公开(公告)号：US20240050516A1

公开(公告)日：2024-02-15

申请号：US18379626

申请日：2023-10-12

Applicant: Hoffmann-La Roche Inc.

Inventor： Konrad BLEICHER ,  Daniella CHEANG ,  Patrick DI GIORGIO ,  Taishan HU ,  Christian JENNY ,  Patrizio MATTEI ,  Petra SCHMITZ ,  Theodor STOLL

IPC: A61K38/12 ,  A61P31/04

CPC classification number: A61K38/12 ,  A61P31/04

Abstract: The present invention provides compounds of formula (I)






wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.

公开(公告)号：US20230382911A1

公开(公告)日：2023-11-30

申请号：US18361526

申请日：2023-07-28

Applicant: Hoffmann-La Roche Inc.

Inventor： Andrew Simon BELL ,  Jérémy BESNARD ,  Anthony Richard BRADLEY ,  Luke GREEN ,  Wolfgang HAAP ,  Buelent KOCER ,  Andreas KUGLSTATTER ,  Xavier LUCAS ,  Patrizio MATTEI ,  Dmitry MAZUNIN ,  Claus RIEMER ,  Willem Paul VAN HOORN

IPC: C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds of formula I or II:




wherein X1, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

公开(公告)号：US20200339522A1

公开(公告)日：2020-10-29

申请号：US16811656

申请日：2020-03-06

Applicant: Hoffmann-La Roche Inc.

Inventor： Jerome HERT ,  Daniel HUNZIKER ,  Holger KUEHNE ,  Thomas LUEBBERS ,  Rainer E. MARTIN ,  Patrizio MATTEI ,  Werner NEIDHART ,  Hans RICHTER ,  Markus RUDOLPH ,  Emmanuel PINARD

IPC: C07D249/08 ,  C07D487/04 ,  C07D249/12 ,  C07D409/12 ,  C07D413/12 ,  C07D231/12 ,  C07F7/08 ,  C07D401/12 ,  C07D407/12 ,  C07D407/04 ,  C07D471/04 ,  C07D237/14 ,  C07D403/12 ,  C07D417/12 ,  C07D231/56 ,  A61P27/02 ,  C07B41/04 ,  C07D231/20 ,  C07D249/04

Abstract: The invention provides novel compounds having the general formula (I) wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20200291038A1

公开(公告)日：2020-09-17

申请号：US16889322

申请日：2020-06-01

Applicant: Hoffmann-La Roche Inc.

Inventor： Jerome HERT ,  Daniel HUNZIKER ,  Patrizio MATTEI ,  Markus RUDOLPH ,  Petra Schmitz ,  Christoph ULLMER

IPC: C07D487/04 ,  A61P27/02

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R9, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20200216457A1

公开(公告)日：2020-07-09

申请号：US16827136

申请日：2020-03-23

Applicant: Hoffmann-La Roche Inc.

Inventor： Patrick DI GIORGIO ,  Jerome HERT ,  Daniel HUNZIKER ,  Holger KUEHNE ,  Patrizio MATTEI ,  Markus RUDOLPH

IPC: C07D487/04 ,  A61P3/00 ,  A61P1/16 ,  C07D519/00

Abstract: Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.

公开(公告)号：US20200207769A1

公开(公告)日：2020-07-02

申请号：US16817329

申请日：2020-03-12

Applicant: Hoffmann-La Roche Inc.

Inventor： Daniel HUNZIKER ,  Patrizio MATTEI ,  Harald MAUSER ,  Marco PRUNOTTO ,  Christoph ULLMER

IPC: C07D471/10 ,  C07D403/10 ,  C07D401/12 ,  C07D401/10 ,  C07D519/00 ,  C07D403/12 ,  C07D205/12 ,  C07D487/10 ,  C07D249/18 ,  C07D413/12 ,  C07D405/12 ,  C07D405/06

Abstract: Compounds having the general formula (I) wherein R1, R2, Y and W are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.

公开(公告)号：US20190321440A1

公开(公告)日：2019-10-24

申请号：US16389292

申请日：2019-04-19

Applicant: Hoffmann-La Roche Inc.

Inventor： Konrad BLEICHER ,  Daniella CHEANG ,  Patrick DI GIORGIO ,  Taishan HU ,  Christian JENNY ,  Patrizio MATTEI ,  Petra SCHMITZ ,  Theodor STOLL

IPC: A61K38/12 ,  A61P31/04

Abstract: The present invention provides compounds of formula (I) wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.