公开(公告)号：US20100076300A1

公开(公告)日：2010-03-25

申请号：US12564635

申请日：2009-09-22

申请人： Roger E. Arseneau ,  James Frank Caruba ,  Michael E. Casey ,  Mark Musrock ,  Nan Zhang

发明人： Roger E. Arseneau ,  James Frank Caruba ,  Michael E. Casey ,  Mark Musrock ,  Nan Zhang

IPC分类号： A61B5/055

CPC分类号： G01T1/1603 ,  A61B6/037 ,  A61B6/5247

摘要： A data processing process and embodiment for optimizing the signal path for multi-modality imaging is described. The embodiment and process optimizes the signal to noise ratio in a positron emission tomography (PET) signal path utilizing scintillation crystals, avalanche photo diodes, and charge sensitive preamplifiers in a dual modality MRI/PET scanner. The dual use of both and analog pole zero circuit and a digital filter enables higher signal levels or a fixed ADC input range and thus a higher possible signal to noise ratio in the presence of significant pileup caused by high positron activity. The higher signal to noise ratio is needed in the PET signal architecture, because of the presence of non-modal time varying electromagnetic fields from the MR, which are a significant source of noise for the wideband PET signal modality.

摘要翻译： 描述了用于优化用于多模态成像的信号路径的数据处理过程和实施例。 实施例和过程利用双重模式MRI / PET扫描器中的闪烁晶体，雪崩光电二极管和电荷敏感前置放大器在正电子发射断层摄影（PET）信号路径中优化信噪比。 双重使用模拟极零电路和数字滤波器可实现更高的信号电平或固定的ADC输入范围，从而在存在由高正电子活动引起的重大堆积的情况下，可能的信噪比更高。 在PET信号架构中需要更高的信噪比，因为存在来自MR的非模态时变电磁场，这是对于宽带PET信号模态的噪声的重要来源。

公开(公告)号：US09606199B2

公开(公告)日：2017-03-28

申请号：US12260966

申请日：2008-10-29

申请人： Johannes Breuer ,  Ronald Grazioso ,  James Corbeil ,  Nan Zhang ,  Matthias J. Schmand

发明人： Johannes Breuer ,  Ronald Grazioso ,  James Corbeil ,  Nan Zhang ,  Matthias J. Schmand

IPC分类号： G01R33/28 ,  A61B5/15 ,  G01R33/48 ,  G01T1/16

CPC分类号： G01R33/28 ,  A61B5/150992 ,  G01R33/481 ,  G01T1/1603

摘要： An automated blood sampling system for PET imaging applications that can be operated in or very near to the field of view (FOV) of an MR scanner, such as in a combined MR/PET imaging system. A radiation detector uses APDs (avalanche photo-diodes) to collect scintillation light from crystals in which the positron-electron annihilation photons are absorbed. The necessary gamma shielding is made from a suitable shielding material, preferably tungsten polymer composite. Because the APDs are quite small and are magnetically insensitive, they can be operated in the strong magnetic field of an MR apparatus without disturbance.

公开(公告)号：US09588230B2

公开(公告)日：2017-03-07

申请号：US12560054

申请日：2009-09-15

申请人： Ronald Grazioso ,  Debora Henseler ,  Nan Zhang

发明人： Ronald Grazioso ,  Debora Henseler ,  Nan Zhang

IPC分类号： G01D18/00 ,  G12B13/00 ,  G01T1/164 ,  A61B6/03

CPC分类号： G01T1/1644 ,  A61B6/037 ,  G01T1/1648

摘要： A representative positron emission tomography (PET) system includes a positron emission tomography detector having one or more silicon photomultipliers that output silicon photomultipliers signals. The PET system further includes a calibration system that is electrically coupled to the silicon photomultipliers. The calibration system determines a single photoelectron response of the silicon photomultipliers signals and adjusts a gain of the silicon photomultipliers based on the single photoelectron response.

摘要翻译： 代表性的正电子发射断层摄影（PET）系统包括正电子发射断层摄影检测器，其具有输出硅光电倍增管信号的一个或多个硅光电倍增管。 PET系统还包括电耦合到硅光电倍增管的校准系统。 校准系统确定硅光电倍增管信号的单个光电子响应，并且基于单个光电子响应调整硅光电倍增管的增益。

