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公开(公告)号：US20220348647A1
公开(公告)日：2022-11-03
申请号：US17853218
申请日：2022-06-29
Applicant: Janssen Biotech, Inc.
Inventor： Ken Boakye , Alfred Del Vecchio , John Kehoe , Eilyn Lacy , Lynne Murray , Mary Ryan , Sandra Santulli-Marotto , John Wheeler , Brian Whitaker , Alexey Teplyakov
IPC: C07K16/24
Abstract: The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
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公开(公告)号：US10689453B2
公开(公告)日：2020-06-23
申请号：US16382645
申请日：2019-04-12
Applicant: Janssen Biotech, Inc
Inventor： John Chen , Johan Fransson , Natalie Fursov , Damon Hamel , Thomas Malia , Galina Obmolova , Tatiana Ort , Michael Rycyzyn , Michael Scully , Raymond Sweet , Alexey Teplyakov , John Wheeler , Juan Carlos Almagro
Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
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公开(公告)号：US20170355742A1
公开(公告)日：2017-12-14
申请号：US15616216
申请日：2017-06-07
Applicant: Janssen Biotech, Inc.
Inventor： Thomas Rutkoski , Alexey Teplyakov , Nicole Wunderler
IPC: C07K14/535 , A61K45/06 , A61K38/19
Abstract: GM-CSF variants, polynucleotides encoding them, and methods of making and using the foregoing are useful in treatment of immune-related disorders, such as inflammatory bowel disease (IBD).
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公开(公告)号：US20170088624A1
公开(公告)日：2017-03-30
申请号：US15281670
申请日：2016-09-30
Applicant: Janssen Biotech, Inc.
Inventor： Johan Fransson , Paul Kim , Michael Quigley , Andressa Smith , Alexey Teplyakov , Hong Zhou
IPC: C07K16/28 , A61K45/06 , C07K16/42 , A61K39/395
Abstract: The present invention relates to agonistic antibodies specifically binding human CD40, polynucleotides encoding the antibodies or antigen-binding fragments, and methods of making and using the foregoing.
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15.发明授权Method of treating an inflammatory condition by administering toll-like 3 receptor antagonists 有权通过施用toll样3受体拮抗剂治疗炎性病症的方法公开(公告)号：US09522957B2
公开(公告)日：2016-12-20
申请号：US13973187
申请日：2013-08-22
Applicant: Janssen Biotech, Inc.
Inventor： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
IPC: A61K39/395 , C07K16/28 , C07H21/04 , C12N15/117 , C07K14/705 , A61K39/00 , C07K16/18 , C12N5/10 , C12N5/12 , C12N15/63
CPC classification number: C07K16/2896 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N5/12 , C12N15/117 , C12N15/63 , C12N2310/17 , A61K39/00 , A61K2300/00
Abstract: Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
Abstract translation: 公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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Patent Agency Ranking
公开(公告)号：US11787875B2
公开(公告)日：2023-10-17
申请号：US16994065
申请日：2020-08-14
Applicant: Janssen Biotech, Inc.
Inventor： Jinquan Luo , Lauren Boucher , Michael Feldkamp , Michael Diem , Anthony A. Armstrong , Alexey Teplyakov , Chichi Huang
IPC: C07K16/00 , C07K16/42 , C07K14/705
CPC classification number: C07K16/4283 , C07K14/705 , C07K16/00 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/567 , C07K2317/622 , C07K2317/624 , C07K2317/94
Abstract: Disclosed are materials and methods for improved single chain variable fragments.
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公开(公告)号：US11732050B2
公开(公告)日：2023-08-22
申请号：US16878209
申请日：2020-05-19
Applicant: Janssen Biotech, Inc
Inventor： John Chen , Johan Fransson , Natalie Fursov , Damon Hamel , Thomas Malia , Galina Obmolova , Tatiana Ort , Michael Rycyzyn , Michael Scully , Raymond Sweet , Alexey Teplyakov , John Wheeler , Juan Carlos Almagro
CPC classification number: C07K16/2878 , C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
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公开(公告)号：US11421037B2
公开(公告)日：2022-08-23
申请号：US16853786
申请日：2020-04-21
Applicant: Janssen Biotech, Inc.
Inventor： Johan Fransson , Galina Obmolova , Anish Suri , Fang Teng , Alexey Teplyakov , Hong Zhou , Jocelyn Leu
Abstract: The present invention relates to antagonistic antibodies specifically binding CD154, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
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公开(公告)号：US11208450B2
公开(公告)日：2021-12-28
申请号：US16746052
申请日：2020-01-17
Applicant: Janssen Biotech, Inc.
Inventor： Thomas Rutkoski , Alexey Teplyakov , Nicole Wunderler
IPC: C07K14/535 , A61K38/19 , C12N15/00 , C12N5/00 , A61K45/06
Abstract: GM-CSF variants, polynucleotides encoding them, and methods of making and using the foregoing are useful in treatment of immune-related disorders, such as inflammatory bowel disease (IBD).
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公开(公告)号：US20180179294A1
公开(公告)日：2018-06-28
申请号：US15898112
申请日：2018-02-15
Applicant: Janssen Biotech, Inc.
Inventor： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
IPC: C07K16/28 , C12N15/117 , C07H21/04 , A61K39/395 , C07K14/705 , A61K39/00 , C12N5/10 , C12N5/12 , C12N15/63
CPC classification number: C07K16/2896 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N5/12 , C12N15/117 , C12N15/63 , C12N2310/17 , A61K39/00 , A61K2300/00
Abstract: Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
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