公开(公告)号：US5566133A

公开(公告)日：1996-10-15

申请号：US564551

申请日：1995-11-29

Applicant: William E. Engeler ,  Matthew O'Donnell ,  Sharbet E. Noujaim

Inventor： William E. Engeler ,  Matthew O'Donnell ,  Sharbet E. Noujaim

IPC: G01S7/00 ,  H04B11/00 ,  G03B42/06

CPC classification number: H04B11/00 ,  G01S7/003

Abstract: An optical communication system for ultrasound imaging systems employs a light source and photodetector array in the imaging console. The light source and photodetector array are coupled to each other through an optical fiber passing through the probe. Information from the probe is communicated to the console by an optical modulator, situated in the optical path from source to detector. The ultrasound signals are converted into electrical signals by probe electronics, and these electrical signals serve to alter either the phase or amplitude of optical signals passing through the modulator. Since the light source and photodetectors reside in the imaging console, very little power is dissipated in the probe.

Abstract translation: 用于超声成像系统的光通信系统在成像控制台中采用光源和光电检测器阵列。 光源和光电检测器阵列通过穿过探针的光纤彼此耦合。 来自探头的信息通过位于从源到检测器的光路中的光学调制器传送到控制台。 超声信号通过探针电子元件转换为电信号，这些电信号用于改变通过调制器的光信号的相位或幅度。 由于光源和光电检测器位于成像控制台中，因此在探头中消耗的功率很小。

公开(公告)号：US5014712A

公开(公告)日：1991-05-14

申请号：US457134

申请日：1989-12-26

Applicant: Matthew O'Donnell

Inventor： Matthew O'Donnell

IPC: G01S7/52 ,  G01S15/89 ,  G10K11/34

CPC classification number: G01S7/52046 ,  G01S15/8959 ,  G10K11/346

Abstract: A method for imaging a sample with a beam of vibratory energy from an array of transducers excites the array with successive ones of a plurality M of coded excitation signal sets with each set occurring in a different one of successive excitation time intervals. Each different set has signals with a different code. An excitation beam, produced by the array, is focused into the sample at successively smaller distances, along a selected ray path from the array, during each successive excitation time interval. A reception beam is focused along the ray path at successively greater distances from a minimum distance away from the array during each successive one of a like plurality of reception time intervals, for receiving, during each reception time interval, return response signals reflected from the sample. The received signals are processed and all channels are coherently summed prior to cross-correlating the summed signals with reference signals derived from the coded signals of the set used for the associated excitation time interval, to recover a response signal substantially only from a volume of the sample at that distance associated with each time interval. Apparatus for implementing this method is disclosed.

Abstract translation: 用来自振子阵列的振动能量束对样本进行成像的方法用多个编码激励信号组中的连续激励信号组来激发阵列，每组编码激励信号组的每一组发生在不同的连续激发时间间隔中。 每个不同的组具有不同代码的信号。 在每个连续的激发时间间隔期间，由阵列产生的激发光束沿着沿着阵列的选定射线路径连续较小的距离聚焦到样本中。 在相似的多个接收时间间隔中的每个连续的一个期间，接收光束沿着光线路径聚焦在距离阵列的最小距离之间连续更大的距离处，用于在每个接收时间间隔期间接收从样本反射的返回响应信号 。 对所接收的信号进行处理，并且在将求和的信号与从用于相关联的激励时间间隔的集合的编码信号导出的参考信号相互相关之前，将所有信道相加相加，从而基本上仅从 在与每个时间间隔相关联的距离处的样本。 公开了实现该方法的装置。

公开(公告)号：US4731583A

公开(公告)日：1988-03-15

申请号：US798544

申请日：1985-11-15

Applicant: Gary H. Glover ,  Matthew O'Donnell

Inventor： Gary H. Glover ,  Matthew O'Donnell

IPC: A61B10/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/561 ,  G01R33/563 ,  G01R33/567 ,  G01R33/20

CPC classification number: G01R33/56509

Abstract: A technique has been developed which reduces blood-flow artifacts in multi-echo, multi-slice magnetic resonance (MR) imaging by rephasing spins which have arbitrary velocity as well as static spins. The technique requires tailoring of the gradient structure along at least one of the three axes so as to null out in the preferred embodiment the zeroth and first moments of the gradient distributions.