公开(公告)号：US09244975B2

公开(公告)日：2016-01-26

申请号：US13328810

申请日：2011-12-16

申请人： Gautam Das ,  Hao H. Huang ,  Sandor Szalay ,  Nan Zhang

发明人： Gautam Das ,  Hao H. Huang ,  Sandor Szalay ,  Nan Zhang

IPC分类号： G06F17/30

CPC分类号： G06F17/30442

摘要： As file systems reach the petabytes scale, users and administrators are increasingly interested in acquiring high-level analytical information for file management and analysis. Two particularly important tasks are the processing of aggregate and top-k queries which, unfortunately, cannot be quickly answered by hierarchical file systems such as ext3 and NTFS. Existing pre-processing based solutions, e.g., file system crawling and index building, consume a significant amount of time and space (for generating and maintaining the indexes) which in many cases cannot be justified by the infrequent usage of such solutions. User interests can often be sufficiently satisfied by approximate (i.e., statistically accurate) answers. A just-in-time sampling-based system can, after consuming a small number of disk accesses, produce extremely accurate answers for a broad class of aggregate and top-k queries over a file system without the requirement of any prior knowledge. The system is efficient, accurate and scalable.

摘要翻译： 随着文件系统达到PB级，用户和管理员越来越有兴趣获取用于文件管理和分析的高级分析信息。 两个特别重要的任务是处理聚合和top-k查询，不幸的是不能通过分层文件系统（如ext3和NTFS）快速回答。 现有的基于预处理的解决方案，例如文件系统爬行和索引构建，消耗了大量的时间和空间（用于生成和维护索引），这在许多情况下不能被这种解决方案的频繁使用所证明。 用户兴趣通常可以通过近似（即统计准确的）答案来充分满足。 基于时间抽样的系统可以在消耗少量磁盘访问后，通过文件系统为广泛的聚合和顶级查询提供非常准确的答案，而无需任何先前的知识。 该系统是高效，准确和可扩展的。

公开(公告)号：US08884213B2

公开(公告)日：2014-11-11

申请号：US13539931

申请日：2012-07-02

申请人： Ronald Grazioso ,  Debora Henseler ,  Nan Zhang

发明人： Ronald Grazioso ,  Debora Henseler ,  Nan Zhang

IPC分类号： G01T1/202 ,  G01T1/24

CPC分类号： G01T1/248 ,  G01T1/202

摘要： Systems and methods for correcting output signals from non-linear photosensors, specifically silicon photomultipliers (SiPMs). SiPMs are used in a PET detector to readout light emissions from LSO scintillator crystals. The non-linear output of the SiPM can distort and compress the energy spectrum which is crucial in PET imaging. The non-linearity effect for inter-crystal scattered events can place an energy event outside of the PET detector energy window, resulting in a rejected event. Systems and methods to correct the SiPM non-linearity for inter-crystal scattered events, so as to be able to obtain the proper energy event and produce an accurate medical image, are disclosed.

摘要翻译： 用于校正非线性光电传感器，特别是硅光电倍增管（SiPM）的输出信号的系统和方法。 SiPM用于PET检测器以读出LSO闪烁体晶体的光发射。 SiPM的非线性输出可以扭曲和压缩在PET成像中至关重要的能谱。 晶体间散射事件的非线性效应可以将能量事件置于PET检测器能量窗口之外，导致被拒绝的事件。 公开了用于校正晶间散射事件的SiPM非线性的系统和方法，以便能够获得适当的能量事件并产生精确的医学图像。

公开(公告)号：US08859565B2

公开(公告)日：2014-10-14

申请号：US13512524

申请日：2010-07-30

申请人： Nan Zhang ,  Rong Zhong

发明人： Nan Zhang ,  Rong Zhong

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  C07D487/04 ,  C07C59/265

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07C59/265

摘要： The present invention discloses a compound of formula (I) and citrate thereof as type 5 phosphodiesterase inhibitor, a preparation method thereof, and a pharmaceutical composition including the compound of formula (I) and citrate thereof. The experimental results of the present invention prove that the compound of formula (I) and citrate thereof can inhibit activity of type 5 phosphodiesterase, and can be used for treating erectile dysfunction, inhibiting platelet aggregation and treating thrombosis, decreasing pulmonary hypertension and treating cardiovascular diseases, treating asthma and treating diabetes gastroparesis.

摘要翻译： 本发明公开了式（I）化合物及其柠檬酸盐作为5型磷酸二酯酶抑制剂及其制备方法，以及含有式（I）化合物及其柠檬酸盐的药物组合物。 本发明的实验结果证明，式（I）化合物及其柠檬酸盐可抑制5型磷酸二酯酶的活性，可用于治疗勃起功能障碍，抑制血小板聚集和治疗血栓形成，降低肺动脉高压和治疗心血管疾病 治疗哮喘和治疗糖尿病胃轻瘫。

公开(公告)号：US20130004371A1

公开(公告)日：2013-01-03

申请号：US13608408

申请日：2012-09-10

申请人： Zhiliang Wan ,  Nan Zhang

发明人： Zhiliang Wan ,  Nan Zhang

IPC分类号： G01N21/75

CPC分类号： G01N33/558 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/0631 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/165 ,  B01L2400/0406 ,  Y10T137/0318

摘要： Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.

