwarz

    IPC分类号： C07D233/54 ,  C07D233/64 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D487/04 ,  C07D413/06

    CPC分类号： C07D233/64

    摘要： A process for preparing imidazoleacetic acid derivatives of Formula I ##STR1## wherein R.sub.1 is hydrogen, alkyl, cycloalkyl, aralkyl, aryl, a heterocyclic group, amino, or amino substituted by alkyl, cycloalkyl, aralkyl, or aryl,R.sub.2 is hydrogen, alkyl, cycloalkyl, aralkyl, aryl, or a heterocyclic group,R.sub.1 and R.sub.2 together form a ring, andR.sub.3 is alkoxy, aralkoxy, amino, mono- or dialkylamino, pyrrolidino, piperidino, morpholino, or arylamino or heteroarylamino, each optionally substituted in the aryl portion,comprises reacting the corresponding amidine or guanidine of Formula II ##STR2## wherein R.sub.1 and R.sub.2 are as defined above and(HY) represents an optional inorganic mineral acid or an organic acid,with the corresponding acetoacetic acid derivative of Formula III ##STR3## wherein R.sub.3 is as defined above,X is a halogen, andR.sub.4 is trialkyl- or triaralkylsilyl, alkyl, or aralkyl.

    摘要翻译： 制备式I的咪唑乙酸衍生物的方法其中R1是氢，烷基，环烷基，芳烷基，芳基，杂环基，氨基或被烷基，环烷基，芳烷基或芳基取代的氨基，R2是 氢，烷基，环烷基，芳烷基，芳基或杂环基，R 1和R 2一起形成环，R 3是烷氧基，芳烷氧基，氨基，一或二烷基氨基，吡咯烷子基，哌啶子基，吗啉代或芳基氨基或杂芳基氨基， 在芳基部分被取代，包括使相应的式II的脒或胍（II）其中R 1和R 2如上所定义，和（HY）代表任选的无机无机酸或有机酸与相应的乙酰乙酸 式III的衍生物（III）其中R3如上定义，X​​是卤素，R4是三烷基 - 或三烷基甲硅烷基，烷基或芳烷基。

    9-Bromoprostaglandins, their preparation, and their use as medicaments
    14.
    发明授权
    9-Bromoprostaglandins, their preparation, and their use as medicaments 失效
    9-溴前列​​腺素，其制剂及其用作药物

    公开(公告)号：US4487953A

    公开(公告)日：1984-12-11

    申请号：US446888

    申请日：1982-12-06

    申请人： Werner Skuballa ,  Bernd Raduechel ,  Norbert Schwarz ,  Helmut Vorbrueggen ,  Walter Elger

    发明人： Werner Skuballa ,  Bernd Raduechel ,  Norbert Schwarz ,  Helmut Vorbrueggen ,  Walter Elger

    IPC分类号： A61K31/16 ,  A61K31/19 ,  A61K31/20 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D309/12 ,  C07C177/00

    CPC分类号： C07C405/00 ,  C07C405/0016 ,  C07C405/0041

    摘要： Compounds of Formula (I) ##STR1## wherein the 9-bromine atom can be in the .alpha.- or .beta.-position,R.sub.1 is CH.sub.2 OH or C(O)OR.sub.2, wherein R.sub.2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R.sub.1 is C(O)NHR.sub.3 wherein R.sub.3 is an acid residue or R.sub.2 ; andA is --CH.sub.2 --CH.sub.2 -- or cis --CH.dbd.CH--;B is --CH.sub.2 --CH.sub.2 --, trans --CH.dbd.CH--, or --C.tbd.C--;W is a free or functionally modified hydroxymethylene group or a free or functionally modified ##STR2## wherein the OH-group can be in the .alpha.- or .beta.-position; D and E together are a direct bond; orD is straight-chain, branched, or cyclic alkylene of 1-10 carbon atoms, optionally substituted by fluorine atoms; andE is oxygen, sulfur, a direct bond --C.tbd.C--, or --CR.sub.6 .dbd.CR.sub.7 --, wherein R.sub.6 and R.sub.7 are different from each other and each is hydrogen, chlorine, or C.sub.1 -C.sub.4 -alkyl;R.sub.4 is a free or functionally modified hydroxy group;R.sub.5 is hydrogen, alkyl, halo-substituted alkyl, cycloalkyl, optionally substituted aryl, or a heterocyclic group; and, when R.sub.2 is hydrogen, the salts thereof with physiologically compatible bases,are pharmacologically active compounds, e.g., as abortifacients.

