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    ACOUSTICALLY RESPONSIVE PARTICLES WITH DECREASED CAVITATION THRESHOLD
    2.
    发明申请
    ACOUSTICALLY RESPONSIVE PARTICLES WITH DECREASED CAVITATION THRESHOLD 审中-公开
    具有降低裂隙阈值的有声响应的颗粒

    公开(公告)号：US20140046181A1

    公开(公告)日：2014-02-13

    申请号：US13978140

    申请日：2012-01-05

    申请人： Michael Benchimol ,  Sadik C. Esener ,  Dmitri Simberg ,  Stuart Ibsen

    发明人： Michael Benchimol ,  Sadik C. Esener ,  Dmitri Simberg ,  Stuart Ibsen

    IPC分类号： A61K41/00 ,  A61M5/00 ,  A61M37/00

    CPC分类号： A61K41/0047 ,  A61K9/0009 ,  A61K9/1273 ,  A61K41/0028 ,  A61M5/007 ,  A61M37/0092

    摘要： Techniques, systems, devices and materials are disclosed for implementing and fabricating drug delivery and imaging vehicles, which are activated in the body at a tissue of interest by focused ultrasound. In one aspect, a drug delivery vehicle can include a carrier having an outer membrane that envelopes an acoustic sensitizer particle and a payload substance to be delivered to the target tissue. The outer membrane can protect the acoustic sensitizer particle and the payload substance from degradation and opsonization. The outer membrane can be functionalized with a tumor targeting ligand to cause the drug delivery vehicle to selectively accumulate in a tumor region over other tissues, as well as with an agent to increase circulation time by reducing uptake from undesired body tissues, organs, and systems.

    摘要翻译： 公开了用于实施和制造药物递送和成像载体的技术，系统，装置和材料，其通过聚焦超声在感兴趣的组织在体内被激活。 在一个方面，药物递送载体可以包括具有外膜的载体，其包围声敏剂颗粒和有效载体物质被输送到目标组织。 外膜可以保护声学敏化剂颗粒和有效载荷物质免于降解和调理。 外膜可以用肿瘤靶向配体进行功能化，以使药物递送媒介物在其他组织上选择性地积聚在肿瘤区域中，以及通过减少来自不期望的身体组织，器官和系统的摄取而增加循环时间的试剂 。

    Sphingolipids polyalkylamine conjugates for use in transfection
    3.
    发明授权
    Sphingolipids polyalkylamine conjugates for use in transfection 失效
    用于转染的鞘脂聚烷基胺共轭物

    公开(公告)号：US08242089B2

    公开(公告)日：2012-08-14

    申请号：US10560932

    申请日：2004-06-17

    申请人： Yechezkel Barenholz ,  Dmitri Simberg

    发明人： Yechezkel Barenholz ,  Dmitri Simberg

    IPC分类号： A61K48/00 ,  A61K9/127 ,  C12N15/00 ,  C12N15/88

    CPC分类号： A61K31/132 ,  A61K9/1272 ,  A61K38/47 ,  A61K39/39 ,  A61K48/0041 ,  A61K2039/543 ,  A61K2039/55555 ,  A61K2039/55561 ,  C07C271/20 ,  C12N15/88 ,  A61K2300/00

    摘要： The present invention concerns the use of a sphingoid-polyalkylamine conjugate comprising a sphingoid backbone carrying, via a carbamoyl bond, at least one polyalkylamine chains as a capturing agent of nucleic acid molecules. The present invention also provides the use of the sphingoid polyalkylamine conjugate for the preparation of a pharmaceutical composition for the delivery of a nucleic acid molecule into a target cell. In a further aspect the invention provides a method for transfecting a nucleic acid into a target cell, the method comprises contacting said target cell with the sphingoid-polyalkylamine conjugate associated with a nucleic acid molecule, thereby transfecting said target cell with said nucleic acid molecule. Other aspects of the invention concern pharmaceutical compositions comprising said conjugate, therapeutic methods as well as kits, making use of the said conjugate. A preferred conjugate according to the invention is N-palmitoyl D-erythrosphingosyl-1-carbamoyl spermine.