Abstract translation: 已经开发了一种技术，其通过重新形成具有任意速度以及静态旋转的自旋来减少多回波，多层磁共振（MR）成像中的血流伪影。 该技术需要沿着三个轴中的至少一个来定制梯度结构，以便在优选实施例中消除梯度分布的零和第一时刻。

公开(公告)号：US4680551A

公开(公告)日：1987-07-14

申请号：US785140

申请日：1985-10-07

Applicant: Matthew O'Donnell ,  Steven G. Karr ,  William D. Barber ,  Jish M. Wang ,  William A. Edelstein

Inventor： Matthew O'Donnell ,  Steven G. Karr ,  William D. Barber ,  Jish M. Wang ,  William A. Edelstein

IPC: A61B5/055 ,  A61B10/00 ,  G01R33/20 ,  G01R33/24 ,  G01R33/3875 ,  H01F7/20

CPC classification number: G01R33/3875 ,  G01R33/24

Abstract: A method for minimizing the inhomogeneity of a static magnetic field, produced by a main magnet, over a selected arbitrary volume, by operation of a plurality N of shimming coils each independently producing an associated shimming magnetic field having an associated inhomogeneity which is a function of spatial location over that same volume, uses the steps of: measuring the magnitude of the main magnet field, in the absence of all shimming fields, at a plurality of locations X.sub.i upon the surface of an imaginary sphere enclosing the arbitrary volume; measuring the polarity and magnitude of each of the N shimming fields, with respect to the polarity and magnitude of a D.C. current flowing through the associated shimming coil, at the same plurality of locations X.sub.i upon the imaginary sphere surface; determining the weighted mean-square variation of the total field at each of another plurality of points Y.sub.i within the volume of said imaginary sphere; and (d) selecting the current magnitudes and polarities for each of the N shimming coils to provide each of the N associated shimming fields with magnitude and polarity to minimize the inhomogeneity of the main magnetic field in the arbitrary volume. The set of weighting coefficients may be selected to all be equal, or to emphasize at least one desired region of the arbitrary volume.

Abstract translation: 一种用于通过操作多个N个匀场线圈来最小化由主磁体产生的静磁场在选定的任意体积上的不均匀性的方法，每个独立地产生相关联的匀场磁场，其具有相关的不均匀性，该相关的不均匀性是 在相同体积上的空间位置使用以下步骤：在包围任意体积的虚拟球体的表面上的多个位置Xi处，在没有所有匀场的情况下测量主磁场的大小; 相对于流过相关联的调色线圈的直流电流的极性和幅度，在虚拟球体表面上相同的多个位置Xi处，测量每个N个匀场的每个的极性和幅度; 确定所述虚拟球体积内的另一多个点Yi中的每个点处的总场的加权均方差; 并且（d）为N个匀场线圈中的每一个选择当前幅度和极性，以提供N个相关联的匀场中的每一个具有大小和极性以最小化任意体积中的主磁场的不均匀性。 加权系数集合可以被选择为全部相等，或者强调任意卷的至少一个期望区域。

公开(公告)号：US4470303A

公开(公告)日：1984-09-11

申请号：US419679

申请日：1982-09-20

Applicant: Matthew O'Donnell

Inventor： Matthew O'Donnell

IPC: G01S7/52 ,  G01N29/04

CPC classification number: G01S7/52036 ,  G01S7/5205 ,  G01S7/52033

Abstract: A conventional ultrasonic B-scan image is converted into a volume backscatter image by accounting for four propagation effects: dispersion of transmitted energy, beam width and beam intensity variations, inhomogeneous attenuation of ultrasonic energy, and signals resulting from specular reflections at interfaces. These images are a two-dimensional map of backscatter efficiency, are independent of details of the measurement system, and are quantitative images of an intrinsic property of tissue and other materials.

