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    CONTROL OF MATERIALS AND POROUS MAGNETIC PARTICLES
    13.
    发明申请
    CONTROL OF MATERIALS AND POROUS MAGNETIC PARTICLES 有权
    材料和多孔磁性颗粒的控制

    公开(公告)号：US20090179171A1

    公开(公告)日：2009-07-16

    申请号：US12300369

    申请日：2007-05-16

    申请人： Michael J. Sailor ,  Ji-Ho Park ,  Austin M. Derfus ,  Ester Segal ,  Kenneth S. Vecchio ,  Sangeeta N. Bhatia

    发明人： Michael J. Sailor ,  Ji-Ho Park ,  Austin M. Derfus ,  Ester Segal ,  Kenneth S. Vecchio ,  Sangeeta N. Bhatia

    IPC分类号： H01F1/00 ,  H05B6/02

    CPC分类号： H05B6/02 ,  B82Y25/00 ,  H01F1/0063 ,  Y10T428/29 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/32

    摘要： The present invention uses externally applied electromagnetic stimulus to control and heat porous magnetic particles and material associated with the particles. The particles contain magnetic material, such as superparamagnetic iron oxide and are associated with a material. Application of a DC magnetic field allows them to be moved with their associated material, and application of an AC RF electromagnetic field allows them to be heated with their associated material. The material can be associated with the particles by being contained in the pores of the particles, or in other cases the particles can adhere to the associated material, which can be an aqueous droplet. The present invention also provides a multi-layer porous magnetic particle. The particle includes a host layer having pores sized to accept magnetic nanoparticles. Magnetic nanoparticles are infused within pores of the host layer An encoding layer includes pores that define a spectral code. The pores in the encoding layer are sized to substantially exclude the magnetic nanoparticles. The encoding layer can also be a multi-layer, exhibiting, for example, a complex spectral code.

    摘要翻译： 本发明使用外部施加的电磁刺激来控制和加热与颗粒相关联的多孔磁性颗粒和材料。 颗粒含有磁性材料，例如超顺磁性氧化铁，并与材料相关联。 DC磁场的应用允许它们与其相关材料一起移动，并且AC RF电磁场的应用允许它们与其相关材料一起被加热。 该材料可以通过包含在颗粒的孔中与颗粒相关联，或者在其它情况下，颗粒可以附着到可以是水性液滴的相关材料上。 本发明还提供一种多层多孔磁性颗粒。 颗粒包括具有尺寸以接受磁性纳米颗粒的孔的主体层。 磁性纳米颗粒注入到主体层的孔内编码层包括限定光谱代码的孔。 编码层中的孔的大小被确定为基本排除磁性纳米颗粒。 编码层也可以是多层，表现出例如复谱谱。

    Carbon and carbon/silicon composite nanostructured materials and casting formation method
    15.
    发明授权
    Carbon and carbon/silicon composite nanostructured materials and casting formation method 有权
    碳和碳/硅复合纳米结构材料和铸造方法

    公开(公告)号：US09499407B2

    公开(公告)日：2016-11-22

    申请号：US13824125

    申请日：2011-09-29

    申请人： Michael J. Sailor ,  Timothy Kelly

    发明人： Michael J. Sailor ,  Timothy Kelly

    IPC分类号： C01B31/02 ,  D01D5/00 ,  D01F9/14 ,  G02B1/00 ,  B82Y30/00 ,  B82Y40/00 ,  B82B1/00

    CPC分类号： C01B31/022 ,  B82B1/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/158 ,  C01B32/16 ,  C01B32/166 ,  D01D5/00 ,  D01F9/14 ,  G02B1/005 ,  Y10T428/249994 ,  Y10T428/2918

    摘要： The invention provides nanostructure composite porous silicon and carbon materials, and also provides carbon nanofiber arrays having a photonic response in the form of films or particles. Composite materials or carbon nanofiber arrays of the invention are produced by a templating method of the invention, and the resultant nanomaterials have a predetermined photonic response determined by the pattern in the porous silicon template, which is determined by etching conditions for forming the porous silicon. Example nanostructures include rugate filters, single layer structures and double layer structures. In a preferred method of the invention, a carbon precursor is introduced into the pores of a porous silicon film. Carbon is then formed from the carbon precursor. In a preferred method of the invention, liquid carbon-containing polymer precursor is introduced into the pores of an porous silicon film The precursor is thermally polymerized to form a carbon-containing polymer in the pores of the porous silicon film, which is then thermally carbonized to produce the nano structured composite material. A carbon nanofiber array is obtained by dissolving the porous silicon. A carbon nanofiber array can be maintained as a film in liquid, and particles can be formed by drying the material.

