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    Methods For Producing Secreted Polypeptides Having Biological Activity
    13.
    发明申请
    Methods For Producing Secreted Polypeptides Having Biological Activity 失效
    用于生产具有生物活性的分泌多肽的方法

    公开(公告)号：US20090253171A1

    公开(公告)日：2009-10-08

    申请号：US12373470

    申请日：2007-07-13

    申请人： Debbie Yaver ,  Mads Eskelund Bjornvad

    发明人： Debbie Yaver ,  Mads Eskelund Bjornvad

    IPC分类号： C12P21/02 ,  C12N9/20 ,  C12N15/11

    CPC分类号： C12P21/02 ,  C07K14/37 ,  C07K2319/02 ,  C12N9/20 ,  C12N15/625 ,  C12N15/81 ,  C12Y301/01003

    摘要： The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.

    摘要翻译： 本发明涉及生产具有生物活性的多肽的方法，其包括：（a）在有助于产生多肽的培养基中培养真菌宿主细胞，其中真菌宿主细胞包含编码多肽的第一多核苷酸，其可操作地连接到 编码变体信号肽或变体前肽的第二个多核苷酸; 和（b）从培养基中分离具有生物活性的分泌多肽。

    USE OF POLYPEPTIDES HAVING ANTIMICROBIAL ACTIVITY
    14.
    发明申请
    USE OF POLYPEPTIDES HAVING ANTIMICROBIAL ACTIVITY 失效
    使用具有抗微生物活性的多肽

    公开(公告)号：US20090137474A1

    公开(公告)日：2009-05-28

    申请号：US12282429

    申请日：2007-03-20

    申请人： Erik Gormsen ,  Debbie Yaver

    发明人： Erik Gormsen ,  Debbie Yaver

    IPC分类号： A61K38/16 ,  A61L2/18 ,  C11D7/42

    CPC分类号： A61K38/164 ,  A01N37/46 ,  A01N63/02 ,  A61L2/16 ,  C11D3/3719 ,  C11D3/38 ,  C11D3/48

    摘要： The present invention relates to the use of polypeptides related to a Bacillus licheniformis polypeptide (amino acids 1-85 of SEQ ID NO: 2) as antimicrobial agents, for example in pharmaceutical applications, including veterinary applications, as well as for preservation, cleaning and disinfection of various surfaces, objects and substances. The polypeptides may in particular be used to treat textiles or laundry, e.g., in detergents, for reducing microbes on textile or laundry, and/or for odor reduction. The invention also relates to use of Bacillus strains producing these polypeptides as antimicrobial agents. Examples of microorganism inhibited by Lento are Gram positive bacterial strains, such as Bacillus cereus, and various species of Corynebacterium, Enterococcus, Micrococcus, Streptococcus, and Staphylococcus.

    摘要翻译： 本发明涉及与地衣芽孢杆菌多肽（SEQ ID NO：2的氨基酸1-85）相关的多肽作为抗微生物剂的用途，例如在药物应用中，包括兽医应用，以及用于保存，清洁和 消毒各种表面，物体和物质。 多肽可特别用于处理纺织品或衣物，例如在洗涤剂中，用于还原织物或衣物上的微生物和/或降低气味。 本发明还涉及产生这些多肽的芽孢杆菌菌株作为抗微生物剂的用途。 由Lento抑制的微生物的实例是革兰氏阳性细菌菌株，如蜡状芽孢杆菌，以及各种棒状杆菌，肠球菌，微球菌，链球菌和葡萄球菌。