公开(公告)号：US07485315B2

公开(公告)日：2009-02-03

申请号：US10179231

申请日：2002-06-26

Applicant: Carole Guiramand ,  Dominique Caplain ,  Véronique Chevalier ,  Jean-Thierry Simonnet ,  Pascal Richart

Inventor： Carole Guiramand ,  Dominique Caplain ,  Véronique Chevalier ,  Jean-Thierry Simonnet ,  Pascal Richart

IPC: A61K8/02 ,  A61K31/19 ,  A61K31/16

CPC classification number: A61Q19/08 ,  A61K8/37 ,  A61K8/44 ,  A61K8/4953 ,  A61K8/63 ,  A61K31/506 ,  A61K31/5685 ,  A61K31/616 ,  A61K2800/59 ,  A61Q5/08 ,  A61Q19/00 ,  A61Q19/02

Abstract: The invention relates to a process for dissolving at least one compound of low solubility in water, the said process comprising the essential step of mixing the compound of low solubility with at least one lipophilic amino acid derivative. The invention also relates to a cosmetic or dermatological composition comprising, in a physiologically acceptable medium, at least one compound of low solubility and at least one lipophilic amino acid derivative. Among the compounds of low solubility that are especially included are aminophenol derivatives, salicylic acid derivatives, 2-amino-4-alkylaminopyrimidine 3-oxide derivatives and DHEA, and also its chemical or metabolic derivatives and precursors.

Abstract translation: 本发明涉及将至少一种低溶解度的化合物溶于水的方法，所述方法包括将低溶解度化合物与至少一种亲脂性氨基酸衍生物混合的必要步骤。 本发明还涉及化妆品或皮肤病学组合物，其在生理学上可接受的介质中包含至少一种低溶解度的化合物和至少一种亲脂性氨基酸衍生物。 特别包括的低溶解性化合物是氨基苯酚衍生物，水杨酸衍生物，2-氨基-4-烷基氨基嘧啶3-氧化物衍生物和DHEA，以及其化学或代谢衍生物和前体。

公开(公告)号：US20070148771A1

公开(公告)日：2007-06-28

申请号：US11634078

申请日：2006-12-06

Applicant: Melanie Chopart ,  Isabelle Castiel ,  Jean-Thierry Simonnet

Inventor： Melanie Chopart ,  Isabelle Castiel ,  Jean-Thierry Simonnet

IPC: C12N5/08

CPC classification number: A61K8/68 ,  A61K8/14 ,  A61Q19/005 ,  C12N5/0698 ,  C12N2500/36 ,  C12N2500/38 ,  C12N2502/094 ,  C12N2502/1323 ,  Y10S514/943

Abstract: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7 and/or 5.5 compound into the culture medium of such reconstructed epidermis/skin equivalent and/or topically applying onto the face surface of such reconstructed epidermis/skin equivalent a composition which comprises lipid lamellar vesicles incorporating at least one ceramide 7 and/or 5.5 compound.

Abstract translation: 补充有至少一种神经酰胺7和/或5.5化合物的重建表皮/皮肤当量，其适于增强正常人表皮的屏障功能并改善干性皮肤和重建的皮肤或皮肤等同物的屏障功能，通过引入 所述至少一种神经酰胺7和/或5.5化合物进入这种重建的表皮/皮肤等效的培养基中和/或局部施用于这种重建的表皮/皮肤等效物的表面上，该组合物包含掺入至少一种神经酰胺的脂质层状囊泡 7和/或5.5化合物。

公开(公告)号：US07169382B2

公开(公告)日：2007-01-30

申请号：US10766016

申请日：2004-01-29

Applicant: Mélanie Chopart ,  Isabelle Castiel ,  Jean-Thierry Simonnet

Inventor： Mélanie Chopart ,  Isabelle Castiel ,  Jean-Thierry Simonnet

IPC: A61K7/48 ,  A61K7/00 ,  A61K47/22 ,  A61K45/00 ,  C12N5/08

CPC classification number: A61K8/68 ,  A61K8/14 ,  A61Q19/005 ,  C12N5/0698 ,  C12N2500/36 ,  C12N2500/38 ,  C12N2502/094 ,  C12N2502/1323 ,  Y10S514/943

Abstract: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7 and/or 5.5 compound into the culture medium of such reconstructed epidermis/skin equivalent and/or topically applying onto the face surface of such reconstructed epidermis/skin equivalent a composition which comprises lipid lamellar vesicles incorporating at least one ceramide 7 and/or 5.5 compound.