    摘要翻译： 本发明提供纳米结构复合多孔硅和碳材料，并且还提供具有膜或颗粒形式的光子响应的碳纳米纤维阵列。 通过本发明的模板法制备本发明的复合材料或碳纳米纤维阵列，并且所得纳米材料具有由多孔硅模板中的图案确定的预定光子响应，其由用于形成多孔硅的蚀刻条件确定。 示例性纳米结构包括鲁棒过滤器，单层结构和双层结构。 在本发明的优选方法中，将碳前体引入多孔硅膜的孔中。 然后由碳前体形成碳。 在本发明的优选方法中，将含液体碳的聚合物前体引入多孔硅膜的孔中。将前体热聚合以在多孔硅膜的孔中形成含碳聚合物，然后将其热碳化 以生产纳米结构复合材料。 通过溶解多孔硅获得碳纳米纤维阵列。 碳纳米纤维阵列可以作为液体中的膜保持，并且可以通过干燥材料形成颗粒。

    ELECTROADSORPTION AND CHARGE BASED BIOMOLECULE SEPARATION AND DETECTION IN POROUS SENSORS
    16.
    发明申请
    ELECTROADSORPTION AND CHARGE BASED BIOMOLECULE SEPARATION AND DETECTION IN POROUS SENSORS 审中-公开
    多孔传感器中的电吸收和电荷分离生物分离与检测

    公开(公告)号：US20140166485A1

    公开(公告)日：2014-06-19

    申请号：US14114688

    申请日：2012-05-02

    申请人： Michael J. Sailor ,  Michelle Y. Chen

    发明人： Michael J. Sailor ,  Michelle Y. Chen

    IPC分类号： G01N27/447

    CPC分类号： G01N27/447

    摘要： Electroadsorption and charged based biomolecule separation, concentration and detection with porous biosensors. In preferred embodiments, a potential is applied to a porous electrode to separate and concentrate molecules from solution. The bimolecular analytes are captured by the porous electrode itself, the same electrode that is used to generate the electric field for electroadsorption. In additional preferred embodiments, pH of the solution is adjusted to separate and concentrate biomolecules. Setting the pH equal to the protein isoelectric point was determined by the inventors to maximize concentration of biomolecules into the porous biosensor. The methods include simultaneously optically detecting charged molecules captured by the porous electrode. Methods of the invention are benign to biomolecules of interest, which are demonstrated to retain a high percentage of their activity after being released from the biosensor. Methods of the invention provide label-free detection. Advantageously, small voltages and ultrasmall volumes of solution are used in methods of the invention.

    摘要翻译： 电吸收和带电的生物分子分离，浓度和多孔生物传感器的检测。 在优选的实施方案中，将电位施加到多孔电极以从溶液中分离和浓缩分子。 双分子分析物被多孔电极本身捕获，这是用于产生电吸附电场的相同电极。 在另外的优选实施方案中，调节溶液的pH以分离和浓缩生物分子。 通过发明人确定等于蛋白质等电点的pH以使生物分子的浓度最大化到多孔生物传感器中。 所述方法包括同时光学检测由多孔电极捕获的带电分子。 本发明的方法对于感兴趣的生物分子是良性的，其被证明在从生物传感器释放后保留其高活性百分比。 本发明的方法提供无标记检测。 有利地，在本发明的方法中使用小电压和超小体积的溶液。

    CARBON AND CARBON/SILICON COMPOSITE NANOSTRUCTURED MATERIALS AND CASTING FORMATION METHOD
    17.
    发明申请
    CARBON AND CARBON/SILICON COMPOSITE NANOSTRUCTURED MATERIALS AND CASTING FORMATION METHOD 有权
    碳和碳/硅复合材料纳米结构材料和铸造方法

    公开(公告)号：US20130309484A1

    公开(公告)日：2013-11-21

    申请号：US13824125

    申请日：2011-09-29

    申请人： Michael J. Sailor ,  Timothy Kelly

    发明人： Michael J. Sailor ,  Timothy Kelly

    IPC分类号： C01B31/02

    CPC分类号： C01B31/022 ,  B82B1/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/158 ,  C01B32/16 ,  C01B32/166 ,  D01D5/00 ,  D01F9/14 ,  G02B1/005 ,  Y10T428/249994 ,  Y10T428/2918

