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11.发明授权公开(公告)号：US09434719B2
公开(公告)日：2016-09-06
申请号：US14408418
申请日：2014-03-12
申请人： Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
发明人： Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
IPC分类号： C07D413/04 , A61K31/506 , C07D413/14 , C07D417/14 , A61K31/5377
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D417/14
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
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公开(公告)号：US20140288076A1
公开(公告)日：2014-09-25
申请号：US14295398
申请日：2014-06-04
申请人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： C07D409/14 , C07D401/14 , C07D405/14 , C07D401/04
CPC分类号： A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。 还提供了治疗由CDK9介导的疾病或病症的方法。
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公开(公告)号：US08293769B2
公开(公告)日：2012-10-23
申请号：US12451326
申请日：2008-05-20
申请人： Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton , Allan S. Wagman , Marion Wiesmann
发明人： Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton , Allan S. Wagman , Marion Wiesmann
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4745 , A61K31/4545 , A61K31/454 , A61K31/444 , A61K31/4439 , C07D495/04 , C07D487/04 , C07D417/12 , C07D417/14 , C07D413/12 , C07D413/14
CPC分类号： C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要： Benzoxazole and benzothiazole compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF 1R.
摘要翻译： 公开了苯并恶唑和苯并噻唑化合物及其氧化物，酯，前药，溶剂合物及其药学上可接受的盐。 还公开了单独或与至少一种另外的治疗剂组合的化合物与药学上可接受的载体的组合，以及化合物单独或与至少一种另外的治疗剂组合的用途。 这些实施方案可用于抑制细胞增殖，抑制肿瘤的生长和/或复分解，治疗或预防癌症，治疗或预防退行性骨疾病如类风湿性关节炎和/或抑制分子如CSF 1R。
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公开(公告)号：US20130324530A1
公开(公告)日：2013-12-05
申请号：US13885640
申请日：2011-11-17
申请人： William R. Antonios-McCrea , Paul A. Barsanti , Cheng Hu , Xianming Jin , Eric J. Martin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人： William R. Antonios-McCrea , Paul A. Barsanti , Cheng Hu , Xianming Jin , Eric J. Martin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： C07D213/74 , C07D401/14 , C07D409/14 , C07D405/14
CPC分类号： C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are pharmaceutical compositions containing these compounds and methods of treating a disease or condition mediated by CDK9 using these compounds and compositions.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。 还提供含有这些化合物的药物组合物和使用这些化合物和组合物治疗由CDK9介导的疾病或病症的方法。
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公开(公告)号：US20110130380A1
公开(公告)日：2011-06-02
申请号：US12874389
申请日：2010-09-02
申请人： Paul A. Barsanti , Cheng Hu , Xianming Jin , Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton
发明人： Paul A. Barsanti , Cheng Hu , Xianming Jin , Simon C. Ng , Keith B. Pfister , Martin Sendzik , James Sutton
IPC分类号： A61K31/444 , C07D401/14 , A61K31/4545 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14 , A61K31/5377 , A61K31/553 , A61K31/55 , A61P29/00 , A61P37/06 , A61P19/08 , A61P3/00 , A61P25/28 , A61P35/00 , A61P9/00 , A61P11/06 , A61P31/12
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. Also provided is a method of using a compound of Formula I for treating a disease or condition mediated by a CDK inhibitor.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 还提供了使用式I化合物治疗由CDK抑制剂介导的疾病或病症的方法。
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公开(公告)号：US20110028492A1
公开(公告)日：2011-02-03