Abstract translation: 补充有至少一种神经酰胺7和/或5.5化合物的重建表皮/皮肤当量，其适于增强正常人表皮的屏障功能并改善干性皮肤和重建的皮肤或皮肤等同物的屏障功能，通过引入 所述至少一种神经酰胺7和/或5.5化合物进入这种重建的表皮/皮肤等效的培养基中和/或局部施用于这种重建的表皮/皮肤等效物的表面上，该组合物包含掺入至少一种神经酰胺的脂质层状囊泡 7和/或5.5化合物。

公开(公告)号：US07153494B2

公开(公告)日：2006-12-26

申请号：US10688937

申请日：2003-10-21

Applicant: Sandrine Chodorowski-Kimmes ,  Francis Xavier Quinn ,  Jean-Thierry Simonnet

Inventor： Sandrine Chodorowski-Kimmes ,  Francis Xavier Quinn ,  Jean-Thierry Simonnet

IPC: A61Q19/04 ,  A61Q19/00 ,  A61K31/74 ,  A61K8/02 ,  A61K8/00

CPC classification number: A61K8/35 ,  A61K8/90 ,  A61K2800/52 ,  A61Q17/04

Abstract: Topically applicable photostable sunscreen/photoprotective compositions contain at least one dibenzoylmethane UV-sunscreen and an effective photostabilizing amount therefor of at least one amphiphilic block copolymer which comprises at least one nonionic hydrophilic polymer block and at least one hydrophobic polymer block, formulated into a topically applicable, cosmetically acceptable medium therefor.

Abstract translation: 局部适用的光稳定防晒剂/光保护组合物含有至少一种二苯甲酰甲烷紫外线防晒剂和至少一种两亲性嵌段共聚物的有效光稳定剂，其包含至少一种非离子亲水性聚合物嵌段和至少一种疏水性聚合物嵌段，其配制成局部适用的 ，化妆品可接受的介质。

公开(公告)号：US20060263438A1

公开(公告)日：2006-11-23

申请号：US11434828

申请日：2006-05-17

Applicant: Bruno Biatry ,  Jean-Thierry Simonnet

Inventor： Bruno Biatry ,  Jean-Thierry Simonnet

IPC: A61K9/50 ,  A61K9/16

CPC classification number: A61Q19/00 ,  A61K8/025 ,  A61K8/31 ,  A61K8/37 ,  A61K8/44 ,  A61K8/8152 ,  A61K8/88 ,  A61K9/0014 ,  A61K9/1617 ,  A61K9/5123 ,  A61K2800/412 ,  A61K2800/614 ,  A61Q19/008

Abstract: The present invention relates to calibrated and spherical oily particles comprising at least one oily phase structured with at least one gelling polymer, characterized in that they have a mean size of less than or equal to 15 μm, in that the said structured oily phase has a melting point of greater than or equal to 40° C. and in that their circularity index is between 0.9 and 1.

Abstract translation: 本发明涉及校准的和球形的油性颗粒，其包含至少一个由至少一种胶凝聚合物构成的油相，其特征在于它们具有小于或等于15μm的平均尺寸，因为所述结构化的油相具有 熔点大于或等于40℃，其圆形度指数在0.9和1之间。

公开(公告)号：US06461625B1

公开(公告)日：2002-10-08

申请号：US09489839

申请日：2000-01-24

Applicant: Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

Inventor： Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

IPC: A61K600

CPC classification number: C07D401/06 ,  Y10S514/844 ,  Y10S514/873 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939

Abstract: A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising a surfactant chosen from the alkoxylated alkenyl succinates, the alkoxylated alkenyl succinates of glucose and the alkoxylated alkenyl succinates of methylglucose, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition or an ophthalmological composition.

