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公开(公告)号：US09862769B2
公开(公告)日：2018-01-09
申请号：US13700341
申请日：2011-05-27
申请人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Edward N. Van Den Brink
发明人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Edward N. Van Den Brink
IPC分类号： A61K39/395 , C07K16/00 , C07K16/28 , C07K16/32 , A61K39/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related anti-body-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20090081219A1
公开(公告)日：2009-03-26
申请号：US12283775
申请日：2008-09-16
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G.J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G.J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/395 , G01N33/53 , A61P37/02 , A61P37/08
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20050123542A1
公开(公告)日：2005-06-09
申请号：US10982725
申请日：2004-11-04
IPC分类号： C07K16/24 , A61K39/395 , A61K38/17 , A61K38/20
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , Y02A50/41
摘要： Methods for treating disorders involving monocytic activity by administering IL-15 antagonists that induce apoptosis of monocytes are disclosed.
摘要翻译： 公开了通过施用诱导单核细胞凋亡的IL-15拮抗剂来治疗涉及单核细胞活性的疾病的方法。
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公开(公告)号：US20130189271A1
公开(公告)日：2013-07-25
申请号：US13700341
申请日：2011-05-27
申请人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce I. Meesters , Janine Schuurman , Edward Norbert Van Den Brink
发明人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce I. Meesters , Janine Schuurman , Edward Norbert Van Den Brink
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related anti-body-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译： 公开了与人表皮生长因子受体2（HER2）结合的分离的单克隆抗体以及相关的抗体基组合物和分子。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号：US20090155204A1
公开(公告)日：2009-06-18
申请号：US12291494
申请日：2008-11-11
IPC分类号： A61K38/20 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/73 , Y02A50/41
摘要： Methods for treating disorders involving monocytic activity by administering IL-15 antagonists that induce apoptosis of monocytes are disclosed.
摘要翻译： 公开了通过施用诱导单核细胞凋亡的IL-15拮抗剂来治疗涉及单核细胞活性的疾病的方法。
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公开(公告)号：US09068011B2
公开(公告)日：2015-06-30
申请号：US13583743
申请日：2011-03-10
申请人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
发明人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
CPC分类号： C07K16/3076 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/5748 , G01N2333/912
摘要： Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译： 公开了结合人c-Met，肝细胞生长因子受体以及相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号：US20140242075A1
公开(公告)日：2014-08-28
申请号：US14130543
申请日：2012-07-06
IPC分类号： C07K16/28
摘要： Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.
摘要翻译： 本文描述的是包含变体Fc结构域的多肽和相关抗体。 当多肽，抗体或抗体与细胞表面上的其靶标，抗原或抗原结合时，变体Fc结构域提供稳定的Fc：Fc相互作用，从而提供改善的效应子功能，例如CDC反应。
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公开(公告)号：US20140170148A1
公开(公告)日：2014-06-19
申请号：US14112848
申请日：2012-04-20
申请人： Bart De Goeij , Patrick Van Berkel , Kristin Strumane , Aran Frank Labrijn , Joost J. Neijssen , Joyce I. Meesters , Paul Parren , Janine Schuurman
发明人： Bart De Goeij , Patrick Van Berkel , Kristin Strumane , Aran Frank Labrijn , Joost J. Neijssen , Joyce I. Meesters , Paul Parren , Janine Schuurman
IPC分类号： C07K16/32 , A61K45/06 , A61K39/395 , A61K51/10 , A61K47/48
CPC分类号： C07K16/32 , A61K45/06 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6813 , A61K47/6825 , A61K47/6827 , A61K47/6829 , A61K47/6855 , A61K47/6879 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/526 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
摘要翻译： 公开了包含与人表皮生长因子受体2（HER2）的两个不同表位结合的抗原结合区的双特异性抗体以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物和制备和使用抗体的方法。
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公开(公告)号：US20100267934A1
公开(公告)日：2010-10-21
申请号：US12602439
申请日：2008-05-30
申请人： Jan Van De Winkel , Tom Vink , Janine Schuurman , Paul Parren , Rob Aalberse , Marijn Van Der Neut Kolfschote
发明人： Jan Van De Winkel , Tom Vink , Janine Schuurman , Paul Parren , Rob Aalberse , Marijn Van Der Neut Kolfschote
CPC分类号： C07K16/2887 , A61K47/6803 , A61K47/6813 , A61K47/6835 , A61K47/6839 , A61K47/6845 , A61K47/6849 , A61K51/10 , A61K51/1006 , A61K51/1021 , A61K51/1027 , A61K51/103 , A61K51/1039 , A61K2039/505 , C07K16/00 , C07K16/16 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/94
摘要： The present invention relates to stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).
摘要翻译： 本发明涉及稳定的IgG4抗体，涉及产生此类抗体的方法以及此类抗体作为药物的用途。 在一个主要方面，本发明涉及一种稳定的IgG4抗体，其包含重链和轻链，其中所述重链包含具有在位置（409）处的Arg残基取代的人IgG4恒定区， 位置（405）或位置（370）处的Lys残基。
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20.发明申请USE OF EFFECTOR-FUNCTION-DEFICIENT ANTIBODIES FOR TREATMENT OF AUTO-IMMUNE DISEASES 有权用于治疗自身免疫疾病的功效缺乏抗体的应用公开(公告)号：US20090317382A1
公开(公告)日：2009-12-24
申请号：US12096196
申请日：2006-12-15
申请人： Mario Losen , Pilar Martinez-Martinez , Marc H. De Baets , Yvo Graus , Janine Schuurman , Paul Parren
发明人： Mario Losen , Pilar Martinez-Martinez , Marc H. De Baets , Yvo Graus , Janine Schuurman , Paul Parren
IPC分类号： A61K39/395 , C07K16/42 , A61P37/00
CPC分类号： C07K16/286 , A61K2039/505 , C07K2317/24 , C07K2317/71
摘要： The invention relates to the treatment of autoimmune diseases and disorders, in particular myasthenia gravis, by administration of effector-function-deficient antibodies, wherein said effector-function-deficient antibodies are capable of competing with one or more of the auto-antibodies involved in mediating the antibody-mediated auto-immune disease or disorder for binding to a target auto-antigen.
摘要翻译： 本发明涉及通过施用效应子功能缺陷型抗体治疗自身免疫性疾病和病症，特别是重症肌无力，其中所述效应子功能缺陷型抗体能够与参与的一种或多种自身抗体竞争 介导抗体介导的自身免疫疾病或病症以结合靶标自身抗原。
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