申请号：US12843494
申请日：2010-07-26
申请人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： A61K31/497 , C07D213/02 , C07D401/04 , A61K31/444 , A61K31/506 , A61P31/18 , A61P35/00
CPC分类号： A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。 还提供了治疗由CDK9介导的疾病或病症的方法。
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公开(公告)号：US09815813B2
公开(公告)日：2017-11-14
申请号：US15110504
申请日：2015-01-16
申请人： Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Sarah Williams , Martin Sendzik
发明人： Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Sarah Williams , Martin Sendzik
IPC分类号： A61K31/4427 , C07D401/04 , C07D401/14 , C07D241/26 , C07D249/14
CPC分类号： C07D401/04 , C07D241/26 , C07D249/14 , C07D401/14
摘要： The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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公开(公告)号：US08026371B2
公开(公告)日：2011-09-27
申请号：US12896535
申请日：2010-10-01
IPC分类号： C07D263/54 , A61K31/42
CPC分类号： A61K31/343 , A61K31/18 , A61K31/33 , A61K31/34 , A61K31/4015 , A61K31/4415 , A61K41/00 , A61K45/06 , A61N5/10 , C07C259/10 , C07C2601/02 , C07D207/12 , C07D207/327 , C07D207/34 , C07D209/08 , C07D209/18 , C07D209/42 , C07D209/44 , C07D211/46 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/08 , C07D215/18 , C07D215/48 , C07D215/54 , C07D217/04 , C07D217/06 , C07D217/26 , C07D231/56 , C07D235/06 , C07D235/24 , C07D241/52 , C07D249/18 , C07D261/18 , C07D263/58 , C07D277/30 , C07D277/42 , C07D277/56 , C07D277/68 , C07D307/54 , C07D307/68 , C07D307/79 , C07D307/81 , C07D307/85 , C07D307/86 , C07D317/60 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/70 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/04 , C07D417/12 , A61K2300/00
摘要： The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
摘要翻译： 本发明涉及可用于治疗丙型肝炎的某些异羟肟酸衍生物。这些化合物也是组蛋白脱乙酰酶的抑制剂，因此可用于治疗与组蛋白脱乙酰酶活性相关的疾病。 还公开了制备这些化合物的药物组合物和方法。
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公开(公告)号：US07368572B2
公开(公告)日：2008-05-06
申请号：US10922119
申请日：2004-08-19
申请人： Martin Sendzik
发明人： Martin Sendzik
IPC分类号： C07D215/38 , C07D213/72 , C07D277/08 , C07D315/00
CPC分类号： C04B35/632 , C07C259/10 , C07C271/02 , C07C275/30 , C07C275/32 , C07C311/19 , C07D209/42 , C07D215/48 , C07D231/12 , C07D235/24 , C07D239/70 , C07D261/08 , C07D263/34 , C07D277/56 , C07D277/68 , C07D307/85 , C07D333/70 , C07D401/12 , C07D405/12
摘要： The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的某些异羟肟酸衍生物，因此可用于治疗与组蛋白脱乙酰酶活性相关的疾病。 还公开了制备这些化合物的药物组合物和方法。
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公开(公告)号：US20050131018A1
公开(公告)日：2005-06-16
申请号：US10922119
申请日：2004-08-19
申请人： Martin Sendzik
发明人： Martin Sendzik
IPC分类号： A61K31/19 , A61K31/343 , A61K31/381 , A61K31/421 , A61K31/426 , A61K31/47 , A61P35/00 , C07C259/10 , C07C271/02 , C07C275/30 , C07C275/32 , C07C311/19 , C07D209/42 , C07D215/16 , C07D215/48 , C07D231/12 , C07D235/24 , C07D239/70 , C07D261/08 , C07D263/34 , C07D277/56 , C07D277/68 , C07D307/85 , C07D333/70 , C07D333/72 , C07D401/12 , C07D405/12
CPC分类号： C04B35/632 , C07C259/10 , C07C271/02 , C07C275/30 , C07C275/32 , C07C311/19 , C07D209/42 , C07D215/48 , C07D231/12 , C07D235/24 , C07D239/70 , C07D261/08 , C07D263/34 , C07D277/56 , C07D277/68 , C07D307/85 , C07D333/70 , C07D401/12 , C07D405/12
摘要： The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的某些异羟肟酸衍生物，因此可用于治疗与组蛋白脱乙酰酶活性相关的疾病。 还公开了制备这些化合物的药物组合物和方法。
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