Abstract translation: 纳米乳剂，其平均粒径小于100nm的纳米乳液，包含选自烷氧基化烯基琥珀酸盐，葡萄糖的烷氧基化烯基琥珀酸盐和甲基葡萄糖的烷氧基化烯基琥珀酸盐的表面活性剂，以及至少一种具有分子 重量大于400，油相量与表面活性剂的重量比为2至10.所获得的乳液在储存时是透明和稳定的。 它可以包含大量的油，同时保持良好的透明度并且同时具有良好的化妆品性质。 它可以构成用于局部使用的组合物，药物组合物或眼科学组合物。

公开(公告)号：US06375960B1

公开(公告)日：2002-04-23

申请号：US09474074

申请日：1999-12-29

Applicant: Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

Inventor： Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

IPC: A61K600

CPC classification number: A61Q19/00 ,  A61K8/06 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/262 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q19/007 ,  B01F17/0021 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/937 ,  Y10S514/938

Abstract: The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one surfactant that is solid at a temperature of less than or equal to 45° C. and which is selected from the group including ethoxylated fatty ethers and ethoxylated fatty esters, and mixtures thereof; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion, and methods for its use. The emulsion is ideally transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in compositions, including topical, pharmaceutical, cosmetic, opthalmic, ophthalmologic. The composition is also particularly useful in applications to the skin, hair, scalp, mucous membranes, and eyes.

Abstract translation: 本发明提供一种纳米乳液，其包括：分散在水相中的油相; 和至少一种在小于或等于45℃的温度下为固体的表面活性剂，并且其选自乙氧基化脂肪醚和乙氧基化脂肪酯，以及它们的混合物; 其中油相包括数均分子量小于100nm的油球;其中油相包含至少一种分子量大于400的油; 并且其中油相与表面活性剂的重量比为2至10.本发明还提供了制备纳米乳液的方法及其使用方法。 乳液在储存时理想的透明和稳定。 它理想地含有大量的油，同时保持良好的透明度和良好的化妆品性能。 纳米乳液在组合物中特别有用，包​​括局部，药物，化妆品，眼科，眼科学。 该组合物在对皮肤，毛发，头皮，粘膜和眼睛的应用中也特别有用。

公开(公告)号：US6022559A

公开(公告)日：2000-02-08

申请号：US978377

申请日：1997-11-25

Applicant: Jean-Thierry Simonnet

Inventor： Jean-Thierry Simonnet

IPC: A61K9/127 ,  A61K8/00 ,  A61K8/14 ,  A61K8/37 ,  A61K8/39 ,  A61K8/72 ,  A61K8/73 ,  A61K8/81 ,  A61K8/85 ,  A61K8/87 ,  A61K8/98 ,  A61K47/30 ,  A61Q5/00 ,  A61Q19/08 ,  A61K6/00 ,  A61K7/06

CPC classification number: A61Q5/00 ,  A61K8/14 ,  A61K8/85 ,  A61Q19/08

Abstract: A dispersion, in an aqueous medium, of dehydration-resistant vesicles containing a lipid phase and an encapsulated aqueous phase. The dispersion additionally contains, either in the aqueous medium or in the encapsulated aqueous phase or in both, at least one polymer, in the form of particles, which has a glass transition temperature Tg, in the presence or absence of a plasticizing agent, of lower than 70.degree. C. at 0% relative humidity. The dispersion can be used in the cosmetic or pharmaceutical fields for topical application for the care and/or makeup of the skin and for care of the scalp and/or hair.

Abstract translation: 在含水介质中的含有脂质相和封装水相的耐脱水小泡的分散体。 该分散体在含水介质或包封的水相中或在两者中还含有颗粒形式的至少一种聚合物，其在存在或不存在增塑剂的情况下具有玻璃化转变温度Tg， 在0％相对湿度下低于70℃。 分散体可用于化妆品或药物领域，用于局部应用于皮肤护理和/或化妆以及护理头皮和/或头发。

公开(公告)号：US5679691A

公开(公告)日：1997-10-21

申请号：US597101

申请日：1996-02-06

Applicant: Alain Ribier ,  Quang Lan Nguyen ,  Jean-Thierry Simonnet ,  Boudiaf Boussouira

Inventor： Alain Ribier ,  Quang Lan Nguyen ,  Jean-Thierry Simonnet ,  Boudiaf Boussouira