Abstract translation: 通过考虑四种传播效应，传统的超声B扫描图像被转换成体积反向散射图像：传输能量的分散，波束宽度和波束强度变化，超声能量的不均匀衰减以及由界面处的镜面反射产生的信号。 这些图像是反向散射效率的二维图，独立于测量系统的细节，并且是组织和其他材料的固有特性的定量图像。

公开(公告)号：US20140056954A1

公开(公告)日：2014-02-27

申请号：US13381392

申请日：2010-06-30

Applicant: Matthew O'Donnell ,  Robert Graham Hill

Inventor： Matthew O'Donnell ,  Robert Graham Hill

IPC: A61K8/25 ,  A61Q11/00 ,  A61K8/24 ,  A61K8/02 ,  A61K8/27 ,  A61K8/21

CPC classification number: A61K8/25 ,  A61K8/022 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61K8/27 ,  A61K33/08 ,  A61K33/16 ,  A61L27/10 ,  A61L2430/12 ,  A61Q11/00 ,  C03C3/062 ,  C03C3/097 ,  C03C3/112 ,  C03C4/0007 ,  C03C4/0021 ,  C03C4/0035 ,  C03C12/00

Abstract: The present invention relates to multicomponent glasses and their use in powdered form as an additive in personal care products such as toothpastes.

Abstract translation: 本发明涉及多组分玻璃及其在粉末形式中作为个人护理产品如牙膏中的添加剂的用途。

公开(公告)号：US08167804B2

公开(公告)日：2012-05-01

申请号：US11866000

申请日：2007-10-02

Applicant: Kang Kim ,  William F. Weitzel ,  Jonathan M. Rubin ,  Congxian Jia ,  Matthew O'Donnell ,  Theodore J. Kolias

Inventor： Kang Kim ,  William F. Weitzel ,  Jonathan M. Rubin ,  Congxian Jia ,  Matthew O'Donnell ,  Theodore J. Kolias

IPC: A61B8/00

CPC classification number: A61B5/0285 ,  A61B8/06 ,  A61B8/08 ,  A61B8/485 ,  G01S7/52036 ,  G01S7/52042

Abstract: An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.

Abstract translation: 优化的弹性模量重建程序可以从壁内应变和脉搏波速度（PWV）测量中估计血管壁的非线性弹性特性。 使用非侵入性自由手超声扫描程序来施加外力，与测量受试者血压的力相当，以通过平衡内部动脉基线压力来实现更高的应变。 PWV估计在测量壁内应变的相同位置。 重建的弹性模量被优化，并且可以使用简单的双弹性模量重建程序来确定和监测动脉弹性模量。

公开(公告)号：US20110045052A1

公开(公告)日：2011-02-24

申请号：US12809098

申请日：2008-12-19

Applicant: Robert Graham Hill ,  Molly Morag Stevens ,  Matthew O'Donnell

Inventor： Robert Graham Hill ,  Molly Morag Stevens ,  Matthew O'Donnell

IPC: A61K9/14 ,  A61K33/30 ,  A61K33/08 ,  A61K33/42 ,  A61K9/00 ,  A61P43/00 ,  B05D3/02 ,  C23C4/04 ,  C25D13/02

CPC classification number: C03C4/0007 ,  A61C8/0012 ,  A61F2/30767 ,  A61F2310/00928 ,  A61K6/0625 ,  A61L27/306 ,  A61L27/32 ,  C03C3/097 ,  C03C8/08 ,  C03C2204/00

Abstract: The present invention relates to bioactive glass coatings. In particular, the present invention relates to bioactive glass coatings for Ti6Al4V alloys and chrome cobalt alloys, wherein the thermal expansion coefficient of the glass coating is matched to that of the alloy. Such coatings have a particular application in the field of medical prosthetics. The bioactive glass comprises (in mol %) 35-53 SiO2; 2-11 Na20; at least 2% of each of CaO, MgO and K20; 0-15 ZnO; 0-2 B202 and 0-9 P205.