    摘要翻译： 式（I）化合物其中9-溴原子可以是α或β-位，R1是CH2OH或C（O）OR2，其中R2是氢，烷基，环烷基，芳基， 或杂环残基; 或R 1为C（O）NHR 3，其中R 3为酸残基或R 2; 并且A是-CH 2 -CH 2 - 或顺式-CH = CH-; B是-CH 2 -CH 2 - ，反式-CH = CH-或-C 3位C; W是游离或官能改性的羟基亚甲基或游离或官能改性的“IMAGE”，其中OH基可以是α-或β-位; D和E一起是直接的债券; 或D是1-10个碳原子的直链，支链或环状亚烷基，任选被氟原子取代; 并且E是氧，硫，直接键-C 3或C 6或-CR 6 = CR 7 - ，其中R 6和R 7彼此不同，各自是氢，氯或C 1 -C 4 - 烷基; R4是游离的或官能改性的羟基; R5是氢，烷基，卤素取代的烷基，环烷基，任选取代的芳基或杂环基; 并且当R 2为氢时，其与生理上相容的碱的盐是药理活性化合物，例如作为流产者。

    Face equipment for mining machinery
    15.
    发明申请
    Face equipment for mining machinery 审中-公开
    矿山机械设备

    公开(公告)号：US20050053430A1

    公开(公告)日：2005-03-10

    申请号：US10935617

    申请日：2004-09-07

    申请人： Jens Titschert ,  Jurgen Tschope ,  Wilfried Weigel ,  Norbert Schwarz

    发明人： Jens Titschert ,  Jurgen Tschope ,  Wilfried Weigel ,  Norbert Schwarz

    IPC分类号： E21D23/26 ,  E21D23/12

    CPC分类号： E21D23/26

    摘要： Longwall face equipment for use in extraction in underground mining, comprising electrohydraulically operated support units each having a support controller 6, with at least one power unit being provided that supplies at least two support controllers 6 of differing support units with power, and with a bi-directional coupler being connected between the power unit and the at least two support controllers 6 and providing galvanic isolation between the power unit and the support controllers 6 and/or groups I, II of support controllers 6. The couplers permit communication between the two support controllers 6 and/or groups I, II of support controllers. In order to simplify the arrangement of the face, the coupler 12 is integrated into the power unit 11 or is flanged directly onto the housing of the power unit.

    摘要翻译： 用于在地下采矿中提取的长壁面设备，包括每个具有支撑控制器6的电液操作的支撑单元，其中提供至少一个动力单元，其提供具有动力的不同支撑单元的至少两个支撑控制器6， 连接在电力单元和至少两个支撑控制器6之间并且在电源单元和支撑控制器6和/或支撑控制器6的组I，II之间提供电隔离。耦合器允许两个支撑件 控制器6和/或支撑控制器的I，II组。 为了简化面的布置，耦合器12集成到动力单元11中，或直接凸缘到动力单元的壳体上。

    Intrinsically-safe battery power supply for underground mining
    16.
    发明申请
    Intrinsically-safe battery power supply for underground mining 审中-公开
    用于地下采矿的本质安全电池电源

    公开(公告)号：US20050186471A1

    公开(公告)日：2005-08-25

    申请号：US11042371

    申请日：2005-01-25

    申请人： Jens Titschert ,  Norbert Schwarz ,  Jorg Wagener

    发明人： Jens Titschert ,  Norbert Schwarz ,  Jorg Wagener

    IPC分类号： H01M2/02 ,  E21F9/00 ,  E21F17/04 ,  H01M2/10 ,  H01M2/34 ,  H01M10/052 ,  H01M10/34 ,  H01M10/36 ,  H01M10/46 ,  H02J7/00

    CPC分类号： H01M2/1094 ,  H01M10/052 ,  Y02E60/122

    摘要： An intrinsically-safe battery power supply for electrical equipment in underground mining and in other areas exposed to the danger of explosion is disclosed. The power supply includes at least one chargeable storage battery cell disposed in a battery housing. At least one storage battery cell comprises a chargeable lithium storage battery cell and the battery housing is configured to be pressure-resistant and to receive all lithium storage battery cells in a manner so as to be protected from explosion. The pressure-resistant configuration of the battery housing enables the use of lithium storage battery cells in underground mining. Once the battery power supply fulfils all requirements of ignition protection certification, even modern types of lithium storage battery cell can be disposed in the battery housing.