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/06 ,  A61K8/11 ,  A61K8/14 ,  A61K8/19 ,  A61K8/34 ,  A61K8/37 ,  A61K8/39 ,  A61K8/40 ,  A61K8/44 ,  A61K8/49 ,  A61K8/60 ,  A61K8/64 ,  A61K8/66 ,  A61K8/67 ,  A61K8/72 ,  A61K8/73 ,  A61K8/86 ,  A61K8/92 ,  A61K8/97 ,  A61K9/127 ,  A61K31/135 ,  A61K31/15 ,  A61K31/42 ,  A61K31/44 ,  A61K31/445 ,  A61P17/00 ,  A61P17/10 ,  A61P43/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/40 ,  A61K7/42

CPC classification number: B82Y5/00 ,  A61K31/135 ,  A61K31/15 ,  A61K31/42 ,  A61K31/445 ,  A61K8/14 ,  A61K8/4926 ,  A61K9/1272 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  Y10S977/778 ,  Y10S977/78 ,  Y10S977/926

Abstract: The invention relates to the use of a spin trap employed as an electron paramagnetic resonance measurement probe, in a cosmetic or dermatological composition for the light-protective, anti-ageing and/or anti-acne treatment of the skin. In particular, this spin trap is encapsulated in lipid vesicles which are capable of diffusing into the deep layers of the skin.

Abstract translation: 本发明涉及在化妆品或皮肤病学组合物中用作电子顺磁共振测量探针的自旋阱，其用于皮肤的光保护性，抗老化和/或抗痤疮治疗。 特别地，该自旋捕获器被包封在能够扩散到皮肤深层的脂质囊泡中。

公开(公告)号：US5601833A

公开(公告)日：1997-02-11

申请号：US366741

申请日：1994-12-30

Applicant: Alain Ribier ,  Jean-Thierry Simonnet ,  Elisabeth Picard ,  Jacqueline Griat

Inventor： Alain Ribier ,  Jean-Thierry Simonnet ,  Elisabeth Picard ,  Jacqueline Griat

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/14 ,  A61K8/25 ,  A61K8/34 ,  A61K8/37 ,  A61K8/39 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K8/55 ,  A61K8/58 ,  A61K8/60 ,  A61K8/64 ,  A61K8/66 ,  A61K8/67 ,  A61K8/68 ,  A61K8/72 ,  A61K8/73 ,  A61K8/88 ,  A61K8/92 ,  A61K8/96 ,  A61K8/97 ,  A61K8/98 ,  A61Q17/00 ,  A61Q19/00 ,  A61K9/127

CPC classification number: A61K8/4926 ,  A61K8/14 ,  A61K8/42 ,  A61K8/49 ,  A61K8/673 ,  A61K8/678 ,  A61Q17/00 ,  A61Q19/00 ,  A61K2800/59

Abstract: Compositions comprising a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent chosen from anti-oxygenated-free-radical agents, proteins, sugars, enzymes, vitamins, nucleotides and sequences thereof, trace elements, coenzymes, unsaturated fatty acid-rich phospholipids, silicon derivatives and plant extracts, for treating these deep layers, and a second dispersion of lipid vesicles which are capable of penetrating into the surface layers of the skin and which contain at least one active agent chosen from screening agents, anti-oxygenated-free-radical agents, sugars, amino acids, vitamins, ceramides, unsaponifiable products derived from plant oils, and components of sweat, for treating these surface layers, are effective protecting, nourishing and/or firming the skin.

Abstract translation: 包含脂质囊泡的第一分散体的组合物，其能够渗入皮肤的深层并且含有至少一种选自抗氧合自由基剂，蛋白质，糖，酶，维生素，核苷酸和序列的活性剂 微量元素，辅酶，富含不饱和脂肪酸的磷脂，硅衍生物和植物提取物，用于处理这些深层，以及脂质囊泡的第二分散体，其能够渗透到皮肤的表层中并且至少含有 选自筛选剂，抗氧化自由基剂，糖，氨​​基酸，维生素，神经酰胺，来源于植物油的不皂化物和用于处理这些表面层的汗液成分的一种活性剂是有效的保护，滋养和 /或使皮肤紧致。