摘要翻译： 使用毛细管流分析样品的分析柱，系统和方法。 垂直梯度样品过滤将滤液提供到孵育室，由孵育室出口处的流动调节器控制一段时间。 流量调节器可以包括没有侧壁的蛇形毛细管流动路径。 孵育的滤液可以在预定时间后从孵育室流出到检测通道。 检测室可以在多孔基底中包括一个或多个分析区域，用于从相同的样品检测相同盒上的两种或更多种分析物。

公开(公告)号：US20120112083A1

公开(公告)日：2012-05-10

申请号：US12943164

申请日：2010-11-10

申请人： Nan Zhang ,  Ronald Grazioso ,  Debora Henseler ,  Matthias J. Schmand

发明人： Nan Zhang ,  Ronald Grazioso ,  Debora Henseler ,  Matthias J. Schmand

IPC分类号： G01T1/20

CPC分类号： G01T1/1642 ,  A61B6/037

摘要： The present invention is a photodetector including improved photosensors configured of an array of small (sub-millimeter) high-density avalanche photodiode cells utilized to readout a single scintillator. Each photosensor comprises a plurality of avalanche photodiodes cells arranged in an (n×n) array of avalanche photodiode cells (where, n>1) that are coupled to a single scintillation crystal. The overall (n×n) array area as the photosensor is the same as the area of a face of the scintillator and each avalanche photodiode cell has a surface area that is not greater than one square millimeter. The photosensor is also configured to facilitate reading the output of each avalanche photodiode cell in the array. By reading out each small avalanche photodiode cell independently, the noise and capacitance are minimized and thereby provide a more accurate determination of energy and timing.

摘要翻译： 本发明是一种光电检测器，其包括由用于读出单个闪烁体的小（亚毫米）高密度雪崩光电二极管阵列的阵列构成的改进的光电传感器。 每个光传感器包括以与单个闪烁晶体耦合的雪崩光电二极管单元（其中，n> 1）的（n×n）阵列排列的多个雪崩光电二极管单元。 作为光传感器的整体（n×n）阵列区域与闪烁体的面的面积相同，并且每个雪崩光电二极管单元的表面积不大于1平方毫米。 光传感器还被配置为便于读取阵列中每个雪崩光电二极管单元的输出。 通过独立地读出每个小雪崩光电二极管单元，噪声和电容被最小化，从而提供更准确的能量和时间的确定。

公开(公告)号：US20110301385A1

公开(公告)日：2011-12-08

申请号：US13153997

申请日：2011-06-06

申请人： Licai Wang ,  Zhanxian Gao ,  Wei Li ,  Guotong Zheng ,  Qingxin Dong ,  Riping Liu ,  Xiaohuan Wang ,  Nan Zhang ,  Jingzhuang Wang ,  Shimian Cai

发明人： Licai Wang ,  Zhanxian Gao ,  Wei Li ,  Guotong Zheng ,  Qingxin Dong ,  Riping Liu ,  Xiaohuan Wang ,  Nan Zhang ,  Jingzhuang Wang ,  Shimian Cai

IPC分类号： C07C41/01

CPC分类号： C07C37/11 ,  C07C41/16 ,  C07C39/15 ,  C07C43/2055

摘要： A catalyst for olefin polymerization and method of preparing the same are disclosed.

摘要翻译： 公开了一种用于烯烃聚合的催化剂及其制备方法。

公开(公告)号：US20100009430A1

公开(公告)日：2010-01-14

申请号：US12456247

申请日：2009-06-12

申请人： Zhiliang Wan ,  Nan Zhang

发明人： Zhiliang Wan ,  Nan Zhang

IPC分类号： C12M1/00 ,  G01N33/53 ,  G01N21/01 ,  F17D1/00

CPC分类号： G01N33/558 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/0631 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/165 ,  B01L2400/0406 ,  Y10T137/0318

摘要： Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.

摘要翻译： 使用毛细管流分析样品的分析柱，系统和方法。 垂直梯度样品过滤将滤液提供到孵育室，由孵育室出口处的流动调节器控制一段时间。 流量调节器可以包括没有侧壁的蛇形毛细管流动路径。 孵育的滤液可以在预定时间后从孵育室流出到检测通道。 检测室可以在多孔基底中包括一个或多个分析区域，用于从相同的样品检测相同盒上的两种或更多种分析物。