    摘要翻译： 公开了一种用于地下采矿和其他暴露于爆炸危险区域的电气设备的本质安全电池电源。 电源包括设置在电池壳体中的至少一个可充电蓄电池。 至少一个蓄电池单元包括可充电的锂蓄电池单元，并且所述电池壳体被配置为耐压并且以能够防止爆炸的方式接收所有锂蓄电池单元。 电池壳体的耐压构造使得能够在地下采矿中使用锂蓄电池。 一旦电池电源满足点火保护认证的所有要求，即使现代类型的锂蓄电池可以放置在电池外壳中。

    Azaprostacyclins, their preparation and pharmaceutical use
    18.
    发明授权
    Azaprostacyclins, their preparation and pharmaceutical use 失效
    阿沙普罗环素，其制备和药物用途

    公开(公告)号：US4567195A

    公开(公告)日：1986-01-28

    申请号：US591719

    申请日：1984-03-21

    申请人： Norbert Schwarz ,  Werner Skuballa ,  Helmut Vorbrueggen ,  Jorge Casals-Stenzel ,  Ekkehard Schillinger ,  Michael H. Town

    发明人： Norbert Schwarz ,  Werner Skuballa ,  Helmut Vorbrueggen ,  Jorge Casals-Stenzel ,  Ekkehard Schillinger ,  Michael H. Town

    IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/557 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  C07C57/03 ,  C07C57/13 ,  C07C57/26 ,  C07C57/52 ,  C07C405/00 ,  C07D209/52 ,  C07D307/935 ,  C07F9/40

    CPC分类号： C07D307/935 ,  C07C405/00 ,  C07C405/0041 ,  C07C57/03 ,  C07C57/13 ,  C07C57/26 ,  C07C57/52 ,  C07D209/52 ,  C07F9/4015 ,  C07F9/4018

    摘要： Azaprostacyclins of Formula I ##STR1## wherein R.sub.1 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or a phenacyl residue optionally substituted on the phenyl ring by bromine, phenyl, alkoxy, or dialkoxy,W is a free or functionally modified carbonyl group or a ##STR2## wherein R.sub.8 is hydrogen or alkyl of 1-5 carbon atoms and R.sub.9 is hydrogen or a readily cleavable ether or acyl residue and wherein the OR.sub.9 -group can be in the .alpha.- or .beta.-position,R.sub.2 is a free or functionally modified hydroxy group,R.sub.3 and R.sub.4 each independently is hydrogen, alkyl of 1-5 carbon atoms, or fluorine,D is alkylene of 1-2 carbon atoms which can be substituted by alkyl groups of 1-5 carbon atoms,R.sub.5 is hydrogen or alkyl of 1-2 carbon atoms or, when D is alkylene of 1 or 2 carbon atoms, R.sub.5, together with R.sub.6, represents a bond,R.sub.6 and R.sub.7 each independently is hydrogen or alkyl of 1-2 carbon atoms, whereinR.sub.6 (R.sub.7) is halogen when R.sub.7 (R.sub.6), respectively, is alkyl of 1-2 carbon atoms orR.sub.5 and R.sub.7 each independently is hydrogen or alkyl of 1-2 carbon atoms whenD and R.sub.6 together form a carbocyclic ring closed via (CH.sub.2).sub.1-3 with D as --CH

    摘要翻译： 式I的阿沙普罗环素其中R 1是氢，烷基，环烷基，芳基，杂环残基或任选在苯环上被溴，苯基，烷氧基或二烷氧基取代的苯甲酰甲基残基，W是游离或 官能改性的羰基或其中R8是氢或1-5个碳原子的烷基，R9是氢或易裂解的醚或酰基残基，其中OR9-基团可以是α-或β-位， R2是游离的或官能改性的羟基，R 3和R 4各自独立地是氢，1-5个碳原子的烷基或氟，D是可以被1-5个碳原子的烷基取代的1-2个碳原子的亚烷基 原子，R5是氢或1-2个碳原子的烷基，或当D是1或2个碳原子的亚烷基时，R5与R6一起代表键，R6和R7各自独立地是氢或1-2碳的烷基 原子，其中当R 7（R 6）分别为1-2个碳原子的烷基或R 5和R 7 eac时，R 6（R 7）为卤素 h独立地为氢或1-2个碳原子的烷基，当D和R6一起形成通过（CH 2）1-3封闭的碳环，其中D为-CH 3且R 6为-CH 2 - ，当R 1为氢时， 其与碱的生理上相容的盐具有有价值的药理学性质，例如降血压和支气管扩张活性。