    摘要翻译： 本发明涉及包含通过氨基甲酰键携带至少一个聚烷基胺链作为核酸分子的捕获剂的鞘氨醇主链的鞘氨醇 - 多烷基胺缀合物的用途。 本发明还提供了鞘氨醇多烷基胺缀合物用于制备用于将核酸分子递送至靶细胞的药物组合物的用途。 在另一方面，本发明提供了将核酸转染到靶细胞中的方法，所述方法包括使所述靶细胞与与核酸分子相关联的类鞘氨醇 - 多烷基胺缀合物接触，由此用所述核酸分子转染所述靶细胞。 本发明的其它方面涉及包含所述缀合物的药物组合物，治疗方法以及使用所述缀合物的试剂盒。 根据本发明的优选的缀合物是N-棕榈酰基D-赤藻酰基-1-氨基甲酰基精胺。

    Methods and compositions related to clot binding compounds
    6.
    发明授权
    Methods and compositions related to clot binding compounds 有权
    与凝块结合化合物相关的方法和组合物

    公开(公告)号：US09101671B2

    公开(公告)日：2015-08-11

    申请号：US11967509

    申请日：2007-12-31

    申请人： Erkki Ruoslahti ,  Dmitri Simberg

    发明人： Erkki Ruoslahti ,  Dmitri Simberg

    IPC分类号： A61K39/00 ,  A61K47/48 ,  A61K49/18 ,  B82Y5/00

    CPC分类号： A61K47/48861 ,  A61K47/48238 ,  A61K47/48815 ,  A61K47/48884 ,  A61K47/62 ,  A61K47/6911 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1863 ,  A61K49/1866 ,  B82Y5/00 ,  Y10T428/2984

    摘要： Disclosed are compositions and methods related to clot binding compounds. For example, disclosed are conjugates comprising a surface molecule and a plurality of clot binding compounds. The clot binding compounds can selectively bind to clotted plasma protein. The conjugate can, for example, cause clotting and amplify the accumulation of the conjugate in tumors. In one example, the conjugate can comprise a sufficient number and composition of clot binding compounds such that the conjugate causes clotting and amplifies the accumulation of the conjugate in tumors. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.

    摘要翻译： 公开了与凝块结合化合物相关的组合物和方法。 例如，公开了包含表面分子和多个凝块结合化合物的缀合物。 凝块结合化合物可以选择性地结合凝血的血浆蛋白。 结合物可以例如引起凝血并且扩增缀合物在肿瘤中的积累。 在一个实例中，缀合物可以包含足够数量和组合物的凝块结合化合物，使得缀合物引起凝血并扩增缀合物在肿瘤中的积累。 所公开的靶向对于治疗癌症和其它疾病和病症是有用的。

    Layered particles for retrieving DNA released from cells from a gastrointestinal tract sample and methods for making and using them
    8.
    发明授权
    Layered particles for retrieving DNA released from cells from a gastrointestinal tract sample and methods for making and using them 有权

    公开(公告)号：US09730637B2

    公开(公告)日：2017-08-15

    申请号：US14238189

    申请日：2012-08-17

    申请人： Dmitri Simberg ,  Yu-Tsueng Liu

    发明人： Dmitri Simberg ,  Yu-Tsueng Liu

    IPC分类号： G01N21/75 ,  B01D35/00 ,  C12M1/00 ,  A61B5/00 ,  C12Q1/68 ,  A61B5/145 ,  A61B5/1473 ,  A61B10/00

    CPC分类号： A61B5/6861 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/4848 ,  A61B10/0045 ,  A61B2010/0061 ,  C12Q1/6806 ,  C12Q2563/143 ,  C12Q2563/155

    摘要： In alternative embodiments, the invention provides compositions such as devices, pills, beads, capsules, products of manufacture, particles, microparticles, nanoparticles, gels, liquid gels, liquid gel capsules, capsules, tablets, geltabs, liquids, sprays, emulsions, suspensions, pastes or yogurts, for the detection and isolation of biomarkers, nucleic acids, proteins or peptides, proteoglycans, lipids, fats, sugars or polysaccharides in the gastrointestinal tract for e.g., detecting the presence of particular exogenous or endogenous nucleic acids, e.g., DNA or RNA, or proteins, in the gastrointestinal tract, for example, to diagnose the presence of an infectious or exogenous agent such as a virus, a fungus, a parasite, a bacteria, intestinal helminths and protozoan parasites, and the like, or a biomarker such as a cancer-causing or cancer-predisposing allele, e.g., mutations of the KRAS2 oncogene in pancreatic cancer. In alternative embodiments, compositions of the invention comprise magnetic particles such as a magnetically-responsive microparticle or nanoparticle; a superparamagnetic bead or polystyrene bead; a superparamagnetic fine particle; a ferrimagnetic particle; or, a magnetic microsphere, nanosphere, microbead or nanobeads. In alternative embodiments, the invention provides methods for detecting, retrieving, capturing or isolating a sample of a nucleic acid, or an anionic, cationic or hydrophobic protein or peptide, a mucin, a phosphoprotein, a proteoglycan or a polysaccharide, in vivo.