Abstract translation: 本发明涉及生物活性玻璃涂层。 特别地，本发明涉及用于Ti 6 Al 4 V合金和铬钴合金的生物活性玻璃涂层，其中玻璃涂层的热膨胀系数与合金的热膨胀系数相匹配。 这种涂层在医疗假肢领域具有特殊的应用。 生物活性玻璃含有（摩尔％）35-53 SiO2; 2-11 Na20; CaO，MgO和K20中至少有2％ 0-15 ZnO; 0-2 B202和0-9 P205。

公开(公告)号：US20100091613A1

公开(公告)日：2010-04-15

申请号：US12250289

申请日：2008-10-13

Applicant: Russell S. Witte ,  Ragnar Olafsson ,  Sheng-Wen Huang ,  Timothy L. Hall ,  Matthew O'Donnell

Inventor： Russell S. Witte ,  Ragnar Olafsson ,  Sheng-Wen Huang ,  Timothy L. Hall ,  Matthew O'Donnell

IPC: G01H17/00

CPC classification number: G01H11/06

Abstract: An ultrasound system that detects a characteristic of an ultrasound wave. The system includes a circuit member defining a sensing portion operable to be exposed to the ultrasound wave. The system also includes a current generating device that generates a current in the sensing portion of the circuit member. Furthermore, the system includes a voltage sensor that detects a voltage across the sensing portion due to the exposure to the ultrasound wave to thereby detect the characteristic of the ultrasound wave.

Abstract translation: 检测超声波特性的超声波系统。 该系统包括限定可操作以暴露于超声波的感测部分的电路部件。 该系统还包括在电路构件的感测部分中产生电流的电流产生装置。 此外，该系统包括电压传感器，其通过暴露于超声波来检测感测部分两端的电压，从而检测超声波的特性。

公开(公告)号：US07367948B2

公开(公告)日：2008-05-06

申请号：US10643659

申请日：2003-08-19

Applicant: Matthew O'Donnell ,  Jing Yong Ye ,  Theodore B. Norris ,  James R. Baker, Jr. ,  Lajos P. Balogh ,  Susanne M. Milas ,  Stanislav Y. Emelianov ,  Kyle W. Hollman

Inventor： Matthew O'Donnell ,  Jing Yong Ye ,  Theodore B. Norris ,  James R. Baker, Jr. ,  Lajos P. Balogh ,  Susanne M. Milas ,  Stanislav Y. Emelianov ,  Kyle W. Hollman

IPC: A61B8/00 ,  A61B8/12 ,  A61B8/14 ,  A61B6/00 ,  A61H1/00

CPC classification number: B82Y15/00 ,  A61B5/0095 ,  A61B8/481 ,  G01N21/1702 ,  G01N21/718 ,  G01N29/2418 ,  G01N2291/02433 ,  G01N2291/02475 ,  G01N2291/02491 ,  G01N2291/02827

Abstract: An acoustic monitoring method and system in laser-induced optical breakdown (LIOB) provides information which characterize material which is broken down, microbubbles in the material, and/or the microenvironment of the microbubbles. In one embodiment of the invention, femtosecond laser pulses are focused just inside the surface of a volume of aqueous solution which may include dendrimer nanocomposite (DNC) particles. A tightly focused, high frequency, single-element ultrasonic transducer is positioned such that its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a microbubble forms and a shock or pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble may be actively probed with pulse-echo measurements from the same transducer. After the microbubble forms, received pulse-echo signals have an extra pulse, describing the microbubble location and providing a measure of axial microbubble size. Wavefield plots of successive recordings illustrate the generation, growth, and collapse of microbubbles due to optical breakdown. These same plots can also be used to quantify LIOB thresholds.

Abstract translation: 激光诱导光学击穿（LIOB）中的声学监测方法和系统提供表征材料中的材料，材料中的微泡和/或微泡的微环境的信息。 在本发明的一个实施例中，飞秒激光脉冲恰好聚集在一定体积的水溶液的表面内，该溶液可包括树枝状聚合物纳米复合物（DNC）颗粒。 紧密聚焦的高频单元超声波换能器被定位成使得其焦点与该激光焦点轴向和横向重合。 当发生光学击穿时，形成微泡并发射冲击或压力波（即声发射）。 除了这种声学信号之外，微泡可以通过来自相同换能器的脉冲回波测量来主动探测。 在形成微泡后，接收的脉冲回波信号具有额外的脉冲，描述微泡位置并提供轴向微泡尺寸的量度。 连续记录的波场图说明了由于光学破坏引起的微泡的产生，生长和崩溃。 这些相同的图也可以用于量化LIOB阈值。