    Intrinsically-safe battery power supply for underground mining
    19.
    发明授权
    Intrinsically-safe battery power supply for underground mining 有权
    用于地下采矿的本质安全电池电源

    公开(公告)号：US08450004B2

    公开(公告)日：2013-05-28

    申请号：US12341745

    申请日：2008-12-22

    申请人： Jens Titschert ,  Norbert Schwarz ,  Jörg Wagener

    发明人： Jens Titschert ,  Norbert Schwarz ,  Jörg Wagener

    IPC分类号： H01M2/10

    CPC分类号： H01M2/34 ,  H01M2/0267 ,  H01M2/0275 ,  H01M2/0443 ,  H01M2/06 ,  H01M2/1094 ,  H01M2/32 ,  H01M10/052 ,  H01M10/0565 ,  H01M10/46 ,  H02J7/0052 ,  Y02E60/122 ,  Y10T29/49108

    摘要： An intrinsically-safe battery power supply for electrical equipment in underground mining and in other areas exposed to the danger of explosion is disclosed. The power supply includes at least one chargeable storage battery cell disposed in a battery housing. At least one storage battery cell comprises a chargeable lithium storage battery cell and the battery housing is configured to be pressure-resistant and to receive all lithium storage battery cells in a manner so as to be protected from explosion. The pressure-resistant configuration of the battery housing enables the use of lithium storage battery cells in underground mining. Once the battery power supply fulfills all requirements of ignition protection certification, even modern types of lithium storage battery cell can be disposed in the battery housing.

    摘要翻译： 公开了一种用于地下采矿和其他暴露于爆炸危险区域的电气设备的本质安全电池电源。 电源包括设置在电池壳体中的至少一个可充电蓄电池。 至少一个蓄电池单元包括可充电的锂蓄电池单元，并且所述电池壳体被配置为耐压并且以能够防止爆炸的方式接收所有锂蓄电池单元。 电池壳体的耐压构造使得能够在地下采矿中使用锂蓄电池。 一旦电池电源满足点火保护认证的所有要求，即使现代类型的锂蓄电池可以放置在电池外壳中。

    INTRINSICALLY-SAFE BATTERY POWER SUPPLY FOR UNDERGROUND MINING
    20.
    发明申请
    INTRINSICALLY-SAFE BATTERY POWER SUPPLY FOR UNDERGROUND MINING 有权
    用于地下采矿的本质安全电池电源

    公开(公告)号：US20090142629A1

    公开(公告)日：2009-06-04

    申请号：US12341745

    申请日：2008-12-22

    申请人： Jens Titschert ,  Norbert Schwarz ,  Jorg Wagener

    发明人： Jens Titschert ,  Norbert Schwarz ,  Jorg Wagener

    IPC分类号： H01M12/00

    CPC分类号： H01M2/34 ,  H01M2/0267 ,  H01M2/0275 ,  H01M2/0443 ,  H01M2/06 ,  H01M2/1094 ,  H01M2/32 ,  H01M10/052 ,  H01M10/0565 ,  H01M10/46 ,  H02J7/0052 ,  Y02E60/122 ,  Y10T29/49108

    摘要： An intrinsically-safe battery power supply for electrical equipment in underground mining and in other areas exposed to the danger of explosion is disclosed. The power supply includes at least one chargeable storage battery cell disposed in a battery housing. At least one storage battery cell comprises a chargeable lithium storage battery cell and the battery housing is configured to be pressure-resistant and to receive all lithium storage battery cells in a manner so as to be protected from explosion. The pressure-resistant configuration of the battery housing enables the use of lithium storage battery cells in underground mining. Once the battery power supply fulfils all requirements of ignition protection certification, even modern types of lithium storage battery cell can be disposed in the battery housing.

    摘要翻译： 公开了一种用于地下采矿和其他暴露于爆炸危险区域的电气设备的本质安全电池电源。 电源包括设置在电池壳体中的至少一个可充电蓄电池。 至少一个蓄电池单元包括可充电的锂蓄电池单元，并且所述电池壳体被配置为耐压并且以能够防止爆炸的方式接收所有锂蓄电池单元。 电池壳体的耐压构造使得能够在地下采矿中使用锂蓄电池。 一旦电池电源满足点火保护认证的所有要求，即使现代类型的锂蓄电池可以放置在电池外壳中。