    COMPOSITIONS AND DEVICES FOR THE DETECTION OF BIOMARKERS IN THE GASTROINTESTINAL TRACT AND METHODS FOR MAKING AND USING THEM
    9.
    发明申请
    COMPOSITIONS AND DEVICES FOR THE DETECTION OF BIOMARKERS IN THE GASTROINTESTINAL TRACT AND METHODS FOR MAKING AND USING THEM 有权
    用于检测气体诱导物中生物标志物的组合物和装置及其制备和使用它们的方法

    公开(公告)号：US20140288398A1

    公开(公告)日：2014-09-25

    申请号：US14238189

    申请日：2012-08-17

    申请人： Dmitri Simberg ,  Yu-Tsueng Liu

    发明人： Dmitri Simberg ,  Yu-Tsueng Liu

    IPC分类号： A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B10/00

    CPC分类号： A61B5/6861 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/4848 ,  A61B10/0045 ,  A61B2010/0061 ,  C12Q1/6806 ,  C12Q2563/143 ,  C12Q2563/155

    摘要： In alternative embodiments, the invention provides compositions such as devices, pills, beads, capsules, products of manufacture, particles, microparticles, nanoparticles, gels, liquid gels, liquid gel capsules, capsules, tablets, geltabs, liquids, sprays, emulsions, suspensions, pastes or yogurts, for the detection and isolation of biomarkers, nucleic acids, proteins or peptides, proteoglycans, lipids, fats, sugars or polysaccharides in the gastrointestinal tract for e.g., detecting the presence of particular exogenous or endogenous nucleic acids, e.g., DNA or RNA, or proteins, in the gastrointestinal tract, for example, to diagnose the presence of an infectious or exogenous agent such as a virus, a fungus, a parasite, a bacteria, intestinal helminths and protozoan parasites, and the like, or a biomarker such as a cancer-causing or cancer-predisposing allele, e.g., mutations of the KRAS2 oncogene in pancreatic cancer. In alternative embodiments, compositions of the invention comprise magnetic particles such as a magnetically-responsive microparticle or nanoparticle; a superparamagnetic bead or polystyrene bead; a superparamagnetic fine particle; a ferrimagnetic particle; or, a magnetic microsphere, nanosphere, microbead or nanobeads. In alternative embodiments, the invention provides methods for detecting, retrieving, capturing or isolating a sample of a nucleic acid, or an anionic, cationic or hydrophobic protein or peptide, a mucin, a phosphoprotein, a proteoglycan or a polysaccharide, in vivo.

    摘要翻译： 在替代实施方案中，本发明提供组合物，例如装置，丸剂，珠粒，胶囊，制造产品，颗粒，微粒，纳米颗粒，凝胶，液体凝胶，液体凝胶胶囊，胶囊，片剂，凝胶胶囊，液体，喷雾剂，乳液，悬浮液 用于检测和分离胃肠道中的生物标志物，核酸，蛋白质或肽，蛋白聚糖，脂质，脂肪，糖或多糖的例如检测特定的外源或内源核酸的存在，例如DNA 或RNA或蛋白质，例如诊断感染性或外源性药物如病毒，真菌，寄生虫，细菌，肠蠕虫和原生动物寄生虫等的存在，或 生物标志物如癌症或癌症易感性等位基因，例如胰腺癌中KRAS2致癌基因的突变。 在替代实施方案中，本发明的组合物包含磁性颗粒，例如磁响应微粒或纳米颗粒; 超顺磁珠或聚苯乙烯珠; 超顺磁细粒; 亚铁磁颗粒; 或磁性微球，纳米球，微珠或纳米棒。 在替代实施方案中，本发明提供了用于在体内检测，检索，捕获或分离核酸或阴离子，阳离子或疏水蛋白或肽，粘蛋白，磷蛋白，蛋白多糖或多糖的样品的方法。