    摘要： The invention provides nanostructure composite porous silicon and carbon materials, and also provides carbon nanofiber arrays having a photonic response in the form of films or particles. Composite materials or carbon nanofiber arrays of the invention are produced by a templating method of the invention, and the resultant nanomaterials have a predetermined photonic response determined by the pattern in the porous silicon template, which is determined by etching conditions for forming the porous silicon. Example nanostructures include rugate filters, single layer structures and double layer structures. In a preferred method of the invention, a carbon precursor is introduced into the pores of a porous silicon film. Carbon is then formed from the carbon precursor. In a preferred method of the invention, liquid carbon-containing polymer precursor is introduced into the pores of an porous silicon film The precursor is thermally polymerized to form a carbon-containing polymer in the pores of the porous silicon film, which is then thermally carbonized to produce the nano structured composite material. A carbon nanofiber array is obtained by dissolving the porous silicon. A carbon nanofiber array can be maintained as a film in liquid, and particles can be formed by drying the material.

    摘要翻译： 本发明提供纳米结构复合多孔硅和碳材料，并且还提供具有膜或颗粒形式的光子响应的碳纳米纤维阵列。 通过本发明的模板法制备本发明的复合材料或碳纳米纤维阵列，并且所得纳米材料具有由多孔硅模板中的图案确定的预定光子响应，其由用于形成多孔硅的蚀刻条件确定。 示例性纳米结构包括鲁棒过滤器，单层结构和双层结构。 在本发明的优选方法中，将碳前体引入多孔硅膜的孔中。 然后由碳前体形成碳。 在本发明的优选方法中，将含液体碳的聚合物前体引入多孔硅膜的孔中。将前体热聚合以在多孔硅膜的孔中形成含碳聚合物，然后将其热碳化 以生产纳米结构复合材料。 通过溶解多孔硅获得碳纳米纤维阵列。 碳纳米纤维阵列可以作为液体中的膜保持，并且可以通过干燥材料形成颗粒。

    Optical sensor for detecting chemical reaction activity
    20.
    发明授权
    Optical sensor for detecting chemical reaction activity 失效
    用于检测化学反应活性的光学传感器

    公开(公告)号：US07759129B2

    公开(公告)日：2010-07-20

    申请号：US12087691

    申请日：2007-01-10

    申请人： Michael J. Sailor ,  Manuel M. Orosco ,  Claudia Pacholski ,  Gordon M. Miskelly

    发明人： Michael J. Sailor ,  Manuel M. Orosco ,  Claudia Pacholski ,  Gordon M. Miskelly

    IPC分类号： G01N21/00

    CPC分类号： G01N33/552 ,  Y10S435/808 ,  Y10S435/973 ,  Y10S436/805

    摘要： The invention provides an optical sensor for detecting chemical reaction activity, including, e.g., enzyme activity and catalytic or reactive molecule activity. An optical sensor of the invention includes a porous photonic film that produces a predetermined spectral reflectance response. In preferred embodiments, the film has a chemical coating (such as a hydrophobic layer) within its pores with an affinity for the reaction product(s) of the catalytic or otherwise reactive analyte A coating can also act as a protective layer in preferred embodiment. A thin substrate susceptible to reaction by at least one analyte of interest is on the surface of the thin film to block pores of the thin film. A method of detecting chemical reaction activity of the invention exposes the optical sensor to an analyte of interest, such as an enzyme or otherwise catalytic or reactive molecule. The optical sensor is subjected to light and the reflectivity spectrum of the optical sensor is monitored for a change indicative of reaction activity. Monitoring can include observation for a visible change or data acquisition via instruments such as a spectrometer for monitoring for a change in interferometric reflectance spectra.

    摘要翻译： 本发明提供了一种用于检测化学反应活性的光学传感器，包括例如酶活性和催化或反应性分子活性。 本发明的光学传感器包括产生预定光谱反射响应的多孔光子膜。 在优选的实施方案中，膜在其孔内具有对催化或其它反应性分析物的反应产物具有亲和性的化学涂层（例如疏水层）。在优选实施方案中，涂层也可以用作保护层。 易受至少一种感兴趣的分析物反应的薄基材在薄膜的表面上，以阻挡薄膜的孔。 检测本发明的化学反应活性的方法将光学传感器暴露于感兴趣的分析物，例如酶或其它催化或反应性分子。 对光学传感器进行光照射，并且监测光学传感器的反射光谱以表明反应活性。 监测可以包括通过诸如用于监测干涉反射光谱变化的光谱仪等仪器进行可见变化或数据采集的观察。